iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-034381

UUCD1 version

UUC-EqC-00357

Ensembl Protein ID

ENSECAP00000018058.1

UniProt Accession

F6VZG9; F6VZG9_HORSE

Protein Name

Uncharacterized protein

Gene Name

KEAP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000020533.1	ENSECAT00000021886.1	ENSECAP00000018058.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	1.40e-16	60.8	62	133
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	6.10e-09	35.1	166	196

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvv.....ggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +Dv+l+v        +f ahk+vLa+sS+vF+a+f+++l+e+   + v i+++ p+v++ l++F Yt ++++ 
   Q: 62   CDVTLQVkyedvPAAQFMAHKVVLASSSPVFKAMFTNGLREQG-MEVVSIEGIHPTVMERLIEFAYTASISMG 133
           8999999555444999*************************98.***********************998875 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           ++N++gi  fA++ +c +L+++a+++i  hF
   Q: 166  PSNAIGIANFAEQIGCAELHQRAREYIYMHF 196
           89****************************9 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

FLPLRSQRPE GAGPTVMFAS TECKAEVTPS QHGNRTFSYT LEDHTKQAFG IMNELRLSQQ 60
LCDVTLQVKY EDVPAAQFMA HKVVLASSSP VFKAMFTNGL REQGMEVVSI EGIHPTVMER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCCTGCCCT TGCGGTCACA GCGCCCGGAG GGGGCGGGGC CCACGGTGAT GTTCGCGTCC 60
ACCGAGTGCA AGGCGGAGGT GACGCCCTCG CAGCACGGCA ACCGCACGTT CAGCTACACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR030563--KEAP1
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0005884--C:actin filament
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005815--C:microtubule organizing center
GO:0030496--C:midbody
GO:0005654--C:nucleoplasm
GO:0008134--F:transcription factor binding
GO:0071353--P:cellular response to interleukin-4
GO:0042994--P:cytoplasmic sequestering of transcription factor
GO:0001701--P:in utero embryonic development
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0010499--P:proteasomal ubiquitin-independent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0045604--P:regulation of epidermal cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001377	Ailuropoda melanoleuca	94.42	0.00e+00	1218.00
IUUC-Aca-005389	Anolis carolinensis	83.33	0.00e+00	1058.00
IUUC-Ame-010749	Astyanax mexicanus	77.11	0.00e+00	948.00
IUUC-Bta-013505	Bos taurus	93.92	0.00e+00	1212.00
IUUC-Cja-018823	Callithrix jacchus	93.27	0.00e+00	1202.00
IUUC-Cfa-021202	Canis familiaris	94.42	0.00e+00	1217.00
IUUC-Cpo-021830	Cavia porcellus	92.23	0.00e+00	815.00
IUUC-Csa-023728	Chlorocebus sabaeus	93.60	0.00e+00	1205.00
IUUC-Cin-025195	Ciona intestinalis	54.31	0.00e+00	664.00
IUUC-Csv-026155	Ciona savignyi	52.89	2.00e-176	612.00
IUUC-Dre-027388	Danio rerio	75.04	0.00e+00	922.00
IUUC-Dno-029066	Dasypus novemcinctus	84.89	0.00e+00	1062.00
IUUC-Dor-030674	Dipodomys ordii	91.48	0.00e+00	810.00
IUUC-Dme-032165	Drosophila melanogaster	48.48	2.00e-159	556.00
IUUC-Ete-032255	Echinops telfairi	92.86	1.00e-97	349.00
IUUC-Eeu-034791	Erinaceus europaeus	89.12	0.00e+00	795.00
IUUC-Fca-036067	Felis catus	94.91	0.00e+00	1222.00
IUUC-Gmo-039691	Gadus morhua	75.51	0.00e+00	927.00
IUUC-Gga-040266	Gallus gallus	79.03	0.00e+00	987.00
IUUC-Gac-041866	Gasterosteus aculeatus	75.42	0.00e+00	932.00
IUUC-Ggo-044719	Gorilla gorilla	93.76	0.00e+00	1208.00
IUUC-Hsa-046255	Homo sapiens	93.76	0.00e+00	1208.00
IUUC-Itr-048457	Ictidomys tridecemlineatus	93.43	0.00e+00	1203.00
IUUC-Lch-049646	Latimeria chalumnae	80.41	0.00e+00	1014.00
IUUC-Loc-052296	Lepisosteus oculatus	56.79	0.00e+00	639.00
IUUC-Laf-054579	Loxodonta africana	93.60	0.00e+00	1209.00
IUUC-Mcc-055315	Macaca mulatta	93.60	0.00e+00	1205.00
IUUC-Meu-056288	Macropus eugenii	85.86	0.00e+00	1082.00
IUUC-Mmr-061639	Microcebus murinus	93.60	0.00e+00	1209.00
IUUC-Mdo-062072	Monodelphis domestica	91.45	0.00e+00	1175.00
IUUC-Mmu-063622	Mus musculus	93.43	0.00e+00	1202.00
IUUC-Mpu-066737	Mustela putorius furo	91.63	0.00e+00	1174.00
IUUC-Mlu-068173	Myotis lucifugus	93.76	0.00e+00	1210.00
IUUC-Ncr-068890	Neurospora crassa	21.88	1.50e+00	26.90
IUUC-Nle-069336	Nomascus leucogenys	62.60	0.00e+00	689.00
IUUC-Opr-070432	Ochotona princeps	92.65	0.00e+00	1179.00
IUUC-Ont-072160	Oreochromis niloticus	75.46	0.00e+00	926.00
IUUC-Oan-072691	Ornithorhynchus anatinus	79.66	0.00e+00	962.00
IUUC-Ocu-073798	Oryctolagus cuniculus	93.10	0.00e+00	1207.00
IUUC-Ola-086367	Oryzias latipes	72.68	0.00e+00	893.00
IUUC-Oga-088231	Otolemur garnettii	93.60	0.00e+00	1207.00
IUUC-Oar-089227	Ovis aries	92.61	0.00e+00	1187.00
IUUC-Ptr-091460	Pan troglodytes	93.76	0.00e+00	1208.00
IUUC-Pan-092713	Papio anubis	93.60	0.00e+00	1205.00
IUUC-Pfo-096468	Poecilia formosa	76.57	0.00e+00	935.00
IUUC-Pab-098357	Pongo abelii	93.92	0.00e+00	1210.00
IUUC-Pca-100837	Procavia capensis	92.78	0.00e+00	1192.00
IUUC-Pva-103249	Pteropus vampyrus	91.63	0.00e+00	1150.00
IUUC-Rno-106086	Rattus norvegicus	92.61	0.00e+00	1184.00
IUUC-Sha-107245	Sarcophilus harrisii	90.95	0.00e+00	1171.00
IUUC-Sar-112985	Sorex araneus	92.28	0.00e+00	1191.00
IUUC-Ssc-115756	Sus scrofa	94.91	0.00e+00	1223.00
IUUC-Tgu-116838	Taeniopygia guttata	53.79	9.00e-116	409.00
IUUC-Tru-117644	Takifugu rubripes	74.96	0.00e+00	951.00
IUUC-Tni-120245	Tetraodon nigroviridis	76.32	0.00e+00	941.00
IUUC-Tbe-127472	Tupaia belangeri	95.92	6.00e-146	511.00
IUUC-Ttr-128953	Tursiops truncatus	92.42	0.00e+00	663.00
IUUC-Vpa-130683	Vicugna pacos	91.88	0.00e+00	1058.00
IUUC-Xtr-132827	Xenopus tropicalis	74.44	0.00e+00	930.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence