iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
dbPPT	dbPTM
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	17872410; 16002617; 14628054; 10847687

Organism

Arabidopsis thaliana

Functional Description
(View)

Component of an E3 ubiquitin ligase complex that plays a central role in blue light-dependent circadian cycles. Acts as a blue light photoreceptor, due to the presence of FMN, that mediates light-regulated protein degradation of critical clock components by targeting them to the proteasome complex. The SCF(ADO3) E3 ubiquitin ligase complex is involved in the regulation of circadian clock-dependent processes including transition to flowering time, hypocotyl elongation, cotyledons and leaf movement rhythms. Forms a complex with 'GIGANTEA' (GI) to regulates 'CONSTANS' (CO) expression. Promotes CO expression during the light period of long days by decreasing the stability of CDF1 and CDF2 and by interacting directly with the CO protein and stabilizing it. ADO3 function is mainly GI dependent. Does not act as a regulator of CDF1 transcription. The interactions of ADO1/ZTL and ADO2 with ADO3 prevent its interaction with CDF1.

Protein Sequence
(Fasta)

MAREHAIGEA TGKRKKRGRV EEAEEYCNDG IEEQVEDEKL PLEVGMFYYP MTPPSFIVSD 60
ALEPDFPLIY VNRVFEVFTG YRADEVLGRN CRFLQYRDPR AQRRHPLVDP VVVSEIRRCL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGATATTTTA AAAGTTTAAA CAGACACAAA AAGAAATAAA ATATCATAAG GCTGAGAGCT 60
TATCAGAGAA GAAGAAGATA TTTCTGTAAG CGAGAAAAAT GGCGAGAGAA CATGCGATCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0090--Biological rhythms
KW-0157--Chromophore
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0285--Flavoprotein
KW-0287--Flowering
KW-0288--FMN
KW-0880--Kelch repeat
KW-0539--Nucleus
KW-0600--Photoreceptor protein
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0716--Sensory transduction
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom
IPR015915--Kelch-typ_b-propeller
IPR011498--Kelch_2
IPR001610--PAC
IPR000014--PAS

PROSITE

PS50112--PAS

Pfam

PF07646--Kelch_2
PF13426--PAS_9

SMART

SM00086--PAC

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0001047--F:core promoter binding
GO:0009881--F:photoreceptor activity
GO:0007623--P:circadian rhythm
GO:0009908--P:flower development
GO:0009911--P:positive regulation of flower development
GO:0016567--P:protein ubiquitination
GO:0018298--P:protein-chromophore linkage
GO:0010468--P:regulation of gene expression
GO:0006355--P:regulation of transcription, DNA-templated
GO:0009637--P:response to blue light

KEGG

ath:AT1G68050

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002676	Amborella trichopoda	75.19	0.00e+00	773.00
IUUC-Aly-006079	Arabidopsis lyrata	95.35	0.00e+00	1135.00
IUUC-Ago-007713	Ashbya gossypii	27.89	2.00e-11	64.70
IUUC-Bgr-012217	Blumeria graminis	30.57	2.00e-09	57.40
IUUC-Bta-012889	Bos taurus	27.27	3.00e-13	70.10
IUUC-Bdi-014314	Brachypodium distachyon	73.10	0.00e+00	846.00
IUUC-Cja-019262	Callithrix jacchus	27.32	4.00e-10	59.30
IUUC-Cgl-026387	Colletotrichum gloeosporioides	32.56	4.00e-11	62.80
IUUC-Cne-027059	Cryptococcus neoformans	36.61	1.00e-15	79.00
IUUC-Dme-031647	Drosophila melanogaster	25.40	6.00e-10	58.90
IUUC-Eca-033693	Equus caballus	27.32	5.00e-10	58.90
IUUC-Eeu-034815	Erinaceus europaeus	25.54	2.00e-09	57.80
IUUC-Ggr-039868	Gaeumannomyces graminis	33.33	2.00e-11	63.50
IUUC-Gga-040374	Gallus gallus	27.80	2.00e-10	60.80
IUUC-Gma-044305	Glycine max	85.52	0.00e+00	975.00
IUUC-Ggo-044616	Gorilla gorilla	27.32	4.00e-10	59.30
IUUC-Hvu-047513	Hordeum vulgare	72.15	0.00e+00	835.00
IUUC-Lpe-051405	Leersia perrieri	76.19	0.00e+00	865.00
IUUC-Mcc-055897	Macaca mulatta	25.76	1.00e-10	61.60
IUUC-Meu-056603	Macropus eugenii	30.86	3.00e-10	59.30
IUUC-Mtr-057666	Medicago truncatula	83.65	0.00e+00	973.00
IUUC-Mvi-060551	Microbotryum violaceum	35.59	3.90e-01	30.80
IUUC-Mac-065674	Musa acuminata	69.93	0.00e+00	766.00
IUUC-Nle-070165	Nomascus leucogenys	27.32	4.00e-10	59.30
IUUC-Opr-071213	Ochotona princeps	27.32	6.00e-10	58.90
IUUC-Oan-073729	Ornithorhynchus anatinus	29.89	6.00e-10	58.50
IUUC-Oba-075670	Oryza barthii	76.60	0.00e+00	865.00
IUUC-Obr-076287	Oryza brachyantha	75.53	0.00e+00	769.00
IUUC-Ogl-077276	Oryza glaberrima	76.89	0.00e+00	811.00
IUUC-Ogu-078304	Oryza glumaepatula	76.60	0.00e+00	865.00
IUUC-Oin-079279	Oryza indica	76.23	0.00e+00	772.00
IUUC-Ome-081307	Oryza meridionalis	74.44	0.00e+00	853.00
IUUC-Oni-082839	Oryza nivara	72.16	0.00e+00	800.00
IUUC-Opu-083251	Oryza punctata	71.96	0.00e+00	798.00
IUUC-Oru-084639	Oryza rufipogon	71.99	0.00e+00	798.00
IUUC-Osa-085827	Oryza sativa	76.60	0.00e+00	865.00
IUUC-Ola-087296	Oryzias latipes	26.99	2.00e-10	60.80
IUUC-Oar-089465	Ovis aries	29.71	3.00e-09	56.60
IUUC-Psi-093738	Pelodiscus sinensis	28.78	2.00e-11	63.50
IUUC-Pop-099596	Populus trichocarpa	82.58	0.00e+00	977.00
IUUC-Ppe-101872	Prunus persica	83.90	0.00e+00	952.00
IUUC-Sha-107432	Sarcophilus harrisii	27.45	2.00e-10	60.10
IUUC-Sit-109972	Setaria italica	76.26	0.00e+00	857.00
IUUC-Sly-111113	Solanum lycopersicum	75.60	0.00e+00	871.00
IUUC-Stu-112379	Solanum tuberosum	81.62	0.00e+00	950.00
IUUC-Sbi-114740	Sorghum bicolor	75.67	0.00e+00	861.00
IUUC-Tca-120928	Theobroma cacao	85.49	0.00e+00	966.00
IUUC-Tae-123716	Triticum aestivum	71.75	0.00e+00	852.00
IUUC-Tur-126133	Triticum urartu	72.09	0.00e+00	838.00
IUUC-Tbe-127786	Tupaia belangeri	26.18	2.00e-10	60.80
IUUC-Vpa-130757	Vicugna pacos	36.05	3.00e-06	46.60
IUUC-Vvi-131645	Vitis vinifera	83.33	0.00e+00	953.00
IUUC-Xtr-132341	Xenopus tropicalis	31.43	3.00e-11	63.20
IUUC-Yli-134330	Yarrowia lipolytica	25.70	3.00e-09	56.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence