iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cpo-021487

Ensembl Protein ID

ENSCPOP00000014330.1

UniProt Accession

H0VUF7; H0VUF7_CAVPO

Genbank Protein ID

ENSCPOP00000014330

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02027937

Gene Name

NCK2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000025206.1	ENSCPOT00000027936.1	ENSCPOP00000014330.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.10e-45	151.6	194	253

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++vq+ly++++++++eL++ kG++++viek e+d +W+k+ k+ +g+ Gl+P+n+v+ l+
   Q: 194  LHVVQTLYPFSSATEEELNFDKGETMEVIEKPENDPEWWKC-KNSRGQVGLVPKNYVVVLS 253
           689**************************************.7**************9886 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MTEEVIVIAK WDYTAQQDQE LDIKKNERLW LLDDSKTWWR VRNAANRTGY VPSNYVERKN 60
SLKKGSLVKN LKDTLGLGRT RRKPSARDAS PTPSTEAEFP ANGAADRIYD LSIPAFVKFA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACAGAGG AAGTCATCGT CATAGCCAAG TGGGACTACA CGGCCCAGCA GGACCAGGAG 60
CTGGACATCA AGAAGAACGA GCGCCTGTGG CTGCTGGACG ACTCTAAGAC CTGGTGGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0012506--C:vesicle membrane
GO:0007015--P:actin filament organization
GO:0016477--P:cell migration
GO:0048013--P:ephrin receptor signaling pathway
GO:0030032--P:lamellipodium assembly
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0030838--P:positive regulation of actin filament polymerization
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001404	Ailuropoda melanoleuca	87.63	0.00e+00	667.00
IUUC-Apl-003456	Anas platyrhynchos	84.47	0.00e+00	651.00
IUUC-Aca-005105	Anolis carolinensis	84.07	0.00e+00	647.00
IUUC-Ame-010966	Astyanax mexicanus	75.46	2.00e-167	581.00
IUUC-Bta-012424	Bos taurus	85.86	2.00e-176	610.00
IUUC-Cel-018144	Caenorhabditis elegans	42.65	3.00e-77	281.00
IUUC-Cja-019898	Callithrix jacchus	88.68	0.00e+00	674.00
IUUC-Cfa-020830	Canis familiaris	88.42	0.00e+00	669.00
IUUC-Csa-023693	Chlorocebus sabaeus	88.95	0.00e+00	675.00
IUUC-Cin-025348	Ciona intestinalis	37.47	5.00e-67	248.00
IUUC-Dre-028334	Danio rerio	77.23	2.00e-167	581.00
IUUC-Dno-028973	Dasypus novemcinctus	85.53	0.00e+00	654.00
IUUC-Dor-031003	Dipodomys ordii	88.95	0.00e+00	642.00
IUUC-Ete-032792	Echinops telfairi	77.86	1.00e-171	595.00
IUUC-Eca-033656	Equus caballus	88.16	0.00e+00	669.00
IUUC-Fca-036347	Felis catus	87.89	0.00e+00	669.00
IUUC-Fal-037095	Ficedula albicollis	83.95	0.00e+00	650.00
IUUC-Gmo-039410	Gadus morhua	70.92	2.00e-158	551.00
IUUC-Gga-040155	Gallus gallus	84.47	0.00e+00	651.00
IUUC-Gac-041787	Gasterosteus aculeatus	73.86	2.00e-165	575.00
IUUC-Ggo-044805	Gorilla gorilla	88.95	0.00e+00	674.00
IUUC-Hsa-046585	Homo sapiens	88.95	0.00e+00	674.00
IUUC-Itr-048887	Ictidomys tridecemlineatus	88.16	0.00e+00	654.00
IUUC-Lch-049795	Latimeria chalumnae	81.84	0.00e+00	634.00
IUUC-Loc-051985	Lepisosteus oculatus	81.32	1.00e-177	615.00
IUUC-Laf-054228	Loxodonta africana	86.05	0.00e+00	659.00
IUUC-Mcc-055402	Macaca mulatta	88.95	0.00e+00	675.00
IUUC-Mga-059374	Meleagris gallopavo	84.47	0.00e+00	651.00
IUUC-Mmr-061453	Microcebus murinus	87.63	0.00e+00	667.00
IUUC-Mdo-063080	Monodelphis domestica	82.89	0.00e+00	642.00
IUUC-Mmu-063529	Mus musculus	88.68	0.00e+00	657.00
IUUC-Mpu-066815	Mustela putorius furo	87.63	0.00e+00	667.00
IUUC-Nle-069371	Nomascus leucogenys	88.95	0.00e+00	674.00
IUUC-Opr-070948	Ochotona princeps	86.74	0.00e+00	629.00
IUUC-Ont-071410	Oreochromis niloticus	73.05	6.00e-160	556.00
IUUC-Oan-073304	Ornithorhynchus anatinus	81.05	3.00e-142	497.00
IUUC-Ocu-074783	Oryctolagus cuniculus	87.89	0.00e+00	657.00
IUUC-Ola-086808	Oryzias latipes	72.82	1.00e-156	545.00
IUUC-Oga-088391	Otolemur garnettii	88.16	0.00e+00	655.00
IUUC-Oar-090025	Ovis aries	82.28	1.00e-164	572.00
IUUC-Ptr-090975	Pan troglodytes	88.95	0.00e+00	674.00
IUUC-Pan-092287	Papio anubis	88.95	0.00e+00	675.00
IUUC-Psi-093413	Pelodiscus sinensis	84.47	0.00e+00	651.00
IUUC-Pfo-097129	Poecilia formosa	75.26	9.00e-164	569.00
IUUC-Pab-098756	Pongo abelii	88.95	0.00e+00	674.00
IUUC-Pca-100235	Procavia capensis	74.21	3.00e-165	574.00
IUUC-Pva-102294	Pteropus vampyrus	84.47	0.00e+00	633.00
IUUC-Rno-105090	Rattus norvegicus	88.42	0.00e+00	656.00
IUUC-Sha-107521	Sarcophilus harrisii	82.89	0.00e+00	645.00
IUUC-Sar-113697	Sorex araneus	86.98	0.00e+00	648.00
IUUC-Ssc-115958	Sus scrofa	84.59	8.00e-156	542.00
IUUC-Tgu-116559	Taeniopygia guttata	82.37	0.00e+00	626.00
IUUC-Tru-117677	Takifugu rubripes	74.18	7.00e-162	563.00
IUUC-Tni-120434	Tetraodon nigroviridis	76.03	6.00e-161	560.00
IUUC-Tbe-127931	Tupaia belangeri	86.35	7.00e-163	566.00
IUUC-Ttr-128993	Tursiops truncatus	86.84	1.00e-179	622.00
IUUC-Xtr-132543	Xenopus tropicalis	77.69	4.00e-177	613.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence