iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011258

Ensembl Protein ID

ENSAMXP00000008324.1

UniProt Accession

W5KL62; W5KL62_ASTMX

Genbank Protein ID

ENSAMXP00000008324

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

APWO01111530

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000008101.1	ENSAMXT00000008324.1	ENSAMXP00000008324.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.60e-121	403.5	2066	2524

Active Site

Position(s)	Description	Evidence
2493	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysen..dketlqpnpdsglknp..................... 65
           ++d k++levef+gEeg++l G+t+ef+al+++e+q+++lg++l++++  d+e++q++   glk+p                     
   Q: 2066 HADKKSVLEVEFQGEEGTGL-GPTLEFYALVAAEFQRTSLGIWLCDDDfpDDESRQVDLGGGLKPPgyyvqrscglfpapfpqdnde 2151
           678999**************.******************************************988********************* PP
   S: 66   ..ehlklFeflGrllgkalqdgrlldlplsksfykll.................................................. 100
             + +klF flG++l+k++qd+rl+dlp+s++f+kll                                                  
   Q: 2152 leRITKLFLFLGIFLAKCIQDNRLVDLPISQPFFKLLcmgdiksnmskllyqthgdsdhrfseiqleasteegqdtysmgsfdedsk 2238
           *************************************99999999999999999999999999999988888888888887777777 PP
   S: 101  ...............lgkklsledleevdpelykslkeikena........es..........................dieelgld 138
                           +  l++ed+e v+p+++++lke+k++a        ++                          ++e+lgl+
   Q: 2239 sefildppkpkppawYHGILTWEDFELVNPHRARFLKEMKDLAvkrrqilgNKslsedekntrlqdlmlknpmgsgpplSVEDLGLN 2325
           7777666665555555557***********************97666655511566677788999999999999************* PP
   S: 139  ltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeid 225
           ++f++s+++ g  +++ Lkp+G++++Vt+eN+eeYv+l++++++++gi++q+eafr+Gfn+v+p+e+ls+F+++e+++++cG+   +
   Q: 2326 FQFCPSSKVHGFSAVD-LKPNGDDEMVTMENAEEYVELMFDFCMHTGIQKQMEAFRDGFNRVFPMEKLSSFSHKEVQMILCGN---Q 2408
           ******9988888777.******************************************************************...5 PP
   S: 226  vedlkket..ky...kggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfn 306
           ++++++e+  +y   k gyt+dsp++ +F++vl+++ss+erkafLqF+Tg+s+lP+gG+a+l+prl+++rk da+d+++Ps+nTC++
   Q: 2409 SPSWTAEDivNYtepKLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTIVRKvDATDASYPSVNTCVH 2495
           555555555544555************************************************************************ PP
   S: 307  yLkLPeYsskeilkekLlyAieetkgFels 336
           yLkLPeYss+ei++e+Ll+A++e kgF+l+
   Q: 2496 YLKLPEYSSEEIMRERLLAATME-KGFHLN 2524
           ***********************.****86 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP RTFLPALCKI 60
FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK ALCNRLVVVE LNNRTSRDLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGAAGACTT CATGAGCCAA CAGGAGGACT AGTGACTGCC CCCGTTCTTT TCTCTCTTAT 60
TACTGGCGGA TGCTTTGACT GGGCGACAGG TGGACAGGGT AGCAGCGCGT CATGGCGGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000421--FA58C
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50022--FA58C_3
PS50237--HECT
PS51416--MIB_HERC2

Pfam

PF12796--Ank_2
PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001987	Ailuropoda melanoleuca	87.40	0.00e+00	2546.00
IUUC-Apl-003493	Anas platyrhynchos	87.62	0.00e+00	2551.00
IUUC-Aca-004521	Anolis carolinensis	87.29	0.00e+00	4039.00
IUUC-Bta-012835	Bos taurus	87.28	0.00e+00	2549.00
IUUC-Cel-018153	Caenorhabditis elegans	52.09	5.00e-168	586.00
IUUC-Cja-019174	Callithrix jacchus	85.97	0.00e+00	2471.00
IUUC-Cfa-021115	Canis familiaris	87.05	0.00e+00	2496.00
IUUC-Cpo-022382	Cavia porcellus	81.74	0.00e+00	2309.00
IUUC-Csa-023230	Chlorocebus sabaeus	87.40	0.00e+00	2546.00
IUUC-Cho-024711	Choloepus hoffmanni	84.75	0.00e+00	1480.00
IUUC-Cin-025342	Ciona intestinalis	53.03	0.00e+00	1363.00
IUUC-Csv-026031	Ciona savignyi	51.04	0.00e+00	1334.00
IUUC-Dre-027435	Danio rerio	94.67	0.00e+00	2680.00
IUUC-Dno-029954	Dasypus novemcinctus	87.58	0.00e+00	2523.00
IUUC-Dor-030734	Dipodomys ordii	90.64	0.00e+00	1369.00
IUUC-Dme-031739	Drosophila melanogaster	59.76	0.00e+00	1578.00
IUUC-Ete-033192	Echinops telfairi	86.89	0.00e+00	1142.00
IUUC-Eca-033434	Equus caballus	86.67	0.00e+00	2514.00
IUUC-Eeu-035031	Erinaceus europaeus	79.16	0.00e+00	1032.00
IUUC-Fca-035998	Felis catus	90.10	0.00e+00	2572.00
IUUC-Fal-037468	Ficedula albicollis	87.05	0.00e+00	4004.00
IUUC-Gmo-038495	Gadus morhua	92.81	0.00e+00	1388.00
IUUC-Gga-040736	Gallus gallus	87.79	0.00e+00	4013.00
IUUC-Gac-041777	Gasterosteus aculeatus	91.94	0.00e+00	2376.00
IUUC-Ggo-044677	Gorilla gorilla	83.26	0.00e+00	2365.00
IUUC-Hsa-045879	Homo sapiens	87.40	0.00e+00	2546.00
IUUC-Itr-048664	Ictidomys tridecemlineatus	87.34	0.00e+00	2548.00
IUUC-Lch-050444	Latimeria chalumnae	87.25	0.00e+00	2468.00
IUUC-Loc-051986	Lepisosteus oculatus	93.70	0.00e+00	2678.00
IUUC-Laf-054230	Loxodonta africana	87.02	0.00e+00	2492.00
IUUC-Mcc-054787	Macaca mulatta	87.40	0.00e+00	2546.00
IUUC-Meu-056502	Macropus eugenii	81.28	0.00e+00	1216.00
IUUC-Mga-059409	Meleagris gallopavo	95.30	0.00e+00	1897.00
IUUC-Mmr-061667	Microcebus murinus	86.65	0.00e+00	2515.00
IUUC-Mdo-061960	Monodelphis domestica	87.53	0.00e+00	2529.00
IUUC-Mmu-063941	Mus musculus	86.55	0.00e+00	2502.00
IUUC-Mpu-065939	Mustela putorius furo	87.40	0.00e+00	2544.00
IUUC-Mlu-068112	Myotis lucifugus	87.58	0.00e+00	2547.00
IUUC-Nle-069001	Nomascus leucogenys	87.40	0.00e+00	2547.00
IUUC-Opr-071222	Ochotona princeps	90.37	0.00e+00	2027.00
IUUC-Ont-072101	Oreochromis niloticus	86.38	0.00e+00	4011.00
IUUC-Oan-072814	Ornithorhynchus anatinus	87.81	0.00e+00	2523.00
IUUC-Ocu-074011	Oryctolagus cuniculus	87.46	0.00e+00	2547.00
IUUC-Ola-086412	Oryzias latipes	95.57	0.00e+00	2376.00
IUUC-Oar-089668	Ovis aries	87.28	0.00e+00	2543.00
IUUC-Ptr-090517	Pan troglodytes	86.89	0.00e+00	2506.00
IUUC-Pan-091849	Papio anubis	83.21	0.00e+00	2414.00
IUUC-Psi-093390	Pelodiscus sinensis	89.06	0.00e+00	4050.00
IUUC-Pma-094628	Petromyzon marinus	82.57	0.00e+00	1541.00
IUUC-Pfo-097075	Poecilia formosa	95.72	0.00e+00	2434.00
IUUC-Pab-098176	Pongo abelii	87.40	0.00e+00	2546.00
IUUC-Pca-101123	Procavia capensis	80.70	0.00e+00	1396.00
IUUC-Pva-103008	Pteropus vampyrus	95.67	0.00e+00	1541.00
IUUC-Rno-105885	Rattus norvegicus	87.05	0.00e+00	2534.00
IUUC-Sha-107048	Sarcophilus harrisii	87.29	0.00e+00	2515.00
IUUC-Sar-113071	Sorex araneus	89.91	0.00e+00	1231.00
IUUC-Ssc-115963	Sus scrofa	86.33	0.00e+00	2540.00
IUUC-Tgu-117167	Taeniopygia guttata	87.09	0.00e+00	1514.00
IUUC-Tru-118626	Takifugu rubripes	88.69	0.00e+00	2615.00
IUUC-Tsy-119504	Tarsius syrichta	83.26	0.00e+00	1978.00
IUUC-Tni-119877	Tetraodon nigroviridis	95.50	0.00e+00	2380.00
IUUC-Tbe-127602	Tupaia belangeri	86.80	0.00e+00	1009.00
IUUC-Ttr-128394	Tursiops truncatus	85.80	0.00e+00	1507.00
IUUC-Vpa-130280	Vicugna pacos	86.81	0.00e+00	2524.00
IUUC-Xtr-131787	Xenopus tropicalis	82.11	0.00e+00	3812.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence