iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054071

UUCD1 version

UUC-LoA-00666

Ensembl Protein ID

ENSLAFP00000016749.2

UniProt Accession

G3TNE0; G3TNE0_LOXAF

Protein Name

Uncharacterized protein

Gene Name

TBL1Y

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000021416.2	ENSLAFT00000021727.2	ENSLAFP00000016749.2
ENSLAFG00000021416.2	ENSLAFT00000028873.1	ENSLAFP00000023708.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.70e-53	176.5	456	494
UBD/Beta-Prp	8.50e-64	215.9	333	528

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           H+++v+++af +d ++l+sGs D+ +++W++ +g l++s
   Q: 456  HQEPVYSVAFsPDgKYLASGSFDKCVHIWNTQSGSLVHS 494
           9**********999******************9999875 PP

UBD/Beta-Prp

   S: 21   dksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsp..... 104
           +++ +a+ s+d +i v ++     +++++gh++ev+a+k++p+g +l+++s+D+t+k+w++++  cvh l++h+++++++++ p     
   Q: 333  NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWGPtgpat 421
           56677777888888888888777788888888888888888888888888888888888888888888888888888887766655555 PP
   S: 105  ....sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfd 189
               s+  l+s+s d+t+r+wd+e g c++ tl++h++ v +v+++pdg++l+sGs D++v +W+ ++g+l++  +g  t+ +  + ++
   Q: 422  snpsSNIMLASASFDSTVRLWDVERGVCIH-TLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGSLVHSYRG--TGGIFEVCWN 507
           444344567888888888888888888888.8888888888888888888888888888888888888888888887..8888888888 PP
   S: 190  sngkelvsgsldgtvklwdlq 210
             g  + + + dg+v + dl+
   Q: 508  ARGDKVGASASDGSVCVLDLR 528
           888888888888888777765 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MSITSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GTLVPPAALI SILQKGLQYV 60
EAEISINEDG TVFDGRPIES LSLIDAVMPD VVQTRQQAFR EKLAQQQASA AAAAAATAAA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCATAA CCAGTGACGA GGTGAACTTT TTGGTGTATC GGTACCTCCA GGAGTCAGGT 60
AGGTGGCTCG CTTTTGTCAG CAGGAGGTTT ATCTTCAACG TACCATGTGC AGACGCTCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005667--C:transcription factor complex
GO:0003682--F:chromatin binding
GO:0003714--F:transcription corepressor activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0045444--P:fat cell differentiation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043627--P:response to estrogen
GO:0048545--P:response to steroid hormone

KEGG

lav:100657866

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001450	Ailuropoda melanoleuca	92.06	0.00e+00	992.00
IUUC-Apl-003232	Anas platyrhynchos	94.52	0.00e+00	998.00
IUUC-Aca-005035	Anolis carolinensis	95.27	0.00e+00	1004.00
IUUC-Bta-013202	Bos taurus	96.79	0.00e+00	1006.00
IUUC-Cja-019281	Callithrix jacchus	91.68	0.00e+00	979.00
IUUC-Cfa-020929	Canis familiaris	96.22	0.00e+00	1000.00
IUUC-Cre-022979	Chlamydomonas reinhardtii	60.88	4.00e-131	461.00
IUUC-Csa-023943	Chlorocebus sabaeus	93.19	0.00e+00	976.00
IUUC-Cin-025704	Ciona intestinalis	71.77	0.00e+00	788.00
IUUC-Csv-026257	Ciona savignyi	68.97	0.00e+00	756.00
IUUC-Cne-026946	Cryptococcus neoformans	38.46	1.00e-30	128.00
IUUC-Dno-028926	Dasypus novemcinctus	95.65	0.00e+00	992.00
IUUC-Dme-031939	Drosophila melanogaster	81.20	1.00e-175	609.00
IUUC-Ete-032822	Echinops telfairi	83.93	0.00e+00	847.00
IUUC-Eca-033897	Equus caballus	96.79	0.00e+00	1003.00
IUUC-Fca-036462	Felis catus	96.98	0.00e+00	1002.00
IUUC-Fal-037388	Ficedula albicollis	94.71	0.00e+00	1010.00
IUUC-Gga-040671	Gallus gallus	94.90	0.00e+00	1010.00
IUUC-Gac-041851	Gasterosteus aculeatus	88.85	0.00e+00	932.00
IUUC-Ggo-045373	Gorilla gorilla	93.38	0.00e+00	986.00
IUUC-Hsa-045841	Homo sapiens	93.57	0.00e+00	986.00
IUUC-Itr-048236	Ictidomys tridecemlineatus	98.66	0.00e+00	777.00
IUUC-Lch-050535	Latimeria chalumnae	90.55	0.00e+00	976.00
IUUC-Mcc-055233	Macaca mulatta	92.34	0.00e+00	961.00
IUUC-Mga-059895	Meleagris gallopavo	96.03	0.00e+00	1010.00
IUUC-Mmr-061286	Microcebus murinus	95.85	0.00e+00	1011.00
IUUC-Mmu-063447	Mus musculus	96.79	0.00e+00	1004.00
IUUC-Nle-069151	Nomascus leucogenys	93.01	0.00e+00	982.00
IUUC-Ont-072252	Oreochromis niloticus	88.85	0.00e+00	956.00
IUUC-Oan-073562	Ornithorhynchus anatinus	96.41	0.00e+00	1006.00
IUUC-Opu-083505	Oryza punctata	48.11	1.00e-142	499.00
IUUC-Oar-089506	Ovis aries	93.57	0.00e+00	1000.00
IUUC-Ptr-090793	Pan troglodytes	91.49	0.00e+00	950.00
IUUC-Pan-091909	Papio anubis	92.48	0.00e+00	986.00
IUUC-Psi-093358	Pelodiscus sinensis	90.74	0.00e+00	955.00
IUUC-Pfo-097214	Poecilia formosa	87.52	0.00e+00	927.00
IUUC-Pab-098317	Pongo abelii	93.26	0.00e+00	965.00
IUUC-Pop-098989	Populus trichocarpa	57.14	2.00e-128	452.00
IUUC-Rno-105857	Rattus norvegicus	96.79	0.00e+00	1004.00
IUUC-Sha-107326	Sarcophilus harrisii	93.95	0.00e+00	1013.00
IUUC-Ssc-115646	Sus scrofa	97.92	0.00e+00	1018.00
IUUC-Tgu-116898	Taeniopygia guttata	94.71	0.00e+00	1000.00
IUUC-Tru-117862	Takifugu rubripes	89.04	0.00e+00	944.00
IUUC-Tni-119656	Tetraodon nigroviridis	89.60	0.00e+00	943.00
IUUC-Tae-125368	Triticum aestivum	49.37	1.00e-152	533.00
IUUC-Ttr-128826	Tursiops truncatus	94.87	0.00e+00	917.00
IUUC-Uma-129469	Ustilago maydis	44.08	3.00e-58	220.00
IUUC-Vvi-131193	Vitis vinifera	55.26	2.00e-128	452.00
IUUC-Xma-133591	Xiphophorus maculatus	87.33	0.00e+00	925.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence