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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063353
UUCD1 version UUC-MuM-00710
Ensembl Protein ID ENSMUSP00000026256.2
UniProt Accession Q91W61; Q3T9R4; FXL15_MOUSE
Genbank Protein ID BAE42956.1; EDL41989.1; AAH16499.1
Protein Name F-box/LRR-repeat protein 15; F-box only protein 37
Genbank Nucleotide ID AK003032; CH466534; BC016499
Gene Name Fbxl15; Fbxo37
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000025226.11 ENSMUST00000026256.8 ENSMUSP00000026256.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/SCF/F-box 96.33 3.00e-149 525.00 IUUC-Hsa-046910
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity).
 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity).
Protein Sequence
(Fasta)
MEPPMEQSGG EQEPGAVRLL DLPWEDVLLP HVLNWVPLRQ LLRLQRVSRA FRALVQLHLA 60
RLRRFDAAQV GPQIPRAALA RLLRDAEGLQ ELALAPCHEW LSDEDLVPVL ARNPQLRSVA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063353|E3,F-box|Mus musculus
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Nucleotide Sequence
(Fasta)
ACCACTCAGA GGCGGCTACT GGCCCGCAAC GGAGACCGAA AGCAGTGTTC GCTCGCCGCT 60
ACTCCAGCCT CGGGCTTCAA GCCCTGTAGC TGAGAAGACA TCTAATGGTA CATCACTGGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063353|E3,F-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0433--Leucine-rich repeat
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR006553--Leu-rich_rpt_Cys-con_subtyp
Pfam

PF00646--F-box
PF13516--LRR_6
SMART

SM00367--LRR_CC
Gene Ontology

GO:0005737--C:cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030282--P:bone mineralization
GO:0009953--P:dorsal/ventral pattern formation
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0030513--P:positive regulation of BMP signaling pathway
GO:0016567--P:protein ubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
KEGG mmu:68431
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002259 Ailuropoda melanoleuca 93.33 1.00e-144 505.00
IUUC-Apl-003471 Anas platyrhynchos 65.75 5.00e-80 290.00
IUUC-Aca-005211 Anolis carolinensis 62.42 9.00e-101 360.00
IUUC-Ame-011477 Astyanax mexicanus 56.48 3.00e-95 341.00
IUUC-Bta-013461 Bos taurus 96.33 3.00e-161 560.00
IUUC-Cja-019278 Callithrix jacchus 97.99 5.00e-147 513.00
IUUC-Cfa-020248 Canis familiaris 97.00 1.00e-152 532.00
IUUC-Cpo-021313 Cavia porcellus 92.98 1.00e-130 458.00
IUUC-Csa-023633 Chlorocebus sabaeus 96.00 4.00e-159 553.00
IUUC-Cin-025760 Ciona intestinalis 30.47 8.00e-37 147.00
IUUC-Csv-025866 Ciona savignyi 31.54 5.00e-40 157.00
IUUC-Dre-027366 Danio rerio 58.42 1.00e-99 356.00
IUUC-Dno-029700 Dasypus novemcinctus 96.33 3.00e-150 524.00
IUUC-Dor-031069 Dipodomys ordii 93.62 4.00e-154 537.00
IUUC-Dme-031701 Drosophila melanogaster 31.91 3.00e-27 115.00
IUUC-Ete-032998 Echinops telfairi 87.29 4.00e-132 464.00
IUUC-Eca-034140 Equus caballus 97.67 2.00e-147 514.00
IUUC-Fca-035431 Felis catus 97.67 1.00e-152 532.00
IUUC-Fal-036960 Ficedula albicollis 64.89 2.00e-101 362.00
IUUC-Gmo-039411 Gadus morhua 57.45 4.00e-95 340.00
IUUC-Gga-040351 Gallus gallus 65.60 3.00e-100 358.00
IUUC-Gac-041972 Gasterosteus aculeatus 58.16 2.00e-87 315.00
IUUC-Ggo-044538 Gorilla gorilla 96.00 7.00e-145 506.00
IUUC-Hsa-046910 Homo sapiens 96.33 2.00e-145 507.00
IUUC-Itr-048011 Ictidomys tridecemlineatus 96.99 1.00e-150 525.00
IUUC-Lch-049710 Latimeria chalumnae 55.96 3.00e-99 354.00
IUUC-Loc-052288 Lepisosteus oculatus 58.78 7.00e-99 353.00
IUUC-Lma-053024 Leptosphaeria maculans 29.05 6.00e-12 66.20
IUUC-Laf-053590 Loxodonta africana 88.44 4.00e-134 470.00
IUUC-Meu-056548 Macropus eugenii 80.22 8.00e-123 432.00
IUUC-Mga-059794 Meleagris gallopavo 64.54 1.00e-98 352.00
IUUC-Mmr-060829 Microcebus murinus 96.00 4.00e-150 523.00
IUUC-Mdo-062207 Monodelphis domestica 81.42 2.00e-133 468.00
IUUC-Mpu-065841 Mustela putorius furo 97.33 7.00e-152 529.00
IUUC-Mlu-068035 Myotis lucifugus 93.77 5.00e-140 489.00
IUUC-Nle-069269 Nomascus leucogenys 97.33 1.00e-146 511.00
IUUC-Opr-070289 Ochotona princeps 89.83 3.00e-109 388.00
IUUC-Ont-072581 Oreochromis niloticus 55.86 3.00e-94 337.00
IUUC-Oan-073529 Ornithorhynchus anatinus 66.96 9.00e-78 282.00
IUUC-Ocu-074827 Oryctolagus cuniculus 96.33 6.00e-155 539.00
IUUC-Ola-087306 Oryzias latipes 55.70 5.00e-97 347.00
IUUC-Oga-088596 Otolemur garnettii 95.56 1.00e-135 475.00
IUUC-Oar-089473 Ovis aries 75.59 8.00e-84 302.00
IUUC-Ptr-091197 Pan troglodytes 96.33 1.00e-145 508.00
IUUC-Pan-092908 Papio anubis 96.67 3.00e-155 540.00
IUUC-Psi-093318 Pelodiscus sinensis 60.28 6.00e-69 253.00
IUUC-Pfo-097479 Poecilia formosa 56.76 6.00e-97 347.00
IUUC-Pab-097744 Pongo abelii 96.33 2.00e-145 508.00
IUUC-Pca-100930 Procavia capensis 92.67 3.00e-140 491.00
IUUC-Pva-102763 Pteropus vampyrus 87.14 3.00e-56 212.00
IUUC-Rno-105651 Rattus norvegicus 99.00 2.00e-161 561.00
IUUC-Sja-107658 Schizosaccharomyces japonicus 29.27 3.00e-09 57.00
IUUC-Tgu-117097 Taeniopygia guttata 65.60 3.00e-103 367.00
IUUC-Tru-118057 Takifugu rubripes 56.90 4.00e-95 341.00
IUUC-Tni-120693 Tetraodon nigroviridis 56.90 5.00e-94 337.00
IUUC-Tbe-127992 Tupaia belangeri 97.91 3.00e-104 371.00
IUUC-Xtr-132283 Xenopus tropicalis 56.51 3.00e-99 354.00
IUUC-Xma-134238 Xiphophorus maculatus 57.19 9.00e-96 343.00
Created Date 25-Jun-2017

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