iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-064066

Ensembl Protein ID

ENSMUSP00000028259.5

UniProt Accession

Q8R5F7; A2AUY7; Q3U6S2; Q68EM4; Q8BYC9; Q8BZ01; Q8K5C7; Q8R144; Q8VE79; Q99KS4; Q9D2Z5; IFIH1_MOUSE

Genbank Protein ID

AAL77205.1; AAM21359.1; BAB31303.2; BAC29687.2; BAC30614.1; BAE31652.1; CAM21790.1; AAH04031.1; AAH19605.1; AAH25508.1; AAH80200.1

Protein Name

Interferon-induced helicase C domain-containing protein 1; Helicase with 2 CARD domains; Interferon induced with helicase C domain protein 1; Melanoma differentiation-associated protein 5; RIG-I-like receptor 2

Genbank Nucleotide ID

AY075132; AF374384; AK018602; AK037057; AK040519; AK153018; AL929246; BC004031; BC019605; BC025508; BC080200

Gene Name

Ifih1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000026896.14	ENSMUST00000028259.11	ENSMUSP00000028259.5
ENSMUSG00000026896.14	ENSMUST00000112459.3	ENSMUSP00000108078.3

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/CARD	1.10e-33	116.7	111	182

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/CARD

   S: 2    deeyrlllstlqdrvrklLdvtdvldkylseflleeekelilaaaetkgnmqaaelLLktLvqkegWfrefl 73
           ++e + ll +lq++++++L++ dvld + +  ll+ e+++++ aa ++gn++++++LL ++vqke+Wf++fl
   Q: 111  HDECLHLLTLLQPTLVDKLLINDVLDTCFEKGLLTVEDRNRISAAGNSGNESGVRELLRRIVQKENWFSTFL 182
           89********************************************************************96 PP

Organism

Mus musculus

Functional Description
(View)

Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV), mengo encephalomyocarditis virus (ENMG), and theiler's murine encephalomyelitis virus (TMEV). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.

Protein Sequence
(Fasta)

MSIVCSAEDS FRNLILFFRP RLKMYIQVEP VLDHLIFLSA ETKEQILKKI NTCGNTSAAE 60
LLLSTLEQGQ WPLGWTQMFV EALEHSGNPL AARYVKPTLT DLPSPSSETA HDECLHLLTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTGACGTTA GGAAAGTCTG GAGAAGAGAA TCGAAACAGA AACCGATCTG TGGGTGGAAG 60
GCAATACTTA AAGCTCCCTG AGGGTGAACG TCCCAGCGGC CGCAGAGCGA GAGCGGTCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0051--Antiviral defense
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0347--Helicase
KW-0378--Hydrolase
KW-0391--Immunity
KW-0399--Innate immunity
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0832--Ubl conjugation
KW-0862--Zinc

Interpro

IPR031964--CARD_dom
IPR011029--DEATH-like_dom
IPR006935--Helicase/UvrB_N
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR021673--RLR_CTR

PROSITE

PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS51789--RLR_CTR

Pfam

PF16739--CARD_2
PF00271--Helicase_C
PF04851--ResIII
PF11648--RIG-I_C-RD

SMART

SM00487--DEXDc
SM00490--HELICc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0003677--F:DNA binding
GO:0003725--F:double-stranded RNA binding
GO:0004386--F:helicase activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0003727--F:single-stranded RNA binding
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0039530--P:MDA-5 signaling pathway
GO:0032727--P:positive regulation of interferon-alpha production
GO:0032728--P:positive regulation of interferon-beta production
GO:0016925--P:protein sumoylation
GO:0009615--P:response to virus

KEGG

mmu:71586

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001336	Ailuropoda melanoleuca	77.65	0.00e+00	1509.00
IUUC-Apl-003900	Anas platyrhynchos	60.64	0.00e+00	1194.00
IUUC-Aca-005329	Anolis carolinensis	58.42	0.00e+00	1015.00
IUUC-Ame-011305	Astyanax mexicanus	47.07	0.00e+00	860.00
IUUC-Bta-012361	Bos taurus	77.30	0.00e+00	1469.00
IUUC-Cja-018760	Callithrix jacchus	78.36	0.00e+00	1497.00
IUUC-Cfa-020321	Canis familiaris	76.76	0.00e+00	1453.00
IUUC-Cpo-022450	Cavia porcellus	73.32	0.00e+00	1456.00
IUUC-Cre-022916	Chlamydomonas reinhardtii	34.19	8.00e-13	69.70
IUUC-Csa-024194	Chlorocebus sabaeus	79.43	0.00e+00	1489.00
IUUC-Cho-024364	Choloepus hoffmanni	68.83	0.00e+00	969.00
IUUC-Dre-028305	Danio rerio	54.27	0.00e+00	709.00
IUUC-Dno-029831	Dasypus novemcinctus	77.07	0.00e+00	1512.00
IUUC-Dor-030410	Dipodomys ordii	73.58	0.00e+00	1182.00
IUUC-Ete-032950	Echinops telfairi	71.72	1.00e-178	620.00
IUUC-Eca-034279	Equus caballus	78.45	0.00e+00	1487.00
IUUC-Eeu-034678	Erinaceus europaeus	73.98	0.00e+00	1468.00
IUUC-Fca-035618	Felis catus	82.25	0.00e+00	935.00
IUUC-Fal-037106	Ficedula albicollis	67.82	0.00e+00	968.00
IUUC-Gmo-038598	Gadus morhua	48.61	0.00e+00	669.00
IUUC-Gga-040467	Gallus gallus	60.47	0.00e+00	1163.00
IUUC-Gac-042316	Gasterosteus aculeatus	48.18	0.00e+00	858.00
IUUC-Ggo-045461	Gorilla gorilla	79.92	0.00e+00	1477.00
IUUC-Hsa-045771	Homo sapiens	78.65	0.00e+00	1474.00
IUUC-Itr-048762	Ictidomys tridecemlineatus	78.17	0.00e+00	1498.00
IUUC-Lch-049913	Latimeria chalumnae	65.57	0.00e+00	922.00
IUUC-Loc-052768	Lepisosteus oculatus	53.73	0.00e+00	996.00
IUUC-Laf-053933	Loxodonta africana	78.09	0.00e+00	1484.00
IUUC-Mcc-054695	Macaca mulatta	79.53	0.00e+00	1494.00
IUUC-Meu-056829	Macropus eugenii	70.91	0.00e+00	1083.00
IUUC-Mga-059205	Meleagris gallopavo	60.60	0.00e+00	1153.00
IUUC-Mvi-060497	Microbotryum violaceum	33.33	3.00e-17	84.70
IUUC-Mmr-060703	Microcebus murinus	78.46	0.00e+00	1461.00
IUUC-Mdo-063079	Monodelphis domestica	68.87	0.00e+00	1384.00
IUUC-Mpu-066261	Mustela putorius furo	76.53	0.00e+00	1448.00
IUUC-Mlu-068196	Myotis lucifugus	77.38	0.00e+00	1468.00
IUUC-Nfi-068405	Neosartorya fischeri	24.70	6.00e-24	107.00
IUUC-Nle-069479	Nomascus leucogenys	77.00	0.00e+00	1445.00
IUUC-Opr-070717	Ochotona princeps	69.24	0.00e+00	1062.00
IUUC-Ont-071702	Oreochromis niloticus	47.12	0.00e+00	873.00
IUUC-Oan-073639	Ornithorhynchus anatinus	64.26	0.00e+00	1150.00
IUUC-Ocu-074521	Oryctolagus cuniculus	77.88	0.00e+00	1517.00
IUUC-Ola-086351	Oryzias latipes	45.41	0.00e+00	815.00
IUUC-Oga-088539	Otolemur garnettii	77.17	0.00e+00	1472.00
IUUC-Oar-090186	Ovis aries	77.77	0.00e+00	1450.00
IUUC-Ptr-090575	Pan troglodytes	77.10	0.00e+00	1448.00
IUUC-Pan-092371	Papio anubis	79.63	0.00e+00	1493.00
IUUC-Psi-093072	Pelodiscus sinensis	62.27	0.00e+00	1214.00
IUUC-Pma-094345	Petromyzon marinus	43.23	4.00e-95	341.00
IUUC-Pfo-096401	Poecilia formosa	51.74	0.00e+00	674.00
IUUC-Pab-097623	Pongo abelii	78.75	0.00e+00	1488.00
IUUC-Pca-100993	Procavia capensis	70.70	0.00e+00	1199.00
IUUC-Pva-102227	Pteropus vampyrus	73.78	0.00e+00	1369.00
IUUC-Rno-105198	Rattus norvegicus	93.18	0.00e+00	1915.00
IUUC-Sha-107622	Sarcophilus harrisii	69.64	0.00e+00	1382.00
IUUC-Sar-113625	Sorex araneus	80.12	2.00e-149	523.00
IUUC-Tgu-117486	Taeniopygia guttata	58.62	0.00e+00	1106.00
IUUC-Tru-118445	Takifugu rubripes	45.30	0.00e+00	824.00
IUUC-Tsy-119512	Tarsius syrichta	78.17	0.00e+00	1419.00
IUUC-Tni-120711	Tetraodon nigroviridis	44.25	0.00e+00	834.00
IUUC-Tre-122194	Trichoderma reesei	35.00	8.00e-13	70.10
IUUC-Tbe-127644	Tupaia belangeri	69.95	0.00e+00	1306.00
IUUC-Ttr-128989	Tursiops truncatus	74.46	0.00e+00	1459.00
IUUC-Vpa-130587	Vicugna pacos	73.94	0.00e+00	1194.00
IUUC-Xtr-132127	Xenopus tropicalis	52.20	0.00e+00	979.00
IUUC-Xma-133493	Xiphophorus maculatus	45.85	0.00e+00	818.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence