iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-060178

UUCD1 version

UUC-MeG-00826

Ensembl Protein ID

ENSMGAP00000005317.2

UniProt Accession

G1N1E1; G1N1E1_MELGA

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Gene Name

UCHL5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000005403.2	ENSMGAT00000006050.2	ENSMGAP00000005317.2
ENSMGAG00000005403.2	ENSMGAT00000020326.1	ENSMGAP00000017245.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	4.00e-89	299.0	1	296

Active Site

Position(s)	Description	Evidence
63	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
139	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 26   gvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvigNsCatyAllsvllncedk 114
           g+++  qvee++sL+pen++++ +pv+gl++lFk+++ +e +          +vv+++ ++tiffakqvi+N+Cat+A++svllnc ++
   Q: 1    GCRGA-QVEEIWSLEPENFEKL-KPVHGLIFLFKWQPGEEPAG---------SVVQDSRLDTIFFAKQVINNACATQAIVSVLLNCAHQ 78
           78899.****************.********************.........899********************************** PP
   S: 115  lldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyvningrlyeldglkpfPldl 203
            + lG+tls++ke+++++++ +k+lal+n++v++++hns+ar+++++ + + +++    +++afhfvsyv++ngrlyeldgl++ P+dl
   Q: 79   DIRLGETLSEFKEFSQSFDAAMKGLALSNSEVIRQVHNSFARQQMFEFDAKSSAK----EEDAFHFVSYVPVNGRLYELDGLREGPIDL 163
           *************************************************888776....89**************************** PP
   S: 204  gkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid.........keLlkLlkdieseeekieaqldde 283
           g+ ++++++ ++++ v+   +ri++++++eirfnl+aiv+dr++i+++r+  l+ +          +  ++l+ i+se++k+++ +++e
   Q: 164  GS-CNQDDWISAVRPVI--EKRIQKYSEGEIRFNLMAIVSDRKMIYEQRIAELQRQlaeeepmdtDQSSNMLSSIQSEVAKYQMLIEEE 249
           *9.78999*********..******************************977666567888888755678******************* PP
   S: 284  kekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefg 333
           ++k k++ki++irR++ny  fi++++k+la++++l  lve+      +++
   Q: 250  NQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKAK---EKQN 296
           ***************************************9942...2333 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

GCRGAQVEEI WSLEPENFEK LKPVHGLIFL FKWQPGEEPA GSVVQDSRLD TIFFAKQVIN 60
NACATQAIVS VLLNCAHQDI RLGETLSEFK EFSQSFDAAM KGLALSNSEV IRQVHNSFAR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCTGCAGAG GAGCACAAGT AGAAGAAATA TGGAGTTTAG AACCAGAAAA CTTCGAAAAA 60
TTGAAGTAAG GAACTTTCCT TTCTAAGTTG TATGTTTTTT ATTTATATTT GTGTGAACTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005829--C:cytosol
GO:0031011--C:Ino80 complex
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0004866--F:endopeptidase inhibitor activity
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0048853--P:forebrain morphogenesis
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0016579--P:protein deubiquitination
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	45.69	3.00e-75	274.00
IUUC-Aml-001866	Ailuropoda melanoleuca	95.83	4.00e-166	576.00
IUUC-Atr-002966	Amborella trichopoda	47.98	5.00e-78	284.00
IUUC-Apl-003306	Anas platyrhynchos	90.66	5.00e-173	599.00
IUUC-Aca-004763	Anolis carolinensis	96.53	2.00e-167	580.00
IUUC-Aly-005581	Arabidopsis lyrata	47.57	7.00e-71	259.00
IUUC-Ath-007283	Arabidopsis thaliana	47.25	8.00e-73	266.00
IUUC-Ago-007999	Ashbya gossypii	37.16	1.00e-27	116.00
IUUC-Acl-008231	Aspergillus clavatus	42.66	3.00e-46	178.00
IUUC-Afl-008557	Aspergillus flavus	36.62	1.00e-47	182.00
IUUC-Afu-008988	Aspergillus fumigatus	44.04	5.00e-47	180.00
IUUC-Ani-009420	Aspergillus nidulans	37.58	1.00e-47	182.00
IUUC-Ang-009859	Aspergillus niger	40.81	2.00e-42	166.00
IUUC-Aor-010145	Aspergillus oryzae	36.62	1.00e-47	182.00
IUUC-Ate-010347	Aspergillus terreus	41.38	2.00e-46	178.00
IUUC-Ame-010791	Astyanax mexicanus	90.46	3.00e-168	583.00
IUUC-Bgr-012298	Blumeria graminis	38.49	3.00e-44	171.00
IUUC-Bta-013251	Bos taurus	95.49	2.00e-164	570.00
IUUC-Bci-013786	Botrytis cinerea	36.79	2.00e-50	192.00
IUUC-Bdi-014132	Brachypodium distachyon	47.87	2.00e-72	265.00
IUUC-Bol-015611	Brassica oleracea	48.53	4.00e-76	277.00
IUUC-Bra-017769	Brassica rapa	48.53	6.00e-76	276.00
IUUC-Cel-018604	Caenorhabditis elegans	44.86	5.00e-71	260.00
IUUC-Cja-019768	Callithrix jacchus	86.08	7.00e-159	552.00
IUUC-Cfa-020207	Canis familiaris	95.83	4.00e-166	576.00
IUUC-Cpo-021925	Cavia porcellus	91.32	8.00e-157	545.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	44.67	6.00e-66	243.00
IUUC-Csa-023958	Chlorocebus sabaeus	94.79	3.00e-163	567.00
IUUC-Cho-024928	Choloepus hoffmanni	96.10	2.00e-41	162.00
IUUC-Cin-025771	Ciona intestinalis	51.83	2.00e-88	318.00
IUUC-Csv-026149	Ciona savignyi	55.56	4.00e-92	330.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	37.59	1.00e-51	196.00
IUUC-Cne-026955	Cryptococcus neoformans	35.46	2.00e-46	179.00
IUUC-Cme-027104	Cyanidioschyzon merolae	32.02	4.00e-40	158.00
IUUC-Dre-027409	Danio rerio	90.79	1.00e-167	581.00
IUUC-Dno-028921	Dasypus novemcinctus	95.49	4.00e-165	573.00
IUUC-Dse-031170	Dothistroma septosporum	36.25	9.00e-51	193.00
IUUC-Dme-031677	Drosophila melanogaster	60.34	7.00e-103	366.00
IUUC-Ete-032707	Echinops telfairi	69.85	1.00e-103	369.00
IUUC-Eca-033776	Equus caballus	95.49	5.00e-166	576.00
IUUC-Eeu-035305	Erinaceus europaeus	73.62	3.00e-65	241.00
IUUC-Fca-035846	Felis catus	87.62	3.00e-161	560.00
IUUC-Fal-037597	Ficedula albicollis	98.61	6.00e-164	569.00
IUUC-Fox-037670	Fusarium oxysporum	49.21	3.00e-47	181.00
IUUC-Fso-038243	Fusarium solani	49.21	1.00e-46	179.00
IUUC-Gmo-038499	Gadus morhua	85.42	3.00e-150	523.00
IUUC-Ggr-039975	Gaeumannomyces graminis	42.54	7.00e-43	167.00
IUUC-Gga-040904	Gallus gallus	99.67	2.00e-180	624.00
IUUC-Gac-042058	Gasterosteus aculeatus	90.62	9.00e-160	555.00
IUUC-Gma-043030	Glycine max	48.11	7.00e-77	280.00
IUUC-Ggo-044699	Gorilla gorilla	88.65	3.00e-148	517.00
IUUC-Hsa-046227	Homo sapiens	95.14	3.00e-165	573.00
IUUC-Hvu-047359	Hordeum vulgare	46.13	9.00e-74	269.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	86.52	8.00e-161	559.00
IUUC-Lch-049829	Latimeria chalumnae	93.75	7.00e-163	565.00
IUUC-Lpe-050899	Leersia perrieri	46.64	3.00e-69	254.00
IUUC-Loc-052264	Lepisosteus oculatus	92.04	7.00e-161	559.00
IUUC-Lma-053110	Leptosphaeria maculans	36.82	2.00e-42	166.00
IUUC-Laf-053639	Loxodonta africana	95.83	4.00e-166	576.00
IUUC-Mcc-055506	Macaca mulatta	94.79	4.00e-163	566.00
IUUC-Mor-057001	Magnaporthe oryzae	43.81	5.00e-48	184.00
IUUC-Mpo-057608	Magnaporthe poae	39.76	5.00e-27	113.00
IUUC-Mtr-057731	Medicago truncatula	47.47	3.00e-76	278.00
IUUC-Mla-059016	Melampsora laricipopulina	42.62	9.00e-38	149.00
IUUC-Mvi-060353	Microbotryum violaceum	38.06	8.00e-49	186.00
IUUC-Mmr-060738	Microcebus murinus	95.14	4.00e-165	573.00
IUUC-Mdo-062266	Monodelphis domestica	95.68	1.00e-106	377.00
IUUC-Mmu-063619	Mus musculus	93.40	1.00e-162	565.00
IUUC-Mac-065301	Musa acuminata	50.17	4.00e-80	290.00
IUUC-Mpu-066058	Mustela putorius furo	96.18	1.00e-166	578.00
IUUC-Mlu-067292	Myotis lucifugus	94.44	1.00e-162	564.00
IUUC-Nfi-068275	Neosartorya fischeri	37.33	1.00e-48	186.00
IUUC-Ncr-068713	Neurospora crassa	38.51	4.00e-52	197.00
IUUC-Nle-069013	Nomascus leucogenys	94.44	2.00e-162	564.00
IUUC-Opr-070628	Ochotona princeps	86.31	9.00e-159	552.00
IUUC-Ont-072688	Oreochromis niloticus	91.03	3.00e-159	553.00
IUUC-Oan-073004	Ornithorhynchus anatinus	96.30	5.00e-141	492.00
IUUC-Ocu-074303	Oryctolagus cuniculus	96.18	9.00e-167	579.00
IUUC-Oba-075002	Oryza barthii	47.12	2.00e-73	268.00
IUUC-Obr-076392	Oryza brachyantha	47.99	4.00e-71	261.00
IUUC-Ogl-077271	Oryza glaberrima	47.12	2.00e-73	268.00
IUUC-Ogu-078493	Oryza glumaepatula	46.96	8.00e-74	270.00
IUUC-Oin-080084	Oryza indica	46.96	8.00e-74	270.00
IUUC-Olo-080803	Oryza longistaminata	46.65	2.00e-73	268.00
IUUC-Ome-081146	Oryza meridionalis	46.01	2.00e-72	265.00
IUUC-Oni-082146	Oryza nivara	46.96	8.00e-74	270.00
IUUC-Opu-083633	Oryza punctata	47.32	6.00e-70	256.00
IUUC-Oru-084789	Oryza rufipogon	46.96	8.00e-74	270.00
IUUC-Osa-086196	Oryza sativa	46.96	8.00e-74	270.00
IUUC-Ola-087126	Oryzias latipes	91.32	3.00e-155	540.00
IUUC-Olu-087665	Ostreococcus lucimarinus	41.26	2.00e-61	228.00
IUUC-Oga-089140	Otolemur garnettii	86.35	1.00e-159	555.00
IUUC-Oar-090296	Ovis aries	95.83	1.00e-166	578.00
IUUC-Ptr-090566	Pan troglodytes	95.14	3.00e-165	573.00
IUUC-Pan-092052	Papio anubis	94.79	3.00e-163	566.00
IUUC-Psi-093723	Pelodiscus sinensis	97.22	1.00e-168	585.00
IUUC-Pma-094568	Petromyzon marinus	60.42	9.00e-108	382.00
IUUC-Pno-095120	Phaeosphaeria nodorum	37.02	2.00e-43	169.00
IUUC-Ppa-095761	Physcomitrella patens	46.75	2.00e-76	278.00
IUUC-Pfo-096210	Poecilia formosa	90.28	2.00e-159	554.00
IUUC-Pab-098463	Pongo abelii	95.14	3.00e-165	573.00
IUUC-Pop-099423	Populus trichocarpa	48.58	1.00e-76	278.00
IUUC-Pca-100108	Procavia capensis	94.57	3.00e-124	437.00
IUUC-Ppe-101176	Prunus persica	49.36	4.00e-76	277.00
IUUC-Pva-102629	Pteropus vampyrus	92.41	2.00e-129	454.00
IUUC-Pgr-103419	Puccinia graminis	40.32	1.00e-50	192.00
IUUC-Pte-104207	Pyrenophora teres	42.57	1.00e-25	108.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	38.03	7.00e-50	190.00
IUUC-Rno-105579	Rattus norvegicus	83.59	1.00e-157	548.00
IUUC-Sha-106894	Sarcophilus harrisii	93.12	2.00e-154	537.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	37.81	4.00e-52	197.00
IUUC-Spo-108371	Schizosaccharomyces pombe	41.05	4.00e-54	204.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	38.77	8.00e-48	183.00
IUUC-Smo-109396	Selaginella moellendorffii	50.65	1.00e-80	292.00
IUUC-Sit-110630	Setaria italica	49.18	1.00e-77	282.00
IUUC-Sly-110972	Solanum lycopersicum	49.52	4.00e-81	294.00
IUUC-Stu-112185	Solanum tuberosum	47.92	1.00e-80	292.00
IUUC-Sar-113294	Sorex araneus	78.42	4.00e-146	510.00
IUUC-Sbi-113951	Sorghum bicolor	49.51	7.00e-78	283.00
IUUC-Ssc-115501	Sus scrofa	96.18	7.00e-167	578.00
IUUC-Tgu-117152	Taeniopygia guttata	98.26	6.00e-164	569.00
IUUC-Tru-118388	Takifugu rubripes	90.28	2.00e-159	554.00
IUUC-Tsy-119109	Tarsius syrichta	95.49	2.00e-165	574.00
IUUC-Tni-120048	Tetraodon nigroviridis	90.28	6.00e-160	556.00
IUUC-Tca-121750	Theobroma cacao	49.69	3.00e-80	291.00
IUUC-Tre-122130	Trichoderma reesei	37.99	4.00e-49	187.00
IUUC-Tvi-122284	Trichoderma virens	37.84	1.00e-45	176.00
IUUC-Tae-125344	Triticum aestivum	46.25	4.00e-73	267.00
IUUC-Tur-126366	Triticum urartu	44.41	5.00e-66	244.00
IUUC-Tme-127187	Tuber melanosporum	40.07	7.00e-53	200.00
IUUC-Tbe-127619	Tupaia belangeri	86.76	6.00e-140	489.00
IUUC-Ttr-128867	Tursiops truncatus	85.31	1.00e-121	428.00
IUUC-Vda-129912	Verticillium dahliae	37.32	9.00e-47	179.00
IUUC-Vpa-130552	Vicugna pacos	96.74	1.00e-107	382.00
IUUC-Vvi-130881	Vitis vinifera	50.32	2.00e-76	278.00
IUUC-Xtr-131934	Xenopus tropicalis	85.53	9.00e-160	555.00
IUUC-Xma-133312	Xiphophorus maculatus	89.93	2.00e-158	550.00
IUUC-Zma-135462	Zea mays	43.61	1.00e-65	242.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence