iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-027846

Ensembl Protein ID

ENSDARP00000044330.6

UniProt Accession

B0R171; B0R171_DANRE

Genbank Protein ID

AAI60653.1

Protein Name

Coatomer subunit beta'

Genbank Nucleotide ID

AL953896

Gene Name

copb2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000038743.5	ENSDART00000044331.6	ENSDARP00000044330.6

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.60e-32	111.0	227	257
UBD/Beta-Prp	4.70e-72	243.6	13	288

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gH+  v+c++f ++ +++++Gs Dgt+++W 
   Q: 227  GHAQNVSCVNFhPElPIIITGSEDGTVRIWH 257
           8***********999***************6 PP

UBD/Beta-Prp

   S: 8    hhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkgheds 96
           ++++++++v+ +p++++++++ ++g++ vw+ +t++l+++++ ++ +v+a kf  ++++ +tg++D+ i+v++++t + vh +++h+d+
   Q: 13   ARSDRVKSVDLHPSEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRASKFVARKNWVITGADDMQIRVFNYNTLERVHMFEAHSDY 101
           67899************************************************************************************ PP
   S: 97   vlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltgghtdsvy 184
           +++++++p++ ++++ s+d  i++wd+e+++  +++++gh++ v+ +v++p++ n ++s+slDrt+++W+l + +   tl+g h++ v+
   Q: 102  IRCIAVHPTQPYILTSSDDMLIKLWDWEKKWSCSQVFEGHTHYVMQIVINPKDnNQFASASLDRTIKVWQLGSSSPNFTLEG-HDKGVN 189
           *******************************9999**********************************************9.****** PP
   S: 185  slsfdsng..kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisva 271
           ++++ s g  ++l+sg++d+ vk+wd+q+++cv+tl+gh +nv++v+f+p+  ++++gs+Dg++riW + +  l +tl++  ++v++v+
   Q: 190  CIDYYSGGdkPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCVNFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVS 278
           ***8887777******************************************************************************* PP
   S: 272  vlsfgdnvlv 281
           +l+ +++v +
   Q: 279  GLRGSNSVAL 288
           *877776654 PP

Organism

Danio rerio

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

Protein Sequence
(Fasta)

MPLRLDIKRK LTARSDRVKS VDLHPSEPWM LASLYNGSVC VWNHETQTLV KTFEVCDLPV 60
RASKFVARKN WVITGADDMQ IRVFNYNTLE RVHMFEAHSD YIRCIAVHPT QPYILTSSDD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTGCATTGA GGAAGTTCCA CGTCACATTT GTCTGCTGTG CACAAAACTG CAGCCGTAAA 60
AACACATCAG ACTCTCACTG TGGATGATAT AAAAACATTG CAGCTGAAGG AGACCAAACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR006692--Coatomer_WD-assoc_reg
IPR016453--COPB2
IPR020472--G-protein_beta_WD-40_rep
IPR011044--Quino_amine_DH_bsu
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF04053--Coatomer_WDAD
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0006891--P:intra-Golgi vesicle-mediated transport
GO:0006886--P:intracellular protein transport
GO:0030903--P:notochord development
GO:0006890--P:retrograde vesicle-mediated transport, Golgi to ER
GO:0061053--P:somite development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000654	Aegilops tauschii	53.27	0.00e+00	940.00
IUUC-Aml-002154	Ailuropoda melanoleuca	87.42	0.00e+00	1677.00
IUUC-Atr-003090	Amborella trichopoda	58.78	0.00e+00	1071.00
IUUC-Apl-003976	Anas platyrhynchos	93.59	0.00e+00	1701.00
IUUC-Aca-004301	Anolis carolinensis	94.44	0.00e+00	1689.00
IUUC-Aly-006508	Arabidopsis lyrata	61.47	0.00e+00	1096.00
IUUC-Ath-007630	Arabidopsis thaliana	61.99	0.00e+00	1111.00
IUUC-Ago-007914	Ashbya gossypii	46.45	0.00e+00	757.00
IUUC-Acl-008237	Aspergillus clavatus	56.25	0.00e+00	966.00
IUUC-Afl-008535	Aspergillus flavus	55.88	0.00e+00	914.00
IUUC-Afu-008845	Aspergillus fumigatus	55.44	0.00e+00	937.00
IUUC-Ani-009135	Aspergillus nidulans	55.95	0.00e+00	918.00
IUUC-Ang-009654	Aspergillus niger	55.60	0.00e+00	857.00
IUUC-Aor-009939	Aspergillus oryzae	53.46	0.00e+00	971.00
IUUC-Ate-010355	Aspergillus terreus	54.57	0.00e+00	918.00
IUUC-Ame-010922	Astyanax mexicanus	87.83	0.00e+00	1564.00
IUUC-Bgr-012249	Blumeria graminis	54.45	0.00e+00	923.00
IUUC-Bta-013579	Bos taurus	95.51	0.00e+00	1446.00
IUUC-Bci-013866	Botrytis cinerea	55.54	0.00e+00	924.00
IUUC-Bdi-015046	Brachypodium distachyon	61.36	0.00e+00	1104.00
IUUC-Bol-016271	Brassica oleracea	61.84	0.00e+00	1115.00
IUUC-Bra-016617	Brassica rapa	61.86	0.00e+00	1082.00
IUUC-Cel-018387	Caenorhabditis elegans	64.89	0.00e+00	1180.00
IUUC-Cja-019145	Callithrix jacchus	87.75	0.00e+00	1681.00
IUUC-Cfa-020564	Canis familiaris	93.85	0.00e+00	1678.00
IUUC-Cpo-022201	Cavia porcellus	91.08	0.00e+00	1675.00
IUUC-Cre-022938	Chlamydomonas reinhardtii	59.20	0.00e+00	990.00
IUUC-Csa-023383	Chlorocebus sabaeus	94.18	0.00e+00	1148.00
IUUC-Cho-024454	Choloepus hoffmanni	88.71	0.00e+00	1368.00
IUUC-Cin-025681	Ciona intestinalis	77.97	0.00e+00	1380.00
IUUC-Csv-026012	Ciona savignyi	73.02	0.00e+00	1364.00
IUUC-Cgl-026649	Colletotrichum gloeosporioides	52.62	0.00e+00	847.00
IUUC-Cne-026986	Cryptococcus neoformans	50.97	0.00e+00	912.00
IUUC-Cme-027219	Cyanidioschyzon merolae	48.00	0.00e+00	854.00
IUUC-Dor-030462	Dipodomys ordii	89.32	0.00e+00	1239.00
IUUC-Dse-031268	Dothistroma septosporum	54.85	0.00e+00	952.00
IUUC-Dme-031791	Drosophila melanogaster	72.02	0.00e+00	1269.00
IUUC-Ete-033166	Echinops telfairi	84.77	0.00e+00	985.00
IUUC-Eca-034180	Equus caballus	91.24	0.00e+00	1620.00
IUUC-Eeu-035086	Erinaceus europaeus	75.17	0.00e+00	800.00
IUUC-Fca-036265	Felis catus	87.58	0.00e+00	1683.00
IUUC-Fal-037202	Ficedula albicollis	93.73	0.00e+00	1645.00
IUUC-Fox-037711	Fusarium oxysporum	55.62	0.00e+00	885.00
IUUC-Fso-038268	Fusarium solani	55.25	0.00e+00	884.00
IUUC-Gmo-039046	Gadus morhua	94.79	0.00e+00	1697.00
IUUC-Ggr-039863	Gaeumannomyces graminis	55.36	0.00e+00	904.00
IUUC-Gga-041112	Gallus gallus	93.48	0.00e+00	1702.00
IUUC-Gac-041733	Gasterosteus aculeatus	94.94	0.00e+00	1665.00
IUUC-Gma-042910	Glycine max	62.76	0.00e+00	1123.00
IUUC-Ggo-044984	Gorilla gorilla	87.22	0.00e+00	1672.00
IUUC-Hsa-046698	Homo sapiens	87.22	0.00e+00	1672.00
IUUC-Hvu-047669	Hordeum vulgare	70.34	1.00e-167	582.00
IUUC-Itr-048212	Ictidomys tridecemlineatus	93.96	0.00e+00	1675.00
IUUC-Kpa-049265	Komagataella pastoris	49.69	0.00e+00	870.00
IUUC-Lch-050473	Latimeria chalumnae	89.00	0.00e+00	1710.00
IUUC-Lpe-051579	Leersia perrieri	61.35	0.00e+00	1093.00
IUUC-Loc-052675	Lepisosteus oculatus	94.56	0.00e+00	1725.00
IUUC-Lma-053218	Leptosphaeria maculans	54.84	0.00e+00	923.00
IUUC-Laf-053757	Loxodonta africana	87.70	0.00e+00	1668.00
IUUC-Mcc-054859	Macaca mulatta	87.65	0.00e+00	1679.00
IUUC-Meu-056174	Macropus eugenii	90.81	0.00e+00	717.00
IUUC-Mor-057264	Magnaporthe oryzae	55.69	0.00e+00	889.00
IUUC-Mpo-057538	Magnaporthe poae	55.61	0.00e+00	917.00
IUUC-Mtr-058310	Medicago truncatula	62.76	0.00e+00	1131.00
IUUC-Mla-058937	Melampsora laricipopulina	53.71	0.00e+00	909.00
IUUC-Mga-059875	Meleagris gallopavo	93.26	0.00e+00	1696.00
IUUC-Mvi-060240	Microbotryum violaceum	49.76	0.00e+00	902.00
IUUC-Mmr-061261	Microcebus murinus	87.97	0.00e+00	1684.00
IUUC-Mdo-062076	Monodelphis domestica	92.93	0.00e+00	1693.00
IUUC-Mmu-063324	Mus musculus	87.90	0.00e+00	1679.00
IUUC-Mac-064636	Musa acuminata	60.89	0.00e+00	1085.00
IUUC-Mpu-065961	Mustela putorius furo	87.65	0.00e+00	1677.00
IUUC-Mlu-067059	Myotis lucifugus	92.71	0.00e+00	1623.00
IUUC-Nfi-068277	Neosartorya fischeri	55.15	0.00e+00	927.00
IUUC-Ncr-068659	Neurospora crassa	53.41	0.00e+00	918.00
IUUC-Nle-069034	Nomascus leucogenys	87.43	0.00e+00	1679.00
IUUC-Opr-070334	Ochotona princeps	94.83	0.00e+00	1480.00
IUUC-Ont-071563	Oreochromis niloticus	90.72	0.00e+00	1726.00
IUUC-Oan-073416	Ornithorhynchus anatinus	93.78	0.00e+00	1608.00
IUUC-Ocu-074522	Oryctolagus cuniculus	87.97	0.00e+00	1678.00
IUUC-Oba-075760	Oryza barthii	60.34	0.00e+00	1079.00
IUUC-Obr-076201	Oryza brachyantha	61.96	0.00e+00	1104.00
IUUC-Ogl-077450	Oryza glaberrima	61.43	0.00e+00	1107.00
IUUC-Ogu-078994	Oryza glumaepatula	60.34	0.00e+00	1077.00
IUUC-Oin-079856	Oryza indica	60.63	0.00e+00	1077.00
IUUC-Olo-080731	Oryza longistaminata	59.76	0.00e+00	1065.00
IUUC-Ome-081762	Oryza meridionalis	56.60	0.00e+00	1001.00
IUUC-Oni-082324	Oryza nivara	60.34	0.00e+00	1080.00
IUUC-Opu-083400	Oryza punctata	58.67	0.00e+00	1064.00
IUUC-Oru-084829	Oryza rufipogon	60.34	0.00e+00	1080.00
IUUC-Osa-086026	Oryza sativa	61.43	0.00e+00	1108.00
IUUC-Ola-087245	Oryzias latipes	90.72	0.00e+00	1723.00
IUUC-Olu-087655	Ostreococcus lucimarinus	59.98	0.00e+00	1056.00
IUUC-Oga-088163	Otolemur garnettii	84.57	0.00e+00	1609.00
IUUC-Oar-089842	Ovis aries	91.09	0.00e+00	1679.00
IUUC-Ptr-090501	Pan troglodytes	87.33	0.00e+00	1674.00
IUUC-Pan-092011	Papio anubis	87.65	0.00e+00	1680.00
IUUC-Psi-093308	Pelodiscus sinensis	94.35	0.00e+00	1694.00
IUUC-Pma-094695	Petromyzon marinus	76.95	0.00e+00	1456.00
IUUC-Pno-094785	Phaeosphaeria nodorum	62.07	3.00e-111	396.00
IUUC-Ppa-095911	Physcomitrella patens	61.11	0.00e+00	1127.00
IUUC-Pfo-096587	Poecilia formosa	89.51	0.00e+00	1728.00
IUUC-Pab-097926	Pongo abelii	85.62	0.00e+00	1585.00
IUUC-Pop-099634	Populus trichocarpa	62.27	0.00e+00	1111.00
IUUC-Pca-100965	Procavia capensis	92.30	0.00e+00	1634.00
IUUC-Ppe-101470	Prunus persica	62.39	0.00e+00	1117.00
IUUC-Pva-102451	Pteropus vampyrus	88.42	0.00e+00	1231.00
IUUC-Pgr-103453	Puccinia graminis	53.14	0.00e+00	922.00
IUUC-Ptt-103868	Puccinia triticina	53.56	0.00e+00	920.00
IUUC-Pte-104274	Pyrenophora teres	55.51	0.00e+00	953.00
IUUC-Pyt-104794	Pyrenophora triticirepentis	55.11	0.00e+00	905.00
IUUC-Rno-105979	Rattus norvegicus	81.28	0.00e+00	1228.00
IUUC-Sce-106269	Saccharomyces cerevisiae	47.17	0.00e+00	785.00
IUUC-Sha-106905	Sarcophilus harrisii	92.82	0.00e+00	1693.00
IUUC-Sja-107838	Schizosaccharomyces japonicus	48.23	0.00e+00	840.00
IUUC-Spo-108299	Schizosaccharomyces pombe	46.65	0.00e+00	826.00
IUUC-Smo-108695	Selaginella moellendorffii	62.22	0.00e+00	1083.00
IUUC-Sit-110239	Setaria italica	61.55	0.00e+00	1108.00
IUUC-Sly-111775	Solanum lycopersicum	60.26	0.00e+00	1102.00
IUUC-Stu-112906	Solanum tuberosum	60.00	0.00e+00	996.00
IUUC-Sar-113472	Sorex araneus	87.70	0.00e+00	1128.00
IUUC-Sbi-114052	Sorghum bicolor	63.83	0.00e+00	1117.00
IUUC-Sre-115040	Sporisorium reilianum	51.92	0.00e+00	914.00
IUUC-Ssc-115593	Sus scrofa	87.75	0.00e+00	1679.00
IUUC-Tgu-117239	Taeniopygia guttata	93.19	0.00e+00	1702.00
IUUC-Tru-118025	Takifugu rubripes	94.10	0.00e+00	1716.00
IUUC-Tsy-118824	Tarsius syrichta	86.78	0.00e+00	1135.00
IUUC-Tni-120142	Tetraodon nigroviridis	93.76	0.00e+00	1707.00
IUUC-Tca-121613	Theobroma cacao	61.91	0.00e+00	1112.00
IUUC-Tre-122072	Trichoderma reesei	54.56	0.00e+00	933.00
IUUC-Tvi-122546	Trichoderma virens	54.99	0.00e+00	919.00
IUUC-Tae-125292	Triticum aestivum	62.02	0.00e+00	1100.00
IUUC-Tur-126283	Triticum urartu	54.37	0.00e+00	940.00
IUUC-Tme-127041	Tuber melanosporum	56.41	0.00e+00	977.00
IUUC-Tbe-127770	Tupaia belangeri	89.16	0.00e+00	1242.00
IUUC-Ttr-129294	Tursiops truncatus	87.54	0.00e+00	1676.00
IUUC-Uma-129351	Ustilago maydis	50.79	0.00e+00	905.00
IUUC-Vda-129716	Verticillium dahliae	55.49	0.00e+00	955.00
IUUC-Vpa-130037	Vicugna pacos	76.78	0.00e+00	832.00
IUUC-Vvi-131689	Vitis vinifera	61.86	0.00e+00	1110.00
IUUC-Xtr-132633	Xenopus tropicalis	92.78	0.00e+00	1659.00
IUUC-Xma-133347	Xiphophorus maculatus	91.09	0.00e+00	1738.00
IUUC-Yli-134455	Yarrowia lipolytica	50.51	0.00e+00	841.00
IUUC-Zma-135867	Zea mays	64.00	0.00e+00	1113.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence