iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000032307.16	ENSMUST00000059555.14	ENSMUSP00000059798.8
ENSMUSG00000032307.16	ENSMUST00000121677.7	ENSMUSP00000113336.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	3.40e-17	63.6	270	363

Active Site

Position(s)	Description	Evidence
307	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 46   vFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsilkeeekWspalsvesvllsiqsll..aepnpesplneeaaellkknre 131
           +  l+++f++++Pf+PP v+++ +++++ +    G++C+++l +++ Ws+a+s+esv+++i+++l   +++++ ++n+++++l +++++
   Q: 270  YILLNFSFKDNFPFDPPFVRVVLPVLSGGYVLGgGALCMELL-TKQGWSSAYSIESVIMQINATLvkGKARVQFGANKNQYNLARAQQS 357
           45789***********************999998********.59********************87789************9999998 PP
   S: 132  eykkkvr 138
            y+++v+
   Q: 358  -YNSIVQ 363
           .999885 PP

Organism

Mus musculus

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination.

Protein Sequence
(Fasta)

MSVSGLKAEL KFLASIFDKN HERFRIVSWK LDELHCQFLV PPPPPPPGSS LSPPPPLTLH 60
CNITESYPSS SPIWFVDSDD PNLTSVLERL EDTKNNSSLR QQLKWLICDL CRLYNLPKHL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGGAGTACA AGTCTGGAGA GAAGGACCTT TCGGGAGTCA CACTTAGAAA AGTGGTGGGT 60
GGTTCAGCGC GGAGCGAGAG CAACATACGT GAAGGTGCTA GGCGCACACC TCTCATCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0070936--P:protein K48-linked ubiquitination

KEGG

mmu:109161

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003420	Anas platyrhynchos	90.03	2.00e-159	554.00
IUUC-Afl-008523	Aspergillus flavus	31.69	8.00e-17	82.80
IUUC-Afu-009025	Aspergillus fumigatus	35.17	4.00e-15	77.40
IUUC-Ani-009397	Aspergillus nidulans	34.25	4.00e-15	77.80
IUUC-Ang-009729	Aspergillus niger	31.15	9.00e-21	96.30
IUUC-Aor-010200	Aspergillus oryzae	31.69	1.00e-16	82.80
IUUC-Ate-010283	Aspergillus terreus	35.47	2.00e-17	84.70
IUUC-Ame-011351	Astyanax mexicanus	78.29	3.00e-156	544.00
IUUC-Bta-012944	Bos taurus	86.77	4.00e-170	590.00
IUUC-Bci-013792	Botrytis cinerea	34.08	1.00e-17	85.90
IUUC-Cel-018705	Caenorhabditis elegans	44.56	1.00e-85	310.00
IUUC-Cfa-020582	Canis familiaris	92.59	0.00e+00	658.00
IUUC-Cpo-022469	Cavia porcellus	93.39	0.00e+00	663.00
IUUC-Csa-023724	Chlorocebus sabaeus	92.08	0.00e+00	672.00
IUUC-Cin-025383	Ciona intestinalis	50.13	3.00e-102	364.00
IUUC-Cgl-026471	Colletotrichum gloeosporioides	35.62	2.00e-19	92.40
IUUC-Dre-028429	Danio rerio	76.21	8.00e-160	556.00
IUUC-Dse-031418	Dothistroma septosporum	33.51	2.00e-19	92.00
IUUC-Dme-031720	Drosophila melanogaster	49.14	1.00e-107	383.00
IUUC-Ete-032744	Echinops telfairi	62.10	3.00e-85	308.00
IUUC-Eca-033376	Equus caballus	95.50	0.00e+00	681.00
IUUC-Fca-036101	Felis catus	95.24	0.00e+00	663.00
IUUC-Fal-036837	Ficedula albicollis	85.75	2.00e-174	605.00
IUUC-Fox-038074	Fusarium oxysporum	32.81	1.00e-13	72.40
IUUC-Fso-038245	Fusarium solani	29.19	3.00e-14	74.30
IUUC-Gmo-039573	Gadus morhua	81.41	4.00e-169	587.00
IUUC-Ggr-039776	Gaeumannomyces graminis	33.33	1.00e-16	82.80
IUUC-Gac-041518	Gasterosteus aculeatus	80.63	6.00e-170	590.00
IUUC-Hsa-046577	Homo sapiens	91.56	0.00e+00	662.00
IUUC-Lch-049959	Latimeria chalumnae	77.14	4.00e-155	540.00
IUUC-Loc-052754	Lepisosteus oculatus	80.20	8.00e-173	599.00
IUUC-Lma-052975	Leptosphaeria maculans	32.61	4.00e-23	104.00
IUUC-Mor-057265	Magnaporthe oryzae	30.20	1.00e-12	69.70
IUUC-Mpo-057298	Magnaporthe poae	32.65	2.00e-14	75.90
IUUC-Mga-059200	Meleagris gallopavo	90.79	1.00e-156	545.00
IUUC-Mmr-061213	Microcebus murinus	94.97	0.00e+00	674.00
IUUC-Mdo-062562	Monodelphis domestica	77.75	1.00e-156	545.00
IUUC-Mpu-066198	Mustela putorius furo	96.30	0.00e+00	678.00
IUUC-Nfi-068376	Neosartorya fischeri	34.48	3.00e-15	77.80
IUUC-Nle-069221	Nomascus leucogenys	92.08	0.00e+00	671.00
IUUC-Opr-070331	Ochotona princeps	77.24	8.00e-132	463.00
IUUC-Ont-071632	Oreochromis niloticus	80.15	7.00e-171	593.00
IUUC-Oan-072781	Ornithorhynchus anatinus	92.50	1.00e-140	491.00
IUUC-Ocu-074097	Oryctolagus cuniculus	94.44	0.00e+00	671.00
IUUC-Ola-087271	Oryzias latipes	76.61	1.00e-169	589.00
IUUC-Olu-087612	Ostreococcus lucimarinus	30.15	7.00e-12	63.50
IUUC-Oga-089115	Otolemur garnettii	94.97	0.00e+00	666.00
IUUC-Oar-090270	Ovis aries	89.36	0.00e+00	659.00
IUUC-Ptr-090599	Pan troglodytes	91.56	0.00e+00	669.00
IUUC-Pan-092455	Papio anubis	92.35	0.00e+00	676.00
IUUC-Pno-095082	Phaeosphaeria nodorum	35.29	1.00e-18	89.00
IUUC-Pfo-097215	Poecilia formosa	81.56	1.00e-171	595.00
IUUC-Pva-102975	Pteropus vampyrus	97.13	1.00e-169	588.00
IUUC-Pte-104028	Pyrenophora teres	35.75	3.00e-20	94.40
IUUC-Pyt-104588	Pyrenophora triticirepentis	35.75	3.00e-19	91.30
IUUC-Rno-105714	Rattus norvegicus	93.92	0.00e+00	652.00
IUUC-Sha-106904	Sarcophilus harrisii	88.82	8.00e-157	546.00
IUUC-Ssl-108486	Sclerotinia sclerotiorum	34.66	1.00e-18	86.30
IUUC-Sar-113657	Sorex araneus	95.22	2.00e-165	574.00
IUUC-Ssc-116046	Sus scrofa	93.67	0.00e+00	661.00
IUUC-Tgu-116888	Taeniopygia guttata	85.40	1.00e-155	541.00
IUUC-Tru-118721	Takifugu rubripes	80.00	1.00e-166	579.00
IUUC-Tsy-118894	Tarsius syrichta	89.29	1.00e-124	438.00
IUUC-Tni-120346	Tetraodon nigroviridis	78.53	2.00e-167	582.00
IUUC-Tre-122084	Trichoderma reesei	30.68	2.00e-16	81.60
IUUC-Tvi-122420	Trichoderma virens	32.97	5.00e-15	77.00
IUUC-Tme-127145	Tuber melanosporum	39.58	3.00e-18	87.80
IUUC-Ttr-128707	Tursiops truncatus	95.24	0.00e+00	679.00
IUUC-Vda-129662	Verticillium dahliae	31.33	1.00e-11	65.90
IUUC-Vpa-130455	Vicugna pacos	98.41	3.00e-172	597.00
IUUC-Xtr-132483	Xenopus tropicalis	85.49	7.00e-177	612.00
IUUC-Xma-134189	Xiphophorus maculatus	77.12	8.00e-161	559.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence