iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020177

Ensembl Protein ID

ENSCAFP00000027471.3

UniProt Accession

F1PIY1; F1PIY1_CANLF

Genbank Protein ID

ENSCAFP00000027471

Protein Name

Non-specific serine/threonine protein kinase

Genbank Nucleotide ID

AAEX03003150

Gene Name

PRKAA1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000018614.3	ENSCAFT00000029555.3	ENSCAFP00000027471.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UBA	51.81	7.00e-114	408.00	IUUC-Ath-007014
UBD/Alpha-Helix/UBA	39.10	3.00e-96	347.00	IUUC-Spo-108202

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Canis familiaris

Protein Sequence
(Fasta)

MVKSRLALGN EGVYKTKDKR NCTVVIHRVG KHELTGHKVA VKILNRQKIR SLDVVGKIRR 60
EIQNLKLFRH PHIIKLYQVI STPSDIFMVM EYVSGGELFD YICKNGRLDE KESRRLFQQI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTGAAGT CCAGATTAGC ACTTGGAAAT GAGGGAGTCT ATAAAACTAA AGACAAAAGG 60
AACTGCACAG TTGTTATCCA CAGAGGTAGG GTTAACAATT CTATTTCCAT AAATACATCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase

Interpro

IPR032270--AMPK_C
IPR028375--KA1/Ssp2_C
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF16579--AdenylateSensor
PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016607--C:nuclear speck
GO:0005634--C:nucleus
GO:0004679--F:AMP-activated protein kinase activity
GO:0005524--F:ATP binding
GO:0003682--F:chromatin binding
GO:0035174--F:histone serine kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0061762--P:CAMKK-AMPK signaling cascade
GO:0042149--P:cellular response to glucose starvation
GO:0071380--P:cellular response to prostaglandin E stimulus
GO:0019395--P:fatty acid oxidation
GO:0042593--P:glucose homeostasis
GO:0006006--P:glucose metabolic process
GO:0035556--P:intracellular signal transduction
GO:0008610--P:lipid biosynthetic process
GO:0043066--P:negative regulation of apoptotic process
GO:0050995--P:negative regulation of lipid catabolic process
GO:0032007--P:negative regulation of TOR signaling
GO:0010508--P:positive regulation of autophagy
GO:0010628--P:positive regulation of gene expression
GO:0048643--P:positive regulation of skeletal muscle tissue development
GO:0006468--P:protein phosphorylation
GO:0042752--P:regulation of circadian rhythm
GO:0033135--P:regulation of peptidyl-serine phosphorylation
GO:1901563--P:response to camptothecin
GO:0010332--P:response to gamma radiation
GO:0042542--P:response to hydrogen peroxide
GO:0009411--P:response to UV

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000713	Aegilops tauschii	46.25	5.00e-114	405.00
IUUC-Aml-001907	Ailuropoda melanoleuca	99.81	0.00e+00	997.00
IUUC-Atr-002770	Amborella trichopoda	47.58	5.00e-118	417.00
IUUC-Apl-003395	Anas platyrhynchos	74.48	0.00e+00	803.00
IUUC-Aca-004480	Anolis carolinensis	75.15	0.00e+00	769.00
IUUC-Aly-006289	Arabidopsis lyrata	51.81	2.00e-116	412.00
IUUC-Ath-007014	Arabidopsis thaliana	52.29	9.00e-118	417.00
IUUC-Ago-007957	Ashbya gossypii	40.97	3.00e-107	382.00
IUUC-Acl-008103	Aspergillus clavatus	60.23	1.00e-94	340.00
IUUC-Afl-008555	Aspergillus flavus	59.46	9.00e-95	341.00
IUUC-Afu-008949	Aspergillus fumigatus	59.85	2.00e-94	340.00
IUUC-Ani-009408	Aspergillus nidulans	60.55	9.00e-95	341.00
IUUC-Ang-009551	Aspergillus niger	60.23	2.00e-95	343.00
IUUC-Aor-010176	Aspergillus oryzae	59.46	9.00e-95	341.00
IUUC-Ate-010287	Aspergillus terreus	59.85	2.00e-94	340.00
IUUC-Ame-011019	Astyanax mexicanus	72.83	0.00e+00	780.00
IUUC-Bgr-012045	Blumeria graminis	57.92	8.00e-93	334.00
IUUC-Bta-012786	Bos taurus	99.61	0.00e+00	1004.00
IUUC-Bci-013774	Botrytis cinerea	59.07	2.00e-94	340.00
IUUC-Bdi-014319	Brachypodium distachyon	46.38	3.00e-114	405.00
IUUC-Bol-016242	Brassica oleracea	51.60	4.00e-119	421.00
IUUC-Bra-016750	Brassica rapa	52.57	2.00e-119	422.00
IUUC-Cel-018518	Caenorhabditis elegans	57.93	2.00e-168	585.00
IUUC-Cja-019386	Callithrix jacchus	74.05	0.00e+00	798.00
IUUC-Cpo-021805	Cavia porcellus	73.47	0.00e+00	793.00
IUUC-Cre-022915	Chlamydomonas reinhardtii	55.12	3.00e-88	318.00
IUUC-Csa-024267	Chlorocebus sabaeus	73.47	0.00e+00	791.00
IUUC-Cho-024859	Choloepus hoffmanni	96.99	0.00e+00	991.00
IUUC-Cin-025550	Ciona intestinalis	58.21	2.00e-179	622.00
IUUC-Csv-026139	Ciona savignyi	56.76	6.00e-179	620.00
IUUC-Cne-027044	Cryptococcus neoformans	45.65	2.00e-96	347.00
IUUC-Cme-027289	Cyanidioschyzon merolae	45.08	1.00e-101	363.00
IUUC-Dre-027749	Danio rerio	82.84	0.00e+00	891.00
IUUC-Dno-030006	Dasypus novemcinctus	99.61	0.00e+00	996.00
IUUC-Dor-030578	Dipodomys ordii	74.43	0.00e+00	793.00
IUUC-Dse-031507	Dothistroma septosporum	60.45	7.00e-98	352.00
IUUC-Dme-031704	Drosophila melanogaster	56.14	1.00e-172	599.00
IUUC-Ete-033055	Echinops telfairi	95.84	0.00e+00	1020.00
IUUC-Eca-034239	Equus caballus	99.81	0.00e+00	1003.00
IUUC-Fca-035754	Felis catus	96.79	0.00e+00	981.00
IUUC-Fal-037363	Ficedula albicollis	94.76	0.00e+00	968.00
IUUC-Fox-038073	Fusarium oxysporum	54.79	5.00e-95	342.00
IUUC-Fso-038236	Fusarium solani	54.11	1.00e-91	331.00
IUUC-Gmo-039633	Gadus morhua	81.77	0.00e+00	913.00
IUUC-Ggr-039987	Gaeumannomyces graminis	49.71	2.00e-95	343.00
IUUC-Gga-040546	Gallus gallus	74.24	0.00e+00	796.00
IUUC-Gac-041822	Gasterosteus aculeatus	71.54	0.00e+00	754.00
IUUC-Gma-042712	Glycine max	46.91	2.00e-117	416.00
IUUC-Ggo-044797	Gorilla gorilla	99.42	0.00e+00	993.00
IUUC-Hsa-045867	Homo sapiens	99.61	0.00e+00	995.00
IUUC-Hvu-047406	Hordeum vulgare	46.57	6.00e-115	407.00
IUUC-Itr-048134	Ictidomys tridecemlineatus	73.85	0.00e+00	795.00
IUUC-Kpa-049190	Komagataella pastoris	43.10	5.00e-109	388.00
IUUC-Lch-049623	Latimeria chalumnae	89.94	0.00e+00	917.00
IUUC-Lpe-051392	Leersia perrieri	51.60	1.00e-117	416.00
IUUC-Loc-052362	Lepisosteus oculatus	89.96	0.00e+00	877.00
IUUC-Lma-053054	Leptosphaeria maculans	57.75	4.00e-99	356.00
IUUC-Laf-053799	Loxodonta africana	99.22	0.00e+00	1027.00
IUUC-Mcc-055862	Macaca mulatta	74.62	0.00e+00	798.00
IUUC-Mor-057170	Magnaporthe oryzae	50.00	1.00e-95	344.00
IUUC-Mpo-057302	Magnaporthe poae	49.71	1.00e-95	344.00
IUUC-Mtr-058309	Medicago truncatula	47.02	2.00e-118	419.00
IUUC-Mla-059058	Melampsora laricipopulina	40.43	3.00e-98	352.00
IUUC-Mga-059206	Meleagris gallopavo	74.52	0.00e+00	794.00
IUUC-Mvi-060337	Microbotryum violaceum	49.41	3.00e-93	336.00
IUUC-Mmr-061761	Microcebus murinus	99.81	0.00e+00	997.00
IUUC-Mdo-062160	Monodelphis domestica	74.05	0.00e+00	795.00
IUUC-Mmu-063406	Mus musculus	74.05	0.00e+00	790.00
IUUC-Mac-064518	Musa acuminata	49.07	5.00e-110	391.00
IUUC-Mpu-066326	Mustela putorius furo	74.95	0.00e+00	795.00
IUUC-Mlu-068227	Myotis lucifugus	98.45	0.00e+00	997.00
IUUC-Nfi-068493	Neosartorya fischeri	59.85	2.00e-94	340.00
IUUC-Ncr-068665	Neurospora crassa	59.25	3.00e-97	349.00
IUUC-Nle-070158	Nomascus leucogenys	74.62	0.00e+00	798.00
IUUC-Opr-070272	Ochotona princeps	95.46	0.00e+00	973.00
IUUC-Ont-072027	Oreochromis niloticus	83.06	0.00e+00	890.00
IUUC-Oan-073322	Ornithorhynchus anatinus	92.46	0.00e+00	973.00
IUUC-Ocu-074188	Oryctolagus cuniculus	96.40	0.00e+00	980.00
IUUC-Oba-075436	Oryza barthii	47.53	1.00e-118	419.00
IUUC-Obr-076507	Oryza brachyantha	47.42	3.00e-118	418.00
IUUC-Ogl-077718	Oryza glaberrima	51.33	5.00e-115	407.00
IUUC-Ogu-078349	Oryza glumaepatula	47.53	2.00e-118	419.00
IUUC-Oin-079889	Oryza indica	46.50	2.00e-115	409.00
IUUC-Olo-080521	Oryza longistaminata	47.53	1.00e-118	420.00
IUUC-Ome-081630	Oryza meridionalis	47.31	3.00e-118	418.00
IUUC-Oni-082211	Oryza nivara	47.53	4.00e-119	421.00
IUUC-Opu-083617	Oryza punctata	47.21	1.00e-117	417.00
IUUC-Oru-084252	Oryza rufipogon	47.53	1.00e-118	420.00
IUUC-Osa-085548	Oryza sativa	47.53	1.00e-118	420.00
IUUC-Ola-086366	Oryzias latipes	83.64	0.00e+00	905.00
IUUC-Olu-087861	Ostreococcus lucimarinus	49.51	1.00e-110	393.00
IUUC-Oga-088003	Otolemur garnettii	99.81	0.00e+00	997.00
IUUC-Oar-089933	Ovis aries	99.61	0.00e+00	1004.00
IUUC-Ptr-090718	Pan troglodytes	99.61	0.00e+00	995.00
IUUC-Pan-092526	Papio anubis	99.42	0.00e+00	993.00
IUUC-Psi-094034	Pelodiscus sinensis	93.98	0.00e+00	956.00
IUUC-Pno-095030	Phaeosphaeria nodorum	57.39	2.00e-97	349.00
IUUC-Ppa-095615	Physcomitrella patens	50.59	3.00e-116	412.00
IUUC-Pfo-097050	Poecilia formosa	82.65	0.00e+00	890.00
IUUC-Pab-098519	Pongo abelii	99.61	0.00e+00	995.00
IUUC-Pop-099781	Populus trichocarpa	53.19	3.00e-119	422.00
IUUC-Pca-101104	Procavia capensis	95.42	0.00e+00	704.00
IUUC-Ppe-101642	Prunus persica	48.58	1.00e-116	413.00
IUUC-Pva-102470	Pteropus vampyrus	74.43	0.00e+00	787.00
IUUC-Pgr-103406	Puccinia graminis	60.57	3.00e-84	306.00
IUUC-Ptt-103713	Puccinia triticina	53.88	2.00e-69	257.00
IUUC-Pte-104259	Pyrenophora teres	56.40	3.00e-97	350.00
IUUC-Pyt-104752	Pyrenophora triticirepentis	49.73	5.00e-98	352.00
IUUC-Rno-104960	Rattus norvegicus	74.05	0.00e+00	793.00
IUUC-Sce-106290	Saccharomyces cerevisiae	39.89	1.00e-105	377.00
IUUC-Sha-107603	Sarcophilus harrisii	97.47	0.00e+00	984.00
IUUC-Sja-107772	Schizosaccharomyces japonicus	52.47	2.00e-101	362.00
IUUC-Spo-108202	Schizosaccharomyces pombe	39.51	1.00e-99	357.00
IUUC-Ssl-108535	Sclerotinia sclerotiorum	58.30	5.00e-93	335.00
IUUC-Smo-109309	Selaginella moellendorffii	45.51	3.00e-115	409.00
IUUC-Sit-109745	Setaria italica	52.43	2.00e-120	426.00
IUUC-Sly-110890	Solanum lycopersicum	52.31	9.00e-118	417.00
IUUC-Stu-112144	Solanum tuberosum	45.40	1.00e-110	393.00
IUUC-Sar-113521	Sorex araneus	89.73	0.00e+00	868.00
IUUC-Sbi-114764	Sorghum bicolor	47.57	2.00e-121	429.00
IUUC-Sre-115141	Sporisorium reilianum	65.87	5.00e-104	372.00
IUUC-Ssc-115732	Sus scrofa	99.81	0.00e+00	1003.00
IUUC-Tgu-117190	Taeniopygia guttata	94.17	0.00e+00	961.00
IUUC-Tru-118735	Takifugu rubripes	72.30	0.00e+00	771.00
IUUC-Tsy-119503	Tarsius syrichta	72.22	0.00e+00	750.00
IUUC-Tni-119833	Tetraodon nigroviridis	83.64	0.00e+00	886.00
IUUC-Tca-121386	Theobroma cacao	46.92	2.00e-118	419.00
IUUC-Tre-122070	Trichoderma reesei	49.03	2.00e-97	350.00
IUUC-Tvi-122305	Trichoderma virens	55.83	2.00e-95	343.00
IUUC-Tae-123515	Triticum aestivum	47.00	3.00e-118	418.00
IUUC-Tur-126416	Triticum urartu	46.25	6.00e-114	404.00
IUUC-Tme-127174	Tuber melanosporum	39.38	3.00e-68	252.00
IUUC-Tbe-127791	Tupaia belangeri	77.83	1.00e-102	366.00
IUUC-Ttr-129224	Tursiops truncatus	95.46	0.00e+00	991.00
IUUC-Uma-129372	Ustilago maydis	65.48	4.00e-103	369.00
IUUC-Vda-129819	Verticillium dahliae	50.00	3.00e-79	289.00
IUUC-Vpa-130220	Vicugna pacos	74.52	0.00e+00	788.00
IUUC-Vvi-131649	Vitis vinifera	47.88	4.00e-118	418.00
IUUC-Xtr-132954	Xenopus tropicalis	73.76	0.00e+00	801.00
IUUC-Xma-134082	Xiphophorus maculatus	83.10	0.00e+00	814.00
IUUC-Yli-134422	Yarrowia lipolytica	42.55	6.00e-109	388.00
IUUC-Zma-135621	Zea mays	53.97	7.00e-113	401.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence