iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	PINA	HINT
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	3.20e-09	38.1	34	94

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +Dv++ v+ +ef+ah+ vLa  S++F+ lf        ++  ++++ ++p+ f+++l++ Yt +l+ 
   Q: 34   CDVVIMVDSQEFHAHRTVLACTSKMFEILFHR------NSQHYTLDFLSPKTFQQILEYAYTATLQA 94
           8*****************************33......3668889989***************9985 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MDLTKMGMIQ LQNPSHPTGL LCKANQMRLA GTLCDVVIMV DSQEFHAHRT VLACTSKMFE 60
ILFHRNSQHY TLDFLSPKTF QQILEYAYTA TLQAKAEDLD DLLYAAEILE IEYLEEQCLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGAGTTAA GGGTGACGAG AGCGGGTACT GCGAACTGCC GGGCGATGCC GCCGCTGCCG 60
CCGTGAGATC CGGAGCAACA GTTCCCCAGC AACACCCCTT CCCCGATCCA GGCACACCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0016607--C:nuclear speck
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0016605--C:PML body
GO:0017053--C:transcriptional repressor complex
GO:0003677--F:DNA binding
GO:0042802--F:identical protein binding
GO:0046872--F:metal ion binding
GO:0042803--F:protein homodimerization activity
GO:0000980--F:RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001206--F:transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0009952--P:anterior/posterior pattern specification
GO:0051216--P:cartilage development
GO:0007417--P:central nervous system development
GO:0042733--P:embryonic digit morphogenesis
GO:0035116--P:embryonic hindlimb morphogenesis
GO:0009880--P:embryonic pattern specification
GO:0035136--P:forelimb morphogenesis
GO:0030097--P:hemopoiesis
GO:0035137--P:hindlimb morphogenesis
GO:0048133--P:male germ-line stem cell asymmetric division
GO:0001823--P:mesonephros development
GO:0008285--P:negative regulation of cell proliferation
GO:0045638--P:negative regulation of myeloid cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043065--P:positive regulation of apoptotic process
GO:0061036--P:positive regulation of cartilage development
GO:0032332--P:positive regulation of chondrocyte differentiation
GO:0045600--P:positive regulation of fat cell differentiation
GO:0051138--P:positive regulation of NK T cell differentiation
GO:0045778--P:positive regulation of ossification
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0034504--P:protein localization to nucleus
GO:0006355--P:regulation of transcription, DNA-templated
GO:0001501--P:skeletal system development

KEGG

mmu:235320

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001304	Ailuropoda melanoleuca	95.54	0.00e+00	1262.00
IUUC-Apl-003955	Anas platyrhynchos	86.63	0.00e+00	1158.00
IUUC-Aca-005156	Anolis carolinensis	72.27	4.00e-147	514.00
IUUC-Ame-011629	Astyanax mexicanus	77.86	0.00e+00	946.00
IUUC-Bta-012807	Bos taurus	96.14	0.00e+00	1280.00
IUUC-Cja-019347	Callithrix jacchus	96.73	0.00e+00	1315.00
IUUC-Cfa-020219	Canis familiaris	94.80	0.00e+00	1240.00
IUUC-Cpo-021404	Cavia porcellus	93.91	0.00e+00	1228.00
IUUC-Csa-023837	Chlorocebus sabaeus	96.73	0.00e+00	1312.00
IUUC-Cho-024691	Choloepus hoffmanni	82.62	0.00e+00	829.00
IUUC-Dre-027842	Danio rerio	79.23	0.00e+00	991.00
IUUC-Dno-029711	Dasypus novemcinctus	95.69	0.00e+00	1272.00
IUUC-Ete-032980	Echinops telfairi	94.35	0.00e+00	1261.00
IUUC-Eca-033437	Equus caballus	96.58	0.00e+00	1287.00
IUUC-Fca-035631	Felis catus	93.60	0.00e+00	713.00
IUUC-Fal-037329	Ficedula albicollis	81.15	0.00e+00	1008.00
IUUC-Gmo-039421	Gadus morhua	72.27	0.00e+00	850.00
IUUC-Gga-041063	Gallus gallus	86.03	0.00e+00	1124.00
IUUC-Gac-041889	Gasterosteus aculeatus	71.60	0.00e+00	865.00
IUUC-Ggo-045452	Gorilla gorilla	96.88	0.00e+00	1313.00
IUUC-Hsa-046824	Homo sapiens	96.73	0.00e+00	1315.00
IUUC-Itr-048417	Ictidomys tridecemlineatus	94.35	0.00e+00	1267.00
IUUC-Lch-049446	Latimeria chalumnae	71.60	4.00e-160	557.00
IUUC-Loc-051811	Lepisosteus oculatus	80.83	0.00e+00	1029.00
IUUC-Laf-053594	Loxodonta africana	95.54	0.00e+00	1307.00
IUUC-Mcc-054941	Macaca mulatta	96.88	0.00e+00	1315.00
IUUC-Mga-059231	Meleagris gallopavo	86.18	0.00e+00	1119.00
IUUC-Mmr-061486	Microcebus murinus	92.06	0.00e+00	1212.00
IUUC-Mdo-063075	Monodelphis domestica	92.28	0.00e+00	1254.00
IUUC-Mpu-066057	Mustela putorius furo	95.10	0.00e+00	1274.00
IUUC-Mlu-067412	Myotis lucifugus	94.07	0.00e+00	1284.00
IUUC-Nle-069210	Nomascus leucogenys	96.88	0.00e+00	1313.00
IUUC-Opr-070631	Ochotona princeps	90.80	0.00e+00	1186.00
IUUC-Ont-071326	Oreochromis niloticus	75.88	0.00e+00	921.00
IUUC-Oan-073311	Ornithorhynchus anatinus	71.73	1.00e-79	288.00
IUUC-Ocu-074156	Oryctolagus cuniculus	96.14	0.00e+00	1256.00
IUUC-Ola-086952	Oryzias latipes	58.28	0.00e+00	676.00
IUUC-Oga-088714	Otolemur garnettii	97.18	0.00e+00	1283.00
IUUC-Ptr-090490	Pan troglodytes	95.67	0.00e+00	1144.00
IUUC-Pan-092563	Papio anubis	96.88	0.00e+00	1315.00
IUUC-Psi-093644	Pelodiscus sinensis	84.70	0.00e+00	1111.00
IUUC-Pma-094677	Petromyzon marinus	50.59	1.00e-160	560.00
IUUC-Pfo-096399	Poecilia formosa	75.55	0.00e+00	923.00
IUUC-Pab-097934	Pongo abelii	96.66	0.00e+00	1153.00
IUUC-Pca-101003	Procavia capensis	88.56	0.00e+00	1187.00
IUUC-Pva-102802	Pteropus vampyrus	95.14	0.00e+00	1120.00
IUUC-Rno-105871	Rattus norvegicus	98.96	0.00e+00	1347.00
IUUC-Sha-107295	Sarcophilus harrisii	90.95	0.00e+00	1177.00
IUUC-Spo-108233	Schizosaccharomyces pombe	25.00	3.60e-01	29.30
IUUC-Sar-113057	Sorex araneus	90.28	0.00e+00	660.00
IUUC-Ssc-116179	Sus scrofa	94.79	0.00e+00	744.00
IUUC-Tgu-116805	Taeniopygia guttata	72.92	0.00e+00	820.00
IUUC-Tru-118282	Takifugu rubripes	59.29	0.00e+00	696.00
IUUC-Tni-120296	Tetraodon nigroviridis	59.52	0.00e+00	710.00
IUUC-Tbe-127742	Tupaia belangeri	87.63	0.00e+00	1147.00
IUUC-Ttr-128285	Tursiops truncatus	95.99	0.00e+00	1275.00
IUUC-Xtr-132970	Xenopus tropicalis	77.60	0.00e+00	1006.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence