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Tag Content
iUUCD ID IUUC-Xtr-132927
Ensembl Protein ID ENSXETP00000049978.3
UniProt Accession Q6P2Y3; DNJC2_XENTR
Genbank Protein ID AAH64251.1
Protein Name DnaJ homolog subfamily C member 2
Genbank Nucleotide ID BC064251
Gene Name dnajc2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSXETG00000023108.3 ENSXETT00000061716.1 ENSXETP00000063020.1
ENSXETG00000023108.3 ENSXETT00000049978.3 ENSXETP00000049978.3
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Other/Other 80.90 1.00e-125 448.00 IUUC-Hsa-045972
UBD/Other/Other 83.87 5.00e-119 426.00 IUUC-Mmu-063361
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Xenopus tropicalis
Functional Description
(View)

Functional Description


     Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation (By similarity).
 Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation (By similarity).
Protein Sequence
(Fasta)
RGSAHSGSVL ADPGTMLIEA QAEQCTFVTR GLCAAAVLCQ VEPVGRWFEA FIKRRNRNVS 60
ASFQELEDEK ESSEESEDEE FQLEEFPLLK TLDPKDWKNQ DHYAVLGLKN LRYKATQRQI 120
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Protein Fasta Sequence


>IUUC-Xtr-132927|UBD,UBD/Other/Other|Xenopus tropicalis
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGAGGATCT GCGCACAGTG GCTCGGTGCT TGCTGACCCC GGTACTATGC TAATAGAGGC 60
GCAGGCAGAG CAATGCACCT TTGTCACCAG AGGCCTGTGT GCAGGTAGTA TATTTTCGTG 120
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Nucleotide Fasta Sequence


>IUUC-Xtr-132927|UBD,UBD/Other/Other|Xenopus tropicalis
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0143--Chaperone
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR001623--DnaJ_domain
IPR018253--DnaJ_domain_CS
IPR009057--Homeobox-like
IPR032003--RAC_head
IPR001005--SANT/Myb
IPR017884--SANT_dom
PROSITE

PS00636--DNAJ_1
PS50076--DNAJ_2
PS51293--SANT
Pfam

PF00226--DnaJ
PF00249--Myb_DNA-binding
PF16717--RAC_head
SMART

SM00271--DnaJ
SM00717--SANT
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0042393--F:histone binding
GO:0043130--F:ubiquitin binding
GO:0016569--P:covalent chromatin modification
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG xtr:394933
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000523 Aegilops tauschii 48.29 5.00e-51 196.00
IUUC-Aml-001384 Ailuropoda melanoleuca 83.85 0.00e+00 815.00
IUUC-Atr-002863 Amborella trichopoda 47.29 3.00e-51 196.00
IUUC-Apl-004102 Anas platyrhynchos 84.73 2.00e-120 426.00
IUUC-Aca-004586 Anolis carolinensis 84.72 0.00e+00 796.00
IUUC-Aly-006535 Arabidopsis lyrata 48.28 3.00e-49 189.00
IUUC-Ath-007402 Arabidopsis thaliana 48.28 1.00e-50 194.00
IUUC-Afl-008435 Aspergillus flavus 45.32 3.00e-56 212.00
IUUC-Afu-008810 Aspergillus fumigatus 46.13 3.00e-56 212.00
IUUC-Ani-009141 Aspergillus nidulans 46.27 2.00e-54 206.00
IUUC-Aor-010002 Aspergillus oryzae 45.32 3.00e-56 212.00
IUUC-Ame-011909 Astyanax mexicanus 79.86 2.00e-111 395.00
IUUC-Bta-012870 Bos taurus 83.55 0.00e+00 821.00
IUUC-Bci-013889 Botrytis cinerea 42.66 2.00e-54 206.00
IUUC-Bdi-014225 Brachypodium distachyon 48.51 8.00e-52 198.00
IUUC-Bol-015562 Brassica oleracea 49.27 1.00e-52 201.00
IUUC-Bra-017547 Brassica rapa 49.27 2.00e-53 203.00
IUUC-Cel-018685 Caenorhabditis elegans 41.33 9.00e-80 290.00
IUUC-Cja-019293 Callithrix jacchus 82.74 0.00e+00 817.00
IUUC-Cfa-020528 Canis familiaris 78.88 0.00e+00 755.00
IUUC-Cpo-022171 Cavia porcellus 76.78 9.00e-111 394.00
IUUC-Cre-022887 Chlamydomonas reinhardtii 47.18 5.00e-46 179.00
IUUC-Csa-023129 Chlorocebus sabaeus 82.45 0.00e+00 815.00
IUUC-Cho-025056 Choloepus hoffmanni 70.64 0.00e+00 642.00
IUUC-Cin-025527 Ciona intestinalis 62.26 7.00e-69 254.00
IUUC-Cgl-026448 Colletotrichum gloeosporioides 40.96 1.00e-44 174.00
IUUC-Cme-027325 Cyanidioschyzon merolae 36.54 6.00e-29 122.00
IUUC-Dre-028808 Danio rerio 80.58 2.00e-116 413.00
IUUC-Dno-029938 Dasypus novemcinctus 82.61 0.00e+00 784.00
IUUC-Dor-030802 Dipodomys ordii 74.36 2.00e-81 296.00
IUUC-Dme-031862 Drosophila melanogaster 59.33 2.00e-75 276.00
IUUC-Ete-032900 Echinops telfairi 88.11 1.00e-89 323.00
IUUC-Eca-034311 Equus caballus 83.23 0.00e+00 823.00
IUUC-Eeu-034969 Erinaceus europaeus 69.42 2.00e-97 349.00
IUUC-Fca-036146 Felis catus 83.39 0.00e+00 818.00
IUUC-Fal-036866 Ficedula albicollis 88.72 1.00e-121 430.00
IUUC-Fox-038071 Fusarium oxysporum 40.00 1.00e-45 177.00
IUUC-Gmo-039191 Gadus morhua 74.23 0.00e+00 719.00
IUUC-Gga-040158 Gallus gallus 86.33 9.00e-123 434.00
IUUC-Gac-041990 Gasterosteus aculeatus 77.38 0.00e+00 744.00
IUUC-Gma-043759 Glycine max 47.80 4.00e-51 196.00
IUUC-Ggo-045049 Gorilla gorilla 80.15 3.00e-113 402.00
IUUC-Hsa-045972 Homo sapiens 83.06 0.00e+00 809.00
IUUC-Hvu-047309 Hordeum vulgare 47.78 3.00e-50 192.00
IUUC-Itr-048875 Ictidomys tridecemlineatus 85.22 0.00e+00 759.00
IUUC-Kpa-049255 Komagataella pastoris 42.22 9.00e-50 190.00
IUUC-Lch-049756 Latimeria chalumnae 84.08 0.00e+00 810.00
IUUC-Lpe-051235 Leersia perrieri 46.27 9.00e-47 181.00
IUUC-Loc-052580 Lepisosteus oculatus 75.61 3.00e-88 318.00
IUUC-Laf-054095 Loxodonta africana 83.06 0.00e+00 825.00
IUUC-Mcc-054797 Macaca mulatta 79.03 0.00e+00 748.00
IUUC-Meu-056077 Macropus eugenii 90.53 7.00e-83 301.00
IUUC-Mpo-057559 Magnaporthe poae 42.20 3.00e-50 192.00
IUUC-Mtr-058690 Medicago truncatula 49.50 1.00e-50 194.00
IUUC-Mga-059854 Meleagris gallopavo 88.59 5.00e-119 421.00
IUUC-Mmr-061638 Microcebus murinus 83.39 0.00e+00 825.00
IUUC-Mdo-062704 Monodelphis domestica 84.53 3.00e-121 428.00
IUUC-Mmu-063361 Mus musculus 82.61 0.00e+00 842.00
IUUC-Mac-065182 Musa acuminata 45.36 2.00e-46 180.00
IUUC-Mpu-065792 Mustela putorius furo 83.55 0.00e+00 825.00
IUUC-Mlu-067874 Myotis lucifugus 83.76 0.00e+00 812.00
IUUC-Nle-069392 Nomascus leucogenys 82.90 0.00e+00 781.00
IUUC-Opr-070583 Ochotona princeps 88.37 1.00e-117 416.00
IUUC-Ont-071387 Oreochromis niloticus 80.07 1.00e-112 400.00
IUUC-Oan-073081 Ornithorhynchus anatinus 81.89 4.00e-120 425.00
IUUC-Ocu-074901 Oryctolagus cuniculus 83.74 0.00e+00 824.00
IUUC-Oba-075416 Oryza barthii 48.28 2.00e-50 194.00
IUUC-Obr-076383 Oryza brachyantha 48.00 1.00e-50 194.00
IUUC-Ogl-077602 Oryza glaberrima 27.04 2.00e-12 65.90
IUUC-Ogu-078774 Oryza glumaepatula 48.00 9.00e-51 195.00
IUUC-Oin-079255 Oryza indica 42.48 7.00e-19 89.00
IUUC-Olo-080628 Oryza longistaminata 48.00 9.00e-51 194.00
IUUC-Ome-081488 Oryza meridionalis 48.00 8.00e-51 195.00
IUUC-Oni-082149 Oryza nivara 47.70 6.00e-42 165.00
IUUC-Opu-083627 Oryza punctata 47.50 2.00e-50 193.00
IUUC-Oru-084567 Oryza rufipogon 48.00 9.00e-51 194.00
IUUC-Osa-086150 Oryza sativa 25.09 9.00e-13 67.00
IUUC-Ola-086782 Oryzias latipes 80.54 8.00e-70 255.00
IUUC-Olu-087582 Ostreococcus lucimarinus 40.00 1.00e-32 133.00
IUUC-Oga-089051 Otolemur garnettii 83.87 0.00e+00 785.00
IUUC-Oar-090356 Ovis aries 83.74 0.00e+00 820.00
IUUC-Ptr-090858 Pan troglodytes 82.90 0.00e+00 806.00
IUUC-Pan-091826 Papio anubis 82.61 0.00e+00 814.00
IUUC-Psi-094066 Pelodiscus sinensis 84.19 0.00e+00 772.00
IUUC-Ppa-095598 Physcomitrella patens 47.47 9.00e-48 184.00
IUUC-Pfo-097101 Poecilia formosa 80.58 9.00e-114 404.00
IUUC-Pab-098089 Pongo abelii 82.10 0.00e+00 786.00
IUUC-Pop-099771 Populus trichocarpa 47.26 2.00e-50 193.00
IUUC-Pca-100615 Procavia capensis 73.35 1.00e-158 552.00
IUUC-Ppe-101366 Prunus persica 48.77 7.00e-52 198.00
IUUC-Pva-102536 Pteropus vampyrus 84.70 5.00e-117 414.00
IUUC-Pgr-103582 Puccinia graminis 52.91 2.00e-53 203.00
IUUC-Ptt-103970 Puccinia triticina 51.48 1.00e-45 176.00
IUUC-Pte-104323 Pyrenophora teres 44.06 1.00e-53 204.00
IUUC-Rno-105279 Rattus norvegicus 82.13 0.00e+00 825.00
IUUC-Sha-107457 Sarcophilus harrisii 85.97 5.00e-124 437.00
IUUC-Sja-107842 Schizosaccharomyces japonicus 42.55 4.00e-43 168.00
IUUC-Spo-108041 Schizosaccharomyces pombe 47.08 2.00e-55 209.00
IUUC-Ssl-108474 Sclerotinia sclerotiorum 43.06 2.00e-43 169.00
IUUC-Smo-109454 Selaginella moellendorffii 49.24 3.00e-52 199.00
IUUC-Sit-110667 Setaria italica 47.80 1.00e-50 194.00
IUUC-Sly-111760 Solanum lycopersicum 46.55 1.00e-43 170.00
IUUC-Stu-112803 Solanum tuberosum 47.78 1.00e-52 201.00
IUUC-Sar-113066 Sorex araneus 82.30 9.00e-89 320.00
IUUC-Sbi-114777 Sorghum bicolor 47.78 1.00e-49 191.00
IUUC-Ssc-115941 Sus scrofa 83.39 0.00e+00 823.00
IUUC-Tgu-116799 Taeniopygia guttata 88.93 3.00e-120 425.00
IUUC-Tru-118137 Takifugu rubripes 81.41 1.00e-103 370.00
IUUC-Tsy-118984 Tarsius syrichta 82.58 0.00e+00 810.00
IUUC-Tni-120898 Tetraodon nigroviridis 79.36 3.00e-113 402.00
IUUC-Tca-120925 Theobroma cacao 47.78 2.00e-51 197.00
IUUC-Tvi-122560 Trichoderma virens 42.65 2.00e-55 209.00
IUUC-Tae-123257 Triticum aestivum 48.29 5.00e-51 195.00
IUUC-Tur-126859 Triticum urartu 48.29 2.00e-50 194.00
IUUC-Tme-127035 Tuber melanosporum 45.83 3.00e-61 229.00
IUUC-Tbe-127978 Tupaia belangeri 76.26 5.00e-104 371.00
IUUC-Ttr-128247 Tursiops truncatus 76.65 0.00e+00 700.00
IUUC-Uma-129601 Ustilago maydis 54.90 3.00e-55 209.00
IUUC-Vda-129704 Verticillium dahliae 39.38 2.00e-51 196.00
IUUC-Vpa-130249 Vicugna pacos 77.83 0.00e+00 729.00
IUUC-Vvi-131626 Vitis vinifera 47.78 1.00e-52 201.00
IUUC-Xma-133433 Xiphophorus maculatus 83.46 3.00e-111 395.00
IUUC-Zma-135295 Zea mays 48.29 5.00e-51 195.00
Created Date 25-Jun-2017

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