iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-044692

UUCD1 version

UUC-GoG-00492

Ensembl Protein ID

ENSGGOP00000012529.2

UniProt Accession

G3RAQ2; G3RAQ2_GORGO

Protein Name

Uncharacterized protein

Gene Name

HERC2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000012785.2	ENSGGOT00000012891.2	ENSGGOP00000012529.2
ENSGGOG00000012785.2	ENSGGOT00000026446.1	ENSGGOP00000017742.1
ENSGGOG00000012785.2	ENSGGOT00000022760.1	ENSGGOP00000027692.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.10e-84	284.2	4171	4500

Active Site

Position(s)	Description	Evidence
4469	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgrll 88
           ++++v+fvgE++ d+gG  +e +a++++elqn  ++l+  ++n++ +   n+d +l +p      h ++F+flG+llg+a+++g  l
   Q: 4171 RVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLSPaarapVHSSMFRFLGVLLGIAIRTGSHL 4257
           4566****************************************************99999999*********************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
            l+l+++++k+l g +l++ dl+evd++++  l++i++n+ ++ e +++ l f+     +++++ +++  +++++++t +N+ eYv+
   Q: 4258 SLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMSLPFT-----VPSASGQDIQLSSKHTHITLDNRAEYVR 4339
           ***************************************9999999999***99.....788999999******************* PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           l ++yrl+e ++eqv+a+reG+++v+p  llslFt  ele+++cG+++i ++ lk+ ++ykg +++  + iqwFwev+e+fs++e +
   Q: 4340 LAINYRLHE-FDEQVAAVREGMSRVVPVPLLSLFTGYELETMVCGSPDILLHLLKSVATYKG-IEPPASLIQWFWEVMESFSNTEHS 4424
           *********.**************************************************77.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirk....dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
            fL+Fv+g+ rlP + +a+++ r fvi+     +  d+ lP+s TCf++LkLP+Ys k++l+ekL yAi+ +k++++
   Q: 4425 LFLRFVWGRTRLP-RTIADFRGRDFVIQVldkyNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDT 4500
           *************.8*************999988888***********************************99875 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

LAFTRDGLCG LWNEMVKDGE IVYTGTESTQ NGELPPRKDD SVEPSGTKKE DLNDKEKKDE 60
EETPAPIYRA KSILDSWVWG KQPDVNELKE CLSVLVKEQQ ALAVQSATTT LSALRLKQRL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTGCATTCA CAAGAGATGG GCTCTGTGGT CTGTGGAATG AAATGGTTAA AGATGGAGAA 60
ATTGTATACA CTGGAACAGA ATCAACCCAG AACGGAGAGC TCCCTCCTAG AAAAGGTAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004939--APC_su10/DOC_dom
IPR016186--C-type_lectin-like/link
IPR021097--CPH_domain
IPR001199--Cyt_B5-like_heme/steroid-bd
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR014722--Rib_L2_dom2
IPR000433--Znf_ZZ

PROSITE

PS50255--CYTOCHROME_B5_2
PS51284--DOC
PS50237--HECT
PS51416--MIB_HERC2
PS00626--RCC1_2
PS50012--RCC1_3
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00173--Cyt-b5
PF00632--HECT
PF06701--MIB_HERC2
PF00415--RCC1
PF00569--ZZ

PRINTS

PR00633--RCCNDNSATION

SMART

SM01337--APC10
SM01117--Cyt-b5
SM00119--HECTc
SM00291--ZnF_ZZ

Gene Ontology

GO:0005743--C:mitochondrial inner membrane
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007283--P:spermatogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002112	Ailuropoda melanoleuca	97.53	0.00e+00	4335.00
IUUC-Atr-003065	Amborella trichopoda	35.29	4.00e-51	196.00
IUUC-Apl-003983	Anas platyrhynchos	94.62	0.00e+00	4207.00
IUUC-Aca-004300	Anolis carolinensis	93.56	0.00e+00	4161.00
IUUC-Aly-006441	Arabidopsis lyrata	34.15	1.00e-44	175.00
IUUC-Ame-010621	Astyanax mexicanus	90.53	0.00e+00	4023.00
IUUC-Bta-013067	Bos taurus	96.43	0.00e+00	4268.00
IUUC-Bdi-014093	Brachypodium distachyon	33.25	2.00e-49	191.00
IUUC-Bol-015203	Brassica oleracea	34.55	1.00e-52	201.00
IUUC-Bra-016737	Brassica rapa	34.55	4.00e-48	186.00
IUUC-Cja-019687	Callithrix jacchus	98.10	0.00e+00	4284.00
IUUC-Cfa-020672	Canis familiaris	97.22	0.00e+00	4325.00
IUUC-Cpo-021819	Cavia porcellus	93.04	0.00e+00	4066.00
IUUC-Csa-023817	Chlorocebus sabaeus	99.21	0.00e+00	4383.00
IUUC-Cho-024387	Choloepus hoffmanni	96.77	0.00e+00	1420.00
IUUC-Cin-025709	Ciona intestinalis	54.32	0.00e+00	2191.00
IUUC-Csv-026336	Ciona savignyi	53.78	0.00e+00	2207.00
IUUC-Dre-027717	Danio rerio	89.30	0.00e+00	4000.00
IUUC-Dno-029296	Dasypus novemcinctus	96.17	0.00e+00	4284.00
IUUC-Dor-030979	Dipodomys ordii	90.26	0.00e+00	1831.00
IUUC-Dme-032171	Drosophila melanogaster	60.10	0.00e+00	1516.00
IUUC-Ete-032687	Echinops telfairi	84.30	0.00e+00	2820.00
IUUC-Eca-034046	Equus caballus	95.77	0.00e+00	4247.00
IUUC-Eeu-034859	Erinaceus europaeus	94.92	0.00e+00	1935.00
IUUC-Fca-036262	Felis catus	97.44	0.00e+00	4335.00
IUUC-Fal-037562	Ficedula albicollis	94.40	0.00e+00	4193.00
IUUC-Gmo-039054	Gadus morhua	85.71	0.00e+00	1033.00
IUUC-Gga-040359	Gallus gallus	94.44	0.00e+00	4182.00
IUUC-Gac-041879	Gasterosteus aculeatus	89.86	0.00e+00	1027.00
IUUC-Hsa-045995	Homo sapiens	99.47	0.00e+00	4392.00
IUUC-Hvu-047529	Hordeum vulgare	35.65	3.00e-49	190.00
IUUC-Itr-048553	Ictidomys tridecemlineatus	95.50	0.00e+00	1392.00
IUUC-Lch-049808	Latimeria chalumnae	87.01	0.00e+00	3343.00
IUUC-Lpe-051482	Leersia perrieri	33.94	4.00e-46	180.00
IUUC-Loc-052685	Lepisosteus oculatus	91.82	0.00e+00	4112.00
IUUC-Laf-053372	Loxodonta africana	96.43	0.00e+00	4266.00
IUUC-Mcc-054693	Macaca mulatta	99.03	0.00e+00	4376.00
IUUC-Meu-056660	Macropus eugenii	95.82	0.00e+00	1912.00
IUUC-Mga-059371	Meleagris gallopavo	94.10	0.00e+00	4168.00
IUUC-Mmr-060787	Microcebus murinus	98.37	0.00e+00	4366.00
IUUC-Mdo-062518	Monodelphis domestica	89.94	0.00e+00	3992.00
IUUC-Mmu-063690	Mus musculus	96.83	0.00e+00	4267.00
IUUC-Mpu-066478	Mustela putorius furo	96.26	0.00e+00	4270.00
IUUC-Mlu-067596	Myotis lucifugus	93.32	0.00e+00	2882.00
IUUC-Nle-069445	Nomascus leucogenys	97.97	0.00e+00	2221.00
IUUC-Opr-070990	Ochotona princeps	88.03	0.00e+00	2964.00
IUUC-Ont-072285	Oreochromis niloticus	90.44	0.00e+00	4018.00
IUUC-Oan-072721	Ornithorhynchus anatinus	86.37	0.00e+00	3435.00
IUUC-Ocu-074273	Oryctolagus cuniculus	97.71	0.00e+00	4324.00
IUUC-Oba-075573	Oryza barthii	33.68	2.00e-45	178.00
IUUC-Obr-076107	Oryza brachyantha	33.77	3.00e-50	194.00
IUUC-Ogl-077193	Oryza glaberrima	33.68	9.00e-46	179.00
IUUC-Ogu-078817	Oryza glumaepatula	33.68	2.00e-45	178.00
IUUC-Oin-079609	Oryza indica	32.75	1.00e-49	191.00
IUUC-Olo-080629	Oryza longistaminata	33.68	1.00e-45	178.00
IUUC-Ome-081686	Oryza meridionalis	33.68	4.00e-46	180.00
IUUC-Opu-084137	Oryza punctata	33.94	2.00e-46	181.00
IUUC-Oru-085013	Oryza rufipogon	33.68	2.00e-45	178.00
IUUC-Osa-085597	Oryza sativa	33.68	2.00e-45	178.00
IUUC-Ola-087346	Oryzias latipes	91.76	0.00e+00	1181.00
IUUC-Oga-088742	Otolemur garnettii	97.27	0.00e+00	4286.00
IUUC-Oar-090093	Ovis aries	96.74	0.00e+00	4285.00
IUUC-Ptr-091034	Pan troglodytes	91.80	0.00e+00	3989.00
IUUC-Pan-092783	Papio anubis	98.24	0.00e+00	4325.00
IUUC-Psi-094027	Pelodiscus sinensis	93.48	0.00e+00	4180.00
IUUC-Pfo-096208	Poecilia formosa	75.01	0.00e+00	2973.00
IUUC-Pab-097681	Pongo abelii	94.35	0.00e+00	2289.00
IUUC-Pca-100705	Procavia capensis	95.51	0.00e+00	1172.00
IUUC-Pva-103147	Pteropus vampyrus	86.35	0.00e+00	2366.00
IUUC-Rno-105458	Rattus norvegicus	97.00	0.00e+00	4256.00
IUUC-Sha-106959	Sarcophilus harrisii	89.06	0.00e+00	3878.00
IUUC-Sit-109917	Setaria italica	36.47	3.00e-48	187.00
IUUC-Sly-110961	Solanum lycopersicum	34.65	3.00e-53	203.00
IUUC-Sar-113532	Sorex araneus	84.62	0.00e+00	1810.00
IUUC-Sbi-114352	Sorghum bicolor	32.39	8.00e-50	192.00
IUUC-Ssc-115337	Sus scrofa	95.03	0.00e+00	2628.00
IUUC-Tgu-116789	Taeniopygia guttata	94.32	0.00e+00	4189.00
IUUC-Tru-118129	Takifugu rubripes	89.86	0.00e+00	4017.00
IUUC-Tsy-119302	Tarsius syrichta	85.20	0.00e+00	1276.00
IUUC-Tni-120374	Tetraodon nigroviridis	89.62	0.00e+00	4006.00
IUUC-Tca-121094	Theobroma cacao	35.31	8.00e-54	205.00
IUUC-Tae-124157	Triticum aestivum	33.51	1.00e-49	191.00
IUUC-Tur-126300	Triticum urartu	35.29	1.00e-49	192.00
IUUC-Tbe-128137	Tupaia belangeri	86.45	0.00e+00	2261.00
IUUC-Ttr-128273	Tursiops truncatus	89.42	0.00e+00	3860.00
IUUC-Vpa-130471	Vicugna pacos	83.17	0.00e+00	1472.00
IUUC-Xtr-132185	Xenopus tropicalis	90.10	0.00e+00	3944.00
IUUC-Xma-133233	Xiphophorus maculatus	90.48	0.00e+00	3985.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence