iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053394

UUCD1 version

UUC-LoA-00276

Ensembl Protein ID

ENSLAFP00000006799.4

UniProt Accession

G3T175; G3T175_LOXAF

Protein Name

Uncharacterized protein

Gene Name

HECTD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000008109.4	ENSLAFT00000008111.4	ENSLAFP00000006799.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.80e-79	265.8	3761	4121

Active Site

Position(s)	Description	Evidence
4095	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.......lysendketlqpnpdsglknpehlklFeflGrllgkalq 83
           d ++ ++++f+gEe+++++G++r+fl++++kelq++ l+l+       + ++++k+ l+p+p ++     +++l +flG+llg+a++
   Q: 3761 DPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSALSLLllcpssaVSKNKGKYILTPSPITY----GEEQLLHFLGQLLGIAIR 3843
           5667788********************************99999999777777***********9....789*************** PP
   S: 84   dgrlldlplsksfyklllgkklsl.edleevdpelyks.lkeikenaesdieelgldltfsvseei...............lgetke 153
            + +l+l+l +sf+k+l+g++l+   dl+e d  +y++ +k+ + n+e+++e+l+++++++   ++                 + +e
   Q: 3844 ADVPLPLDLLPSFWKTLVGEPLDPdLDLKEADILTYNYvKKFESINDETELEALCAEIASQHLASEspdgpnrpccrftylTMTGEE 3930
           ************************89************6666667779999999999999944444579**********65555566 PP
   S: 154  eeLkpgGenipVtneNkeeYvklvveyrlke.gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggy 239
           +eL++ G++ipV++eNk+ Y  ++ ++rl+e +  e+v+a+r+G+  +ipl+ll+ +++ e+el +cG ++i++e lk++t+y+ g+
   Q: 3931 VELCSHGRHIPVAWENKDTYAAAIRSLRLQElQNVECVTAVRAGLGAIIPLQLLTTLSPLEMELRTCGLPYINLEFLKAHTMYQVGL 4017
           67*****************************9******************************************************* PP
   S: 240  tedspaiqwFwevleefsseerkafLqFvTgssrlPl......gGfaelk....prlfvirk...dasddrlPssnTCfnyLkLPeY 313
           +e++++i++Fw +le+f +ee ++f++F+++++r+P+      gG ++ +    p+++  ++    + d+r+++++TC++++kLP+Y
   Q: 4018 METDQHIEFFWGALEMFAQEELCKFIKFACNQERIPFtcpckdGGPDTAHvppyPMKIAPPDgtaGSPDSRYIRVETCMFMIKLPQY 4104
           *******************************************99999999988888888889955555****************** PP
   S: 314  sskeilkekLlyAieet 330
           ss ei+ ekL++Ai+++
   Q: 4105 SSLEIMLEKLRCAIHYR 4121
           **************986 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MLPAPDSNTG SSSENKDADL GRCLTADGLY LYTTNSVGRG VSKLGSGLHG TLRGFVYCRN 60
EELEPGWVAF GSGSLLHRPV SFDNKPHSLF QVIDQNTLQV CQMVPMPTNH LPVGSTMSTV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTACCAG CGCCGGATAG CAACACTGGC TCCAGTTCTG AAAATAAAGG TAATGTAAGG 60
GTTTTTTTTG TCCTGGGATT TCAATTAAGA TGTAAAAATC ATGGTTTTAG ATCCTTGTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002256	Ailuropoda melanoleuca	96.21	0.00e+00	7192.00
IUUC-Apl-004161	Anas platyrhynchos	92.20	0.00e+00	5157.00
IUUC-Aca-005341	Anolis carolinensis	88.34	0.00e+00	6592.00
IUUC-Ame-011574	Astyanax mexicanus	81.96	0.00e+00	4721.00
IUUC-Bta-012514	Bos taurus	96.12	0.00e+00	1922.00
IUUC-Cja-019148	Callithrix jacchus	96.19	0.00e+00	5227.00
IUUC-Cfa-020499	Canis familiaris	97.63	0.00e+00	7535.00
IUUC-Cpo-021894	Cavia porcellus	96.70	0.00e+00	2750.00
IUUC-Csa-023079	Chlorocebus sabaeus	97.36	0.00e+00	7517.00
IUUC-Cho-024415	Choloepus hoffmanni	92.82	0.00e+00	5062.00
IUUC-Dre-027452	Danio rerio	80.35	0.00e+00	4690.00
IUUC-Dno-029595	Dasypus novemcinctus	97.27	0.00e+00	7538.00
IUUC-Dor-030849	Dipodomys ordii	97.18	0.00e+00	1791.00
IUUC-Ete-032563	Echinops telfairi	91.27	0.00e+00	1645.00
IUUC-Eca-034202	Equus caballus	96.53	0.00e+00	7149.00
IUUC-Eeu-035175	Erinaceus europaeus	96.20	0.00e+00	1070.00
IUUC-Fca-036295	Felis catus	97.29	0.00e+00	7103.00
IUUC-Fal-037003	Ficedula albicollis	92.63	0.00e+00	6474.00
IUUC-Gmo-038579	Gadus morhua	84.80	0.00e+00	2862.00
IUUC-Gga-040961	Gallus gallus	92.69	0.00e+00	7272.00
IUUC-Gac-041899	Gasterosteus aculeatus	84.47	0.00e+00	2886.00
IUUC-Ggo-045099	Gorilla gorilla	96.92	0.00e+00	6350.00
IUUC-Hsa-046331	Homo sapiens	97.15	0.00e+00	7558.00
IUUC-Itr-048190	Ictidomys tridecemlineatus	95.92	0.00e+00	2140.00
IUUC-Lch-049923	Latimeria chalumnae	83.80	0.00e+00	2623.00
IUUC-Loc-052630	Lepisosteus oculatus	83.91	0.00e+00	4031.00
IUUC-Mcc-055763	Macaca mulatta	97.46	0.00e+00	7519.00
IUUC-Meu-056039	Macropus eugenii	88.65	0.00e+00	5046.00
IUUC-Mga-059500	Meleagris gallopavo	91.14	0.00e+00	6933.00
IUUC-Mmr-060868	Microcebus murinus	93.80	0.00e+00	7237.00
IUUC-Mdo-062772	Monodelphis domestica	94.12	0.00e+00	7354.00
IUUC-Mmu-063606	Mus musculus	96.05	0.00e+00	7477.00
IUUC-Mpu-065860	Mustela putorius furo	94.33	0.00e+00	7057.00
IUUC-Mlu-067376	Myotis lucifugus	95.61	0.00e+00	5319.00
IUUC-Nle-069693	Nomascus leucogenys	94.81	0.00e+00	7329.00
IUUC-Opr-071065	Ochotona princeps	95.56	0.00e+00	1210.00
IUUC-Ont-072470	Oreochromis niloticus	82.17	0.00e+00	4603.00
IUUC-Oan-073693	Ornithorhynchus anatinus	92.12	0.00e+00	5199.00
IUUC-Ocu-074032	Oryctolagus cuniculus	95.73	0.00e+00	7468.00
IUUC-Ola-087433	Oryzias latipes	82.58	0.00e+00	1569.00
IUUC-Oga-088546	Otolemur garnettii	97.46	0.00e+00	6924.00
IUUC-Oar-089643	Ovis aries	90.66	0.00e+00	754.00
IUUC-Ptr-090504	Pan troglodytes	96.13	0.00e+00	7239.00
IUUC-Pan-092543	Papio anubis	97.36	0.00e+00	7509.00
IUUC-Psi-093952	Pelodiscus sinensis	89.48	0.00e+00	6809.00
IUUC-Pfo-096356	Poecilia formosa	83.38	0.00e+00	4791.00
IUUC-Pab-098240	Pongo abelii	97.31	0.00e+00	7510.00
IUUC-Pca-100994	Procavia capensis	97.49	0.00e+00	2992.00
IUUC-Pva-102263	Pteropus vampyrus	95.28	0.00e+00	7108.00
IUUC-Rno-104888	Rattus norvegicus	96.00	0.00e+00	7432.00
IUUC-Sha-106944	Sarcophilus harrisii	92.16	0.00e+00	7045.00
IUUC-Sar-113556	Sorex araneus	82.85	0.00e+00	984.00
IUUC-Ssc-116187	Sus scrofa	97.46	0.00e+00	5157.00
IUUC-Tgu-116655	Taeniopygia guttata	91.92	0.00e+00	5114.00
IUUC-Tru-118093	Takifugu rubripes	83.39	0.00e+00	2985.00
IUUC-Tni-119739	Tetraodon nigroviridis	82.80	0.00e+00	1592.00
IUUC-Tbe-127962	Tupaia belangeri	91.40	0.00e+00	1186.00
IUUC-Ttr-128819	Tursiops truncatus	92.59	0.00e+00	2868.00
IUUC-Vpa-130482	Vicugna pacos	94.07	0.00e+00	4442.00
IUUC-Xtr-132222	Xenopus tropicalis	85.70	0.00e+00	6549.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence