iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059972

UUCD1 version

UUC-MeG-00869

Ensembl Protein ID

ENSMGAP00000010048.2

UniProt Accession

G1NBM3; G1NBM3_MELGA

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP13

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000009725.2	ENSMGAT00000010894.2	ENSMGAP00000010048.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.70e-55	185.8	286	827
UBD/Alpha-Helix/UBA	4.60e-19	67.6	693	730

Active Site

Position(s)	Description	Evidence
295	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
790	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tG+kNlgN+CY+N+v+Q++++ipe+++++   + +++ + +p +p++++ ++++kl + l                       k +++ 
   Q: 286  TGMKNLGNSCYLNAVMQAIFSIPEFQRAYVG-NLQRIFDYSPLDPTQDFNTQMAKLGHGLlsgqyskppmkselieqvmkeeHKPQQNG 373
           7******************************.7777778889******************8888888888888877765543378888* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           +sp+++++ ++k + efs+++qqDaqEf+ +l++ +e++                               +++  sd+F++ ++++++c
   Q: 374  ISPQMFKAFISKDHTEFSSNRQQDAQEFFLHLINLVERNP-----------------------------VGSENPSDVFRFLVEERTQC 433
           ************************************9998.............................788899************** PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeae 218
            + ++v  +e   + ++lpv ++  t+k                             ++ cL++f+++ ++e+   ++++  ++k+  +
   Q: 434  CQSRKVRYTERVDYIMQLPVAMEAATNKDeliayelkrreaeaarrappelvrakiPFSACLQAFSEPSNVED---FWSSALQAKSAGV 519
           *******99999999*****99998888799*****************************************7...************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................ 267
           k+ ++ ++P++L++++k+f+f  + + ++k++ ++++p+ Ld+++  +                                         
   Q: 520  KTSRFASFPQYLVVQIKKFTFGLD-WIPKKLDVSIDMPDFLDINHLRAMglqpgeeelpdiappiiipedpkgsdfcspdvhhetknlv 607
           *********************997.*******************766667888888888888888888888888888888888777777 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 608  petvsaldidessvmqlaemgfpleacrkavyytgnlgaevafnwiiahmeepdfaeplvvpvfggtassgvagfgavgldnqppeemv 696
           77777777777777777777777777777777777777777777777777666666666666666666666666666666666666666 PP
   S: 268  ...................peekqke....................................................kkkYeLiavvv 285
                              +     +                                                    + +YeL++ ++
   Q: 697  siiismgfqrslaiqalkaT-----NnnleralewifnhpeleeedgepalsmmdlenhtnanilaearsegprikdgPGRYELFGFIS 780
           66666666666655555550.....05555566666666666666666777777777777777888888888889999*********** PP
   S: 286  HsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           H+G s+ sGHYv++ k+ +g+W+ ++D +V ++  e+  +   + +Y++fY+r
   Q: 781  HMGtSTMSGHYVCHLKK-EGRWVIYNDLRVCAS--ERPPK---DLGYIYFYHR 827
           *****************.9***********999..78888...89******97 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e+++  +++MGF r++a+qaL a+nnnle+A+e+++++
   Q: 693  EEMVSIIISMGFQRSLAIQALKATNNNLERALEWIFNH 730
           899*********************************97 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

DSEGGLYVCM NTFLGFGREH IERHYRKTGQ FAHHHLRHLM NHQKKKVPGA SGGALPKRRN 60
AKLFLDLEAN GDLSSDDFEY EDEAKLVIFP DHYEISLPNI EELPALVSEH VTIASDALLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATTCAGAAG GAGGTCTCTA TGTGTGCATG AACACGTTTC TGGGATTTGG AAGGGAACAC 60
ATTGAAAGGC ATTACCGGAA AACAGGACAG TGTGTGTATT TGCATCTGAA ACGACATGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904454--F:ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0035523--P:protein K29-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001356	Ailuropoda melanoleuca	80.00	0.00e+00	1266.00
IUUC-Apl-003712	Anas platyrhynchos	89.90	0.00e+00	1438.00
IUUC-Aca-004634	Anolis carolinensis	83.15	0.00e+00	1334.00
IUUC-Ame-011470	Astyanax mexicanus	70.82	0.00e+00	1170.00
IUUC-Bta-013349	Bos taurus	79.66	0.00e+00	1288.00
IUUC-Cja-019021	Callithrix jacchus	79.78	0.00e+00	1261.00
IUUC-Cfa-020614	Canis familiaris	80.24	0.00e+00	1269.00
IUUC-Cpo-022484	Cavia porcellus	80.02	0.00e+00	1268.00
IUUC-Csa-024078	Chlorocebus sabaeus	80.14	0.00e+00	1270.00
IUUC-Cho-024522	Choloepus hoffmanni	66.55	0.00e+00	1019.00
IUUC-Cme-027335	Cyanidioschyzon merolae	26.48	3.00e-44	173.00
IUUC-Dre-027651	Danio rerio	71.09	0.00e+00	1222.00
IUUC-Dno-028975	Dasypus novemcinctus	79.59	0.00e+00	1259.00
IUUC-Dor-030130	Dipodomys ordii	65.51	0.00e+00	717.00
IUUC-Ete-032251	Echinops telfairi	67.03	0.00e+00	1051.00
IUUC-Eca-033568	Equus caballus	80.14	0.00e+00	1267.00
IUUC-Fca-036280	Felis catus	80.36	0.00e+00	1271.00
IUUC-Fal-036610	Ficedula albicollis	88.69	0.00e+00	1398.00
IUUC-Gmo-038906	Gadus morhua	70.17	0.00e+00	1138.00
IUUC-Gga-041215	Gallus gallus	93.86	0.00e+00	1494.00
IUUC-Gac-042441	Gasterosteus aculeatus	69.98	0.00e+00	1159.00
IUUC-Ggo-044446	Gorilla gorilla	80.26	0.00e+00	1271.00
IUUC-Hsa-046546	Homo sapiens	80.02	0.00e+00	1266.00
IUUC-Itr-048147	Ictidomys tridecemlineatus	78.80	0.00e+00	1239.00
IUUC-Lch-050425	Latimeria chalumnae	76.89	0.00e+00	1275.00
IUUC-Loc-052072	Lepisosteus oculatus	71.19	0.00e+00	1179.00
IUUC-Laf-053909	Loxodonta africana	78.42	0.00e+00	1254.00
IUUC-Mcc-054686	Macaca mulatta	80.26	0.00e+00	1271.00
IUUC-Meu-056361	Macropus eugenii	81.60	0.00e+00	955.00
IUUC-Mmr-060916	Microcebus murinus	79.88	0.00e+00	1264.00
IUUC-Mdo-062302	Monodelphis domestica	81.81	0.00e+00	1350.00
IUUC-Mmu-063639	Mus musculus	79.18	0.00e+00	1297.00
IUUC-Mpu-066533	Mustela putorius furo	80.24	0.00e+00	1270.00
IUUC-Mlu-067786	Myotis lucifugus	77.00	0.00e+00	1218.00
IUUC-Nle-069997	Nomascus leucogenys	80.29	0.00e+00	1255.00
IUUC-Ont-071859	Oreochromis niloticus	68.71	0.00e+00	1172.00
IUUC-Oan-072959	Ornithorhynchus anatinus	84.10	9.00e-123	431.00
IUUC-Ocu-074265	Oryctolagus cuniculus	79.78	0.00e+00	1263.00
IUUC-Ola-087344	Oryzias latipes	70.90	0.00e+00	1191.00
IUUC-Oga-088734	Otolemur garnettii	79.90	0.00e+00	1268.00
IUUC-Oar-089636	Ovis aries	78.75	0.00e+00	1290.00
IUUC-Ptr-090982	Pan troglodytes	80.14	0.00e+00	1269.00
IUUC-Pan-091991	Papio anubis	80.26	0.00e+00	1272.00
IUUC-Psi-093509	Pelodiscus sinensis	84.36	0.00e+00	1384.00
IUUC-Pfo-096029	Poecilia formosa	70.13	0.00e+00	1202.00
IUUC-Pab-098672	Pongo abelii	75.93	0.00e+00	1170.00
IUUC-Ppe-101315	Prunus persica	42.64	2.00e-173	602.00
IUUC-Pva-102545	Pteropus vampyrus	79.08	0.00e+00	1061.00
IUUC-Rno-105210	Rattus norvegicus	78.94	0.00e+00	1277.00
IUUC-Sar-113733	Sorex araneus	81.02	0.00e+00	669.00
IUUC-Tgu-116591	Taeniopygia guttata	88.81	0.00e+00	1423.00
IUUC-Tru-118627	Takifugu rubripes	70.52	0.00e+00	1192.00
IUUC-Tsy-119278	Tarsius syrichta	72.05	0.00e+00	1132.00
IUUC-Tni-120804	Tetraodon nigroviridis	71.04	0.00e+00	1194.00
IUUC-Ttr-128295	Tursiops truncatus	72.72	0.00e+00	1128.00
IUUC-Vpa-130170	Vicugna pacos	70.76	0.00e+00	1098.00
IUUC-Xtr-132809	Xenopus tropicalis	71.24	0.00e+00	1152.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence