iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091317

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AACZ03087254

Gene Name

WSB2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000005510.3	ENSPTRT00000010119.3	ENSPTRP00000049881.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	6.50e-15	54.8	354	401
E3 adaptor/Cullin RING/DCX/DWD	3.70e-32	109.0	149	182
UBD/Beta-Prp	4.10e-46	157.5	123	358

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyed 51
           ++++w++++   SL+hLCR+a r++l+++++    +LP+Pk++k++L y++
   Q: 354  HVQFWTAPRVLSSLKHLCRKALRSFLTTYQV---LALPIPKKMKEFLTYRT 401
           689****************************...***************86 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlr 31
           gH+d v++l+f  s+  +lvs+s+D+t+++WDl 
   Q: 149  GHQDVVRDLSFtpSGsLILVSASRDKTLRIWDLN 182
           8***********6556779*************85 PP

UBD/Beta-Prp

   S: 24   llatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfspsgdklv 110
           +latg  dg ik+w+v+tg ll  lsgh++ v++++f p+g+ ilv++s+D+t+++wdl+  gk++++l+gh + v+++s+sp+ + l 
   Q: 123  VLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSlILVSASRDKTLRIWDLNkHGKQIQVLSGHLQWVYCCSISPDCSMLC 211
           79****************************************9****************9789********************99**** PP
   S: 111  sGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl...........tgghtdsvyslsf 188
           s+   + + +w +++++ ++  l+gh+++v +  ++pd+ llv++s+D+ v +Wd  tg+ lr l           +  h +s +s+ f
   Q: 212  SAAGEKSVFLWSMRSYTLIR-KLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLhhtqvdpamddSDVHISSLRSVCF 299
           ********************.********************************************99999999888777888888888* PP
   S: 189  dsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           +++g +l+++++d+ +++w l+ ++   +  +  +n ++  f+p++  +++g+ Dg +++W
   Q: 300  SPEGLYLATVADDRLLRIWALELKT--PIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFW 358
           *********************9885..7899****************************** PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

APEEPLLLAE LKPGRPHQFD WKSSCETWSV AFSPDGSWFA WSQGHCIVKL IPWPLEEQFI 60
PKGFEAKSRS SKNETKGRGS PKEKTLDCGQ IVWGLAFSPW PSPPSRKLWA RHHPQVPDVS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCCCAGAGG AACCGCTGCT GCTGGCCGAA CTCAAGCCCG GGCGCCCCCA CCAGTTTGAC 60
TGGAAGTCCA GCTGTGAAAC CTGGAGCGTC GCCTTCTCCC CAGATGGCTC CTGGTTTGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR001496--SOCS_box
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50225--SOCS
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07525--SOCS_box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00253--SOCS
SM00969--SOCS_box
SM00320--WD40

Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002221	Ailuropoda melanoleuca	98.25	0.00e+00	812.00
IUUC-Apl-004107	Anas platyrhynchos	69.29	9.00e-132	462.00
IUUC-Aca-004354	Anolis carolinensis	73.63	8.00e-169	586.00
IUUC-Bta-012627	Bos taurus	98.72	0.00e+00	778.00
IUUC-Cja-018897	Callithrix jacchus	98.20	0.00e+00	784.00
IUUC-Cfa-020122	Canis familiaris	98.50	0.00e+00	813.00
IUUC-Cpo-022540	Cavia porcellus	97.44	0.00e+00	790.00
IUUC-Csa-023719	Chlorocebus sabaeus	99.74	0.00e+00	797.00
IUUC-Cho-024367	Choloepus hoffmanni	97.32	4.00e-172	596.00
IUUC-Dno-029021	Dasypus novemcinctus	98.21	0.00e+00	794.00
IUUC-Dor-030321	Dipodomys ordii	97.68	0.00e+00	785.00
IUUC-Ete-032955	Echinops telfairi	97.24	0.00e+00	780.00
IUUC-Eca-033485	Equus caballus	98.47	0.00e+00	768.00
IUUC-Fca-035389	Felis catus	98.20	0.00e+00	791.00
IUUC-Fal-037184	Ficedula albicollis	84.45	9.00e-143	499.00
IUUC-Gga-041014	Gallus gallus	77.75	2.00e-176	612.00
IUUC-Ggo-045585	Gorilla gorilla	100.00	0.00e+00	805.00
IUUC-Hsa-046344	Homo sapiens	100.00	0.00e+00	805.00
IUUC-Itr-049085	Ictidomys tridecemlineatus	97.94	0.00e+00	792.00
IUUC-Lch-050131	Latimeria chalumnae	70.54	1.00e-167	582.00
IUUC-Loc-052807	Lepisosteus oculatus	53.92	3.00e-117	415.00
IUUC-Laf-053528	Loxodonta africana	98.21	0.00e+00	775.00
IUUC-Mcc-055665	Macaca mulatta	100.00	0.00e+00	805.00
IUUC-Meu-056054	Macropus eugenii	87.88	0.00e+00	699.00
IUUC-Mga-059326	Meleagris gallopavo	77.44	0.00e+00	630.00
IUUC-Mmr-060815	Microcebus murinus	96.93	0.00e+00	787.00
IUUC-Mdo-062000	Monodelphis domestica	90.57	0.00e+00	747.00
IUUC-Mmu-063927	Mus musculus	96.14	0.00e+00	780.00
IUUC-Mpu-065726	Mustela putorius furo	96.40	0.00e+00	776.00
IUUC-Mlu-067527	Myotis lucifugus	97.14	2.00e-119	421.00
IUUC-Nle-069680	Nomascus leucogenys	99.49	0.00e+00	797.00
IUUC-Opr-070356	Ochotona princeps	97.74	0.00e+00	802.00
IUUC-Oan-073647	Ornithorhynchus anatinus	83.94	2.00e-136	478.00
IUUC-Ocu-073973	Oryctolagus cuniculus	97.19	0.00e+00	784.00
IUUC-Oga-088797	Otolemur garnettii	98.98	0.00e+00	794.00
IUUC-Oar-089187	Ovis aries	98.72	0.00e+00	778.00
IUUC-Pan-092694	Papio anubis	91.95	0.00e+00	687.00
IUUC-Psi-093392	Pelodiscus sinensis	79.40	0.00e+00	642.00
IUUC-Pab-098145	Pongo abelii	99.74	0.00e+00	796.00
IUUC-Pca-100454	Procavia capensis	88.72	0.00e+00	720.00
IUUC-Pva-102986	Pteropus vampyrus	89.97	0.00e+00	728.00
IUUC-Rno-104931	Rattus norvegicus	94.85	0.00e+00	767.00
IUUC-Sha-106476	Sarcophilus harrisii	91.77	0.00e+00	746.00
IUUC-Ssc-115643	Sus scrofa	98.71	0.00e+00	790.00
IUUC-Tgu-117522	Taeniopygia guttata	64.44	2.00e-136	478.00
IUUC-Tsy-119301	Tarsius syrichta	99.50	0.00e+00	818.00
IUUC-Ttr-128683	Tursiops truncatus	98.71	0.00e+00	791.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence