iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Rno-104902

Ensembl Protein ID

ENSRNOP00000012245.3

UniProt Accession

Q7TNY1; BACD2_RAT

Genbank Protein ID

AAP97077.1; AAI28705.1

Protein Name

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; BTB/POZ domain-containing protein TNFAIP1; Tumor necrosis factor-induced protein 1

Genbank Nucleotide ID

AY336949; BC128704

Gene Name

Tnfaip1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000009069.4	ENSRNOT00000012245.4	ENSRNOP00000012245.3

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	6.80e-07	29.9	29	94

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 2    DvilvvggeeffahkivLaasSsvFyalflmele.esksklmveikdvqpevfrallkFlYtgklde 67
            v+l+vgg+   ++   L+++  +++a+f++ +e  +++++ + i+ +  ++f ++l++l+ +++++
   Q: 29   YVQLNVGGSLHYTTVRALTRHDTMLKAMFSGRMEvLTDKEGWILID-RCGKHFGTILNYLRDDTVTL 94
           599********************************9999******9.**************999876 PP

Organism

Rattus norvegicus

Functional Description
(View)

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis (By similarity). May enhance the PCNA-dependent DNA polymerase delta activity.

Protein Sequence
(Fasta)

MSGDTCLCPA SGAKPKISGF KGGGLGNKYV QLNVGGSLHY TTVRALTRHD TMLKAMFSGR 60
MEVLTDKEGW ILIDRCGKHF GTILNYLRDD TVTLPQSRQE IQELMAEAKY YLIQGLVSLC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCGGGTCTT GTAGTCTGTT TCCCCGATAT GCAGGGTTGG GCTGTAACTC CGAAGTCGGC 60
GGGCGCAGGA TGTGAGCTCA CAGCCGAGAT TGCAGATAGC TAGCTACAGG CCAGAGGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR003131--T1-type_BTB

Pfam

PF02214--BTB_2

SMART

SM00225--BTB

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005768--C:endosome
GO:0005730--C:nucleolus
GO:0017049--F:GTP-Rho binding
GO:0019904--F:protein domain specific binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030036--P:actin cytoskeleton organization
GO:0016477--P:cell migration
GO:0006281--P:DNA repair
GO:0006260--P:DNA replication
GO:0009790--P:embryo development
GO:0006955--P:immune response
GO:0035024--P:negative regulation of Rho protein signal transduction
GO:0045740--P:positive regulation of DNA replication
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051291--P:protein heterooligomerization
GO:0051260--P:protein homooligomerization
GO:0016567--P:protein ubiquitination
GO:0006355--P:regulation of transcription, DNA-templated
GO:0043149--P:stress fiber assembly

KEGG

rno:287543

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001724	Ailuropoda melanoleuca	95.25	0.00e+00	634.00
IUUC-Apl-003702	Anas platyrhynchos	89.84	4.00e-168	583.00
IUUC-Aca-004408	Anolis carolinensis	82.28	3.00e-146	510.00
IUUC-Afl-008662	Aspergillus flavus	34.48	1.00e-01	31.20
IUUC-Ang-009546	Aspergillus niger	30.51	2.50e-01	28.90
IUUC-Ame-010738	Astyanax mexicanus	76.74	3.00e-123	434.00
IUUC-Bta-013551	Bos taurus	94.62	4.00e-171	593.00
IUUC-Cja-019122	Callithrix jacchus	96.20	0.00e+00	641.00
IUUC-Cfa-020193	Canis familiaris	95.89	0.00e+00	639.00
IUUC-Cpo-022024	Cavia porcellus	96.20	0.00e+00	640.00
IUUC-Csa-024138	Chlorocebus sabaeus	96.20	0.00e+00	642.00
IUUC-Dno-029163	Dasypus novemcinctus	94.94	0.00e+00	637.00
IUUC-Dor-030970	Dipodomys ordii	96.20	0.00e+00	639.00
IUUC-Eca-034114	Equus caballus	95.89	0.00e+00	640.00
IUUC-Eeu-034709	Erinaceus europaeus	95.25	0.00e+00	630.00
IUUC-Fca-036397	Felis catus	94.94	1.00e-171	595.00
IUUC-Fal-037588	Ficedula albicollis	89.49	3.00e-168	583.00
IUUC-Gga-040445	Gallus gallus	89.49	1.00e-167	582.00
IUUC-Ggo-045312	Gorilla gorilla	96.20	0.00e+00	642.00
IUUC-Hsa-046091	Homo sapiens	96.20	0.00e+00	642.00
IUUC-Itr-048608	Ictidomys tridecemlineatus	96.52	0.00e+00	643.00
IUUC-Lch-049970	Latimeria chalumnae	88.71	1.00e-168	585.00
IUUC-Laf-054286	Loxodonta africana	94.30	0.00e+00	632.00
IUUC-Meu-056850	Macropus eugenii	85.89	1.00e-152	532.00
IUUC-Mga-060119	Meleagris gallopavo	92.56	5.00e-133	466.00
IUUC-Mdo-061847	Monodelphis domestica	92.16	3.00e-166	577.00
IUUC-Mmu-063130	Mus musculus	98.42	0.00e+00	650.00
IUUC-Mpu-066060	Mustela putorius furo	96.20	0.00e+00	640.00
IUUC-Mlu-067951	Myotis lucifugus	95.89	0.00e+00	639.00
IUUC-Nle-069523	Nomascus leucogenys	96.20	0.00e+00	642.00
IUUC-Opr-070426	Ochotona princeps	95.25	0.00e+00	637.00
IUUC-Ont-072156	Oreochromis niloticus	69.51	1.00e-129	456.00
IUUC-Oan-073164	Ornithorhynchus anatinus	85.45	1.00e-73	268.00
IUUC-Ocu-074319	Oryctolagus cuniculus	95.89	0.00e+00	641.00
IUUC-Oga-088279	Otolemur garnettii	95.57	0.00e+00	641.00
IUUC-Oar-089368	Ovis aries	94.94	0.00e+00	636.00
IUUC-Ptr-091204	Pan troglodytes	95.89	9.00e-175	605.00
IUUC-Pan-092880	Papio anubis	96.19	0.00e+00	640.00
IUUC-Psi-093768	Pelodiscus sinensis	88.82	2.00e-166	577.00
IUUC-Pab-098414	Pongo abelii	94.62	0.00e+00	625.00
IUUC-Pca-100380	Procavia capensis	89.87	2.00e-171	594.00
IUUC-Pva-102366	Pteropus vampyrus	95.57	0.00e+00	637.00
IUUC-Ptt-103935	Puccinia triticina	27.96	1.10e-01	30.40
IUUC-Sha-106996	Sarcophilus harrisii	91.54	5.00e-166	576.00
IUUC-Ssc-116300	Sus scrofa	95.89	0.00e+00	639.00
IUUC-Tgu-116738	Taeniopygia guttata	88.85	3.00e-167	580.00
IUUC-Tru-117840	Takifugu rubripes	72.96	6.00e-116	410.00
IUUC-Tsy-119370	Tarsius syrichta	64.56	9.00e-109	386.00
IUUC-Tni-119857	Tetraodon nigroviridis	71.17	2.00e-129	455.00
IUUC-Tbe-127709	Tupaia belangeri	95.25	0.00e+00	634.00
IUUC-Ttr-129110	Tursiops truncatus	95.25	0.00e+00	639.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence