iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004744

UUCD1 version

UUC-AnC-00398

Ensembl Protein ID

ENSACAP00000009808.3

UniProt Accession

H9GFW3; H9GFW3_ANOCA

Protein Name

Uncharacterized protein

Gene Name

NEDD4L

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000009877.3	ENSACAT00000010008.3	ENSACAP00000009808.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.40e-120	400.3	640	827

Active Site

Position(s)	Description	Evidence
921	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 640  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVYHGKLLDG 728
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G++i VtneNk+eY++lv++
   Q: 729  FFIRPFYKMMLGKPITLKDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQTYQVDLKPNGSEITVTNENKREYIDLVIQ 812
           ***********************************99...6666..7****************************************** PP
   S: 180  yrlkegikeqveafr 194
           +r+ +++++q++af 
   Q: 813  WRFVNRVQKQMNAFL 827
           **************7 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MATGMVEPVY GLSEEEEESR VLRVKVVAGI DLAKKDIFGA SDPYVKLSLY ASDESRELAL 60
VQTKTIKKTL NPKWNEEFYF RVNPSNHRLL FEVFDENRLT RDDFLGQVDV PLNHLPTEDP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCATTGCAT CTCCTAGTTC CTCTTTGAGG TTTGGCAACG GGAGAGGAAG GAAAGCACCA 60
GTTCCTCTCC ACCTGGATCC GTGCAAAGAT CCTGACAGGC TTGCAAAGAG CAGGGAGAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

PRINTS

PR00360--C2DOMAIN

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	88.87	0.00e+00	1558.00
IUUC-Apl-003893	Anas platyrhynchos	89.81	0.00e+00	1656.00
IUUC-Ame-010810	Astyanax mexicanus	82.80	0.00e+00	978.00
IUUC-Bta-012679	Bos taurus	89.87	0.00e+00	1469.00
IUUC-Cel-018564	Caenorhabditis elegans	53.01	1.00e-178	619.00
IUUC-Cja-018732	Callithrix jacchus	90.80	0.00e+00	1696.00
IUUC-Cfa-021226	Canis familiaris	89.92	0.00e+00	1642.00
IUUC-Cpo-021671	Cavia porcellus	88.98	0.00e+00	1605.00
IUUC-Csa-023344	Chlorocebus sabaeus	89.13	0.00e+00	1689.00
IUUC-Cho-024832	Choloepus hoffmanni	92.61	0.00e+00	681.00
IUUC-Cin-025157	Ciona intestinalis	62.38	0.00e+00	754.00
IUUC-Csv-026098	Ciona savignyi	56.76	6.00e-176	610.00
IUUC-Dre-027770	Danio rerio	75.00	0.00e+00	1374.00
IUUC-Dno-029466	Dasypus novemcinctus	90.78	0.00e+00	1701.00
IUUC-Dor-030138	Dipodomys ordii	85.55	0.00e+00	1503.00
IUUC-Dme-032166	Drosophila melanogaster	64.99	0.00e+00	678.00
IUUC-Ete-033145	Echinops telfairi	82.78	0.00e+00	1177.00
IUUC-Eca-033445	Equus caballus	90.65	0.00e+00	1462.00
IUUC-Eeu-035247	Erinaceus europaeus	89.44	0.00e+00	1288.00
IUUC-Fca-035489	Felis catus	87.80	0.00e+00	1413.00
IUUC-Fal-037604	Ficedula albicollis	87.13	0.00e+00	1657.00
IUUC-Gmo-039674	Gadus morhua	74.34	0.00e+00	1333.00
IUUC-Gga-040703	Gallus gallus	90.88	0.00e+00	1698.00
IUUC-Gac-042020	Gasterosteus aculeatus	76.32	0.00e+00	1367.00
IUUC-Ggo-045332	Gorilla gorilla	89.77	0.00e+00	1605.00
IUUC-Hsa-045968	Homo sapiens	90.88	0.00e+00	1702.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	63.54	0.00e+00	782.00
IUUC-Lch-050443	Latimeria chalumnae	84.66	0.00e+00	1390.00
IUUC-Loc-052662	Lepisosteus oculatus	77.42	0.00e+00	1392.00
IUUC-Laf-053850	Loxodonta africana	89.99	0.00e+00	1646.00
IUUC-Mcc-055821	Macaca mulatta	90.93	0.00e+00	1671.00
IUUC-Meu-056712	Macropus eugenii	78.46	0.00e+00	731.00
IUUC-Mga-059362	Meleagris gallopavo	61.72	0.00e+00	1105.00
IUUC-Mmr-060798	Microcebus murinus	90.66	0.00e+00	1616.00
IUUC-Mdo-062173	Monodelphis domestica	89.75	0.00e+00	1700.00
IUUC-Mmu-064136	Mus musculus	89.97	0.00e+00	1663.00
IUUC-Mpu-066765	Mustela putorius furo	90.51	0.00e+00	1639.00
IUUC-Mlu-067565	Myotis lucifugus	89.43	0.00e+00	1461.00
IUUC-Nle-069070	Nomascus leucogenys	87.81	0.00e+00	1617.00
IUUC-Opr-071044	Ochotona princeps	89.63	0.00e+00	1108.00
IUUC-Ont-072044	Oreochromis niloticus	75.34	0.00e+00	1411.00
IUUC-Oan-073032	Ornithorhynchus anatinus	87.19	0.00e+00	1344.00
IUUC-Ocu-074160	Oryctolagus cuniculus	88.23	0.00e+00	1583.00
IUUC-Ola-087467	Oryzias latipes	76.58	0.00e+00	1396.00
IUUC-Oga-088460	Otolemur garnettii	86.45	0.00e+00	1457.00
IUUC-Oar-090198	Ovis aries	89.99	0.00e+00	1623.00
IUUC-Ptr-090939	Pan troglodytes	90.88	0.00e+00	1702.00
IUUC-Pan-092284	Papio anubis	90.98	0.00e+00	1704.00
IUUC-Psi-093645	Pelodiscus sinensis	90.47	0.00e+00	1694.00
IUUC-Pma-094364	Petromyzon marinus	79.24	0.00e+00	813.00
IUUC-Pfo-096768	Poecilia formosa	86.58	0.00e+00	898.00
IUUC-Pab-098088	Pongo abelii	90.78	0.00e+00	1678.00
IUUC-Pca-100714	Procavia capensis	71.64	0.00e+00	1198.00
IUUC-Pva-102354	Pteropus vampyrus	89.20	0.00e+00	1556.00
IUUC-Rno-105318	Rattus norvegicus	89.27	0.00e+00	1616.00
IUUC-Sha-107482	Sarcophilus harrisii	91.16	0.00e+00	1506.00
IUUC-Ssc-115950	Sus scrofa	65.32	0.00e+00	1091.00
IUUC-Tgu-117130	Taeniopygia guttata	89.70	0.00e+00	1681.00
IUUC-Tru-118610	Takifugu rubripes	76.99	0.00e+00	1417.00
IUUC-Tsy-119492	Tarsius syrichta	85.70	0.00e+00	1509.00
IUUC-Tni-120113	Tetraodon nigroviridis	71.88	0.00e+00	1297.00
IUUC-Tbe-127441	Tupaia belangeri	83.91	0.00e+00	724.00
IUUC-Ttr-128235	Tursiops truncatus	81.02	0.00e+00	1381.00
IUUC-Vpa-130544	Vicugna pacos	69.87	0.00e+00	797.00
IUUC-Xtr-132859	Xenopus tropicalis	86.39	0.00e+00	1575.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence