iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000029658.17	ENSMUST00000110502.6	ENSMUSP00000106128.1
ENSMUSG00000029658.17	ENSMUST00000201525.3	ENSMUSP00000144234.1
ENSMUSG00000029658.17	ENSMUST00000202902.1	ENSMUSP00000144385.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RAID2
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.20e-32	109.0	318	354
UBD/Beta-Prp	3.30e-53	181.9	270	603

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 4    dsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           +++tcl f s+ ++lv+G++Dg +k+W++  g++l++
   Q: 318  AGITCLTFdSSgRRLVTGGRDGCLKIWSYNNGHCLHT 354
           46******95569*********************986 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrsl..sgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk.. 91
            +h++++ c  + p  +++++ ++ + +kvwd++tg  ++++     +a++t+++f+++g  lvtg++D+ +k+w++++g c+htl+  
   Q: 270  RSHQEPVVCCRYNPAFRHVVSCCEASVVKVWDFETGRQVSEFigTHGNAGITCLTFDSSGRRLVTGGRDGCLKIWSYNNGHCLHTLQhd 358
           567777777999******************************75566889*************************************77 PP
   S: 92   ghedsvlslsfsp.sg.dklvsGshdrtirv..........wdletgqclee........tlsghdgvvncvvvhpdgnllvsGslDrt 160
           +++++v+++++++ ++   +++ ++dr i+v          +         +        ++ gh++ + cv+  p  +ll+++s+D+ 
   Q: 359  ENQSEVCDCTYMEvNRnRCVIAVGWDRRINVyfdiprdfhhFR--------KpqphwqddLNHGHKEDILCVAQCP-PFLLATSSYDGE 438
           77889********96647788889*******844444443333........255566666*******999987666.6*********** PP
   S: 161  vrlWdlktgkllrtl...........tgghtdsvysls........fdsngkelvsgsldgtvklwdlqtgec.vr..tlnghtdnvks 227
           + +W++ +g +  +l           ++g ++sv  l+        +ds +  l+s +  g+v +w l +g+  v   t    +++v+ 
   Q: 439  IIVWNVISGHMYCKLntpspmdgqdhREGPDRSVSQLAflktrltkLDSASAALISNGPGGSVCFWKLFSGSGlVAnfTPSREKAQVSG 527
           ******88888888888899988777555777777777555555555555599999999999999999866552220133335588888 PP
   S: 228  vrfspnderlvsgssDgsiriWdlrsgdllkt.lqlhn......ssvisvav..lsfgdnvlvlgsedskvniwkl 294
           + +++ d++ + + ++g i ++d++   l +t lq +n       +v+ v+   l  g++++++ s d++v++w++
   Q: 528  IVVTSGDTLAYLADQHGFIHVYDIQEYGLQGTeLQAPNtvtswrAHVSMVTSleLIEGGSIVLSSSLDCTVRLWSQ 603
           8888888888888899999999888777665436777765555533333333323334666666666999999876 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MYQLQGCVNI LFLASVGELL RTWKKMPRVE DMPSITLHSV MASPNAEYVR WKVHGDFVSQ 60
LNYYESMKAV ISSSNHEPTA LVIGSLLNRL EHGGFTVGAT DIKEKLNEIR NVGKNVKMGN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGAGACCT CAGCTCTCTG TTGATGGAAG GCTGTTGCTG TTTGACAGGC TGATGCCTCT 60
TTGTTTGGAA AGATGAGTTA GAATCGTTAG CAGGTAATGT CACAAGGCCC CTGGGGTGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001921	Ailuropoda melanoleuca	75.39	0.00e+00	807.00
IUUC-Ame-011582	Astyanax mexicanus	47.29	0.00e+00	638.00
IUUC-Bta-013034	Bos taurus	71.37	0.00e+00	758.00
IUUC-Cin-025633	Ciona intestinalis	46.23	2.00e-101	362.00
IUUC-Csv-026326	Ciona savignyi	43.14	3.00e-130	458.00
IUUC-Dre-027573	Danio rerio	40.77	2.00e-174	606.00
IUUC-Dno-030073	Dasypus novemcinctus	62.92	0.00e+00	924.00
IUUC-Dme-031984	Drosophila melanogaster	28.82	2.00e-38	154.00
IUUC-Eca-033354	Equus caballus	70.38	0.00e+00	733.00
IUUC-Fca-036185	Felis catus	69.89	0.00e+00	744.00
IUUC-Gmo-039551	Gadus morhua	41.40	5.00e-108	384.00
IUUC-Gac-041482	Gasterosteus aculeatus	47.08	2.00e-146	512.00
IUUC-Itr-049019	Ictidomys tridecemlineatus	77.90	0.00e+00	849.00
IUUC-Lch-050242	Latimeria chalumnae	58.02	0.00e+00	814.00
IUUC-Loc-052710	Lepisosteus oculatus	55.50	0.00e+00	765.00
IUUC-Mdo-062347	Monodelphis domestica	61.73	0.00e+00	866.00
IUUC-Mpu-065721	Mustela putorius furo	76.08	1.00e-97	348.00
IUUC-Ont-071688	Oreochromis niloticus	48.30	2.00e-140	492.00
IUUC-Oan-072752	Ornithorhynchus anatinus	59.09	2.00e-163	568.00
IUUC-Ocu-074780	Oryctolagus cuniculus	64.06	4.00e-102	363.00
IUUC-Ola-086449	Oryzias latipes	46.08	1.00e-125	442.00
IUUC-Pma-094599	Petromyzon marinus	51.23	1.00e-158	553.00
IUUC-Ppa-095538	Physcomitrella patens	30.97	5.00e-18	86.30
IUUC-Pfo-096408	Poecilia formosa	44.39	1.00e-167	583.00
IUUC-Rno-105331	Rattus norvegicus	82.62	0.00e+00	1016.00
IUUC-Sha-106832	Sarcophilus harrisii	62.88	0.00e+00	690.00
IUUC-Smo-109247	Selaginella moellendorffii	27.86	8.00e-52	199.00
IUUC-Ssc-116310	Sus scrofa	70.11	0.00e+00	750.00
IUUC-Tru-117666	Takifugu rubripes	47.74	6.00e-140	490.00
IUUC-Tni-120449	Tetraodon nigroviridis	26.29	1.00e-35	144.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence