iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118156

UUCD1 version

UUC-TaR-01131

Ensembl Protein ID

ENSTRUP00000038292.1

UniProt Accession

H2UMX1; H2UMX1_TAKRU

Protein Name

Ubiquitinyl hydrolase 1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000014984.1	ENSTRUT00000038429.1	ENSTRUP00000038292.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.40e-97	325.6	287	685

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenp.............................................. 42
           tGl+NlgNtCYmNS+LQ+Ls+++ +re++l+   +++l+  ++                                              
   Q: 287  TGLRNLGNTCYMNSILQVLSHLHVFRECFLRlDLTQALELLASavqgqlvgkishlsltqrkgfqsssgsgsglsggasrgrsmeliqp 375
           7******************************7444444444446678888888999999999999999999999999999999999999 PP
   S: 43   ...kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsd 128
              ++++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld+++ el++  ++++++           
   Q: 376  kepSSEHISLCHELHTLFQVMWSGKWALVSPFAMLHSVWQLIPAFRGYAQQDAQEFLCELLDKVQHELESAGKHTTTTGV--------P 456
           98899999************************************************************553333333332........2 PP
   S: 129  eaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke........slqdcLesftkeeelegenkyyce 209
           + +++  k+  s+++++F+gql sq++cl+c+++s++ epf+dlsl++p++ +++ +         l+++L++ft++e leg n y c+
   Q: 457  QTQKRLIKQVLSVVNTIFHGQLLSQVTCLACGHRSNTVEPFWDLSLEFPERYHSNSResaaqtscHLTEMLAKFTETEALEG-NIYACD 544
           34789999*****************************************9998766689999999****************9.77**** PP
   S: 210  kckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts....peekqke....kkkYe 279
           +c++ ++           a+k+l+++klP+vL lhLkRf++s + ++reki  +v+f + Ld++p+c +    +     +    +  Y+
   Q: 545  HCNSARRrttsksvllteAQKRLMVHKLPQVLRLHLKRFRWSGR-NHREKIGVHVSFDQLLDVEPYCYQepspKG----SphhkHFLYD 628
           ***888888888888888***********************997.8889*********9*********9544433....2444499*** PP
   S: 280  LiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           L+avv+H+G +++sGHY++y++n++g+ W++++Dsk ++++ eev++   ++aY+lfY++
   Q: 629  LSAVVMHHGkGFGSGHYTSYCYNTEGGfWVHCNDSKLNVCSVEEVCR---AQAYILFYTQ 685
           ***********************9999********************...********98 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MDRCKHVGRL RLASDHSILN PQKWHCVDCN TSESIWACLS CSHVACGRYI EEHALQHFQQ 60
QRHPLAIEVN ELYVFCYLCD DYVLNDNATG DLKLLRSTLS AIQSQRYEVT TRSGRTLRSA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACAGGT GTAAGCATGT TGGGCGGCTG AGGCTGGCCT CAGACCACTC CATCCTCAAC 60
CCCCAAAAGT GGCACTGCGT GGACTGCAAC ACGTCCGAGT CTATCTGGGC CTGCTTGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	61.29	0.00e+00	838.00
IUUC-Apl-003673	Anas platyrhynchos	66.67	0.00e+00	893.00
IUUC-Aca-004434	Anolis carolinensis	66.76	0.00e+00	878.00
IUUC-Ame-010986	Astyanax mexicanus	79.38	0.00e+00	657.00
IUUC-Bta-012774	Bos taurus	61.76	0.00e+00	840.00
IUUC-Cja-019619	Callithrix jacchus	60.93	0.00e+00	831.00
IUUC-Cfa-020957	Canis familiaris	61.91	0.00e+00	848.00
IUUC-Csa-023177	Chlorocebus sabaeus	60.54	0.00e+00	832.00
IUUC-Cho-024877	Choloepus hoffmanni	57.52	8.00e-148	517.00
IUUC-Cin-025587	Ciona intestinalis	47.15	2.00e-108	386.00
IUUC-Dre-027878	Danio rerio	80.00	0.00e+00	658.00
IUUC-Dno-029832	Dasypus novemcinctus	61.44	0.00e+00	843.00
IUUC-Ete-032627	Echinops telfairi	60.80	0.00e+00	835.00
IUUC-Eca-033863	Equus caballus	60.49	0.00e+00	819.00
IUUC-Eeu-035225	Erinaceus europaeus	59.34	0.00e+00	781.00
IUUC-Fca-036288	Felis catus	61.47	0.00e+00	830.00
IUUC-Fal-037207	Ficedula albicollis	65.29	0.00e+00	860.00
IUUC-Gga-040457	Gallus gallus	67.24	0.00e+00	878.00
IUUC-Gac-042371	Gasterosteus aculeatus	81.46	0.00e+00	660.00
IUUC-Ggo-044926	Gorilla gorilla	62.41	0.00e+00	833.00
IUUC-Hsa-046079	Homo sapiens	62.55	0.00e+00	832.00
IUUC-Itr-048737	Ictidomys tridecemlineatus	62.22	0.00e+00	834.00
IUUC-Lch-050260	Latimeria chalumnae	65.43	0.00e+00	847.00
IUUC-Loc-051981	Lepisosteus oculatus	75.52	0.00e+00	631.00
IUUC-Laf-054491	Loxodonta africana	61.43	0.00e+00	831.00
IUUC-Mcc-055694	Macaca mulatta	60.68	0.00e+00	831.00
IUUC-Mga-059523	Meleagris gallopavo	66.81	0.00e+00	881.00
IUUC-Mmr-060885	Microcebus murinus	61.97	0.00e+00	847.00
IUUC-Mdo-063018	Monodelphis domestica	68.28	0.00e+00	897.00
IUUC-Mpu-066207	Mustela putorius furo	63.26	0.00e+00	848.00
IUUC-Mlu-066929	Myotis lucifugus	59.65	0.00e+00	804.00
IUUC-Ont-071637	Oreochromis niloticus	86.72	0.00e+00	1096.00
IUUC-Oan-073030	Ornithorhynchus anatinus	65.66	0.00e+00	717.00
IUUC-Ocu-074836	Oryctolagus cuniculus	59.47	0.00e+00	808.00
IUUC-Ola-087058	Oryzias latipes	73.91	5.00e-155	540.00
IUUC-Oga-088367	Otolemur garnettii	61.53	0.00e+00	833.00
IUUC-Oar-089953	Ovis aries	61.79	0.00e+00	847.00
IUUC-Ptr-090980	Pan troglodytes	62.70	0.00e+00	836.00
IUUC-Pan-092748	Papio anubis	60.91	0.00e+00	837.00
IUUC-Pma-094155	Petromyzon marinus	57.29	2.00e-82	298.00
IUUC-Pfo-096860	Poecilia formosa	79.18	0.00e+00	1051.00
IUUC-Pab-098514	Pongo abelii	63.02	0.00e+00	844.00
IUUC-Pca-100449	Procavia capensis	61.40	0.00e+00	773.00
IUUC-Pva-102984	Pteropus vampyrus	60.62	0.00e+00	835.00
IUUC-Rno-106019	Rattus norvegicus	59.60	0.00e+00	774.00
IUUC-Sha-106965	Sarcophilus harrisii	67.23	0.00e+00	895.00
IUUC-Ssc-115299	Sus scrofa	61.65	0.00e+00	843.00
IUUC-Tgu-117160	Taeniopygia guttata	65.76	0.00e+00	885.00
IUUC-Tni-119733	Tetraodon nigroviridis	83.47	0.00e+00	1112.00
IUUC-Tbe-128084	Tupaia belangeri	60.25	0.00e+00	804.00
IUUC-Ttr-128928	Tursiops truncatus	62.18	0.00e+00	846.00
IUUC-Vpa-130706	Vicugna pacos	61.42	0.00e+00	848.00
IUUC-Xtr-132061	Xenopus tropicalis	66.47	0.00e+00	825.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence