iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000011393.3	ENSSSCT00000036320.1	ENSSSCP00000030275.1
ENSSSCG00000011393.3	ENSSSCT00000033540.1	ENSSSCP00000029718.1
ENSSSCG00000011393.3	ENSSSCT00000033864.1	ENSSSCP00000029827.1
ENSSSCG00000011393.3	ENSSSCT00000034482.1	ENSSSCP00000029664.1
ENSSSCG00000011393.3	ENSSSCT00000012471.2	ENSSSCP00000012146.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	8.80e-206	684.2	415	890

Active Site

Position(s)	Description	Evidence
599	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Qi+++G++ qe+l+ +++llvGag++GcEllK ++l+G+     g +tv Dmd+ve snl+rqFLfr++d+g+ KAevaaea+++l
   Q: 415  YDGQIAVFGAHFQERLSHQHYLLVGAGAIGCELLKGFALVGLgaggsGGVTVADMDHVERSNLSRQFLFRPQDIGRLKAEVAAEAAHRL 503
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dpp 167
           n+d  v++  +++++++e+i+   Ff+ +d+V++ald+++arr+v+ +c+++ +pl+e+gt G++G + v++++lte y+++     ++
   Q: 504  NSDLLVTPLPYQLDPTTEHIYgdnFFSSVDGVAAALDSFQARRYVAARCTHYLKPLLEAGTKGTWGSACVFVPHLTEGYRAPAsaaASE 592
           ************************************************************************************999** PP
   S: 168  qktiPfctlketpnaaehtiewa........vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakt 248
           ++++P+ct++++p++aeht++wa        +lf+++++ ++++ +  ++ld  ++++ +++v   l++ +++++ +++ +a+ +++ +
   Q: 593  DTSYPICTVRHFPSTAEHTLQWArdefeglfRLFAETINRHQQALTPPADLDGPQMLNLLQVVLGVLRE-RPQTWRDCVVWALGHWQLR 680
           ***************************************************************666555.7****************** PP
   S: 249  tinsikqllksfecdivtkskspfwv................................................sfcsnaealqvpekv 289
           ++++i+qll++f++d+v ++++pfw+                                                ++ ++ + +   +  
   Q: 681  FHYGIEQLLRHFPPDKVLEDGTPFWSgpkqcpqplefdasqdmhllfvlaaanlyaqmhglpgsqdqtalkdllQLLPLPDPQYLAPIF 769
           *************************************************************9999999999999999999999999999 PP
   S: 290  ekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiat 371
           ++d e   asa+     l+ l +ale+++    +kp  l+fekddds  +vd+v aaa+lra+++gi+p +++ + k+i+g+iipaiat
   Q: 770  ASDLELTLASAEfgperLKKLHEALETWRMGAPLKP--LMFEKDDDSnfHVDFVVAAASLRAQNYGIPP-ANRAKSKQIVGRIIPAIAT 855
           99999999999999999******************9..*******************************.******************* PP
   S: 372  tnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
           t+a+v+Gl+++E++Kvv g  + +++++ +l++ae
   Q: 856  TTAAVAGLVCLELYKVVGGprPLTAFRHSYLHLAE 890
           *******************8888888888888765 PP

Organism

Sus scrofa

Protein Sequence
(Fasta)

MDVQETSKLL DEELYSRQLY VLGLPAMERI QGAKVLLSGL QGLGAEIAKN LVLMGIGSLT 60
LHDPHPTCWS DLAAQFFLSE QDLGRSRAEA SQELLAKLNG AVQVCIHKGD ITEDLLLHFQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGCTCTGCC CTCTAGGGTG TCTAAGTCTC TGTGTGAATA AGAGGCCAGG CGAGTCCTCA 60
GGATAAGGGA GTTCTCACCA GCTCTCTGCG GCAGGAAACC CATTCAGGCA GGGGGTTAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0019782--F:ISG15 activating enzyme activity
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001816	Ailuropoda melanoleuca	80.68	0.00e+00	1527.00
IUUC-Bta-012665	Bos taurus	79.76	0.00e+00	1447.00
IUUC-Cja-019047	Callithrix jacchus	80.14	0.00e+00	1499.00
IUUC-Cfa-021225	Canis familiaris	80.04	0.00e+00	1528.00
IUUC-Cpo-022336	Cavia porcellus	69.25	0.00e+00	1259.00
IUUC-Csa-023462	Chlorocebus sabaeus	82.41	0.00e+00	1499.00
IUUC-Cho-024436	Choloepus hoffmanni	79.32	2.00e-103	370.00
IUUC-Dno-029347	Dasypus novemcinctus	78.06	0.00e+00	1461.00
IUUC-Dor-030997	Dipodomys ordii	73.52	0.00e+00	1343.00
IUUC-Ete-033124	Echinops telfairi	73.68	0.00e+00	955.00
IUUC-Eca-033929	Equus caballus	82.21	0.00e+00	1605.00
IUUC-Eeu-034717	Erinaceus europaeus	69.49	0.00e+00	975.00
IUUC-Fca-036564	Felis catus	81.26	0.00e+00	1519.00
IUUC-Ggo-044480	Gorilla gorilla	82.05	0.00e+00	1495.00
IUUC-Hsa-046498	Homo sapiens	81.72	0.00e+00	1461.00
IUUC-Itr-048657	Ictidomys tridecemlineatus	76.42	0.00e+00	1412.00
IUUC-Laf-054119	Loxodonta africana	77.57	0.00e+00	1494.00
IUUC-Mcc-055597	Macaca mulatta	80.47	0.00e+00	1425.00
IUUC-Mdo-063058	Monodelphis domestica	58.03	0.00e+00	1031.00
IUUC-Mmu-063578	Mus musculus	70.62	0.00e+00	1358.00
IUUC-Mpu-066255	Mustela putorius furo	80.08	0.00e+00	1512.00
IUUC-Mlu-067814	Myotis lucifugus	75.02	0.00e+00	1340.00
IUUC-Nle-069193	Nomascus leucogenys	80.93	0.00e+00	1471.00
IUUC-Opr-070715	Ochotona princeps	71.03	0.00e+00	1309.00
IUUC-Ocu-074162	Oryctolagus cuniculus	77.66	0.00e+00	1427.00
IUUC-Oga-088895	Otolemur garnettii	78.03	0.00e+00	1428.00
IUUC-Oar-089579	Ovis aries	79.76	0.00e+00	1443.00
IUUC-Ptr-090581	Pan troglodytes	81.97	0.00e+00	1432.00
IUUC-Pan-092458	Papio anubis	82.51	0.00e+00	1490.00
IUUC-Pab-098653	Pongo abelii	76.09	0.00e+00	1390.00
IUUC-Pca-100578	Procavia capensis	73.20	0.00e+00	844.00
IUUC-Pva-102914	Pteropus vampyrus	80.38	0.00e+00	1229.00
IUUC-Rno-106066	Rattus norvegicus	71.12	0.00e+00	1370.00
IUUC-Sha-107368	Sarcophilus harrisii	60.43	0.00e+00	1121.00
IUUC-Tbe-127587	Tupaia belangeri	74.75	0.00e+00	1256.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence