iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046791

UUCD1 version

UUC-HoS-01088

Ensembl Protein ID

ENSP00000381863.2

UniProt Accession

O94966; A5PKX8; A6H8U2; B4DGT3; B4DTZ0; E7EN22; E7ETS0; E9PEG8; Q3KQW4; Q641Q9; Q6NZY8; Q86XV9; UBP19_HUMAN

Genbank Protein ID

BAA74914.1; BAG57894.1; BAG62152.1; AAH48269.1; AAH65909.1; AAH82241.1; AAI06030.1; AAI42661.1; AAI46753.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 19; Deubiquitinating enzyme 19; Ubiquitin thioesterase 19; Ubiquitin-specific-processing protease 19; Zinc finger MYND domain-containing protein 9

Genbank Nucleotide ID

AB020698; AK294756; AK300425; AC135506; BC065909; BC082241; BC106029; BC142660; BC146752

Gene Name

USP19; KIAA0891; ZMYND9

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000172046.18	ENST00000398896.5	ENSP00000381870.2
ENSG00000172046.18	ENST00000398898.6	ENSP00000381872.2
ENSG00000172046.18	ENST00000417901.5	ENSP00000395260.1
ENSG00000172046.18	ENST00000453664.5	ENSP00000400090.1
ENSG00000172046.18	ENST00000398892.7	ENSP00000381867.3
ENSG00000172046.18	ENST00000398888.6	ENSP00000381863.2
ENSG00000172046.18	ENST00000434032.6	ENSP00000401197.2
ENSG00000172046.18	ENST00000306026.5	ENSP00000303503.5
ENSG00000172046.18	ENST00000479073.2	ENSP00000428539.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	21264218; 12401499; 19773570

Classification

Family	E-value	Score	Start	End
DUB/USP	1.20e-114	384.7	497	1214

Active Site

Position(s)	Description	Evidence
506	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
1165	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++ +++ ++n +np ++ g+l+  ++ l+++lwk++++a++p++l+++++++a++f+gy+q
   Q: 497  TGLVNLGNTCFMNSVIQSLSNTRELRDFFHDrSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQ 586
           7*****************************999********************************************************* PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
           +DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++de     a++++k++n+s+i+dlFqgq+ks+++c+ c++vs +++pfl+l++
   Q: 587  HDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSD--GRPDEvvaeeAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPV 674
           *****************************9999..6666666777********************************************* PP
   S: 175  pvpgkeetkke............................................................................... 185
           p+p+k++  +                                                                                
   Q: 675  PLPQKQKVLPVfyfarephskpikflvsvskenstasevldslsqsvhvkpenlrlaeviknrfhrvflpshsldtvspsdtllcfells 764
           ******87666******************************************************************************* PP
   S: 186  .......................................................................................... 185
                                                                                                     
   Q: 765  selakervvvlevqqrpqvpsvpiskcaacqrkqqsedeklkrctrcyrvgycnqlcqkthwpdhkglcrpenigypflvsvpasrltya 854
           ****************************************************************************************** PP
   S: 186  .......................................................................................... 185
                                                                                                     
   Q: 855  rlaqllegyarysvsvfqppfqpgrmalesqspgcttllstgsleagdserdpiqppelqlvtpmaegdtglprvwaapdrgpvpstsgi 944
           ****************************************************************************************** PP
   S: 186  .......................................................................................... 185
                                                                                                     
   Q: 945  ssemlasgpievgslpagervsrpeaavpgyqhpseamnahtpqffiykidssnreqrledkgdtplelgddcslalvwrnnerlqefvl 1034
           ****************************************************************************************** PP
   S: 186  ........................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekink 251
                                   +l++cL+ ft++e l  e+++yc++ck+++ea+k+l l++lP+vLi++LkRfsf++  +++ kin+
   Q: 1035 vaskelecaedpgsageaaraghfTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRD-KIND 1123
           *********************************************************************************8886.**** PP
   S: 252  kvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk........WllfdDskVtevkeeevleetgstaYv 332
            vefp + Ldls+fc+ ++e+q    +Y+L+av++H+G++ +GHY+a+++  +++        W lfdDs+Vt+v+e++v++   + aYv
   Q: 1124 LVEFPVRnLDLSKFCIGQKEEQ--LPSYDLYAVINHYGGMIGGHYTACARLPNDRssqrsdvgWRLFDDSTVTTVDESQVVT---RYAYV 1208
           ******9**********99888..9**************************544445566777*******************...***** PP
   S: 333  lfYkrr 338
           lfY+rr
   Q: 1209 LFYRRR 1214
           ***996 PP

Organism

Homo sapiens

Functional Description
(View)

Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains.

Protein Sequence
(Fasta)

MSGGASATGP RRGPPGLEDT TSKKKQKDRA NQESKDGDPR KETGSRYVAQ AGLEPLASGD 60
PSASASHAAG ITGSRHRTRL FFPSSSGSAS TPQEEQTKEG ACEDPHDLLA TPTPELLLDW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTTGGCGC TCCGCCTCCC TCGGCCTTAG CTAGAAGTCG AAACAAAACA AGCCGCTAAG 60
GCGGTGGCGG CGGCGCCGGG ACGGGGGAGG GGCGCGCCGG AACCGGAACC GACCTGCGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0378--Hydrolase
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0051879--F:Hsp90 protein binding
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0048642--P:negative regulation of skeletal muscle tissue development
GO:0090068--P:positive regulation of cell cycle process
GO:0016579--P:protein deubiquitination
GO:0050821--P:protein stabilization
GO:1900037--P:regulation of cellular response to hypoxia
GO:1904292--P:regulation of ERAD pathway
GO:0031647--P:regulation of protein stability
GO:0034976--P:response to endoplasmic reticulum stress
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

hsa:10869

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001999	Ailuropoda melanoleuca	95.34	0.00e+00	1979.00
IUUC-Apl-003368	Anas platyrhynchos	73.74	0.00e+00	1494.00
IUUC-Aca-004267	Anolis carolinensis	77.12	0.00e+00	1479.00
IUUC-Ame-010970	Astyanax mexicanus	70.91	0.00e+00	1329.00
IUUC-Bta-012905	Bos taurus	93.39	0.00e+00	1959.00
IUUC-Cel-018257	Caenorhabditis elegans	43.00	1.00e-91	331.00
IUUC-Cja-018789	Callithrix jacchus	97.40	0.00e+00	2143.00
IUUC-Cfa-021004	Canis familiaris	94.56	0.00e+00	1980.00
IUUC-Cpo-021529	Cavia porcellus	90.50	0.00e+00	1986.00
IUUC-Csa-024035	Chlorocebus sabaeus	97.69	0.00e+00	2051.00
IUUC-Cho-025036	Choloepus hoffmanni	86.39	0.00e+00	838.00
IUUC-Cin-025451	Ciona intestinalis	43.41	3.00e-85	310.00
IUUC-Csv-025931	Ciona savignyi	36.73	6.00e-112	398.00
IUUC-Dre-028556	Danio rerio	68.14	0.00e+00	1311.00
IUUC-Dno-029240	Dasypus novemcinctus	89.19	0.00e+00	1922.00
IUUC-Dor-030495	Dipodomys ordii	95.55	0.00e+00	1293.00
IUUC-Ete-032741	Echinops telfairi	92.33	0.00e+00	1858.00
IUUC-Eca-033661	Equus caballus	95.41	0.00e+00	2073.00
IUUC-Eeu-034648	Erinaceus europaeus	82.75	0.00e+00	1034.00
IUUC-Fca-035646	Felis catus	94.36	0.00e+00	1959.00
IUUC-Fal-037094	Ficedula albicollis	73.69	0.00e+00	1593.00
IUUC-Gmo-038869	Gadus morhua	72.10	0.00e+00	845.00
IUUC-Gga-041170	Gallus gallus	73.10	0.00e+00	1559.00
IUUC-Gac-041901	Gasterosteus aculeatus	60.31	0.00e+00	1424.00
IUUC-Ggo-044708	Gorilla gorilla	99.20	0.00e+00	2194.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	92.64	0.00e+00	1996.00
IUUC-Lch-050456	Latimeria chalumnae	63.62	0.00e+00	1130.00
IUUC-Loc-052861	Lepisosteus oculatus	61.65	0.00e+00	1128.00
IUUC-Laf-053788	Loxodonta africana	92.55	0.00e+00	2012.00
IUUC-Mcc-055693	Macaca mulatta	97.89	0.00e+00	2068.00
IUUC-Meu-055921	Macropus eugenii	78.82	0.00e+00	1518.00
IUUC-Mga-059879	Meleagris gallopavo	73.10	0.00e+00	1546.00
IUUC-Mmr-060802	Microcebus murinus	95.56	0.00e+00	2082.00
IUUC-Mdo-061856	Monodelphis domestica	73.95	0.00e+00	1784.00
IUUC-Mmu-063874	Mus musculus	92.41	0.00e+00	2006.00
IUUC-Mpu-066166	Mustela putorius furo	94.46	0.00e+00	1957.00
IUUC-Nle-070161	Nomascus leucogenys	98.22	0.00e+00	2180.00
IUUC-Opr-071015	Ochotona princeps	87.69	0.00e+00	2106.00
IUUC-Ont-072308	Oreochromis niloticus	68.06	0.00e+00	1357.00
IUUC-Oan-072723	Ornithorhynchus anatinus	72.12	0.00e+00	1529.00
IUUC-Ocu-073938	Oryctolagus cuniculus	94.59	0.00e+00	1921.00
IUUC-Ola-086375	Oryzias latipes	70.50	0.00e+00	1333.00
IUUC-Oga-088297	Otolemur garnettii	95.36	0.00e+00	2053.00
IUUC-Oar-089675	Ovis aries	86.45	0.00e+00	1669.00
IUUC-Ptr-091621	Pan troglodytes	99.24	0.00e+00	2568.00
IUUC-Pan-092118	Papio anubis	98.08	0.00e+00	2056.00
IUUC-Pma-094154	Petromyzon marinus	51.78	4.00e-114	405.00
IUUC-Pfo-097246	Poecilia formosa	68.22	0.00e+00	1330.00
IUUC-Pab-098551	Pongo abelii	98.48	0.00e+00	2532.00
IUUC-Pca-100158	Procavia capensis	88.02	0.00e+00	1927.00
IUUC-Pva-103160	Pteropus vampyrus	94.94	0.00e+00	2036.00
IUUC-Rno-105355	Rattus norvegicus	92.74	0.00e+00	2005.00
IUUC-Sha-107057	Sarcophilus harrisii	80.22	0.00e+00	1581.00
IUUC-Sar-113011	Sorex araneus	90.02	0.00e+00	1575.00
IUUC-Ssc-115761	Sus scrofa	94.03	0.00e+00	1982.00
IUUC-Tgu-116956	Taeniopygia guttata	62.81	0.00e+00	834.00
IUUC-Tru-118739	Takifugu rubripes	69.25	0.00e+00	1345.00
IUUC-Tsy-118827	Tarsius syrichta	92.11	0.00e+00	942.00
IUUC-Tni-119921	Tetraodon nigroviridis	64.22	0.00e+00	1313.00
IUUC-Tbe-128017	Tupaia belangeri	92.11	0.00e+00	1989.00
IUUC-Ttr-128869	Tursiops truncatus	93.97	0.00e+00	2025.00
IUUC-Vpa-130427	Vicugna pacos	95.94	0.00e+00	931.00
IUUC-Xtr-132734	Xenopus tropicalis	71.03	0.00e+00	1440.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence