iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mcc-055402

Ensembl Protein ID

ENSMMUP00000036193.1

UniProt Accession

F7D094; F7D094_MACMU

Genbank Protein ID

EHH22396.1

Protein Name

Putative uncharacterized protein

Genbank Nucleotide ID

JSUE03011660

Gene Name

NCK2; EGK_05646

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000001390.3	ENSMMUT00000043184.2	ENSMMUP00000036193.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	6.10e-45	152.1	199	258

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++vq+ly++++++++eL+++kG++++viek e+d +W+k+ k+++g+ Gl+P+n+v+ l+
   Q: 199  LHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKC-KNARGQVGLVPKNYVVVLS 258
           689**************************************.7**************9886 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MKMTEEVIVI AKWDYTAQQD QELDIKKNER LWLLDDSKTW WRVRNAANRT GYVPSNYVER 60
KNSLKKGSLV KNLKDTLGLG KTRRKTSARD ASPTPSTDAE YPANGSSADR IYDLNIPAFV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTTCATGTG TTCCTTGTAT ACAAGCGACG TCCCAAATTA TAATTCTCTG CTGAGATTTG 60
AGAATTTGGA GAATCCCTGC AGCTTTGTAA CTTCAGAGGT GTAATTAGCT GAAAAGTCAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0012506--C:vesicle membrane
GO:0007015--P:actin filament organization
GO:0016477--P:cell migration
GO:0048013--P:ephrin receptor signaling pathway
GO:0030032--P:lamellipodium assembly
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0030838--P:positive regulation of actin filament polymerization
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress

KEGG

mcc:713287

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001404	Ailuropoda melanoleuca	97.37	0.00e+00	752.00
IUUC-Apl-003456	Anas platyrhynchos	93.18	0.00e+00	731.00
IUUC-Aca-005105	Anolis carolinensis	92.37	0.00e+00	725.00
IUUC-Ame-010966	Astyanax mexicanus	78.65	8.00e-177	612.00
IUUC-Bta-012424	Bos taurus	88.68	0.00e+00	652.00
IUUC-Cel-018144	Caenorhabditis elegans	42.40	3.00e-77	281.00
IUUC-Cja-019898	Callithrix jacchus	99.47	0.00e+00	763.00
IUUC-Cfa-020830	Canis familiaris	97.37	0.00e+00	750.00
IUUC-Cpo-021487	Cavia porcellus	88.95	0.00e+00	661.00
IUUC-Csa-023693	Chlorocebus sabaeus	100.00	0.00e+00	770.00
IUUC-Cho-024368	Choloepus hoffmanni	64.76	1.00e-130	458.00
IUUC-Cin-025348	Ciona intestinalis	37.10	1.00e-66	246.00
IUUC-Csv-026046	Ciona savignyi	39.15	4.00e-69	255.00
IUUC-Dre-028334	Danio rerio	81.20	1.00e-179	622.00
IUUC-Dno-028973	Dasypus novemcinctus	94.47	0.00e+00	735.00
IUUC-Dor-031003	Dipodomys ordii	96.05	0.00e+00	709.00
IUUC-Dme-031846	Drosophila melanogaster	41.50	1.00e-89	323.00
IUUC-Ete-032792	Echinops telfairi	86.46	0.00e+00	665.00
IUUC-Eca-033656	Equus caballus	98.16	0.00e+00	756.00
IUUC-Eeu-034743	Erinaceus europaeus	63.09	1.00e-138	485.00
IUUC-Fca-036347	Felis catus	97.63	0.00e+00	753.00
IUUC-Fal-037095	Ficedula albicollis	93.18	0.00e+00	733.00
IUUC-Gmo-039410	Gadus morhua	71.17	6.00e-162	563.00
IUUC-Gga-040155	Gallus gallus	93.16	0.00e+00	730.00
IUUC-Gac-041787	Gasterosteus aculeatus	73.10	2.00e-166	578.00
IUUC-Ggo-044805	Gorilla gorilla	99.74	0.00e+00	765.00
IUUC-Hsa-046585	Homo sapiens	99.74	0.00e+00	764.00
IUUC-Itr-048887	Ictidomys tridecemlineatus	96.58	0.00e+00	724.00
IUUC-Lch-049795	Latimeria chalumnae	88.95	0.00e+00	698.00
IUUC-Loc-051985	Lepisosteus oculatus	88.45	0.00e+00	674.00
IUUC-Laf-054228	Loxodonta africana	95.53	0.00e+00	741.00
IUUC-Meu-056139	Macropus eugenii	65.87	3.00e-143	501.00
IUUC-Mga-059374	Meleagris gallopavo	93.16	0.00e+00	730.00
IUUC-Mmr-061453	Microcebus murinus	98.16	0.00e+00	757.00
IUUC-Mdo-063080	Monodelphis domestica	91.84	0.00e+00	724.00
IUUC-Mmu-063529	Mus musculus	95.79	0.00e+00	724.00
IUUC-Mpu-066815	Mustela putorius furo	97.37	0.00e+00	752.00
IUUC-Mlu-067132	Myotis lucifugus	94.10	5.00e-165	573.00
IUUC-Nle-069371	Nomascus leucogenys	99.74	0.00e+00	764.00
IUUC-Opr-070948	Ochotona princeps	96.82	0.00e+00	707.00
IUUC-Ont-071410	Oreochromis niloticus	75.06	6.00e-164	570.00
IUUC-Oan-073304	Ornithorhynchus anatinus	91.83	2.00e-165	574.00
IUUC-Ocu-074783	Oryctolagus cuniculus	97.37	0.00e+00	729.00
IUUC-Opu-083278	Oryza punctata	42.11	2.40e-01	29.30
IUUC-Ola-086808	Oryzias latipes	73.33	7.00e-162	563.00
IUUC-Oga-088391	Otolemur garnettii	98.68	0.00e+00	738.00
IUUC-Oar-090025	Ovis aries	82.37	2.00e-169	587.00
IUUC-Ptr-090975	Pan troglodytes	99.74	0.00e+00	764.00
IUUC-Pan-092287	Papio anubis	100.00	0.00e+00	770.00
IUUC-Psi-093413	Pelodiscus sinensis	93.68	0.00e+00	733.00
IUUC-Pfo-097129	Poecilia formosa	76.71	9.00e-170	589.00
IUUC-Pab-098756	Pongo abelii	99.74	0.00e+00	764.00
IUUC-Pca-100235	Procavia capensis	82.37	0.00e+00	650.00
IUUC-Pva-102294	Pteropus vampyrus	94.21	0.00e+00	719.00
IUUC-Rno-105090	Rattus norvegicus	95.53	0.00e+00	723.00
IUUC-Sha-107521	Sarcophilus harrisii	92.37	0.00e+00	728.00
IUUC-Sar-113697	Sorex araneus	89.06	0.00e+00	669.00
IUUC-Ssc-115958	Sus scrofa	87.97	3.00e-167	580.00
IUUC-Tgu-116559	Taeniopygia guttata	91.05	0.00e+00	705.00
IUUC-Tru-117677	Takifugu rubripes	76.46	8.00e-168	583.00
IUUC-Tsy-119184	Tarsius syrichta	62.47	3.00e-126	444.00
IUUC-Tni-120434	Tetraodon nigroviridis	76.02	3.00e-165	574.00
IUUC-Tbe-127931	Tupaia belangeri	96.84	0.00e+00	636.00
IUUC-Ttr-128993	Tursiops truncatus	88.68	0.00e+00	654.00
IUUC-Vpa-130344	Vicugna pacos	67.80	3.00e-154	538.00
IUUC-Xtr-132543	Xenopus tropicalis	83.99	0.00e+00	673.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence