iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108368

Ensembl Protein ID

SPAC21E11.05c.1:pep

UniProt Accession

Q09928; PPIL2_SCHPO

Genbank Protein ID

CAA91964.1

Protein Name

Peptidyl-prolyl cis-trans isomerase cyp8; RING-type E3 ubiquitin transferase cyp8; Rotamase cyp8

Genbank Nucleotide ID

CU329670

Gene Name

cyp8; SPAC21E11.05c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPAC21E11.05c	SPAC21E11.05c.1	SPAC21E11.05c.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	Mentha
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	5.20e-09	34.2	44	112

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 7    lCpIslelMrdPvvlp..sG..itydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawceen 72
            C++sl+++++P++l   +   i +d + I  wl++ g+ +P+++q+ + +dl+  ++ ++  +++c+  
   Q: 44   YCSLSLQPFNHPCCLVdeTKqaIIFDFRFIVPWLRKHGT-NPINGQKASMSDLIKLKFAKNSAEEYCDPV 112
           6*************9733332279**********99998.***************************875 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.

Protein Sequence
(Fasta)

MGKNTDKLYI TQTEHSGVHG WHGGMSGIAQ KNSTTSYKQL PFNYCSLSLQ PFNHPCCLVD 60
ETKQAIIFDF RFIVPWLRKH GTNPINGQKA SMSDLIKLKF AKNSAEEYCD PVTMKSFTRF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTACTACACC AACGCTATTC GACAACGTAT ACTTGTAGTT CGCATATATA TTACTAGAAA 60
TTAATTACTT TATCGCCTTA AAATATCATA AAATTAAGAA CTTTTATTTT TATTTTTTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0413--Isomerase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0697--Rotamase
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR029000--Cyclophilin-like_dom
IPR024936--Cyclophilin-type_PPIase
IPR020892--Cyclophilin-type_PPIase_CS
IPR002130--Cyclophilin-type_PPIase_dom
IPR003613--Ubox_domain
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS00170--CSA_PPIASE_1
PS50072--CSA_PPIASE_2
PS51698--U_BOX

Pfam

PF00160--Pro_isomerase

PRINTS

PR00153--CSAPPISMRASE

SMART

SM00504--Ubox

Gene Ontology

GO:0005634--C:nucleus
GO:0003755--F:peptidyl-prolyl cis-trans isomerase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0006457--P:protein folding

KEGG

spo:SPAC21E11.05c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000982	Aegilops tauschii	47.66	1.00e-46	178.00
IUUC-Aml-002351	Ailuropoda melanoleuca	38.77	4.00e-98	350.00
IUUC-Atr-002724	Amborella trichopoda	46.21	4.00e-55	207.00
IUUC-Apl-003515	Anas platyrhynchos	45.54	4.00e-89	320.00
IUUC-Aca-004802	Anolis carolinensis	42.09	6.00e-100	355.00
IUUC-Aly-005928	Arabidopsis lyrata	52.97	2.00e-46	178.00
IUUC-Ath-007574	Arabidopsis thaliana	54.10	4.00e-42	164.00
IUUC-Acl-008183	Aspergillus clavatus	48.75	3.00e-118	416.00
IUUC-Afl-008382	Aspergillus flavus	50.00	1.00e-124	437.00
IUUC-Afu-008952	Aspergillus fumigatus	47.60	1.00e-116	411.00
IUUC-Ani-009146	Aspergillus nidulans	46.69	3.00e-120	423.00
IUUC-Ang-009743	Aspergillus niger	50.41	6.00e-126	442.00
IUUC-Aor-010027	Aspergillus oryzae	51.28	6.00e-124	435.00
IUUC-Ate-010569	Aspergillus terreus	48.51	2.00e-121	427.00
IUUC-Ame-010783	Astyanax mexicanus	42.39	2.00e-99	353.00
IUUC-Bgr-012172	Blumeria graminis	39.70	3.00e-88	317.00
IUUC-Bta-012459	Bos taurus	38.84	6.00e-95	339.00
IUUC-Bci-013693	Botrytis cinerea	46.32	2.00e-123	434.00
IUUC-Bdi-014623	Brachypodium distachyon	45.45	2.00e-51	194.00
IUUC-Bol-015781	Brassica oleracea	52.97	7.00e-52	196.00
IUUC-Bra-016624	Brassica rapa	37.13	1.00e-83	301.00
IUUC-Cel-018328	Caenorhabditis elegans	36.95	4.00e-84	303.00
IUUC-Cja-019427	Callithrix jacchus	41.37	2.00e-97	347.00
IUUC-Cfa-020829	Canis familiaris	42.67	1.00e-101	361.00
IUUC-Cpo-022189	Cavia porcellus	41.15	3.00e-97	347.00
IUUC-Cre-022723	Chlamydomonas reinhardtii	48.43	3.00e-52	197.00
IUUC-Csa-024212	Chlorocebus sabaeus	41.67	2.00e-99	354.00
IUUC-Cin-025720	Ciona intestinalis	43.53	3.00e-103	366.00
IUUC-Csv-026137	Ciona savignyi	44.25	6.00e-94	335.00
IUUC-Cgl-026532	Colletotrichum gloeosporioides	45.88	1.00e-128	451.00
IUUC-Cne-026830	Cryptococcus neoformans	41.22	2.00e-101	360.00
IUUC-Dre-028561	Danio rerio	42.25	3.00e-99	353.00
IUUC-Dno-029029	Dasypus novemcinctus	35.27	2.00e-76	278.00
IUUC-Dse-031506	Dothistroma septosporum	46.11	5.00e-125	439.00
IUUC-Dme-032058	Drosophila melanogaster	38.42	2.00e-92	330.00
IUUC-Ete-033157	Echinops telfairi	33.58	8.00e-65	239.00
IUUC-Eeu-034470	Erinaceus europaeus	36.52	1.00e-55	208.00
IUUC-Fca-036571	Felis catus	42.16	1.00e-100	358.00
IUUC-Fal-037613	Ficedula albicollis	40.57	5.00e-97	345.00
IUUC-Fox-037795	Fusarium oxysporum	42.81	6.00e-121	425.00
IUUC-Fso-038213	Fusarium solani	42.18	2.00e-112	397.00
IUUC-Gmo-039609	Gadus morhua	40.67	6.00e-93	332.00
IUUC-Ggr-039825	Gaeumannomyces graminis	42.32	4.00e-118	416.00
IUUC-Gga-041191	Gallus gallus	40.49	2.00e-95	341.00
IUUC-Gac-041524	Gasterosteus aculeatus	44.00	1.00e-95	342.00
IUUC-Gma-042925	Glycine max	55.94	6.00e-49	186.00
IUUC-Ggo-045352	Gorilla gorilla	41.56	1.00e-99	355.00
IUUC-Hsa-045709	Homo sapiens	41.56	1.00e-99	354.00
IUUC-Hvu-047058	Hordeum vulgare	47.86	6.00e-52	196.00
IUUC-Itr-048483	Ictidomys tridecemlineatus	44.44	6.00e-98	348.00
IUUC-Kpa-049357	Komagataella pastoris	65.00	1.00e+00	27.70
IUUC-Lch-049681	Latimeria chalumnae	44.67	2.00e-90	324.00
IUUC-Lpe-050799	Leersia perrieri	52.97	8.00e-52	196.00
IUUC-Loc-052566	Lepisosteus oculatus	48.06	3.00e-44	171.00
IUUC-Lma-053028	Leptosphaeria maculans	47.34	8.00e-122	428.00
IUUC-Laf-054547	Loxodonta africana	41.93	9.00e-99	352.00
IUUC-Mcc-054753	Macaca mulatta	44.69	8.00e-97	345.00
IUUC-Meu-056855	Macropus eugenii	34.16	9.00e-36	141.00
IUUC-Mor-056941	Magnaporthe oryzae	44.82	1.00e-108	384.00
IUUC-Mpo-057306	Magnaporthe poae	43.12	5.00e-121	426.00
IUUC-Mtr-058349	Medicago truncatula	53.96	1.00e-47	182.00
IUUC-Mla-058842	Melampsora laricipopulina	47.49	8.00e-102	362.00
IUUC-Mga-060099	Meleagris gallopavo	38.77	1.00e-84	305.00
IUUC-Mvi-060413	Microbotryum violaceum	40.07	7.00e-101	358.00
IUUC-Mmr-061530	Microcebus murinus	42.12	3.00e-101	360.00
IUUC-Mdo-062668	Monodelphis domestica	43.58	2.00e-94	337.00
IUUC-Mmu-063871	Mus musculus	40.78	4.00e-97	346.00
IUUC-Mac-064559	Musa acuminata	52.97	1.00e-52	199.00
IUUC-Mpu-065919	Mustela putorius furo	41.34	5.00e-97	346.00
IUUC-Mlu-067846	Myotis lucifugus	36.51	3.00e-86	310.00
IUUC-Nfi-068507	Neosartorya fischeri	48.02	2.00e-115	407.00
IUUC-Ncr-068805	Neurospora crassa	46.20	6.00e-52	196.00
IUUC-Nle-070125	Nomascus leucogenys	39.07	1.00e-88	318.00
IUUC-Opr-070486	Ochotona princeps	39.95	1.00e-71	261.00
IUUC-Ont-071597	Oreochromis niloticus	42.14	2.00e-100	357.00
IUUC-Ocu-074411	Oryctolagus cuniculus	43.39	8.00e-95	338.00
IUUC-Oba-075040	Oryza barthii	52.48	2.00e-51	195.00
IUUC-Obr-076727	Oryza brachyantha	52.97	1.00e-51	195.00
IUUC-Ogl-077605	Oryza glaberrima	52.48	2.00e-51	195.00
IUUC-Ogu-078177	Oryza glumaepatula	52.48	2.00e-51	195.00
IUUC-Oin-079549	Oryza indica	50.50	2.00e-46	178.00
IUUC-Olo-081090	Oryza longistaminata	52.48	1.00e-51	195.00
IUUC-Ome-081979	Oryza meridionalis	52.48	1.00e-51	195.00
IUUC-Oni-082819	Oryza nivara	52.48	2.00e-51	195.00
IUUC-Opu-083212	Oryza punctata	51.98	1.00e-50	192.00
IUUC-Oru-084412	Oryza rufipogon	52.48	2.00e-51	195.00
IUUC-Osa-085431	Oryza sativa	38.85	3.00e-25	105.00
IUUC-Ola-086602	Oryzias latipes	45.52	1.00e-89	321.00
IUUC-Olu-087682	Ostreococcus lucimarinus	38.34	4.00e-76	276.00
IUUC-Oga-088999	Otolemur garnettii	38.64	5.00e-91	326.00
IUUC-Oar-089338	Ovis aries	35.87	8.00e-72	262.00
IUUC-Ptr-091185	Pan troglodytes	41.56	1.00e-99	355.00
IUUC-Pan-092321	Papio anubis	41.56	3.00e-101	360.00
IUUC-Psi-094018	Pelodiscus sinensis	43.49	8.00e-53	198.00
IUUC-Pma-094111	Petromyzon marinus	39.72	2.00e-70	257.00
IUUC-Pno-094782	Phaeosphaeria nodorum	48.68	1.00e-123	434.00
IUUC-Ppa-095335	Physcomitrella patens	50.65	5.00e-56	210.00
IUUC-Pfo-097393	Poecilia formosa	42.51	5.00e-101	359.00
IUUC-Pab-098263	Pongo abelii	38.65	3.00e-86	310.00
IUUC-Pop-099316	Populus trichocarpa	43.05	2.00e-83	301.00
IUUC-Ppe-101275	Prunus persica	53.47	2.00e-47	181.00
IUUC-Pva-102150	Pteropus vampyrus	42.25	4.00e-83	299.00
IUUC-Pgr-103378	Puccinia graminis	46.75	3.00e-106	377.00
IUUC-Ptt-103908	Puccinia triticina	44.91	6.00e-95	339.00
IUUC-Pte-104248	Pyrenophora teres	47.09	8.00e-122	428.00
IUUC-Pyt-104645	Pyrenophora triticirepentis	47.44	6.00e-122	429.00
IUUC-Rno-105162	Rattus norvegicus	41.00	1.00e-99	355.00
IUUC-Sha-107123	Sarcophilus harrisii	44.57	5.00e-48	183.00
IUUC-Sja-107828	Schizosaccharomyces japonicus	59.27	8.00e-177	611.00
IUUC-Smo-109102	Selaginella moellendorffii	38.07	2.00e-85	308.00
IUUC-Sit-110821	Setaria italica	53.47	1.00e-51	195.00
IUUC-Sly-111803	Solanum lycopersicum	42.02	4.00e-56	210.00
IUUC-Stu-112730	Solanum tuberosum	42.02	2.00e-55	207.00
IUUC-Sar-113618	Sorex araneus	41.40	2.00e-94	337.00
IUUC-Sbi-114487	Sorghum bicolor	53.47	2.00e-51	195.00
IUUC-Sre-115009	Sporisorium reilianum	38.20	2.00e-91	328.00
IUUC-Ssc-115984	Sus scrofa	41.71	1.00e-98	351.00
IUUC-Tgu-117410	Taeniopygia guttata	40.49	6.00e-98	349.00
IUUC-Tru-118537	Takifugu rubripes	41.39	1.00e-98	351.00
IUUC-Tsy-119318	Tarsius syrichta	30.92	1.00e-33	135.00
IUUC-Tni-120514	Tetraodon nigroviridis	44.57	2.00e-68	251.00
IUUC-Tca-121620	Theobroma cacao	54.46	1.00e-48	185.00
IUUC-Tre-121904	Trichoderma reesei	40.96	4.00e-99	353.00
IUUC-Tvi-122585	Trichoderma virens	42.32	8.00e-98	348.00
IUUC-Tae-125342	Triticum aestivum	47.86	1.00e-51	196.00
IUUC-Tme-126960	Tuber melanosporum	50.00	9.00e-142	494.00
IUUC-Ttr-129173	Tursiops truncatus	34.08	4.00e-67	246.00
IUUC-Uma-129595	Ustilago maydis	35.88	1.00e-79	288.00
IUUC-Vda-130012	Verticillium dahliae	44.08	6.00e-121	426.00
IUUC-Vvi-131156	Vitis vinifera	46.08	5.00e-56	210.00
IUUC-Xtr-132807	Xenopus tropicalis	41.08	5.00e-92	329.00
IUUC-Yli-134361	Yarrowia lipolytica	37.34	6.00e-58	216.00
IUUC-Zma-135759	Zea mays	52.48	7.00e-51	193.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence