iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-061900

Ensembl Protein ID

ENSMODP00000005523.3

UniProt Accession

F6VRF8; F6VRF8_MONDO

Protein Name

Uncharacterized protein

Gene Name

ARHGEF7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000004481.3	ENSMODT00000005641.3	ENSMODP00000005523.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.00e-15	55.7	167	221

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +v++ ++++ +n+deL+++kGd+++v     +++gW++g  + +gk G fP+n+v++++
   Q: 167  VVRAKFNFQQTNEDELSFTKGDIIHVT--RVEEGGWWEG--THNGKTGWFPSNYVREIK 221
           68999*********************7..999*******..8**************997 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MNSAEQTVTW LITLGVLESP KKTISDPEGF LQSSLKDGVV LCRLLDRLLP GTIEKVYPEP 60
RSESECLSNI REFLRGCGSS LRLETFDAND LYQGQNFNKV LSSLVTLNKV TADIGLGSDS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCCGACTAC ATAAATATAT TTTAGCATAC GGATGGGTAT TCCTATTTCC CATGTGTACA 60
GTTTGCATTT GCAGTTTGTT CAGTATAGCA ATCTATGAAT CCTTGGAATT TTGCAAATTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1185--Reference proteome

Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR032409--GEF_CC
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF16523--betaPIX_CC
PF00307--CH
PF00169--PH
PF00621--RhoGEF
PF07653--SH3_2

PRINTS

PR00452--SH3DOMAIN

SMART

SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0030027--C:lamellipodium
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0000322--C:storage vacuole
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0048041--P:focal adhesion assembly
GO:0007030--P:Golgi organization
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0035556--P:intracellular signal transduction
GO:0030032--P:lamellipodium assembly
GO:0043065--P:positive regulation of apoptotic process
GO:0010763--P:positive regulation of fibroblast migration
GO:0060124--P:positive regulation of growth hormone secretion
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:0032092--P:positive regulation of protein binding
GO:1900026--P:positive regulation of substrate adhesion-dependent cell spreading
GO:1904424--P:regulation of GTP binding
GO:0035023--P:regulation of Rho protein signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001259	Ailuropoda melanoleuca	90.08	0.00e+00	1246.00
IUUC-Aca-004591	Anolis carolinensis	93.12	0.00e+00	1247.00
IUUC-Ame-010759	Astyanax mexicanus	75.17	0.00e+00	1049.00
IUUC-Bta-013328	Bos taurus	89.75	0.00e+00	1229.00
IUUC-Cja-018742	Callithrix jacchus	92.42	0.00e+00	1118.00
IUUC-Cfa-020756	Canis familiaris	93.91	0.00e+00	1309.00
IUUC-Cpo-021284	Cavia porcellus	91.07	0.00e+00	1192.00
IUUC-Csa-023162	Chlorocebus sabaeus	93.68	0.00e+00	1293.00
IUUC-Cho-024736	Choloepus hoffmanni	75.30	2.00e-176	612.00
IUUC-Cin-025535	Ciona intestinalis	40.11	7.00e-94	337.00
IUUC-Cgl-026676	Colletotrichum gloeosporioides	42.86	2.00e-11	65.50
IUUC-Cne-026866	Cryptococcus neoformans	49.21	1.00e-12	69.30
IUUC-Dre-028646	Danio rerio	65.97	0.00e+00	1055.00
IUUC-Dno-029461	Dasypus novemcinctus	96.21	0.00e+00	1321.00
IUUC-Dor-030623	Dipodomys ordii	79.79	0.00e+00	999.00
IUUC-Dme-032219	Drosophila melanogaster	44.84	1.00e-101	364.00
IUUC-Ete-032236	Echinops telfairi	81.06	0.00e+00	808.00
IUUC-Eca-034137	Equus caballus	94.59	0.00e+00	1138.00
IUUC-Fca-035742	Felis catus	92.41	0.00e+00	1279.00
IUUC-Fal-037205	Ficedula albicollis	95.32	0.00e+00	1004.00
IUUC-Gmo-039475	Gadus morhua	75.50	0.00e+00	1138.00
IUUC-Gga-040539	Gallus gallus	96.13	0.00e+00	1179.00
IUUC-Gac-042615	Gasterosteus aculeatus	72.39	0.00e+00	1060.00
IUUC-Ggo-044470	Gorilla gorilla	92.14	0.00e+00	1123.00
IUUC-Hsa-046398	Homo sapiens	90.86	0.00e+00	1272.00
IUUC-Loc-052146	Lepisosteus oculatus	86.12	0.00e+00	1191.00
IUUC-Laf-053891	Loxodonta africana	91.29	0.00e+00	1248.00
IUUC-Mcc-055483	Macaca mulatta	90.72	0.00e+00	1271.00
IUUC-Mga-059410	Meleagris gallopavo	93.51	0.00e+00	1153.00
IUUC-Mmr-060758	Microcebus murinus	93.96	0.00e+00	1249.00
IUUC-Mmu-063849	Mus musculus	91.71	0.00e+00	1234.00
IUUC-Mpu-065876	Mustela putorius furo	92.46	0.00e+00	1296.00
IUUC-Mlu-067970	Myotis lucifugus	93.96	0.00e+00	1131.00
IUUC-Nle-069685	Nomascus leucogenys	90.87	0.00e+00	1189.00
IUUC-Opr-071132	Ochotona princeps	58.60	8.00e-179	620.00
IUUC-Ont-071815	Oreochromis niloticus	68.75	0.00e+00	1111.00
IUUC-Oan-073057	Ornithorhynchus anatinus	95.86	0.00e+00	1019.00
IUUC-Ola-086663	Oryzias latipes	65.93	0.00e+00	961.00
IUUC-Oga-088103	Otolemur garnettii	91.64	0.00e+00	1072.00
IUUC-Ptr-091162	Pan troglodytes	89.87	0.00e+00	1164.00
IUUC-Pan-092093	Papio anubis	82.39	0.00e+00	1146.00
IUUC-Pma-094701	Petromyzon marinus	63.61	9.00e-135	473.00
IUUC-Pfo-096736	Poecilia formosa	75.25	0.00e+00	1164.00
IUUC-Pab-097641	Pongo abelii	94.40	0.00e+00	1467.00
IUUC-Pva-102819	Pteropus vampyrus	91.01	0.00e+00	1230.00
IUUC-Rno-106099	Rattus norvegicus	91.71	0.00e+00	1238.00
IUUC-Sha-106845	Sarcophilus harrisii	98.76	0.00e+00	1368.00
IUUC-Ssc-116036	Sus scrofa	92.09	0.00e+00	1268.00
IUUC-Tgu-117498	Taeniopygia guttata	90.73	0.00e+00	1236.00
IUUC-Tru-118278	Takifugu rubripes	72.88	0.00e+00	900.00
IUUC-Tsy-118990	Tarsius syrichta	91.45	0.00e+00	951.00
IUUC-Tni-120852	Tetraodon nigroviridis	73.57	0.00e+00	1130.00
IUUC-Ttr-128922	Tursiops truncatus	85.23	0.00e+00	1064.00
IUUC-Xtr-132012	Xenopus tropicalis	85.13	0.00e+00	1076.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence