iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000003498.4	ENSCAFT00000045531.2	ENSCAFP00000041158.1
ENSCAFG00000003498.4	ENSCAFT00000005638.3	ENSCAFP00000005222.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.30e-87	292.0	190	796

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp..............kepkgellkslqklfeelwkskkkavsprellk 75
           +G++NlgNtC++N+v+Q L++   l+el++e+k++ ++ +                 ++ g+l+++l  +++++ +++k+  sp+ l++
   Q: 190  KGISNLGNTCFFNAVMQNLAQSYILMELMNENKENGTKLK-IfppsdsqldpliveLSSPGPLTSALFLFLHSMKETEKGLLSPKVLFN 277
           59*****************************444444433.24667777777777778888**************************** PP
   S: 76   alkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlksqikcle 158
           +l+++a++f++++qqD+qE+l++lld++++e +k+ + ++ +++++ ++++ de      + +  +  + ++i+++F g+l+s+++c+e
   Q: 278  QLCQKAPRFKSFQQQDSQELLHYLLDAVRTEETKRIQASILKAFNNPTTKTADEdtrkkvKAYGREGVKMNFIDRIFIGELTSTVMCEE 366
           ********************************99888888888888888877773333334445555555******************* PP
   S: 159  cdnvssreepfldlslpvpgkeetkke.............................................................. 185
           c+n+ss ++pf+d+slp+ +++ +k+                                                               
   Q: 367  CANISSVNDPFIDISLPIIEERVSKPVllgrmskcrslqvtddgqygdtvtietthqpratqssskdkkesvpygkktlffffsealek 455
           **********************98777************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 456  tvvgrvnepswhsfppegaespeasggeaggeagasegsadadseasepsssperagllpgrgprgstsaggrptaprtsqaaraaeal 544
           ***************************************************************************************** PP
   S: 186  ..........................................................slqdcLesftkeeelegenkyycekckkkqe 216
                                                                     s+q+cL +ft+ e l g+nk+ ce+c++k++
   Q: 545  selhlsgtvtgpraaqrddqppdapdlscseethllapgpqdafqtlshsyvtasrecSVQSCLYQFTSMELLMGNNKLLCENCTAKKQ 633
           *************************************************************************************9999 PP
   S: 217  ...................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..kkkYeLiavv 284
                              a+k+l ++ +P +LilhLkRf  ++++ s +k+n++v+fpl Ldl+pfc+ +++++++  k+ Y L++vv
   Q: 634  rhrkatscaekkaesiytnARKQLLISAVPAILILHLKRF--HQAGLSLRKVNRHVDFPLILDLAPFCSATCKNVSVgdKVLYGLYGVV 720
           9999999999999999999*********************..9999************************99998777799******** PP
   S: 285  vHsGslssGHYvayvkn..........................ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
            HsGs+++GHY+ayvk                           + ++W++++D++V++v+e++ l+   ++aY+lfY+r
   Q: 721  EHSGSMRGGHYTAYVKVrtpsrkllehitgeknvpglkepdgeSADQWVHVSDTYVQVVPESRALS---AQAYLLFYER 796
           *****************999999999999999999999887766777*******************...********98 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MRVKEPSKAL PEKAKRNKRP AIPRDEDSSD DIPVGFTCQH ISHAISVNHV KKAIAENVWS 60
VCSECLKERR FCDGQPVLPS DVWLCLKCGF QGCGRNSENH HSLRHYKSRR TESHCITISL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGTAAATAA CAGATGCGGG TGAAAGAGCC TTCCAAAGCT TTGCCTGAGA AAGCCAAAAG 60
AAATAAAAGG CCTGCTATAC CTCGTGATGA AGACTCTTCA GACGACATTC CTGGTAAATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002331	Ailuropoda melanoleuca	84.07	0.00e+00	693.00
IUUC-Apl-003512	Anas platyrhynchos	70.81	0.00e+00	647.00
IUUC-Aca-004284	Anolis carolinensis	63.06	6.00e-170	591.00
IUUC-Ame-010735	Astyanax mexicanus	67.29	1.00e-85	310.00
IUUC-Bta-012880	Bos taurus	73.07	0.00e+00	1144.00
IUUC-Cja-019144	Callithrix jacchus	72.38	0.00e+00	1158.00
IUUC-Cpo-022497	Cavia porcellus	79.59	0.00e+00	699.00
IUUC-Csa-023910	Chlorocebus sabaeus	83.61	0.00e+00	756.00
IUUC-Cho-024358	Choloepus hoffmanni	60.47	2.00e-110	392.00
IUUC-Dre-028106	Danio rerio	60.15	2.00e-145	509.00
IUUC-Dno-029456	Dasypus novemcinctus	71.32	3.00e-105	375.00
IUUC-Dor-030438	Dipodomys ordii	64.37	6.00e-157	548.00
IUUC-Dme-031870	Drosophila melanogaster	50.00	2.00e-36	148.00
IUUC-Ete-032736	Echinops telfairi	60.94	0.00e+00	873.00
IUUC-Eca-034211	Equus caballus	73.33	0.00e+00	1184.00
IUUC-Eeu-034797	Erinaceus europaeus	76.53	5.00e-84	305.00
IUUC-Fca-035947	Felis catus	76.18	0.00e+00	1118.00
IUUC-Fal-037199	Ficedula albicollis	69.91	0.00e+00	639.00
IUUC-Gmo-039228	Gadus morhua	61.52	2.00e-141	496.00
IUUC-Gga-040823	Gallus gallus	68.03	2.00e-106	379.00
IUUC-Gac-042406	Gasterosteus aculeatus	58.35	4.00e-137	482.00
IUUC-Ggo-045402	Gorilla gorilla	71.31	0.00e+00	1135.00
IUUC-Hsa-046430	Homo sapiens	71.39	0.00e+00	1143.00
IUUC-Itr-048855	Ictidomys tridecemlineatus	66.73	6.00e-171	593.00
IUUC-Lch-049547	Latimeria chalumnae	63.49	2.00e-161	563.00
IUUC-Loc-052842	Lepisosteus oculatus	61.12	8.00e-158	550.00
IUUC-Laf-053988	Loxodonta africana	82.50	0.00e+00	755.00
IUUC-Mcc-055491	Macaca mulatta	85.60	0.00e+00	712.00
IUUC-Meu-056256	Macropus eugenii	72.87	5.00e-110	392.00
IUUC-Mla-059026	Melampsora laricipopulina	32.68	3.00e-18	87.00
IUUC-Mga-059833	Meleagris gallopavo	67.29	8.00e-106	377.00
IUUC-Mmr-060952	Microcebus murinus	72.98	0.00e+00	1132.00
IUUC-Mdo-062642	Monodelphis domestica	71.88	0.00e+00	641.00
IUUC-Mmu-063945	Mus musculus	72.27	0.00e+00	1135.00
IUUC-Mpu-065944	Mustela putorius furo	87.66	0.00e+00	791.00
IUUC-Mlu-067049	Myotis lucifugus	71.90	0.00e+00	1120.00
IUUC-Nle-069828	Nomascus leucogenys	70.29	0.00e+00	1134.00
IUUC-Opr-070672	Ochotona princeps	67.30	6.00e-135	474.00
IUUC-Ont-072121	Oreochromis niloticus	60.05	7.00e-135	474.00
IUUC-Oan-073656	Ornithorhynchus anatinus	71.78	0.00e+00	660.00
IUUC-Ocu-074323	Oryctolagus cuniculus	71.20	0.00e+00	1116.00
IUUC-Ola-087238	Oryzias latipes	59.61	4.00e-146	512.00
IUUC-Oga-088379	Otolemur garnettii	67.67	0.00e+00	1070.00
IUUC-Oar-089718	Ovis aries	72.17	0.00e+00	1134.00
IUUC-Ptr-091358	Pan troglodytes	71.64	0.00e+00	1145.00
IUUC-Pan-092023	Papio anubis	83.61	0.00e+00	762.00
IUUC-Psi-093256	Pelodiscus sinensis	69.53	1.00e-176	613.00
IUUC-Pfo-097285	Poecilia formosa	54.13	2.00e-118	420.00
IUUC-Pab-098539	Pongo abelii	83.14	0.00e+00	745.00
IUUC-Pca-100610	Procavia capensis	68.53	6.00e-147	514.00
IUUC-Pva-102985	Pteropus vampyrus	89.19	0.00e+00	692.00
IUUC-Rno-105538	Rattus norvegicus	72.15	0.00e+00	1125.00
IUUC-Sha-107022	Sarcophilus harrisii	69.27	2.00e-176	613.00
IUUC-Sja-107712	Schizosaccharomyces japonicus	28.82	9.00e-22	99.00
IUUC-Spo-108149	Schizosaccharomyces pombe	31.37	3.00e-21	97.40
IUUC-Sar-113637	Sorex araneus	80.95	0.00e+00	712.00
IUUC-Ssc-115870	Sus scrofa	72.63	0.00e+00	1166.00
IUUC-Tgu-116907	Taeniopygia guttata	69.23	0.00e+00	633.00
IUUC-Tru-117835	Takifugu rubripes	53.20	4.00e-108	385.00
IUUC-Tsy-118869	Tarsius syrichta	71.35	0.00e+00	969.00
IUUC-Tni-119716	Tetraodon nigroviridis	64.63	4.00e-92	332.00
IUUC-Tbe-128041	Tupaia belangeri	64.27	1.00e-132	467.00
IUUC-Ttr-128901	Tursiops truncatus	79.55	0.00e+00	732.00
IUUC-Vpa-130331	Vicugna pacos	73.58	0.00e+00	1060.00
IUUC-Xtr-131794	Xenopus tropicalis	62.73	8.00e-138	484.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence