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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106167
Ensembl Protein ID YER143W
UniProt Accession P40087; D3DM50; DDI1_YEAST
Genbank Protein ID AAB82066.1; AAC18522.1; AAB64670.1; AAT92964.1; DAA07804.1
Protein Name DNA damage-inducible protein 1; v-SNARE-master 1
Genbank Nucleotide ID U14002; AF034895; U18917; AY692945; BK006939
Gene Name DDI1; VSM1; YER143W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YER143W YER143W YER143W
Annotation
mRNA Expression
GEOFFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMBioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 11323716; 16405905
ULD/UDP/UBQ/UBQ_PIM UBQ_PIM 15209385; 15964793; 18562697; 21094643
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBA 3.40e-10 38.2 391 427
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA
   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLl 39
            e+ + ql++ GF+r+++++aL ++n+n+e A+ +L+
   Q: 391  PEQTIKQLMDLGFPRDAVVKALKQTNGNAEFAASLLF 427
           5899*******************************98 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Acts as a linker between the 19S proteasome and polyubiquitinated proteins like the HO endonuclease and UFO1 via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control. Appears to act as negative regulator of constitutive exocytosis. May act at the level of secretory vesicle docking and fusion as a competitive inhibitor of SNARE assembly.
 Acts as a linker between the 19S proteasome and polyubiquitinated proteins like the HO endonuclease and UFO1 via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control. Appears to act as negative regulator of constitutive exocytosis. May act at the level of secretory vesicle docking and fusion as a competitive inhibitor of SNARE assembly.
Protein Sequence
(Fasta)
MDLTISNELT GEIYGPIEVS EDMALTDLIA LLQADCGFDK TKHDLYYNMD ILDSNRTQSL 60
KELGLKTDDL LLIRGKISNS IQTDAATLSD EAFIEQFRQE LLNNQMLRSQ LILQIPGLND 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106167|UBD,UBA;ULD,UBQ_PIM|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGATTTAA CAATTTCAAA CGAACTTACT GGCGAGATAT ACGGCCCAAT TGAAGTCAGT 60
GAAGATATGG CTTTAACTGA TCTAATAGCA TTACTGCAGG CCGATTGCGG GTTTGACAAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106167|UBD,UBA;ULD,UBQ_PIM|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation
Interpro

IPR033322--DDI1
IPR001995--Peptidase_A2_cat
IPR019103--Peptidase_aspartic_DDI1-type
IPR021109--Peptidase_aspartic_dom
IPR015940--UBA
IPR009060--UBA-like
PROSITE

PS50030--UBA
Pfam

PF09668--Asp_protease
PF00627--UBA
SMART

SM00165--UBA
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0000149--F:SNARE binding
GO:0043130--F:ubiquitin binding
GO:0009306--P:protein secretion
GO:0046686--P:response to cadmium ion
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0016192--P:vesicle-mediated transport
KEGG sce:YER143W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000989 Aegilops tauschii 33.81 9.00e-54 202.00
IUUC-Aml-001440 Ailuropoda melanoleuca 50.30 1.00e-44 171.00
IUUC-Atr-002722 Amborella trichopoda 39.93 3.00e-50 190.00
IUUC-Apl-003902 Anas platyrhynchos 52.21 1.00e-38 151.00
IUUC-Aca-004811 Anolis carolinensis 50.90 2.00e-45 174.00
IUUC-Aly-006104 Arabidopsis lyrata 46.15 5.00e-14 68.90
IUUC-Ath-007673 Arabidopsis thaliana 32.43 1.00e-54 204.00
IUUC-Ago-007981 Ashbya gossypii 54.20 4.00e-99 352.00
IUUC-Acl-008073 Aspergillus clavatus 30.38 3.00e-47 180.00
IUUC-Afl-008728 Aspergillus flavus 31.96 6.00e-54 202.00
IUUC-Afu-008934 Aspergillus fumigatus 32.30 8.00e-52 195.00
IUUC-Ani-009436 Aspergillus nidulans 35.42 7.00e-52 195.00
IUUC-Ang-009596 Aspergillus niger 38.69 2.00e-46 176.00
IUUC-Aor-009968 Aspergillus oryzae 31.96 7.00e-54 202.00
IUUC-Ate-010376 Aspergillus terreus 31.13 1.00e-47 181.00
IUUC-Ame-011570 Astyanax mexicanus 50.87 3.00e-45 173.00
IUUC-Bgr-012020 Blumeria graminis 37.12 1.00e-66 245.00
IUUC-Bta-012334 Bos taurus 50.30 2.00e-44 171.00
IUUC-Bci-013907 Botrytis cinerea 35.55 3.00e-62 230.00
IUUC-Bdi-014595 Brachypodium distachyon 33.64 2.00e-53 201.00
IUUC-Bol-015258 Brassica oleracea 32.71 1.00e-52 198.00
IUUC-Bra-016740 Brassica rapa 32.79 5.00e-53 199.00
IUUC-Cel-018415 Caenorhabditis elegans 40.46 4.00e-32 130.00
IUUC-Cja-018968 Callithrix jacchus 50.30 2.00e-44 171.00
IUUC-Cfa-020530 Canis familiaris 50.30 2.00e-44 171.00
IUUC-Cpo-022103 Cavia porcellus 53.38 3.00e-39 153.00
IUUC-Cre-022841 Chlamydomonas reinhardtii 33.42 3.00e-43 167.00
IUUC-Csa-023591 Chlorocebus sabaeus 51.20 2.00e-45 176.00
IUUC-Cho-024777 Choloepus hoffmanni 36.00 4.00e-21 93.60
IUUC-Cin-025396 Ciona intestinalis 34.52 3.00e-24 102.00
IUUC-Csv-026270 Ciona savignyi 46.45 2.00e-50 191.00
IUUC-Cgl-026570 Colletotrichum gloeosporioides 40.89 2.00e-44 170.00
IUUC-Cne-026974 Cryptococcus neoformans 38.36 3.00e-53 200.00
IUUC-Cme-027324 Cyanidioschyzon merolae 30.00 2.00e-35 141.00
IUUC-Dre-028030 Danio rerio 52.66 7.00e-47 179.00
IUUC-Dno-029264 Dasypus novemcinctus 50.30 1.00e-44 171.00
IUUC-Dor-030621 Dipodomys ordii 48.44 4.00e-12 63.50
IUUC-Dse-031264 Dothistroma septosporum 32.53 3.00e-07 47.40
IUUC-Dme-032067 Drosophila melanogaster 39.48 8.00e-45 172.00
IUUC-Ete-032664 Echinops telfairi 54.92 6.00e-31 126.00
IUUC-Eca-033648 Equus caballus 50.30 1.00e-44 171.00
IUUC-Eeu-035148 Erinaceus europaeus 46.67 1.00e-32 131.00
IUUC-Fca-035376 Felis catus 50.30 1.00e-44 171.00
IUUC-Fal-037210 Ficedula albicollis 26.72 2.00e-07 47.40
IUUC-Fox-037786 Fusarium oxysporum 36.81 6.00e-47 179.00
IUUC-Fso-038336 Fusarium solani 39.39 3.70e-02 30.80
IUUC-Gmo-039324 Gadus morhua 51.48 1.00e-45 174.00
IUUC-Ggr-039750 Gaeumannomyces graminis 41.81 3.00e-45 174.00
IUUC-Gga-040917 Gallus gallus 50.93 4.00e-28 115.00
IUUC-Gac-041785 Gasterosteus aculeatus 50.86 5.00e-47 179.00
IUUC-Gma-043134 Glycine max 31.85 2.00e-49 187.00
IUUC-Ggo-044472 Gorilla gorilla 52.31 2.00e-31 127.00
IUUC-Hsa-046783 Homo sapiens 50.90 2.00e-45 174.00
IUUC-Hvu-047222 Hordeum vulgare 34.28 1.00e-50 191.00
IUUC-Itr-048710 Ictidomys tridecemlineatus 52.63 5.00e-39 153.00
IUUC-Kpa-049208 Komagataella pastoris 39.49 2.00e-70 257.00
IUUC-Lch-049953 Latimeria chalumnae 51.19 2.00e-45 175.00
IUUC-Lpe-050925 Leersia perrieri 33.57 1.00e-46 178.00
IUUC-Loc-052009 Lepisosteus oculatus 39.55 6.00e-49 186.00
IUUC-Lma-053305 Leptosphaeria maculans 40.08 6.00e-47 179.00
IUUC-Laf-054229 Loxodonta africana 50.30 1.00e-44 171.00
IUUC-Mcc-054796 Macaca mulatta 51.20 1.00e-45 176.00
IUUC-Meu-055944 Macropus eugenii 41.32 4.00e-30 123.00
IUUC-Mpo-057402 Magnaporthe poae 37.13 5.00e-53 199.00
IUUC-Mtr-058061 Medicago truncatula 30.11 7.00e-04 35.40
IUUC-Mla-058983 Melampsora laricipopulina 25.32 5.00e-09 52.40
IUUC-Mga-059910 Meleagris gallopavo 50.30 2.00e-44 171.00
IUUC-Mvi-060225 Microbotryum violaceum 42.05 4.00e-51 193.00
IUUC-Mmr-061679 Microcebus murinus 52.63 5.00e-39 153.00
IUUC-Mdo-062992 Monodelphis domestica 50.90 2.00e-45 174.00
IUUC-Mmu-063187 Mus musculus 50.30 1.00e-44 171.00
IUUC-Mac-064640 Musa acuminata 32.95 5.00e-53 199.00
IUUC-Mpu-066770 Mustela putorius furo 48.28 2.00e-34 137.00
IUUC-Mlu-067804 Myotis lucifugus 50.90 4.00e-45 173.00
IUUC-Nfi-068555 Neosartorya fischeri 32.30 7.00e-52 195.00
IUUC-Ncr-068839 Neurospora crassa 37.08 2.00e-53 201.00
IUUC-Nle-069089 Nomascus leucogenys 51.20 1.00e-45 176.00
IUUC-Opr-070199 Ochotona princeps 49.68 1.00e-40 158.00
IUUC-Ont-072300 Oreochromis niloticus 49.72 7.00e-45 172.00
IUUC-Oan-073421 Ornithorhynchus anatinus 50.90 2.00e-45 174.00
IUUC-Ocu-074510 Oryctolagus cuniculus 53.38 3.00e-39 154.00
IUUC-Oba-075183 Oryza barthii 33.88 2.00e-53 200.00
IUUC-Obr-076044 Oryza brachyantha 33.18 6.00e-53 199.00
IUUC-Ogl-077284 Oryza glaberrima 33.88 7.00e-52 195.00
IUUC-Ogu-078171 Oryza glumaepatula 33.88 7.00e-52 196.00
IUUC-Oin-079871 Oryza indica 34.65 3.00e-55 206.00
IUUC-Olo-080579 Oryza longistaminata 35.19 3.00e-55 207.00
IUUC-Ome-081972 Oryza meridionalis 35.03 3.00e-55 207.00
IUUC-Oni-083027 Oryza nivara 33.88 7.00e-52 195.00
IUUC-Opu-083491 Oryza punctata 32.81 1.00e-51 195.00
IUUC-Oru-084589 Oryza rufipogon 33.88 7.00e-52 195.00
IUUC-Osa-085703 Oryza sativa 33.88 7.00e-52 195.00
IUUC-Ola-086911 Oryzias latipes 44.12 9.00e-12 61.60
IUUC-Olu-087654 Ostreococcus lucimarinus 32.18 7.00e-49 185.00
IUUC-Oga-088997 Otolemur garnettii 52.67 1.00e-42 164.00
IUUC-Oar-089924 Ovis aries 50.30 2.00e-44 171.00
IUUC-Ptr-090938 Pan troglodytes 50.90 2.00e-45 174.00
IUUC-Pan-091767 Papio anubis 50.90 1.00e-45 174.00
IUUC-Psi-093426 Pelodiscus sinensis 50.90 2.00e-45 174.00
IUUC-Pma-094508 Petromyzon marinus 44.44 3.00e-03 35.40
IUUC-Pno-094977 Phaeosphaeria nodorum 29.40 8.00e-52 196.00
IUUC-Ppa-095744 Physcomitrella patens 41.24 5.00e-52 196.00
IUUC-Pfo-097404 Poecilia formosa 51.50 7.00e-46 176.00
IUUC-Pab-098128 Pongo abelii 50.90 2.00e-45 174.00
IUUC-Pop-099053 Populus trichocarpa 33.41 2.00e-55 207.00
IUUC-Pca-100554 Procavia capensis 48.73 5.00e-38 149.00
IUUC-Ppe-101690 Prunus persica 40.14 4.00e-53 199.00
IUUC-Pva-102638 Pteropus vampyrus 37.72 2.00e-24 104.00
IUUC-Pgr-103310 Puccinia graminis 58.70 4.00e-13 65.10
IUUC-Ptt-103798 Puccinia triticina 33.16 2.00e-49 187.00
IUUC-Pte-104408 Pyrenophora teres 36.01 5.00e-47 179.00
IUUC-Pyt-104420 Pyrenophora triticirepentis 31.75 2.00e-48 184.00
IUUC-Rno-105333 Rattus norvegicus 33.80 7.00e-45 174.00
IUUC-Sha-107599 Sarcophilus harrisii 50.90 2.00e-45 174.00
IUUC-Sja-107968 Schizosaccharomyces japonicus 52.35 1.00e-46 178.00
IUUC-Spo-108130 Schizosaccharomyces pombe 36.18 2.00e-50 190.00
IUUC-Ssl-108671 Sclerotinia sclerotiorum 34.56 3.00e-62 230.00
IUUC-Sit-109819 Setaria italica 34.50 3.00e-55 207.00
IUUC-Sly-110983 Solanum lycopersicum 40.21 8.00e-52 195.00
IUUC-Stu-112218 Solanum tuberosum 36.36 9.00e-52 195.00
IUUC-Sar-113702 Sorex araneus 25.49 2.00e-04 36.60
IUUC-Sbi-114118 Sorghum bicolor 33.10 2.00e-53 201.00
IUUC-Sre-115084 Sporisorium reilianum 31.34 1.00e-42 165.00
IUUC-Ssc-115545 Sus scrofa 50.30 1.00e-44 171.00
IUUC-Tgu-117353 Taeniopygia guttata 50.90 7.00e-45 172.00
IUUC-Tru-117838 Takifugu rubripes 50.86 6.00e-47 179.00
IUUC-Tsy-118783 Tarsius syrichta 51.49 1.00e-26 112.00
IUUC-Tni-120287 Tetraodon nigroviridis 50.86 7.00e-47 179.00
IUUC-Tca-121513 Theobroma cacao 38.81 1.00e-47 181.00
IUUC-Tae-125534 Triticum aestivum 33.73 6.00e-54 202.00
IUUC-Tur-126159 Triticum urartu 32.62 7.00e-49 185.00
IUUC-Tme-127088 Tuber melanosporum 34.92 1.00e-58 218.00
IUUC-Tbe-127948 Tupaia belangeri 46.91 7.00e-40 155.00
IUUC-Ttr-128560 Tursiops truncatus 50.30 2.00e-44 171.00
IUUC-Uma-129478 Ustilago maydis 41.70 4.00e-40 157.00
IUUC-Vda-129758 Verticillium dahliae 50.62 2.00e-45 174.00
IUUC-Vpa-130132 Vicugna pacos 52.67 1.00e-42 165.00
IUUC-Vvi-131006 Vitis vinifera 33.33 2.00e-48 184.00
IUUC-Xtr-132758 Xenopus tropicalis 51.50 1.00e-45 174.00
IUUC-Xma-133125 Xiphophorus maculatus 51.19 8.00e-45 172.00
IUUC-Yli-134530 Yarrowia lipolytica 33.49 3.00e-57 213.00
IUUC-Zma-135856 Zea mays 33.18 3.00e-51 193.00
Created Date 25-Jun-2017

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