iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-090980

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AACZ03085308

Gene Name

USP44

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000005314.4	ENSPTRT00000009766.3	ENSPTRP00000009031.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.50e-98	328.2	273	677

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle............kkkeklneenp................................... 42
           tGl+NlgNtCYmNSvLQ+Ls++  +r+++l+            +k++      +                                   
   Q: 273  TGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKldlnqwlamtasEKTR------Sckhppvtdtvvyqmnecqekdtgfvrsrqsslssg 355
           7******************************8887766665543333......044455799999999999999999999999999999 PP
   S: 43   ...................kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkekn 112
                              +++  +l+++l+ lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld++++el     
   Q: 356  lsggaskgrkmeliqpkepTSQYISLCHELHALFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKIQREL----- 439
           999999888888888777666677************************************************************..... PP
   S: 113  kpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.......slqdcLesf 194
               e+++++  +l   +++k  k+  ++++++F+gql sq++cl+cdn+s++ epf+dlsl++p++ +++ +        ++++L++f
   Q: 440  ----ETTGTSLPALIPTSQRKLIKQVLNVVNNIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFPERYQCSGKdiasqpcLVTEMLAKF 524
           ....7889999999999************************************************9998877788888889******** PP
   S: 195  tkeeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekq 272
           t++e leg+  y c++c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c++++ k+
   Q: 525  TETEALEGKI-YVCDQCNSKRRrfsskpvvlteAQKQLMICHLPQVLRLHLKRFRWSGR-NNREKIGVHVGFEEILNMEPYCCRETLKS 611
           *******965.*******999999999999999***********************998.7778********************99888 PP
   S: 273  ke..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
            +  + +Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk + ++++ev++   ++aY+lfY++
   Q: 612  LRpeCFIYDLSAVVMHHGkGFGSGHYTAYCYNSEGGfWVHCNDSKLSMCTMDEVCK---AQAYILFYTQ 677
           76779***************************9999********************...********98 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MLAMDKCKHV GQLQLAQDHS SLNPQKWHCV DCNTTESIWA CLSCSHVACG RYIEEHALKH 60
FQESSHPVAL EVNEMYVFCY LCDDYVLNDN ATGDLKLLRS TLSAIKSQNY HCTTRSGRFL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGTCGTCGC GGCCGCCGAA CCGGGGGGCG GGGGGCCGGG GTGAGCGCTA AGATGGCCGC 60
CCCGGCTCGG GCTGGTGAGT GTGCGCGAGG GCGCGCGGCC GCGCCGATTG GCGGAGTGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:1904667--P:negative regulation of ubiquitin protein ligase activity
GO:0016579--P:protein deubiquitination
GO:0090231--P:regulation of spindle checkpoint
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ptr:452142

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	91.16	0.00e+00	1306.00
IUUC-Apl-003673	Anas platyrhynchos	74.79	0.00e+00	1041.00
IUUC-Aca-004434	Anolis carolinensis	73.62	0.00e+00	1003.00
IUUC-Ame-010986	Astyanax mexicanus	64.86	0.00e+00	876.00
IUUC-Bta-012774	Bos taurus	88.78	0.00e+00	1266.00
IUUC-Cja-019619	Callithrix jacchus	93.54	0.00e+00	1322.00
IUUC-Cfa-020957	Canis familiaris	90.04	0.00e+00	1306.00
IUUC-Csa-023177	Chlorocebus sabaeus	94.81	0.00e+00	1335.00
IUUC-Cho-024877	Choloepus hoffmanni	87.61	0.00e+00	833.00
IUUC-Cin-025587	Ciona intestinalis	47.22	2.00e-103	370.00
IUUC-Csv-025814	Ciona savignyi	44.02	1.00e-152	533.00
IUUC-Dre-027878	Danio rerio	63.99	0.00e+00	844.00
IUUC-Dno-029832	Dasypus novemcinctus	91.15	0.00e+00	1318.00
IUUC-Ete-032627	Echinops telfairi	86.12	0.00e+00	1244.00
IUUC-Eca-033863	Equus caballus	86.76	0.00e+00	1209.00
IUUC-Eeu-035225	Erinaceus europaeus	85.69	0.00e+00	1189.00
IUUC-Fca-036288	Felis catus	91.30	0.00e+00	1309.00
IUUC-Fal-037207	Ficedula albicollis	74.82	0.00e+00	1003.00
IUUC-Gmo-039249	Gadus morhua	70.25	2.00e-132	466.00
IUUC-Gga-040457	Gallus gallus	73.94	0.00e+00	1011.00
IUUC-Gac-042595	Gasterosteus aculeatus	53.12	0.00e+00	695.00
IUUC-Ggo-044926	Gorilla gorilla	98.88	0.00e+00	1393.00
IUUC-Hsa-046079	Homo sapiens	99.02	0.00e+00	1392.00
IUUC-Itr-048737	Ictidomys tridecemlineatus	90.45	0.00e+00	1286.00
IUUC-Lch-050260	Latimeria chalumnae	66.71	0.00e+00	915.00
IUUC-Laf-054491	Loxodonta africana	88.41	0.00e+00	1215.00
IUUC-Mcc-055694	Macaca mulatta	95.09	0.00e+00	1335.00
IUUC-Mga-059523	Meleagris gallopavo	73.63	0.00e+00	1023.00
IUUC-Mmr-060885	Microcebus murinus	93.69	0.00e+00	1342.00
IUUC-Mdo-063018	Monodelphis domestica	79.07	0.00e+00	1108.00
IUUC-Mmu-064012	Mus musculus	80.06	0.00e+00	1098.00
IUUC-Mpu-066207	Mustela putorius furo	89.34	0.00e+00	1308.00
IUUC-Mlu-066929	Myotis lucifugus	86.79	0.00e+00	1179.00
IUUC-Nle-069313	Nomascus leucogenys	87.38	0.00e+00	1189.00
IUUC-Opr-070375	Ochotona princeps	81.63	0.00e+00	1117.00
IUUC-Ont-071637	Oreochromis niloticus	63.95	0.00e+00	863.00
IUUC-Oan-073030	Ornithorhynchus anatinus	77.84	0.00e+00	843.00
IUUC-Ocu-074836	Oryctolagus cuniculus	87.87	0.00e+00	1256.00
IUUC-Oga-088367	Otolemur garnettii	92.29	0.00e+00	1301.00
IUUC-Oar-089953	Ovis aries	89.64	0.00e+00	1297.00
IUUC-Pan-092748	Papio anubis	95.51	0.00e+00	1339.00
IUUC-Pfo-096860	Poecilia formosa	70.11	3.00e-169	588.00
IUUC-Pab-098514	Pongo abelii	97.62	0.00e+00	1370.00
IUUC-Pva-102984	Pteropus vampyrus	88.36	0.00e+00	1234.00
IUUC-Rno-106019	Rattus norvegicus	80.00	0.00e+00	1127.00
IUUC-Sha-106965	Sarcophilus harrisii	77.70	0.00e+00	1098.00
IUUC-Ssc-115299	Sus scrofa	90.60	0.00e+00	1316.00
IUUC-Tgu-117160	Taeniopygia guttata	73.72	0.00e+00	1003.00
IUUC-Tru-118156	Takifugu rubripes	60.82	0.00e+00	828.00
IUUC-Tni-119733	Tetraodon nigroviridis	61.78	0.00e+00	851.00
IUUC-Tbe-128084	Tupaia belangeri	85.67	0.00e+00	1208.00
IUUC-Ttr-128928	Tursiops truncatus	91.58	0.00e+00	1324.00
IUUC-Vpa-130706	Vicugna pacos	90.88	0.00e+00	1304.00
IUUC-Xtr-132061	Xenopus tropicalis	71.39	0.00e+00	924.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence