iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-005389

UUCD1 version

UUC-AnC-00660

Ensembl Protein ID

ENSACAP00000008820.3

UniProt Accession

G1KID3; G1KID3_ANOCA

Protein Name

Uncharacterized protein

Gene Name

KEAP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000008991.3	ENSACAT00000009010.3	ENSACAP00000008820.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	1.70e-16	60.2	45	115
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	5.30e-10	38.4	149	179

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvv.....ggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +Dv+l v         f+ahk+vLa+sS+vF+a+f+++l+e+   + v i+++ p+v++ l++F Yt +++ 
   Q: 45   CDVTLRVkykdtPPADFQAHKVVLASSSPVFKAMFTNGLREQG-MEVVPIEGIHPKVMERLIEFAYTASISV 115
           8999999554333679*************************98.***********************98875 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           ++N++gi  fA++ +c++L+++a+++i  hF
   Q: 149  PSNAIGIANFAEQISCTELHQRAREYIYMHF 179
           89****************************9 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MYAPECQAEV TPSHDGNRTF SYTLEDHTKQ AFSIMNQLRL SQQLCDVTLR VKYKDTPPAD 60
FQAHKVVLAS SSPVFKAMFT NGLREQGMEV VPIEGIHPKV MERLIEFAYT ASISVGEHCV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGCAGTGGC GGCTGCCTGA TCGCGCTATG GAGGAGGCAC CGAAGCGCAG GCGGCGGCGG 60
AGAAGGAGAA GAGCTCACCG GGACGGAGGG CGAGAGAGCC GGAAGGCCGC CCAGCTGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR030563--KEAP1
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0005884--C:actin filament
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005815--C:microtubule organizing center
GO:0030496--C:midbody
GO:0005654--C:nucleoplasm
GO:0008134--F:transcription factor binding
GO:0071353--P:cellular response to interleukin-4
GO:0042994--P:cytoplasmic sequestering of transcription factor
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0010499--P:proteasomal ubiquitin-independent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0045604--P:regulation of epidermal cell differentiation

KEGG

acs:100568087

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001377	Ailuropoda melanoleuca	86.34	0.00e+00	1090.00
IUUC-Ame-010749	Astyanax mexicanus	78.62	0.00e+00	970.00
IUUC-Bta-013505	Bos taurus	86.34	0.00e+00	1089.00
IUUC-Cja-018823	Callithrix jacchus	86.00	0.00e+00	1081.00
IUUC-Cfa-021202	Canis familiaris	86.34	0.00e+00	1088.00
IUUC-Cpo-021830	Cavia porcellus	83.50	0.00e+00	745.00
IUUC-Csa-023728	Chlorocebus sabaeus	85.83	0.00e+00	1080.00
IUUC-Cin-025195	Ciona intestinalis	54.48	0.00e+00	672.00
IUUC-Csv-026155	Ciona savignyi	53.42	7.00e-180	623.00
IUUC-Dre-027388	Danio rerio	77.42	0.00e+00	949.00
IUUC-Dno-029066	Dasypus novemcinctus	77.07	0.00e+00	947.00
IUUC-Dor-030674	Dipodomys ordii	83.70	0.00e+00	747.00
IUUC-Dme-032165	Drosophila melanogaster	48.94	1.00e-163	569.00
IUUC-Ete-032255	Echinops telfairi	79.67	2.00e-83	302.00
IUUC-Eca-034381	Equus caballus	83.33	0.00e+00	1058.00
IUUC-Eeu-034791	Erinaceus europaeus	86.67	0.00e+00	741.00
IUUC-Fca-036067	Felis catus	86.00	0.00e+00	1085.00
IUUC-Gmo-039691	Gadus morhua	77.68	0.00e+00	954.00
IUUC-Gga-040266	Gallus gallus	81.17	0.00e+00	1019.00
IUUC-Gac-041866	Gasterosteus aculeatus	77.65	0.00e+00	951.00
IUUC-Ggo-044719	Gorilla gorilla	86.00	0.00e+00	1083.00
IUUC-Hsa-046255	Homo sapiens	86.00	0.00e+00	1083.00
IUUC-Itr-048457	Ictidomys tridecemlineatus	86.17	0.00e+00	1084.00
IUUC-Lch-049646	Latimeria chalumnae	84.17	0.00e+00	1042.00
IUUC-Loc-052296	Lepisosteus oculatus	56.62	0.00e+00	641.00
IUUC-Laf-054579	Loxodonta africana	86.34	0.00e+00	1090.00
IUUC-Mcc-055315	Macaca mulatta	85.83	0.00e+00	1080.00
IUUC-Meu-056288	Macropus eugenii	82.77	0.00e+00	1021.00
IUUC-Mmr-061639	Microcebus murinus	86.34	0.00e+00	1088.00
IUUC-Mdo-062072	Monodelphis domestica	88.18	0.00e+00	1110.00
IUUC-Mmu-063622	Mus musculus	84.49	0.00e+00	1069.00
IUUC-Mpu-066737	Mustela putorius furo	84.82	0.00e+00	1060.00
IUUC-Mlu-068173	Myotis lucifugus	86.34	0.00e+00	1086.00
IUUC-Nle-069336	Nomascus leucogenys	50.50	1.00e-146	513.00
IUUC-Opr-070432	Ochotona princeps	86.68	0.00e+00	1089.00
IUUC-Ont-072160	Oreochromis niloticus	77.13	0.00e+00	948.00
IUUC-Oan-072691	Ornithorhynchus anatinus	77.78	0.00e+00	952.00
IUUC-Ocu-073798	Oryctolagus cuniculus	86.51	0.00e+00	1089.00
IUUC-Ola-086367	Oryzias latipes	74.49	0.00e+00	914.00
IUUC-Oga-088231	Otolemur garnettii	86.68	0.00e+00	1088.00
IUUC-Oar-089227	Ovis aries	84.82	0.00e+00	1061.00
IUUC-Ptr-091460	Pan troglodytes	86.00	0.00e+00	1083.00
IUUC-Pan-092713	Papio anubis	85.83	0.00e+00	1080.00
IUUC-Pfo-096468	Poecilia formosa	79.31	0.00e+00	952.00
IUUC-Pab-098357	Pongo abelii	86.00	0.00e+00	1083.00
IUUC-Pca-100837	Procavia capensis	86.17	0.00e+00	1083.00
IUUC-Pva-103249	Pteropus vampyrus	84.49	0.00e+00	1041.00
IUUC-Rno-106086	Rattus norvegicus	83.64	0.00e+00	1052.00
IUUC-Sha-107245	Sarcophilus harrisii	88.34	0.00e+00	1112.00
IUUC-Sar-112985	Sorex araneus	85.88	0.00e+00	1080.00
IUUC-Ssc-115756	Sus scrofa	86.51	0.00e+00	1090.00
IUUC-Tgu-116838	Taeniopygia guttata	54.19	2.00e-120	424.00
IUUC-Tru-117644	Takifugu rubripes	77.68	0.00e+00	967.00
IUUC-Tni-120245	Tetraodon nigroviridis	78.28	0.00e+00	959.00
IUUC-Tbe-127472	Tupaia belangeri	84.08	1.00e-127	450.00
IUUC-Ttr-128953	Tursiops truncatus	88.07	2.00e-173	602.00
IUUC-Vpa-130683	Vicugna pacos	86.06	0.00e+00	966.00
IUUC-Xtr-132827	Xenopus tropicalis	76.24	0.00e+00	941.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence