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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106269
UUCD1 version UUC-SaC-00148
Ensembl Protein ID YGL137W
UniProt Accession P41811; D6VU12; COPB2_YEAST
Genbank Protein ID AAA61711.1; CAA63359.1; CAA96848.1; DAA07973.1
Protein Name Coatomer subunit beta'; Beta'-coat protein
Genbank Nucleotide ID U11237; X92670; Z72659; BK006941
Gene Name SEC27; YGL137W; G2827
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YGL137W YGL137W YGL137W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
BioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Beta-Prp Beta-Prp 21070969
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 8.60e-32 106.3 183 221
UBD/Beta-Prp 1.30e-81 272.5 5 305
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf...sd.tllvsGsdDgtikvWDlrtgvll 36
           ++ +v+ +++   +d ++++++sdD tik+WD+ t  ++
   Q: 183  QERGVNYVDYyplPDkPYMITASDDLTIKIWDYQTKSCV 221
           56789999988**999****************9998886 PP
   

   UBD/Beta-Prp
   S: 2    iktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsf 102
           ik+ +++++++++ ++f+p +++++t+ ++g++++w+++t+  +rs++  e +v+a kf+ ++++++ gs+D  i+v++++tg+ v+ +++h d+++s+++
   Q: 5    IKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFIARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAV 105
           56778999********************************************************************************************* PP
   S: 103  spsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsng..kelvsgsl 200
           +p++ +++sGs+d t+++w++e+++ le+t++gh+++v+cv+++p++ + ++sG+lDrtv++W+l + +   tlt g+++ v+ +++ +    ++++++s+
   Q: 106  HPTKPYVLSGSDDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDpSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPdkPYMITASD 206
           **************************************************************************999*********7754344******** PP
   S: 201  dgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkknep 299
           d t+k+wd+qt++cv tl+gh +nv+   f+p   +++sgs+Dg+++iW++ + ++ ktl+   ++++++a++  g++++++ ++d+ + +++l ++ep
   Q: 207  DLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEP 305
           ************************************************************************8888999999999********999876 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
 The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Protein Sequence
(Fasta)
MKLDIKKTFS NRSDRVKGID FHPTEPWVLT TLYSGRVELW NYETQVEVRS IQVTETPVRA 60
GKFIARKNWI IVGSDDFRIR VFNYNTGEKV VDFEAHPDYI RSIAVHPTKP YVLSGSDDLT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106269|UBD,Beta-Prp;E3,WD_repeat|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAAGTTGG ATATAAAGGT ATGTTACCAG AGCGCGTTTT GCCAATGCAA TTGCGAACAA 60
GCTCCGACAA CTCCTATGAT TAGGAAATGA TCTCGTTCGC GAAGAATACA AAGCCTGCAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106269|UBD,Beta-Prp;E3,WD_repeat|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0903--Direct protein sequencing
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR006692--Coatomer_WD-assoc_reg
IPR016453--COPB2
IPR020472--G-protein_beta_WD-40_rep
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF04053--Coatomer_WDAD
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0043130--F:ubiquitin binding
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0006891--P:intra-Golgi vesicle-mediated transport
GO:0006886--P:intracellular protein transport
GO:0032511--P:late endosome to vacuole transport via multivesicular body sorting pathway
GO:0006890--P:retrograde vesicle-mediated transport, Golgi to ER
KEGG sce:YGL137W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000654 Aegilops tauschii 40.14 1.00e-173 601.00
IUUC-Aml-002154 Ailuropoda melanoleuca 47.30 0.00e+00 790.00
IUUC-Atr-003090 Amborella trichopoda 47.54 0.00e+00 746.00
IUUC-Apl-003976 Anas platyrhynchos 47.55 0.00e+00 786.00
IUUC-Aca-004301 Anolis carolinensis 47.43 0.00e+00 786.00
IUUC-Aly-005643 Arabidopsis lyrata 47.22 0.00e+00 726.00
IUUC-Ath-007630 Arabidopsis thaliana 47.61 0.00e+00 740.00
IUUC-Ago-007914 Ashbya gossypii 69.28 0.00e+00 1212.00
IUUC-Acl-008237 Aspergillus clavatus 50.61 0.00e+00 862.00
IUUC-Afl-008535 Aspergillus flavus 50.26 0.00e+00 818.00
IUUC-Afu-008845 Aspergillus fumigatus 50.97 0.00e+00 849.00
IUUC-Ani-009135 Aspergillus nidulans 50.74 0.00e+00 839.00
IUUC-Ang-009654 Aspergillus niger 54.68 0.00e+00 784.00
IUUC-Aor-009939 Aspergillus oryzae 50.67 0.00e+00 881.00
IUUC-Ate-010355 Aspergillus terreus 51.09 0.00e+00 843.00
IUUC-Ame-010922 Astyanax mexicanus 42.73 0.00e+00 676.00
IUUC-Bgr-012249 Blumeria graminis 51.30 0.00e+00 833.00
IUUC-Bta-013579 Bos taurus 46.77 0.00e+00 717.00
IUUC-Bci-013866 Botrytis cinerea 52.33 0.00e+00 824.00
IUUC-Bdi-015046 Brachypodium distachyon 45.52 0.00e+00 741.00
IUUC-Bol-016271 Brassica oleracea 47.36 0.00e+00 751.00
IUUC-Bra-017758 Brassica rapa 47.10 0.00e+00 748.00
IUUC-Cel-018387 Caenorhabditis elegans 44.06 0.00e+00 734.00
IUUC-Cja-019145 Callithrix jacchus 47.30 0.00e+00 791.00
IUUC-Cfa-020564 Canis familiaris 47.30 0.00e+00 791.00
IUUC-Cpo-022201 Cavia porcellus 47.04 0.00e+00 787.00
IUUC-Cre-022938 Chlamydomonas reinhardtii 46.15 0.00e+00 695.00
IUUC-Csa-023383 Chlorocebus sabaeus 50.00 0.00e+00 627.00
IUUC-Cho-024454 Choloepus hoffmanni 44.28 0.00e+00 685.00
IUUC-Cin-025681 Ciona intestinalis 46.98 0.00e+00 728.00
IUUC-Csv-026012 Ciona savignyi 47.11 0.00e+00 726.00
IUUC-Cgl-026649 Colletotrichum gloeosporioides 48.27 0.00e+00 744.00
IUUC-Cne-026986 Cryptococcus neoformans 47.77 0.00e+00 796.00
IUUC-Cme-027219 Cyanidioschyzon merolae 40.62 0.00e+00 667.00
IUUC-Dre-027846 Danio rerio 47.17 0.00e+00 786.00
IUUC-Dor-030462 Dipodomys ordii 44.46 0.00e+00 627.00
IUUC-Dse-031268 Dothistroma septosporum 49.82 0.00e+00 838.00
IUUC-Dme-031791 Drosophila melanogaster 45.09 0.00e+00 729.00
IUUC-Ete-033166 Echinops telfairi 45.09 1.00e-148 518.00
IUUC-Eca-034180 Equus caballus 46.23 0.00e+00 756.00
IUUC-Eeu-035086 Erinaceus europaeus 35.85 2.00e-72 265.00
IUUC-Fca-036265 Felis catus 47.30 0.00e+00 790.00
IUUC-Fal-037202 Ficedula albicollis 46.88 0.00e+00 743.00
IUUC-Fox-037711 Fusarium oxysporum 52.08 0.00e+00 785.00
IUUC-Fso-038268 Fusarium solani 52.07 0.00e+00 796.00
IUUC-Gmo-039046 Gadus morhua 47.30 0.00e+00 781.00
IUUC-Ggr-039863 Gaeumannomyces graminis 50.68 0.00e+00 797.00
IUUC-Gga-041112 Gallus gallus 46.92 0.00e+00 783.00
IUUC-Gac-041733 Gasterosteus aculeatus 47.17 0.00e+00 763.00
IUUC-Gma-042910 Glycine max 47.55 0.00e+00 756.00
IUUC-Ggo-044984 Gorilla gorilla 47.30 0.00e+00 791.00
IUUC-Hsa-046698 Homo sapiens 47.30 0.00e+00 790.00
IUUC-Hvu-047669 Hordeum vulgare 54.19 4.00e-120 422.00
IUUC-Itr-048212 Ictidomys tridecemlineatus 47.30 0.00e+00 790.00
IUUC-Kpa-049265 Komagataella pastoris 54.42 0.00e+00 967.00
IUUC-Lch-050473 Latimeria chalumnae 47.30 0.00e+00 786.00
IUUC-Lpe-051579 Leersia perrieri 46.98 0.00e+00 739.00
IUUC-Loc-052675 Lepisosteus oculatus 48.06 0.00e+00 791.00
IUUC-Lma-053218 Leptosphaeria maculans 51.60 0.00e+00 835.00
IUUC-Laf-053757 Loxodonta africana 47.43 0.00e+00 788.00
IUUC-Mcc-054859 Macaca mulatta 47.30 0.00e+00 791.00
IUUC-Meu-056174 Macropus eugenii 38.75 1.00e-64 239.00
IUUC-Mor-057264 Magnaporthe oryzae 52.31 0.00e+00 795.00
IUUC-Mpo-057538 Magnaporthe poae 51.29 0.00e+00 817.00
IUUC-Mtr-058310 Medicago truncatula 47.68 0.00e+00 760.00
IUUC-Mla-058937 Melampsora laricipopulina 49.38 0.00e+00 794.00
IUUC-Mga-059875 Meleagris gallopavo 47.18 0.00e+00 780.00
IUUC-Mvi-060240 Microbotryum violaceum 49.12 0.00e+00 779.00
IUUC-Mmr-061261 Microcebus murinus 47.30 0.00e+00 791.00
IUUC-Mdo-062076 Monodelphis domestica 47.17 0.00e+00 789.00
IUUC-Mmu-063324 Mus musculus 47.17 0.00e+00 790.00
IUUC-Mac-064636 Musa acuminata 46.23 0.00e+00 733.00
IUUC-Mpu-065961 Mustela putorius furo 47.30 0.00e+00 790.00
IUUC-Mlu-067059 Myotis lucifugus 46.73 0.00e+00 770.00
IUUC-Nfi-068277 Neosartorya fischeri 50.85 0.00e+00 842.00
IUUC-Ncr-068659 Neurospora crassa 52.55 0.00e+00 865.00
IUUC-Nle-069034 Nomascus leucogenys 47.30 0.00e+00 791.00
IUUC-Opr-070334 Ochotona princeps 47.74 0.00e+00 753.00
IUUC-Ont-071563 Oreochromis niloticus 47.04 0.00e+00 781.00
IUUC-Oan-073416 Ornithorhynchus anatinus 46.35 0.00e+00 741.00
IUUC-Ocu-074522 Oryctolagus cuniculus 47.30 0.00e+00 789.00
IUUC-Oba-075760 Oryza barthii 46.22 0.00e+00 724.00
IUUC-Obr-076163 Oryza brachyantha 47.61 0.00e+00 741.00
IUUC-Ogl-077450 Oryza glaberrima 46.98 0.00e+00 749.00
IUUC-Ogu-078994 Oryza glumaepatula 46.22 0.00e+00 723.00
IUUC-Oin-079856 Oryza indica 47.59 0.00e+00 737.00
IUUC-Olo-080731 Oryza longistaminata 46.68 0.00e+00 709.00
IUUC-Ome-081762 Oryza meridionalis 43.48 0.00e+00 655.00
IUUC-Oni-082324 Oryza nivara 46.22 0.00e+00 723.00
IUUC-Opu-083400 Oryza punctata 46.15 0.00e+00 724.00
IUUC-Oru-084829 Oryza rufipogon 46.22 0.00e+00 724.00
IUUC-Osa-086026 Oryza sativa 47.10 0.00e+00 752.00
IUUC-Ola-087245 Oryzias latipes 46.67 0.00e+00 778.00
IUUC-Olu-087655 Ostreococcus lucimarinus 48.24 0.00e+00 760.00
IUUC-Oga-088163 Otolemur garnettii 45.90 0.00e+00 754.00
IUUC-Oar-089842 Ovis aries 47.04 0.00e+00 788.00
IUUC-Ptr-090501 Pan troglodytes 47.30 0.00e+00 791.00
IUUC-Pan-092011 Papio anubis 47.30 0.00e+00 790.00
IUUC-Psi-093308 Pelodiscus sinensis 47.55 0.00e+00 786.00
IUUC-Pma-094695 Petromyzon marinus 45.05 0.00e+00 714.00
IUUC-Pno-094785 Phaeosphaeria nodorum 57.24 3.00e-100 357.00
IUUC-Ppa-095638 Physcomitrella patens 48.61 0.00e+00 762.00
IUUC-Pfo-096587 Poecilia formosa 47.04 0.00e+00 782.00
IUUC-Pab-097926 Pongo abelii 46.62 0.00e+00 730.00
IUUC-Pop-099634 Populus trichocarpa 46.85 0.00e+00 750.00
IUUC-Pca-100965 Procavia capensis 46.67 0.00e+00 761.00
IUUC-Ppe-101470 Prunus persica 47.61 0.00e+00 756.00
IUUC-Pva-102451 Pteropus vampyrus 45.07 0.00e+00 627.00
IUUC-Pgr-103453 Puccinia graminis 48.77 0.00e+00 795.00
IUUC-Ptt-103868 Puccinia triticina 49.08 0.00e+00 798.00
IUUC-Pte-104274 Pyrenophora teres 51.87 0.00e+00 868.00
IUUC-Pyt-104794 Pyrenophora triticirepentis 49.76 0.00e+00 814.00
IUUC-Rno-105979 Rattus norvegicus 40.08 8.00e-172 595.00
IUUC-Sha-106905 Sarcophilus harrisii 47.17 0.00e+00 789.00
IUUC-Sja-107838 Schizosaccharomyces japonicus 46.77 0.00e+00 748.00
IUUC-Spo-108299 Schizosaccharomyces pombe 46.16 0.00e+00 766.00
IUUC-Smo-108695 Selaginella moellendorffii 46.81 0.00e+00 723.00
IUUC-Sit-110239 Setaria italica 47.04 0.00e+00 750.00
IUUC-Sly-111775 Solanum lycopersicum 46.62 0.00e+00 752.00
IUUC-Stu-112906 Solanum tuberosum 46.71 0.00e+00 671.00
IUUC-Sar-113472 Sorex araneus 43.65 3.00e-161 560.00
IUUC-Sbi-114052 Sorghum bicolor 46.85 0.00e+00 753.00
IUUC-Sre-115040 Sporisorium reilianum 49.25 0.00e+00 764.00
IUUC-Ssc-115593 Sus scrofa 47.17 0.00e+00 789.00
IUUC-Tgu-117239 Taeniopygia guttata 47.43 0.00e+00 786.00
IUUC-Tru-118025 Takifugu rubripes 47.04 0.00e+00 786.00
IUUC-Tsy-118824 Tarsius syrichta 44.24 1.00e-166 577.00
IUUC-Tni-120142 Tetraodon nigroviridis 46.92 0.00e+00 776.00
IUUC-Tca-121613 Theobroma cacao 46.85 0.00e+00 748.00
IUUC-Tre-122072 Trichoderma reesei 51.23 0.00e+00 830.00
IUUC-Tvi-122546 Trichoderma virens 51.60 0.00e+00 833.00
IUUC-Tae-125488 Triticum aestivum 46.68 0.00e+00 741.00
IUUC-Tur-126283 Triticum urartu 40.55 1.00e-173 601.00
IUUC-Tme-127041 Tuber melanosporum 53.12 0.00e+00 870.00
IUUC-Tbe-127770 Tupaia belangeri 47.04 0.00e+00 665.00
IUUC-Ttr-129294 Tursiops truncatus 47.17 0.00e+00 787.00
IUUC-Uma-129351 Ustilago maydis 46.87 0.00e+00 759.00
IUUC-Vda-129716 Verticillium dahliae 52.85 0.00e+00 865.00
IUUC-Vpa-130037 Vicugna pacos 37.94 3.00e-84 304.00
IUUC-Vvi-131689 Vitis vinifera 47.10 0.00e+00 748.00
IUUC-Xtr-132633 Xenopus tropicalis 45.42 0.00e+00 777.00
IUUC-Xma-133347 Xiphophorus maculatus 47.17 0.00e+00 783.00
IUUC-Yli-134455 Yarrowia lipolytica 52.29 0.00e+00 847.00
IUUC-Zma-135867 Zea mays 47.10 0.00e+00 754.00
Created Date 25-Jun-2017

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