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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-047029
Ensembl Protein ID ENSP00000341805.4
UniProt Accession Q8WUB8; Q2YDA3; Q53HG8; Q9BXD2; Q9NV26; PHF10_HUMAN
Genbank Protein ID CAI12316.1; AAH20954.1; AAI10324.1; AAK27451.1; BAA91934.1; CAG33554.1; BAD96332.1
Protein Name PHD finger protein 10; BRG1-associated factor 45a; XAP135
Genbank Nucleotide ID AL513547; BC020954; BC110323; AF338735; AK001837; CR457273; AK222612
Gene Name PHF10; BAF45A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000130024.14 ENST00000366780.8 ENSP00000355743.4
ENSG00000130024.14 ENST00000339209.8 ENSP00000341805.4
ENSG00000130024.14 ENST00000612128.1 ENSP00000479515.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 5.40e-13 50.6 434 480
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrs 53
           k C +Cg+++++e +++ C+ C++ +H  C++l      p+   wiC  C++
   Q: 434  KTCIICGQPHHEE-EMMFCDMCDRGYHTFCVGLG---AIPSGR-WICDCCQR 480
           78*********88.5*******************...999996.******86 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
 Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
Protein Sequence
(Fasta)
MAAAAGPGAA LSPRPCDSDP ATPGAQSPKD DNEDNSNDGT QPSKRRRMGS GDSSRSCETS 60
SQDLGFSYYP AENLIEYKWP PDETGEYYML QEQVSEYLGV TSFKRKYPDL ERRDLSHKEK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-047029|E3,PHD|Homo sapiens
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Nucleotide Sequence
(Fasta)
CAGACAAGAA GTGCGGCGGA AGCTTACACC TGCACGTGGT GGGACAGAGG CAAGAACGGA 60
TGGTCTGGCT GAGGCTGAGA GAACCAAGCT GGATTAGGAT CGGCTTGAGG GCCCGGCGTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-047029|E3,PHD|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF00628--PHD
SMART

SM00249--PHD
Gene Ontology

GO:0071564--C:npBAF complex
GO:0005634--C:nucleus
GO:0008270--F:zinc ion binding
GO:0007399--P:nervous system development
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG hsa:55274
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001967 Ailuropoda melanoleuca 97.01 0.00e+00 829.00
IUUC-Apl-003184 Anas platyrhynchos 90.28 0.00e+00 701.00
IUUC-Aca-005357 Anolis carolinensis 86.68 0.00e+00 768.00
IUUC-Ame-011482 Astyanax mexicanus 74.31 0.00e+00 630.00
IUUC-Bta-013488 Bos taurus 93.17 0.00e+00 636.00
IUUC-Cel-018612 Caenorhabditis elegans 31.99 1.00e-59 223.00
IUUC-Cja-018959 Callithrix jacchus 96.91 0.00e+00 845.00
IUUC-Cfa-020275 Canis familiaris 97.17 0.00e+00 808.00
IUUC-Cpo-021997 Cavia porcellus 97.07 0.00e+00 744.00
IUUC-Csa-024058 Chlorocebus sabaeus 99.56 0.00e+00 834.00
IUUC-Cin-025585 Ciona intestinalis 54.05 9.00e-66 244.00
IUUC-Csv-026176 Ciona savignyi 52.70 6.00e-63 235.00
IUUC-Dre-027911 Danio rerio 73.15 0.00e+00 633.00
IUUC-Dno-028846 Dasypus novemcinctus 98.09 0.00e+00 839.00
IUUC-Dor-030929 Dipodomys ordii 96.83 0.00e+00 735.00
IUUC-Dme-032114 Drosophila melanogaster 31.03 3.00e-32 135.00
IUUC-Ete-032648 Echinops telfairi 91.12 7.00e-94 337.00
IUUC-Eca-034382 Equus caballus 95.85 0.00e+00 728.00
IUUC-Eeu-035027 Erinaceus europaeus 95.85 0.00e+00 731.00
IUUC-Fca-036040 Felis catus 93.56 0.00e+00 756.00
IUUC-Fal-037535 Ficedula albicollis 90.40 0.00e+00 777.00
IUUC-Gmo-038527 Gadus morhua 72.68 3.00e-147 514.00
IUUC-Gga-040769 Gallus gallus 82.65 0.00e+00 640.00
IUUC-Gac-042584 Gasterosteus aculeatus 67.71 4.00e-149 521.00
IUUC-Ggo-045145 Gorilla gorilla 99.51 0.00e+00 747.00
IUUC-Itr-047896 Ictidomys tridecemlineatus 97.65 0.00e+00 828.00
IUUC-Lch-050598 Latimeria chalumnae 69.87 9.00e-174 603.00
IUUC-Loc-052902 Lepisosteus oculatus 82.21 0.00e+00 674.00
IUUC-Laf-053764 Loxodonta africana 91.77 0.00e+00 676.00
IUUC-Mcc-055088 Macaca mulatta 97.53 0.00e+00 848.00
IUUC-Meu-056586 Macropus eugenii 95.28 1.00e-66 246.00
IUUC-Mga-059912 Meleagris gallopavo 81.14 0.00e+00 655.00
IUUC-Mmr-061508 Microcebus murinus 95.93 0.00e+00 844.00
IUUC-Mdo-062561 Monodelphis domestica 95.90 0.00e+00 826.00
IUUC-Mmu-063445 Mus musculus 96.31 0.00e+00 859.00
IUUC-Mpu-066775 Mustela putorius furo 95.85 0.00e+00 731.00
IUUC-Mlu-067747 Myotis lucifugus 94.36 0.00e+00 778.00
IUUC-Nle-069553 Nomascus leucogenys 99.80 0.00e+00 912.00
IUUC-Opr-071037 Ochotona princeps 71.30 2.00e-74 271.00
IUUC-Ont-072137 Oreochromis niloticus 75.73 9.00e-179 619.00
IUUC-Oan-073733 Ornithorhynchus anatinus 95.34 0.00e+00 805.00
IUUC-Ocu-074802 Oryctolagus cuniculus 95.52 0.00e+00 784.00
IUUC-Ola-086309 Oryzias latipes 74.36 2.00e-151 528.00
IUUC-Oga-088663 Otolemur garnettii 97.33 0.00e+00 864.00
IUUC-Oar-089478 Ovis aries 93.25 0.00e+00 765.00
IUUC-Ptr-091474 Pan troglodytes 99.79 0.00e+00 866.00
IUUC-Pan-092456 Papio anubis 98.97 0.00e+00 868.00
IUUC-Psi-093676 Pelodiscus sinensis 91.39 0.00e+00 775.00
IUUC-Pfo-096908 Poecilia formosa 75.27 4.00e-177 614.00
IUUC-Pab-097820 Pongo abelii 99.39 0.00e+00 878.00
IUUC-Pca-100174 Procavia capensis 91.99 0.00e+00 674.00
IUUC-Pva-102571 Pteropus vampyrus 84.63 1.00e-174 605.00
IUUC-Rno-105400 Rattus norvegicus 97.56 0.00e+00 744.00
IUUC-Sha-107024 Sarcophilus harrisii 95.79 0.00e+00 796.00
IUUC-Ssc-115799 Sus scrofa 90.47 0.00e+00 717.00
IUUC-Tgu-116658 Taeniopygia guttata 92.44 0.00e+00 696.00
IUUC-Tru-118269 Takifugu rubripes 69.40 9.00e-142 496.00
IUUC-Tsy-119389 Tarsius syrichta 97.32 0.00e+00 699.00
IUUC-Tni-119914 Tetraodon nigroviridis 71.04 2.00e-143 501.00
IUUC-Tbe-128154 Tupaia belangeri 81.51 0.00e+00 664.00
IUUC-Ttr-129016 Tursiops truncatus 95.60 0.00e+00 702.00
IUUC-Xtr-132371 Xenopus tropicalis 70.97 3.00e-169 588.00
Created Date 25-Jun-2017

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