iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059895

UUCD1 version

UUC-MeG-00670

Ensembl Protein ID

ENSMGAP00000015597.2

UniProt Accession

G1NPE9; G1NPE9_MELGA

Protein Name

Uncharacterized protein

Gene Name

TBL1X

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000014722.2	ENSMGAT00000016555.2	ENSMGAP00000015597.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.60e-54	177.4	451	489
UBD/Beta-Prp	1.90e-64	217.5	327	523

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           H+++v+++af +d ++l+sGs D+ +++W++ +g+l++s
   Q: 451  HQEPVYSVAFsPDgKYLASGSFDKCVHIWNTQSGTLVHS 489
           9**********999*******************999876 PP

UBD/Beta-Prp

   S: 20   pdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsp.... 104
           ++++ +a+ s+d +i v ++     +++++gh++ev+a+k++p+g +l+++s+D+t+k+w++++ +cvh l++h+++++++++sp    
   Q: 327  QNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDTCVHDLQAHSKEIYTIKWSPtgpg 415
           56667777788888888888877778888888888888888888888888888888888888888888888888888888888776666 PP
   S: 105  .....sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsf 188
                s+  l+s+s d+t+r+wd++ g c++ tl++h++ v +v+++pdg++l+sGs D++v +W+ ++g+l++  +g  t+ +  + +
   Q: 416  tsnpnSNIMLASASFDSTVRLWDVDRGVCIH-TLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGTLVHSYRG--TGGIFEVCW 501
           6555333577888888888888888888888.8888888888888888888888888888888888888888888877..888888888 PP
   S: 189  dsngkelvsgsldgtvklwdlq 210
           +  g  + + + dg+v + dl+
   Q: 502  NARGDKVGASASDGSVCVLDLR 523
           8888888888888888777765 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

MSITSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GTLVPPAALI SILQKGLQYV 60
EAEISINEDG TVFDGRPIES LSLIDAVMPD VVQTRQQAFR EKLAQQQASA AAAAAAATAA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTCTCAAAG CCTGGCGTGG AGTCTAACAC TGAAGAAAAT AGAAACATAC ATATTTTGTA 60
AGTCTTCCCT TTTGATTCTG TCAGGTTTTC TGAGCTTCCC ATGGTACACA GCCATTTTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005667--C:transcription factor complex
GO:0003682--F:chromatin binding
GO:0003714--F:transcription corepressor activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0045444--P:fat cell differentiation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043627--P:response to estrogen
GO:0048545--P:response to steroid hormone

KEGG

mgp:100544794

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001450	Ailuropoda melanoleuca	92.75	0.00e+00	994.00
IUUC-Apl-003232	Anas platyrhynchos	98.28	0.00e+00	1013.00
IUUC-Aca-005035	Anolis carolinensis	96.20	0.00e+00	1010.00
IUUC-Ago-007869	Ashbya gossypii	27.68	9.00e-33	134.00
IUUC-Bta-013202	Bos taurus	95.27	0.00e+00	1006.00
IUUC-Cja-019281	Callithrix jacchus	92.37	0.00e+00	978.00
IUUC-Cfa-020929	Canis familiaris	95.25	0.00e+00	1001.00
IUUC-Cre-022979	Chlamydomonas reinhardtii	61.16	9.00e-132	463.00
IUUC-Csa-023943	Chlorocebus sabaeus	93.32	0.00e+00	975.00
IUUC-Cin-025704	Ciona intestinalis	73.05	0.00e+00	798.00
IUUC-Csv-026257	Ciona savignyi	70.70	0.00e+00	764.00
IUUC-Cne-026946	Cryptococcus neoformans	38.91	8.00e-31	128.00
IUUC-Dno-028926	Dasypus novemcinctus	94.31	0.00e+00	986.00
IUUC-Dme-031939	Drosophila melanogaster	81.74	4.00e-176	611.00
IUUC-Ete-032822	Echinops telfairi	84.16	0.00e+00	845.00
IUUC-Eca-033897	Equus caballus	96.20	0.00e+00	1005.00
IUUC-Fca-036462	Felis catus	96.39	0.00e+00	1002.00
IUUC-Fal-037388	Ficedula albicollis	98.47	0.00e+00	1025.00
IUUC-Gga-040671	Gallus gallus	98.47	0.00e+00	1025.00
IUUC-Gac-041851	Gasterosteus aculeatus	90.46	0.00e+00	940.00
IUUC-Gma-044208	Glycine max	48.60	7.00e-153	533.00
IUUC-Ggo-045373	Gorilla gorilla	93.55	0.00e+00	984.00
IUUC-Hsa-045841	Homo sapiens	94.11	0.00e+00	984.00
IUUC-Itr-048236	Ictidomys tridecemlineatus	98.66	0.00e+00	776.00
IUUC-Lch-050535	Latimeria chalumnae	92.18	0.00e+00	986.00
IUUC-Laf-054071	Loxodonta africana	96.03	0.00e+00	1010.00
IUUC-Mcc-055233	Macaca mulatta	91.88	0.00e+00	959.00
IUUC-Mvi-060557	Microbotryum violaceum	37.04	2.00e-70	260.00
IUUC-Mmr-061286	Microcebus murinus	96.42	0.00e+00	1010.00
IUUC-Mmu-063447	Mus musculus	95.64	0.00e+00	1001.00
IUUC-Nle-069151	Nomascus leucogenys	93.51	0.00e+00	984.00
IUUC-Ont-072252	Oreochromis niloticus	90.08	0.00e+00	960.00
IUUC-Oan-073562	Ornithorhynchus anatinus	97.34	0.00e+00	1013.00
IUUC-Oar-089506	Ovis aries	94.27	0.00e+00	1002.00
IUUC-Ptr-090793	Pan troglodytes	92.18	0.00e+00	953.00
IUUC-Pan-091909	Papio anubis	93.17	0.00e+00	984.00
IUUC-Psi-093358	Pelodiscus sinensis	92.56	0.00e+00	962.00
IUUC-Pfo-097214	Poecilia formosa	89.12	0.00e+00	929.00
IUUC-Pab-098317	Pongo abelii	93.99	0.00e+00	963.00
IUUC-Pop-098989	Populus trichocarpa	57.39	3.00e-128	451.00
IUUC-Rno-105857	Rattus norvegicus	95.64	0.00e+00	1001.00
IUUC-Sha-107326	Sarcophilus harrisii	95.42	0.00e+00	1018.00
IUUC-Ssc-115646	Sus scrofa	96.41	0.00e+00	1014.00
IUUC-Tgu-116898	Taeniopygia guttata	98.47	0.00e+00	1015.00
IUUC-Tru-117862	Takifugu rubripes	90.65	0.00e+00	952.00
IUUC-Tni-119656	Tetraodon nigroviridis	91.22	0.00e+00	951.00
IUUC-Tae-125368	Triticum aestivum	49.73	9.00e-154	536.00
IUUC-Ttr-128826	Tursiops truncatus	96.47	0.00e+00	919.00
IUUC-Uma-129469	Ustilago maydis	43.92	5.00e-59	222.00
IUUC-Vvi-131193	Vitis vinifera	55.50	4.00e-129	454.00
IUUC-Xma-133591	Xiphophorus maculatus	88.93	0.00e+00	928.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence