iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066488

Ensembl Protein ID

ENSMPUP00000002999.1

UniProt Accession

M3XV99; M3XV99_MUSPF

Genbank Protein ID

ENSMPUP00000002999

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AEYP01015235

Gene Name

SIAH1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000003029.1	ENSMPUT00000003060.1	ENSMPUP00000002999.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	81.96	2.00e-125	445.00	IUUC-Dme-031700
E3 activity/RING/RING	97.76	0.00e+00	638.00	IUUC-Hsa-046357
E3 activity/RING/RING	99.29	9.00e-168	586.00	IUUC-Mmu-064129

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mustela putorius furo

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MTGKSPLPFL YSWRGVLLTC LPAAGTRKRK EMSRQTATAL PTGTSKCTPS QRVPALTGTT 60
ASNNDLASLF ECPVCFDYVL PPILQCQSGH LVCSNCRPKL TCCPTCRGPL GSIRNLAMEK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACCGGGA AGTCACCCTT ACCTTTTCTG TACTCTTGGA GGGGTGTCTT GCTCACATGT 60
TTACCAGCAG CTGGGACAAG GAAGAGAAAA GGTACTGACA TTAAAAGACT GGGTTGCTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0030877--C:beta-catenin destruction complex
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000061	Aegilops tauschii	37.09	2.00e-44	172.00
IUUC-Aml-001186	Ailuropoda melanoleuca	99.68	0.00e+00	654.00
IUUC-Atr-002857	Amborella trichopoda	36.06	2.00e-44	172.00
IUUC-Apl-003813	Anas platyrhynchos	100.00	2.00e-170	591.00
IUUC-Aca-005014	Anolis carolinensis	100.00	2.00e-171	593.00
IUUC-Aly-006207	Arabidopsis lyrata	33.94	1.00e-41	163.00
IUUC-Ath-007049	Arabidopsis thaliana	32.87	3.00e-42	165.00
IUUC-Ame-011196	Astyanax mexicanus	88.00	2.00e-170	590.00
IUUC-Bta-012887	Bos taurus	99.36	0.00e+00	652.00
IUUC-Bdi-014200	Brachypodium distachyon	37.73	4.00e-45	174.00
IUUC-Bol-016263	Brassica oleracea	33.45	7.00e-43	167.00
IUUC-Bra-016910	Brassica rapa	36.82	2.00e-41	162.00
IUUC-Cel-018320	Caenorhabditis elegans	66.43	3.00e-114	405.00
IUUC-Cja-019796	Callithrix jacchus	97.44	0.00e+00	634.00
IUUC-Cfa-020642	Canis familiaris	100.00	1.00e-172	598.00
IUUC-Cpo-022348	Cavia porcellus	99.65	1.00e-169	588.00
IUUC-Csa-023974	Chlorocebus sabaeus	97.76	0.00e+00	638.00
IUUC-Cin-025674	Ciona intestinalis	78.01	9.00e-135	472.00
IUUC-Csv-026233	Ciona savignyi	84.25	3.00e-132	463.00
IUUC-Dre-028041	Danio rerio	85.93	5.00e-170	589.00
IUUC-Dno-029764	Dasypus novemcinctus	100.00	3.00e-171	593.00
IUUC-Dme-031700	Drosophila melanogaster	83.87	8.00e-120	423.00
IUUC-Ete-032423	Echinops telfairi	99.63	3.00e-160	557.00
IUUC-Eca-033536	Equus caballus	100.00	2.00e-170	591.00
IUUC-Eeu-035314	Erinaceus europaeus	99.63	1.00e-160	558.00
IUUC-Fca-035362	Felis catus	99.04	0.00e+00	650.00
IUUC-Fal-037487	Ficedula albicollis	94.89	1.00e-178	618.00
IUUC-Gga-040269	Gallus gallus	100.00	2.00e-170	591.00
IUUC-Gac-042282	Gasterosteus aculeatus	97.16	1.00e-166	578.00
IUUC-Gma-042926	Glycine max	34.44	1.00e-40	160.00
IUUC-Ggo-045444	Gorilla gorilla	97.76	0.00e+00	638.00
IUUC-Hsa-046357	Homo sapiens	97.76	0.00e+00	638.00
IUUC-Hvu-047574	Hordeum vulgare	36.73	2.00e-44	172.00
IUUC-Itr-048046	Ictidomys tridecemlineatus	99.65	1.00e-169	588.00
IUUC-Lch-049504	Latimeria chalumnae	98.94	6.00e-169	585.00
IUUC-Lpe-050879	Leersia perrieri	40.25	1.00e-42	166.00
IUUC-Loc-052191	Lepisosteus oculatus	97.58	2.00e-170	590.00
IUUC-Laf-053668	Loxodonta africana	100.00	2.00e-170	591.00
IUUC-Mcc-054640	Macaca mulatta	97.76	0.00e+00	638.00
IUUC-Mtr-058747	Medicago truncatula	34.81	3.00e-42	165.00
IUUC-Mga-059503	Meleagris gallopavo	100.00	3.00e-171	593.00
IUUC-Mmr-060794	Microcebus murinus	99.65	1.00e-169	588.00
IUUC-Mmu-064129	Mus musculus	99.29	4.00e-169	586.00
IUUC-Mac-065670	Musa acuminata	36.07	3.00e-42	165.00
IUUC-Mlu-067207	Myotis lucifugus	100.00	2.00e-171	594.00
IUUC-Nle-069706	Nomascus leucogenys	97.12	0.00e+00	635.00
IUUC-Ont-071849	Oreochromis niloticus	97.17	2.00e-167	581.00
IUUC-Ocu-074876	Oryctolagus cuniculus	98.08	0.00e+00	640.00
IUUC-Oba-075454	Oryza barthii	40.66	1.00e-42	166.00
IUUC-Obr-076037	Oryza brachyantha	35.71	2.00e-40	159.00
IUUC-Ogl-077712	Oryza glaberrima	40.66	1.00e-42	166.00
IUUC-Ogu-078910	Oryza glumaepatula	40.66	2.00e-42	166.00
IUUC-Oin-079749	Oryza indica	40.66	1.00e-42	166.00
IUUC-Olo-080244	Oryza longistaminata	35.43	3.00e-40	159.00
IUUC-Ome-081318	Oryza meridionalis	40.66	1.00e-42	166.00
IUUC-Oni-083109	Oryza nivara	40.66	1.00e-42	166.00
IUUC-Opu-084065	Oryza punctata	41.08	6.00e-43	167.00
IUUC-Oru-084785	Oryza rufipogon	40.66	1.00e-42	166.00
IUUC-Osa-085610	Oryza sativa	40.66	1.00e-42	166.00
IUUC-Ola-086814	Oryzias latipes	97.16	1.00e-166	578.00
IUUC-Oga-088399	Otolemur garnettii	99.65	1.00e-169	588.00
IUUC-Oar-089323	Ovis aries	98.72	0.00e+00	647.00
IUUC-Ptr-090692	Pan troglodytes	99.65	2.00e-170	590.00
IUUC-Pan-092012	Papio anubis	97.76	0.00e+00	638.00
IUUC-Psi-093687	Pelodiscus sinensis	95.87	0.00e+00	630.00
IUUC-Pma-094387	Petromyzon marinus	94.01	6.00e-161	559.00
IUUC-Ppa-095212	Physcomitrella patens	36.19	5.00e-41	161.00
IUUC-Pfo-097134	Poecilia formosa	97.16	1.00e-166	578.00
IUUC-Pab-097555	Pongo abelii	97.76	0.00e+00	638.00
IUUC-Pop-099970	Populus trichocarpa	34.90	3.00e-44	171.00
IUUC-Ppe-101760	Prunus persica	36.10	4.00e-44	171.00
IUUC-Rno-104866	Rattus norvegicus	99.29	4.00e-169	586.00
IUUC-Sha-106547	Sarcophilus harrisii	97.76	0.00e+00	638.00
IUUC-Sit-110595	Setaria italica	37.45	1.00e-41	163.00
IUUC-Sbi-114090	Sorghum bicolor	37.11	2.00e-42	165.00
IUUC-Tgu-116579	Taeniopygia guttata	100.00	2.00e-170	591.00
IUUC-Tru-118250	Takifugu rubripes	92.91	2.00e-158	551.00
IUUC-Tni-120488	Tetraodon nigroviridis	96.81	3.00e-163	566.00
IUUC-Tca-121228	Theobroma cacao	35.50	4.00e-41	161.00
IUUC-Tae-123647	Triticum aestivum	37.09	2.00e-44	172.00
IUUC-Tur-126259	Triticum urartu	34.88	8.00e-39	154.00
IUUC-Ttr-129166	Tursiops truncatus	99.17	5.00e-143	500.00
IUUC-Vvi-131233	Vitis vinifera	34.95	2.00e-43	169.00
IUUC-Xtr-132553	Xenopus tropicalis	98.94	2.00e-169	587.00
IUUC-Xma-133670	Xiphophorus maculatus	97.16	1.00e-166	578.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence