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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046340
UUCD1 version UUC-HoS-00402
Ensembl Protein ID ENSP00000247977.3
UniProt Accession Q9NXK8; B3KSJ8; Q9H5K4; FXL12_HUMAN
Genbank Protein ID BAA91002.1; BAB15622.1; BAG52760.1; EAW84051.1; AAH01586.1
Protein Name F-box/LRR-repeat protein 12; F-box and leucine-rich repeat protein 12; F-box protein FBL12
Genbank Nucleotide ID AK000195; AK027004; AK093760; CH471106; BC001586
Gene Name FBXL12; FBL12
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000127452.8 ENST00000592732.5 ENSP00000468766.1
ENSG00000127452.8 ENST00000589438.1 ENSP00000467523.1
ENSG00000127452.8 ENST00000592067.1 ENSP00000464784.1
ENSG00000127452.8 ENST00000586469.1 ENSP00000467859.1
ENSG00000127452.8 ENST00000586073.1 ENSP00000465439.1
ENSG00000127452.8 ENST00000588922.5 ENSP00000468033.1
ENSG00000127452.8 ENST00000589626.5 ENSP00000464858.1
ENSG00000127452.8 ENST00000247977.8 ENSP00000247977.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
microRNATRANSFACTargetScanRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 18660753
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 6.60e-05 24.7 5 47
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 104  drlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
            +lp+ +l+ei+++l+ ++ +r++rvc+rw++l +++ lw++v
   Q: 5    VELPDSVLLEIFSYLPVRDRIRISRVCHRWKRLVDDRWLWRHV 47
           689****************************9999999*9987 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia.
 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia.
Protein Sequence
(Fasta)
MATLVELPDS VLLEIFSYLP VRDRIRISRV CHRWKRLVDD RWLWRHVDLT LYTMRPKVMW 60
HLLRRYMASR LHSLRMGGYL FSGSQAPQLS PALLRALGQK CPNLKRLCLH VADLSMVPIT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046340|E3,F-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTCTGTGGTG TGTTTGCTGT TCCCAGGTAC GGTTTCGGTG TCCCAAGGCT TGACAGGTGT 60
CGCGCCTGTG GTAGGCGCGC CGGGTAGAGA GGGGGGCCTC GGCGGGTTTG TGGCCAGGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046340|E3,F-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0433--Leucine-rich repeat
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
PROSITE

PS50181--FBOX
Pfam

PF12937--F-box-like
SMART

SM00256--FBOX
Gene Ontology

GO:0005829--C:cytosol
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0000209--P:protein polyubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:54850
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001419 Ailuropoda melanoleuca 95.71 0.00e+00 625.00
IUUC-Aca-004405 Anolis carolinensis 37.13 2.00e-46 179.00
IUUC-Aly-006243 Arabidopsis lyrata 28.32 1.00e-05 45.10
IUUC-Ago-007783 Ashbya gossypii 41.30 1.00e-04 42.00
IUUC-Ang-009799 Aspergillus niger 24.75 2.00e-04 41.20
IUUC-Ame-011583 Astyanax mexicanus 36.40 1.00e-16 80.50
IUUC-Bta-013334 Bos taurus 94.17 1.00e-178 618.00
IUUC-Cja-019257 Callithrix jacchus 98.16 0.00e+00 639.00
IUUC-Cfa-020655 Canis familiaris 96.01 0.00e+00 627.00
IUUC-Cpo-021946 Cavia porcellus 83.44 1.00e-149 522.00
IUUC-Csa-024146 Chlorocebus sabaeus 100.00 0.00e+00 650.00
IUUC-Cho-024674 Choloepus hoffmanni 45.00 2.00e-39 155.00
IUUC-Cin-025189 Ciona intestinalis 25.00 7.00e-22 97.80
IUUC-Csv-025971 Ciona savignyi 25.68 2.00e-14 72.80
IUUC-Dno-028860 Dasypus novemcinctus 90.49 1.00e-172 598.00
IUUC-Dme-032163 Drosophila melanogaster 33.82 8.00e-11 62.00
IUUC-Eca-034376 Equus caballus 95.40 0.00e+00 626.00
IUUC-Eeu-035297 Erinaceus europaeus 62.39 3.00e-110 391.00
IUUC-Fca-036044 Felis catus 94.48 1.00e-178 618.00
IUUC-Fal-036630 Ficedula albicollis 33.58 9.00e-29 120.00
IUUC-Fox-037910 Fusarium oxysporum 42.22 1.00e-04 42.00
IUUC-Fso-038397 Fusarium solani 43.90 2.00e-03 38.90
IUUC-Gmo-039360 Gadus morhua 33.72 8.00e-29 120.00
IUUC-Gga-040461 Gallus gallus 41.15 5.00e-22 98.60
IUUC-Gac-041737 Gasterosteus aculeatus 40.28 4.00e-26 112.00
IUUC-Ggo-044537 Gorilla gorilla 99.39 0.00e+00 649.00
IUUC-Itr-048279 Ictidomys tridecemlineatus 94.17 9.00e-179 619.00
IUUC-Lch-050320 Latimeria chalumnae 41.29 7.00e-61 227.00
IUUC-Laf-054250 Loxodonta africana 93.87 1.00e-179 622.00
IUUC-Mcc-055154 Macaca mulatta 99.69 0.00e+00 649.00
IUUC-Mmr-060928 Microcebus murinus 96.34 4.00e-151 526.00
IUUC-Mdo-062488 Monodelphis domestica 50.22 3.00e-56 211.00
IUUC-Mmu-063209 Mus musculus 93.25 8.00e-178 615.00
IUUC-Mac-065258 Musa acuminata 30.77 9.00e-06 44.70
IUUC-Mpu-066145 Mustela putorius furo 96.01 0.00e+00 629.00
IUUC-Nle-069785 Nomascus leucogenys 100.00 0.00e+00 650.00
IUUC-Opr-070335 Ochotona princeps 88.34 2.00e-154 538.00
IUUC-Ont-071234 Oreochromis niloticus 40.55 1.00e-28 120.00
IUUC-Ocu-073801 Oryctolagus cuniculus 93.29 2.00e-161 561.00
IUUC-Oni-082319 Oryza nivara 29.57 7.00e-05 43.90
IUUC-Ola-087439 Oryzias latipes 40.93 5.00e-33 135.00
IUUC-Oga-088576 Otolemur garnettii 96.63 0.00e+00 630.00
IUUC-Oar-090342 Ovis aries 94.17 2.00e-178 618.00
IUUC-Ptr-090775 Pan troglodytes 100.00 0.00e+00 650.00
IUUC-Pan-092039 Papio anubis 99.69 0.00e+00 649.00
IUUC-Psi-093821 Pelodiscus sinensis 39.16 3.00e-44 172.00
IUUC-Pma-094751 Petromyzon marinus 34.45 3.00e-29 122.00
IUUC-Pfo-097122 Poecilia formosa 43.37 1.00e-28 120.00
IUUC-Pab-098147 Pongo abelii 99.69 0.00e+00 647.00
IUUC-Pca-101020 Procavia capensis 93.25 5.00e-178 616.00
IUUC-Pva-102723 Pteropus vampyrus 92.94 5.00e-177 613.00
IUUC-Rno-104905 Rattus norvegicus 92.67 2.00e-147 514.00
IUUC-Sha-107634 Sarcophilus harrisii 48.52 1.00e-58 219.00
IUUC-Ssc-115703 Sus scrofa 96.32 0.00e+00 632.00
IUUC-Tsy-118925 Tarsius syrichta 93.41 2.00e-147 514.00
IUUC-Tni-119768 Tetraodon nigroviridis 39.72 1.00e-30 127.00
IUUC-Tre-122147 Trichoderma reesei 43.90 1.00e-04 42.70
IUUC-Tvi-122469 Trichoderma virens 42.86 3.00e-04 40.80
IUUC-Tur-126494 Triticum urartu 34.48 5.00e-05 42.70
IUUC-Tbe-127446 Tupaia belangeri 91.02 7.00e-124 436.00
IUUC-Xtr-132349 Xenopus tropicalis 38.31 2.00e-49 189.00
Created Date 25-Jun-2017

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