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Tag Content
UUCD2 ID IUUC-Pab-097702
UUCD1 version UUC-PoA-00939
Ensembl Protein ID ENSPPYP00000010362.1
UniProt Accession Q5RCM6; SOCS6_PONAB
Genbank Protein ID CAH90481.1
Protein Name Suppressor of cytokine signaling 6
Genbank Nucleotide ID CR858244
Gene Name SOCS6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSPPYG00000009234.1 ENSPPYT00000010774.1 ENSPPYP00000010362.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 3.40e-17 62.1 488 535
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedy 52
            ++ +++ ++rSLq+LCR++Ir++++++ +   +kLPLP+++kdYL++++y
   Q: 488  TNPVSRFMQVRSLQYLCRFVIRQYTRIDLI---QKLPLPNKMKDYLQEKHY 535
           5788999********************888...***************997 PP
   
Organism Pongo abelii
Functional Description
(View)

Functional Description


     SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor (By similarity).
 SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor (By similarity).
Protein Sequence
(Fasta)
MKKISLKTLR KSFNLNKSKE ETDFMVVQQP SLASDFGKDD SLFGSCYGKD MASCDINGED 60
EKGGKNRSKS ESLMGTLKRR LSAKQKSKGK AGTPSGSSAD EDTFSSSSAP IVFKDVRAQR 120
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Protein Fasta Sequence


>IUUC-Pab-097702|E3,SOCS|Pongo abelii
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Nucleotide Sequence
(Fasta)
GAAAATGGCT CCAAAGGGTA AATGAAGCAG GAAAAATACA TAGATGCAGC CTTGCAGCCT 60
CTCCAGATGT TTGGGGATAA TATTCCAGAT AGAAATATTG ATCCCTTGGA TTAGGTAACT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Pab-097702|E3,SOCS|Pongo abelii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0341--Growth regulation
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0734--Signal transduction inhibitor
KW-0833--Ubl conjugation pathway
Interpro

IPR000980--SH2
IPR028421--SOCS6
IPR001496--SOCS_box
PROSITE

PS50001--SH2
PS50225--SOCS
Pfam

PF00017--SH2
PF07525--SOCS_box
SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box
Gene Ontology

GO:0001772--C:immunological synapse
GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0009968--P:negative regulation of signal transduction
GO:0050868--P:negative regulation of T cell activation
GO:0010498--P:proteasomal protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0040008--P:regulation of growth
KEGG pon:100172146
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001911 Ailuropoda melanoleuca 95.70 0.00e+00 954.00
IUUC-Atr-002940 Amborella trichopoda 27.27 5.70e-02 31.60
IUUC-Apl-004035 Anas platyrhynchos 90.65 0.00e+00 898.00
IUUC-Aca-004782 Anolis carolinensis 88.43 0.00e+00 863.00
IUUC-Ame-011790 Astyanax mexicanus 70.58 0.00e+00 647.00
IUUC-Bta-012579 Bos taurus 94.74 1.00e-108 386.00
IUUC-Bol-015843 Brassica oleracea 28.77 2.70e-02 33.10
IUUC-Cel-018643 Caenorhabditis elegans 33.59 1.00e-11 62.80
IUUC-Cja-019528 Callithrix jacchus 98.32 0.00e+00 1030.00
IUUC-Cfa-020678 Canis familiaris 94.77 0.00e+00 969.00
IUUC-Cpo-021947 Cavia porcellus 95.51 0.00e+00 1004.00
IUUC-Csa-023935 Chlorocebus sabaeus 99.07 0.00e+00 1011.00
IUUC-Cho-024477 Choloepus hoffmanni 91.59 0.00e+00 960.00
IUUC-Cin-025413 Ciona intestinalis 68.24 3.00e-66 245.00
IUUC-Csv-026247 Ciona savignyi 67.47 4.00e-65 241.00
IUUC-Cne-026906 Cryptococcus neoformans 26.04 7.30e-02 32.30
IUUC-Dre-027636 Danio rerio 69.78 0.00e+00 644.00
IUUC-Dno-029048 Dasypus novemcinctus 93.83 0.00e+00 960.00
IUUC-Dor-030401 Dipodomys ordii 91.42 0.00e+00 922.00
IUUC-Ete-033116 Echinops telfairi 49.12 4.00e-58 218.00
IUUC-Eca-033825 Equus caballus 95.70 0.00e+00 934.00
IUUC-Fca-036253 Felis catus 93.64 0.00e+00 879.00
IUUC-Fal-037614 Ficedula albicollis 90.84 0.00e+00 900.00
IUUC-Fox-037898 Fusarium oxysporum 28.40 7.00e-03 34.30
IUUC-Gmo-038928 Gadus morhua 69.74 0.00e+00 681.00
IUUC-Gga-040177 Gallus gallus 90.09 0.00e+00 892.00
IUUC-Gac-042263 Gasterosteus aculeatus 71.27 0.00e+00 707.00
IUUC-Ggo-045288 Gorilla gorilla 98.88 0.00e+00 1014.00
IUUC-Hsa-046409 Homo sapiens 99.25 0.00e+00 1015.00
IUUC-Itr-048996 Ictidomys tridecemlineatus 93.83 0.00e+00 931.00
IUUC-Lch-050354 Latimeria chalumnae 83.77 0.00e+00 871.00
IUUC-Loc-052319 Lepisosteus oculatus 81.53 0.00e+00 827.00
IUUC-Laf-054070 Loxodonta africana 92.34 0.00e+00 910.00
IUUC-Mcc-055045 Macaca mulatta 98.69 0.00e+00 1007.00
IUUC-Meu-055917 Macropus eugenii 90.65 0.00e+00 961.00
IUUC-Mga-059273 Meleagris gallopavo 90.47 0.00e+00 894.00
IUUC-Mmr-061597 Microcebus murinus 97.01 0.00e+00 990.00
IUUC-Mdo-062492 Monodelphis domestica 66.18 3.00e-113 401.00
IUUC-Mmu-063374 Mus musculus 84.01 0.00e+00 834.00
IUUC-Mpu-065967 Mustela putorius furo 89.91 0.00e+00 905.00
IUUC-Mlu-067532 Myotis lucifugus 93.27 0.00e+00 933.00
IUUC-Nle-069373 Nomascus leucogenys 99.63 0.00e+00 1017.00
IUUC-Opr-070873 Ochotona princeps 91.21 0.00e+00 967.00
IUUC-Ont-072498 Oreochromis niloticus 71.59 0.00e+00 738.00
IUUC-Oan-072943 Ornithorhynchus anatinus 71.96 6.00e-99 353.00
IUUC-Ocu-073870 Oryctolagus cuniculus 94.39 0.00e+00 961.00
IUUC-Ola-086866 Oryzias latipes 89.40 2.00e-105 374.00
IUUC-Oga-089057 Otolemur garnettii 93.46 0.00e+00 932.00
IUUC-Oar-089841 Ovis aries 61.94 7.00e-169 587.00
IUUC-Ptr-091054 Pan troglodytes 99.25 0.00e+00 1014.00
IUUC-Pma-094253 Petromyzon marinus 44.17 5.00e-101 361.00
IUUC-Pfo-097179 Poecilia formosa 65.43 3.00e-178 618.00
IUUC-Pca-100671 Procavia capensis 86.30 8.00e-129 453.00
IUUC-Rno-106044 Rattus norvegicus 81.52 0.00e+00 824.00
IUUC-Sha-107139 Sarcophilus harrisii 89.76 0.00e+00 878.00
IUUC-Smo-108823 Selaginella moellendorffii 33.96 3.50e-02 32.00
IUUC-Sly-111748 Solanum lycopersicum 46.15 2.40e-01 30.00
IUUC-Ssc-115343 Sus scrofa 92.71 0.00e+00 952.00
IUUC-Tgu-117061 Taeniopygia guttata 90.65 0.00e+00 899.00
IUUC-Tni-119829 Tetraodon nigroviridis 67.65 0.00e+00 651.00
IUUC-Tae-123723 Triticum aestivum 27.50 1.10e-02 35.40
IUUC-Ttr-129148 Tursiops truncatus 91.96 0.00e+00 901.00
IUUC-Vpa-130780 Vicugna pacos 89.35 0.00e+00 862.00
IUUC-Vvi-130966 Vitis vinifera 32.69 5.70e-02 31.20
IUUC-Xtr-132513 Xenopus tropicalis 82.62 0.00e+00 855.00
IUUC-Xma-133904 Xiphophorus maculatus 69.50 0.00e+00 677.00
Created Date 25-Jun-2017

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