iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ggo-045633

Ensembl Protein ID

ENSGGOP00000025505.1

UniProt Accession

G3SBM8; G3SBM8_GORGO

Protein Name

Uncharacterized protein

Gene Name

TLE4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000000292.2	ENSGGOT00000034006.1	ENSGGOP00000025505.1
ENSGGOG00000000292.2	ENSGGOT00000000294.2	ENSGGOP00000000288.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.30e-22	78.0	634	672
UBD/Beta-Prp	3.90e-40	138.3	502	671

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++  +d t l++G+ D+t++ WDlr+g++l+
   Q: 634  GHTDGASCIDIsNDgTKLWTGGLDNTVRSWDLREGRQLQ 672
           8***********999*********************998 PP

UBD/Beta-Prp

   S: 50   gheaevtavkfspdgkilvtgseDrtikvwdls...tgkcvhtlk..ghedsvlslsfspsgdklvsGshdrtirvwdletgqclee.t 132
           +h + v av++s+ +   v ++  + +kvwd+s   + ++v+ l   + +++++s+++ p+g +l++G++ +t+ +wdl   +   +  
   Q: 502  NHGEVVCAVTISNPTR-HVYTGGKGCVKVWDIShpgNKSPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKaE 589
           5566678889998884.555555579*******999888999988889*******************************9988766658 PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecv 215
           l+    +   ++++pd+++++s++ D+ + +Wdl +++l+r+++g htd   +++++ +g+ l +g+ld+tv+ wdl++g+ +
   Q: 590  LTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQG-HTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQL 671
           88888888999*********************************9.********************************99754 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

APHQPAQPFK FTISESCDRI KEEFQFLQAQ YHSLKLECEK LASEKTEMQR HYVMYYEMSY 60
GLNIEMHKQA EIVKRLNAIC AQVIPFLSQE HQQQVVQAVE RAKQVTMAEL NAIIGQQLQA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGCACCGC ATCAGCCTGC TCAACCCTTT AAATTTACAA TTTCCGAATC CTGTGATCGG 60
ATTAAGGAAG AGTTTCAGTT TTTACAGGCT CAATACCACA GGTAACGATA TTGACTTTAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03920--TLE_N
PF00400--WD40

PRINTS

PR01850--GROUCHOFAMLY

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0003714--F:transcription corepressor activity
GO:0003705--F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016055--P:Wnt signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001359	Ailuropoda melanoleuca	98.43	0.00e+00	1272.00
IUUC-Apl-003434	Anas platyrhynchos	81.47	0.00e+00	1107.00
IUUC-Bta-012646	Bos taurus	92.16	0.00e+00	1317.00
IUUC-Cel-018361	Caenorhabditis elegans	58.99	4.00e-122	431.00
IUUC-Cja-019079	Callithrix jacchus	92.41	0.00e+00	1354.00
IUUC-Cfa-020987	Canis familiaris	92.07	0.00e+00	1330.00
IUUC-Cpo-021606	Cavia porcellus	90.66	0.00e+00	1292.00
IUUC-Csa-023445	Chlorocebus sabaeus	92.78	0.00e+00	1327.00
IUUC-Cho-024590	Choloepus hoffmanni	90.65	0.00e+00	1239.00
IUUC-Cin-025282	Ciona intestinalis	75.69	4.00e-154	538.00
IUUC-Dno-028979	Dasypus novemcinctus	92.06	0.00e+00	1278.00
IUUC-Dor-030533	Dipodomys ordii	94.57	0.00e+00	1169.00
IUUC-Dme-031576	Drosophila melanogaster	86.03	0.00e+00	665.00
IUUC-Ete-032887	Echinops telfairi	90.76	0.00e+00	1266.00
IUUC-Eca-034397	Equus caballus	91.82	0.00e+00	1249.00
IUUC-Eeu-035237	Erinaceus europaeus	89.56	0.00e+00	1201.00
IUUC-Fca-036030	Felis catus	92.29	0.00e+00	1348.00
IUUC-Fal-037460	Ficedula albicollis	92.15	0.00e+00	1324.00
IUUC-Gga-040416	Gallus gallus	92.41	0.00e+00	1320.00
IUUC-Hsa-046461	Homo sapiens	99.75	0.00e+00	1435.00
IUUC-Itr-048974	Ictidomys tridecemlineatus	92.67	0.00e+00	1322.00
IUUC-Lch-049943	Latimeria chalumnae	88.80	0.00e+00	1217.00
IUUC-Loc-052835	Lepisosteus oculatus	91.72	0.00e+00	1246.00
IUUC-Laf-053425	Loxodonta africana	92.66	0.00e+00	1355.00
IUUC-Mcc-055766	Macaca mulatta	99.75	0.00e+00	1434.00
IUUC-Meu-056209	Macropus eugenii	95.82	0.00e+00	1368.00
IUUC-Mmr-061317	Microcebus murinus	97.97	0.00e+00	1395.00
IUUC-Mdo-062956	Monodelphis domestica	91.78	0.00e+00	1310.00
IUUC-Mmu-063576	Mus musculus	92.66	0.00e+00	1316.00
IUUC-Mpu-066410	Mustela putorius furo	92.06	0.00e+00	1254.00
IUUC-Mlu-067456	Myotis lucifugus	90.71	0.00e+00	1261.00
IUUC-Nle-069495	Nomascus leucogenys	92.78	0.00e+00	1327.00
IUUC-Opr-070645	Ochotona princeps	95.52	0.00e+00	1241.00
IUUC-Ont-071419	Oreochromis niloticus	82.49	0.00e+00	1143.00
IUUC-Oan-072842	Ornithorhynchus anatinus	89.27	0.00e+00	1300.00
IUUC-Ocu-074453	Oryctolagus cuniculus	91.62	0.00e+00	1304.00
IUUC-Ola-087090	Oryzias latipes	82.09	0.00e+00	1151.00
IUUC-Oga-087939	Otolemur garnettii	92.54	0.00e+00	1321.00
IUUC-Oar-090347	Ovis aries	91.40	0.00e+00	1227.00
IUUC-Ptr-091048	Pan troglodytes	92.78	0.00e+00	1327.00
IUUC-Pan-091973	Papio anubis	88.23	0.00e+00	1273.00
IUUC-Pfo-097518	Poecilia formosa	81.65	0.00e+00	1108.00
IUUC-Pab-097539	Pongo abelii	99.73	0.00e+00	1337.00
IUUC-Pca-101137	Procavia capensis	93.76	0.00e+00	1244.00
IUUC-Pva-103037	Pteropus vampyrus	95.95	0.00e+00	1392.00
IUUC-Rno-105314	Rattus norvegicus	92.32	0.00e+00	1248.00
IUUC-Sar-113267	Sorex araneus	93.25	0.00e+00	769.00
IUUC-Ssc-116408	Sus scrofa	92.07	0.00e+00	1338.00
IUUC-Tgu-117068	Taeniopygia guttata	91.32	0.00e+00	1317.00
IUUC-Tru-118782	Takifugu rubripes	81.26	0.00e+00	1113.00
IUUC-Tsy-118884	Tarsius syrichta	88.59	0.00e+00	1142.00
IUUC-Tni-120404	Tetraodon nigroviridis	80.75	0.00e+00	1139.00
IUUC-Tbe-128013	Tupaia belangeri	93.80	0.00e+00	1323.00
IUUC-Ttr-129285	Tursiops truncatus	97.22	0.00e+00	1433.00
IUUC-Vpa-130577	Vicugna pacos	90.30	0.00e+00	687.00
IUUC-Xtr-132974	Xenopus tropicalis	90.33	0.00e+00	1247.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence