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Tag Content
UUCD2 ID IUUC-Xtr-132044
UUCD1 version UUC-XeT-01065
Ensembl Protein ID ENSXETP00000028749.3
UniProt Accession Q28CN3; B7ZU27; F7EIJ9; UBP33_XENTR
Genbank Protein ID CAJ82183.1; AAI71081.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 33; Deubiquitinating enzyme 33; Ubiquitin thioesterase 33; Ubiquitin-specific-processing protease 33
Genbank Nucleotide ID CR926290; AAMC01095352
Gene Name usp33; TEgg041n23.1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSXETG00000013118.3 ENSXETT00000028749.3 ENSXETP00000028749.3
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 7.70e-113 377.3 148 664
Active Site
Position(s) Description Evidence
157 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
623 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tGlkN+gNtCYmN++LQ+Lsn+p+l++++l+     +   +++++k +l+ks+qkl++ +w k++ + v p++l++ +k++++ f+gy+
   Q: 148  TGLKNIGNTCYMNAALQALSNCPPLTHYFLD-----CGGLARTDKKPALCKSYQKLMSDIWhKNRPGFVIPTNLFQGIKSVNPTFRGYS 231
           7******************************.....999999*******************99999*********************** PP
   S: 89   qqDaqEflaflldqleeelkk........eknkpkeeeeeedkselsde........................................ 129
           qqDaqEfl++l+d l+eelk+         ++  +ee  +edks+++++                                        
   Q: 232  QQDAQEFLRCLMDVLHEELKEqiveveedAQTGIVEENLDEDKSQSDNDfhscdsgsssdhaesesrklseeltestmlihedqkdves 320
           *******************888887776544444444445554444444899999999999**************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 321  cktwqkekkfsnnlnqnhflqdfekniqstieeseclkqetvkvqiqskaadftaevnmndlptsqtpllnegatthlsssppkpgavw 409
           ***************************************************************************************** PP
   S: 130  ...........aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke...................... 185
                      a+++k+kk++s+i d+F+g++ s+++cl+cd+vs++ e+f+dlslp+pgke+ +k+                      
   Q: 410  tghkkvpglcpAKKRKQKKYHSVIADIFDGTIVSSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLhssshqsslvkagscgeayapq 498
           **************************************************************99888********************** PP
   S: 186  ...................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvef 255
                              +lqdcL++f++++el+g+n+y+cekckk+++ +k +k++k+Pe+L++hLkRf  ++e ++++ki ++v+f
   Q: 499  gwiaffleyfkswfwgptvTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQKFPEILCIHLKRF--RHELMFSTKIGTHVSF 585
           ***********************************************************************..9999************ PP
   S: 256  ple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           ple Ldl+pf+++++ +q   ++Y+L++v++H+G++ssGHY+ay++n+ ++ W++fdD++Vtev+e++v++   ++aYvlfY++
   Q: 586  PLEgLDLQPFLAKDSPSQ--IVTYDLLSVICHHGTASSGHYIAYCRNNLNNlWYEFDDQSVTEVSEATVQN---AEAYVLFYRK 664
           *************88887..9**************************88889*******************...********97 PP
   
Organism Xenopus tropicalis
Functional Description
(View)

Functional Description


     Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of ccp110 in S and G2/M phase, leading to stabilize ccp110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of robo1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of robo1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (arrb1 and arrb2) and beta-2 adrenergic receptor (adrb2). Deubiquitinates dio2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
 Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of ccp110 in S and G2/M phase, leading to stabilize ccp110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of robo1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of robo1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (arrb1 and arrb2) and beta-2 adrenergic receptor (adrb2). Deubiquitinates dio2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
Protein Sequence
(Fasta)
MSSLVCDCPH LESVGEVTKE ELIKKSHGSC QDCRVRGPNL WACLENGCSY VGCGESHVDH 60
STLHSQDTKH CLTVNLTTLR VWCYTCSKEV FLDRKLSTQP TSAKLQDSHT QESKMSSSLT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Xtr-132044|DUB,USP|Xenopus tropicalis
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAGAATTGGA AGCTCCATAA TCTAAAATGT CCTCCTTGGT ATGCGACTGC CCCCATTTAG 60
AGTCAGTGGG AGAAGTAACC AAAGAAGAGC TCATTAAGAA ATCTCACGTG AGTATAAAGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Xtr-132044|DUB,USP|Xenopus tropicalis
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0254--Endocytosis
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP
SMART

SM00695--DUSP
SM00290--ZnF_UBP
Gene Ontology

GO:0005813--C:centrosome
GO:0048471--C:perinuclear region of cytoplasm
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0007411--P:axon guidance
GO:0016477--P:cell migration
GO:0051298--P:centrosome duplication
GO:0006897--P:endocytosis
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG xtr:548982
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001742 Ailuropoda melanoleuca 75.41 0.00e+00 1359.00
IUUC-Apl-003987 Anas platyrhynchos 74.21 0.00e+00 1301.00
IUUC-Aca-004713 Anolis carolinensis 72.73 0.00e+00 1283.00
IUUC-Bta-013132 Bos taurus 76.28 0.00e+00 1375.00
IUUC-Cja-018811 Callithrix jacchus 75.49 0.00e+00 1365.00
IUUC-Cfa-021158 Canis familiaris 75.41 0.00e+00 1358.00
IUUC-Cpo-021910 Cavia porcellus 69.54 0.00e+00 1191.00
IUUC-Csa-023130 Chlorocebus sabaeus 75.49 0.00e+00 1363.00
IUUC-Cho-024383 Choloepus hoffmanni 56.34 9.00e-121 427.00
IUUC-Dre-028639 Danio rerio 69.40 0.00e+00 1233.00
IUUC-Dno-029416 Dasypus novemcinctus 74.05 0.00e+00 1317.00
IUUC-Ete-032994 Echinops telfairi 59.12 1.00e-170 593.00
IUUC-Eca-034248 Equus caballus 75.85 0.00e+00 1364.00
IUUC-Eeu-035357 Erinaceus europaeus 59.96 0.00e+00 956.00
IUUC-Fca-036013 Felis catus 73.61 0.00e+00 1308.00
IUUC-Fal-037509 Ficedula albicollis 75.06 0.00e+00 1333.00
IUUC-Gmo-038944 Gadus morhua 67.23 0.00e+00 1179.00
IUUC-Gga-040647 Gallus gallus 75.86 0.00e+00 1326.00
IUUC-Gac-041752 Gasterosteus aculeatus 68.65 0.00e+00 1223.00
IUUC-Hsa-045694 Homo sapiens 75.16 0.00e+00 1352.00
IUUC-Itr-049041 Ictidomys tridecemlineatus 74.97 0.00e+00 1341.00
IUUC-Kpa-049198 Komagataella pastoris 31.82 3.00e-29 123.00
IUUC-Lch-050400 Latimeria chalumnae 69.73 0.00e+00 1239.00
IUUC-Loc-052616 Lepisosteus oculatus 72.09 0.00e+00 1290.00
IUUC-Laf-053493 Loxodonta africana 75.03 0.00e+00 1354.00
IUUC-Mcc-055542 Macaca mulatta 75.60 0.00e+00 1367.00
IUUC-Meu-056645 Macropus eugenii 64.05 0.00e+00 1087.00
IUUC-Mga-060019 Meleagris gallopavo 75.75 0.00e+00 1116.00
IUUC-Mmr-061241 Microcebus murinus 72.87 0.00e+00 1293.00
IUUC-Mmu-063786 Mus musculus 74.29 0.00e+00 1323.00
IUUC-Mpu-065772 Mustela putorius furo 76.43 0.00e+00 1140.00
IUUC-Mlu-067732 Myotis lucifugus 75.00 0.00e+00 1348.00
IUUC-Nle-069528 Nomascus leucogenys 74.84 0.00e+00 1369.00
IUUC-Opr-070606 Ochotona princeps 71.85 0.00e+00 1218.00
IUUC-Ont-071495 Oreochromis niloticus 69.08 0.00e+00 1233.00
IUUC-Ocu-074457 Oryctolagus cuniculus 74.24 0.00e+00 1340.00
IUUC-Ola-086739 Oryzias latipes 67.50 0.00e+00 1244.00
IUUC-Oga-088720 Otolemur garnettii 75.19 0.00e+00 1374.00
IUUC-Oar-089921 Ovis aries 76.07 0.00e+00 1372.00
IUUC-Ptr-090526 Pan troglodytes 75.27 0.00e+00 1357.00
IUUC-Pan-092396 Papio anubis 75.55 0.00e+00 1365.00
IUUC-Psi-092971 Pelodiscus sinensis 75.05 0.00e+00 1347.00
IUUC-Pfo-097415 Poecilia formosa 67.40 0.00e+00 1224.00
IUUC-Pab-098740 Pongo abelii 75.27 0.00e+00 1379.00
IUUC-Pca-100598 Procavia capensis 70.04 0.00e+00 734.00
IUUC-Pva-102820 Pteropus vampyrus 71.84 0.00e+00 1130.00
IUUC-Rno-104894 Rattus norvegicus 73.66 0.00e+00 1330.00
IUUC-Sha-107244 Sarcophilus harrisii 67.82 0.00e+00 1205.00
IUUC-Sar-113665 Sorex araneus 73.11 0.00e+00 1325.00
IUUC-Ssc-115793 Sus scrofa 75.00 0.00e+00 1325.00
IUUC-Tgu-117487 Taeniopygia guttata 75.51 0.00e+00 1301.00
IUUC-Tru-117694 Takifugu rubripes 67.60 0.00e+00 1254.00
IUUC-Tsy-119598 Tarsius syrichta 67.67 0.00e+00 1133.00
IUUC-Tni-120189 Tetraodon nigroviridis 65.30 0.00e+00 1169.00
IUUC-Tbe-128125 Tupaia belangeri 77.91 1.00e-80 294.00
IUUC-Ttr-128269 Tursiops truncatus 74.54 0.00e+00 1295.00
IUUC-Vpa-130598 Vicugna pacos 73.80 0.00e+00 1315.00
Created Date 25-Jun-2017

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