iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	12859687

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.017	16.0	334	369

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvf.hadClqkwpglknssskefrCPlCr 46
           C iC++   d  ++l CgH+  +++C           ++   CP+Cr
   Q: 334  CRICMDAVID-CVLLECGHMVtCTKC----------GKRMSECPICR 369
           ********99.888*****888****..........777799****8 PP

Organism

Rattus norvegicus

Functional Description
(View)

E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells. Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation.

Protein Sequence
(Fasta)

MKAGATSMWA SCCGLLNEVM GTGAVRGQQA GFPGSTGPFR FTPSSDFPTY PPAATEGPNI 60
VCKACGLSFS VFRKKHVCCD CKKDFCSLCS VSQENLRRCS TCHLLQETAF QRPQLMRLKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCGCCGCCTT AGAAGGAAGG AGGTCCGTTG TGTGAGCAGT CTGCTATGGT GCTGAGTTCC 60
CGGGTAGAGC CGACCGAGCC GAGGCGGTCG CGGCCATGAA GGTGAGGGGC TGGTGGAGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003034--SAP_dom
IPR011011--Znf_FYVE_PHD
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0012505--C:endomembrane system
GO:0016607--C:nuclear speck
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:1901981--F:phosphatidylinositol phosphate binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0070417--P:cellular response to cold
GO:2001271--P:negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1901797--P:negative regulation of signal transduction by p53 class mediator
GO:0035872--P:nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000374--P:regulation of oxygen metabolic process

KEGG

rno:282845

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002341	Ailuropoda melanoleuca	84.78	6.00e-161	560.00
IUUC-Apl-003398	Anas platyrhynchos	72.70	4.00e-138	484.00
IUUC-Aca-005050	Anolis carolinensis	67.45	2.00e-75	275.00
IUUC-Bta-012886	Bos taurus	85.83	4.00e-164	570.00
IUUC-Cja-019045	Callithrix jacchus	85.04	2.00e-166	578.00
IUUC-Cfa-020037	Canis familiaris	82.87	6.00e-153	533.00
IUUC-Cpo-021618	Cavia porcellus	76.64	3.00e-145	507.00
IUUC-Csa-023303	Chlorocebus sabaeus	85.53	1.00e-164	572.00
IUUC-Cho-024671	Choloepus hoffmanni	76.58	3.00e-158	551.00
IUUC-Dre-027887	Danio rerio	55.50	6.00e-96	343.00
IUUC-Dno-029136	Dasypus novemcinctus	85.56	6.00e-173	600.00
IUUC-Dor-030596	Dipodomys ordii	82.63	4.00e-156	543.00
IUUC-Ete-032684	Echinops telfairi	83.64	7.00e-148	516.00
IUUC-Eca-033598	Equus caballus	86.35	6.00e-167	580.00
IUUC-Eeu-034878	Erinaceus europaeus	83.16	5.00e-163	566.00
IUUC-Fca-036370	Felis catus	86.13	3.00e-165	574.00
IUUC-Fal-036937	Ficedula albicollis	73.09	6.00e-136	476.00
IUUC-Gga-040411	Gallus gallus	70.86	6.00e-123	433.00
IUUC-Ggo-044752	Gorilla gorilla	86.05	4.00e-164	570.00
IUUC-Hsa-046299	Homo sapiens	85.83	2.00e-164	571.00
IUUC-Itr-047907	Ictidomys tridecemlineatus	86.35	1.00e-169	589.00
IUUC-Lch-049616	Latimeria chalumnae	63.61	6.00e-108	384.00
IUUC-Loc-052099	Lepisosteus oculatus	60.34	2.00e-119	421.00
IUUC-Laf-054103	Loxodonta africana	81.10	3.00e-159	554.00
IUUC-Mcc-055295	Macaca mulatta	86.09	2.00e-165	574.00
IUUC-Mga-059584	Meleagris gallopavo	70.86	1.00e-125	442.00
IUUC-Mmr-061766	Microcebus murinus	87.40	2.00e-171	595.00
IUUC-Mdo-062738	Monodelphis domestica	71.81	1.00e-130	459.00
IUUC-Mmu-064403	Mus musculus	93.96	9.00e-171	592.00
IUUC-Mpu-066021	Mustela putorius furo	85.30	2.00e-166	577.00
IUUC-Mlu-067144	Myotis lucifugus	84.55	4.00e-160	557.00
IUUC-Nle-070133	Nomascus leucogenys	85.60	3.00e-153	534.00
IUUC-Opr-070683	Ochotona princeps	79.16	1.00e-151	529.00
IUUC-Ont-072065	Oreochromis niloticus	58.68	4.00e-108	384.00
IUUC-Oan-073504	Ornithorhynchus anatinus	75.48	2.00e-134	471.00
IUUC-Ocu-074382	Oryctolagus cuniculus	82.94	2.00e-167	581.00
IUUC-Ola-087022	Oryzias latipes	62.14	2.00e-116	412.00
IUUC-Oga-087963	Otolemur garnettii	85.56	8.00e-173	599.00
IUUC-Oar-089439	Ovis aries	86.35	1.00e-164	572.00
IUUC-Ptr-091616	Pan troglodytes	85.83	7.00e-163	566.00
IUUC-Pan-092754	Papio anubis	85.79	1.00e-164	572.00
IUUC-Psi-093217	Pelodiscus sinensis	67.11	6.00e-122	430.00
IUUC-Pno-094968	Phaeosphaeria nodorum	32.35	3.00e-09	58.50
IUUC-Pab-098124	Pongo abelii	86.32	8.00e-165	572.00
IUUC-Pca-100954	Procavia capensis	84.78	7.00e-164	569.00
IUUC-Pva-102588	Pteropus vampyrus	85.26	2.00e-163	568.00
IUUC-Pte-104027	Pyrenophora teres	32.35	1.00e-09	59.30
IUUC-Sha-106640	Sarcophilus harrisii	75.85	3.00e-139	487.00
IUUC-Sit-110649	Setaria italica	39.66	1.00e-08	51.60
IUUC-Sar-113331	Sorex araneus	86.02	5.00e-166	576.00
IUUC-Tgu-117252	Taeniopygia guttata	72.58	2.00e-131	461.00
IUUC-Tsy-118891	Tarsius syrichta	58.29	4.00e-57	214.00
IUUC-Tni-119741	Tetraodon nigroviridis	54.48	8.00e-106	376.00
IUUC-Tbe-127380	Tupaia belangeri	85.75	3.00e-167	580.00
IUUC-Ttr-128999	Tursiops truncatus	86.84	7.00e-167	579.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence