iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012484

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

POC1 centriolar protein homolog A; WD repeat-containing protein 51A

Genbank Nucleotide ID

BC109862

Gene Name

POC1A; WDR51A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000001471.3	ENSBTAT00000001927.3	ENSBTAP00000001927.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.20e-59	194.0	144	182
UBD/Beta-Prp	1.00e-72	245.0	13	183

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           H ++v+c +f +d +l+vs+sdD+t+k+WD ++  +++s
   Q: 144  HINWVRCAKFsPDgRLIVSASDDKTVKLWDKTSRECVHS 182
           999********999******************9999886 PP

UBD/Beta-Prp

   S: 88   htlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtlt 176
           +++kgh d v+s++fs +++ l+sGs d+ ++vw+++ ++  +  ++gh+++v+cv+++p+g ll+sGs D+tvr+W  + +   + ++
   Q: 13   RHFKGHRDAVTSVDFSLNTKQLASGSMDSCLMVWHMKPQTRAY-RFAGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFR 100
           5678888888888888888888888888888888888888887.788888888888888888888888888888888776666666677 PP
   S: 177  gghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktl 260
             ht  v+s+ f s+g+++v++s+d+tvk+w+ ++++ + +l  h ++v++ +fsp++ ++vs+s+D+++++Wd++s+++++++
   Q: 101  A-HTATVRSVHFCSDGQSFVTASDDKTVKVWSTHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKTSRECVHSY 183
           6.8888888888888888888888888888888888888888888888888888888888888888888888888888887765 PP

Organism

Bos taurus

Functional Description
(View)

Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation (By similarity).

Protein Sequence
(Fasta)

MTAHCPEDPS LERHFKGHRD AVTSVDFSLN TKQLASGSMD SCLMVWHMKP QTRAYRFAGH 60
KDAVTCVNFS PSGHLLASGS RDKTVRIWVP NVKGESTVFR AHTATVRSVH FCSDGQSFVT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCGTTCCTT CACGCTCCTC CGGCGCCTTG GGCGCCCCCG GCCCCGCCAT GACCGCGCAC 60
TGCCCGGTAA GTTTCTGTCA GCGGCGGCCG CCCGAGCTTT AGTCTTTCCG CGGGGACAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0966--Cell projection
KW-0970--Cilium biogenesis/degradation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005814--C:centriole
GO:0036064--C:ciliary basal body
GO:0000922--C:spindle pole
GO:0003431--P:growth plate cartilage chondrocyte development
GO:0007052--P:mitotic spindle organization
GO:1905515--P:non-motile cilium assembly
GO:0010825--P:positive regulation of centrosome duplication
GO:0007283--P:spermatogenesis

KEGG

bta:534489

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001513	Ailuropoda melanoleuca	94.01	0.00e+00	754.00
IUUC-Apl-003466	Anas platyrhynchos	80.00	0.00e+00	664.00
IUUC-Aca-004323	Anolis carolinensis	71.56	0.00e+00	636.00
IUUC-Cja-019067	Callithrix jacchus	91.58	0.00e+00	765.00
IUUC-Cfa-020439	Canis familiaris	93.12	0.00e+00	790.00
IUUC-Cpo-021403	Cavia porcellus	90.02	0.00e+00	763.00
IUUC-Cre-022724	Chlamydomonas reinhardtii	50.37	2.00e-114	405.00
IUUC-Csa-023479	Chlorocebus sabaeus	93.22	0.00e+00	694.00
IUUC-Cho-024354	Choloepus hoffmanni	87.73	3.00e-114	404.00
IUUC-Cin-025258	Ciona intestinalis	52.73	1.00e-143	503.00
IUUC-Csv-025955	Ciona savignyi	63.06	3.00e-146	511.00
IUUC-Dno-029467	Dasypus novemcinctus	78.40	3.00e-128	451.00
IUUC-Dor-030399	Dipodomys ordii	87.96	0.00e+00	746.00
IUUC-Dme-032182	Drosophila melanogaster	46.67	1.00e-80	293.00
IUUC-Eca-034425	Equus caballus	93.27	0.00e+00	750.00
IUUC-Eeu-034607	Erinaceus europaeus	79.85	0.00e+00	632.00
IUUC-Fca-035627	Felis catus	94.53	0.00e+00	770.00
IUUC-Fal-037381	Ficedula albicollis	75.43	0.00e+00	638.00
IUUC-Gmo-038489	Gadus morhua	67.59	2.00e-161	561.00
IUUC-Gga-040559	Gallus gallus	75.74	0.00e+00	635.00
IUUC-Gac-041453	Gasterosteus aculeatus	69.19	2.00e-170	592.00
IUUC-Ggo-044773	Gorilla gorilla	93.12	0.00e+00	758.00
IUUC-Hsa-045823	Homo sapiens	93.61	0.00e+00	763.00
IUUC-Itr-048560	Ictidomys tridecemlineatus	91.02	0.00e+00	773.00
IUUC-Lch-050558	Latimeria chalumnae	68.19	1.00e-178	619.00
IUUC-Loc-052836	Lepisosteus oculatus	69.52	2.00e-178	618.00
IUUC-Laf-053974	Loxodonta africana	83.87	0.00e+00	672.00
IUUC-Mcc-055494	Macaca mulatta	91.13	0.00e+00	740.00
IUUC-Meu-056646	Macropus eugenii	75.17	2.00e-130	458.00
IUUC-Mga-059295	Meleagris gallopavo	68.53	1.00e-176	612.00
IUUC-Mmr-061040	Microcebus murinus	92.63	0.00e+00	783.00
IUUC-Mdo-062519	Monodelphis domestica	78.86	2.00e-179	621.00
IUUC-Mmu-063759	Mus musculus	94.00	2.00e-172	598.00
IUUC-Mpu-066442	Mustela putorius furo	93.61	0.00e+00	775.00
IUUC-Mlu-068163	Myotis lucifugus	92.52	0.00e+00	766.00
IUUC-Nle-070160	Nomascus leucogenys	92.63	0.00e+00	760.00
IUUC-Opr-070192	Ochotona princeps	89.25	0.00e+00	674.00
IUUC-Ont-072539	Oreochromis niloticus	76.55	4.00e-151	527.00
IUUC-Oan-072834	Ornithorhynchus anatinus	61.92	4.00e-114	404.00
IUUC-Ocu-074624	Oryctolagus cuniculus	91.33	0.00e+00	707.00
IUUC-Ola-087268	Oryzias latipes	62.88	1.00e-162	565.00
IUUC-Oga-088964	Otolemur garnettii	86.14	0.00e+00	722.00
IUUC-Oar-090202	Ovis aries	98.50	0.00e+00	785.00
IUUC-Ptr-091164	Pan troglodytes	94.26	0.00e+00	758.00
IUUC-Pan-092805	Papio anubis	92.41	0.00e+00	689.00
IUUC-Psi-093359	Pelodiscus sinensis	86.08	6.00e-166	576.00
IUUC-Pma-094425	Petromyzon marinus	63.80	7.00e-167	580.00
IUUC-Ppa-095677	Physcomitrella patens	46.38	4.00e-82	297.00
IUUC-Pfo-096741	Poecilia formosa	73.99	4.00e-141	494.00
IUUC-Pab-098376	Pongo abelii	92.87	0.00e+00	792.00
IUUC-Pca-101122	Procavia capensis	88.21	0.00e+00	748.00
IUUC-Pva-103104	Pteropus vampyrus	73.22	4.00e-169	587.00
IUUC-Rno-105282	Rattus norvegicus	86.76	0.00e+00	663.00
IUUC-Sha-106840	Sarcophilus harrisii	82.43	3.00e-119	421.00
IUUC-Smo-108731	Selaginella moellendorffii	45.16	2.00e-79	289.00
IUUC-Sar-113262	Sorex araneus	64.37	1.00e-143	502.00
IUUC-Ssc-115392	Sus scrofa	95.15	0.00e+00	660.00
IUUC-Tgu-117340	Taeniopygia guttata	75.00	1.00e-180	625.00
IUUC-Tru-117577	Takifugu rubripes	73.31	4.00e-137	481.00
IUUC-Tsy-119404	Tarsius syrichta	85.54	0.00e+00	712.00
IUUC-Tni-120713	Tetraodon nigroviridis	70.70	4.00e-138	484.00
IUUC-Tbe-127788	Tupaia belangeri	72.31	4.00e-154	537.00
IUUC-Ttr-128608	Tursiops truncatus	90.91	0.00e+00	729.00
IUUC-Xtr-132720	Xenopus tropicalis	63.29	4.00e-161	560.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence