iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000039160.2	ENSBTAT00000005560.5	ENSBTAP00000005560.5
ENSBTAG00000039160.2	ENSBTAT00000056825.2	ENSBTAP00000050922.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.50e-20	73.0	727	778

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ yd+ a +  eL+lk+Gd+v+++ +++  +gW++g  e  g+ G fP+n+ve+
   Q: 727  KARYDFCARDRSELSLKEGDIVKIL-NKKGQQGWWRG--EIYGRIGWFPSNYVEE 778
           788**********************.89999******..9*************86 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

QFLCLKNIRT FLSTCYEKFG LKRSELFEAF DLFDVQDFGK VIYTLSALSW TPIAQNKGIM 60
PFPTEESVGD EDIYSGLSDQ IDDTVEEDED LYDCVENEEA EGDEVYEDLM RSEPVPMPPK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGTTCCTCT GCCTTAAGAA TATCCGCACC TTTCTGTCTA CCTGCTACGA GAAGTTTGGC 60
CTCAAGCGGA GTGAACTCTT TGAGGCCTTC GACCTCTTCG ATGTGCAGGA TTTTGGCAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain

Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR001452--SH3_domain
IPR028530--Vav

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50001--SH2
PS50002--SH3

Pfam

PF00307--CH
PF00621--RhoGEF
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005622--C:intracellular
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0006955--P:immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0030593--P:neutrophil chemotaxis
GO:0006909--P:phagocytosis
GO:0045785--P:positive regulation of cell adhesion
GO:0045954--P:positive regulation of natural killer cell mediated cytotoxicity
GO:0072593--P:reactive oxygen species metabolic process
GO:0008361--P:regulation of cell size
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0030217--P:T cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cja-020009	Callithrix jacchus	80.71	0.00e+00	1241.00
IUUC-Cfa-020768	Canis familiaris	81.85	0.00e+00	1204.00
IUUC-Dno-029602	Dasypus novemcinctus	80.46	0.00e+00	1204.00
IUUC-Eca-033682	Equus caballus	81.85	0.00e+00	1222.00
IUUC-Fca-035629	Felis catus	81.12	0.00e+00	1267.00
IUUC-Hsa-045886	Homo sapiens	80.99	0.00e+00	1246.00
IUUC-Itr-048730	Ictidomys tridecemlineatus	76.04	0.00e+00	1120.00
IUUC-Laf-054537	Loxodonta africana	80.96	0.00e+00	1214.00
IUUC-Mcc-054726	Macaca mulatta	80.46	0.00e+00	1240.00
IUUC-Mmr-060980	Microcebus murinus	80.42	0.00e+00	1211.00
IUUC-Mdo-061926	Monodelphis domestica	73.35	0.00e+00	1070.00
IUUC-Mmu-063942	Mus musculus	78.93	0.00e+00	1184.00
IUUC-Mpu-066000	Mustela putorius furo	81.60	0.00e+00	1201.00
IUUC-Mlu-067818	Myotis lucifugus	81.60	0.00e+00	1228.00
IUUC-Ocu-074830	Oryctolagus cuniculus	70.80	0.00e+00	1045.00
IUUC-Oga-089104	Otolemur garnettii	81.98	0.00e+00	1227.00
IUUC-Oar-089459	Ovis aries	82.21	0.00e+00	1259.00
IUUC-Ptr-090766	Pan troglodytes	80.96	0.00e+00	1247.00
IUUC-Pan-091994	Papio anubis	79.70	0.00e+00	1230.00
IUUC-Psi-093595	Pelodiscus sinensis	66.88	0.00e+00	967.00
IUUC-Pab-098630	Pongo abelii	80.65	0.00e+00	1210.00
IUUC-Pva-102406	Pteropus vampyrus	79.47	0.00e+00	1163.00
IUUC-Rno-105763	Rattus norvegicus	78.75	0.00e+00	1179.00
IUUC-Sha-106683	Sarcophilus harrisii	73.51	0.00e+00	1150.00
IUUC-Sar-113457	Sorex araneus	66.83	0.00e+00	741.00
IUUC-Ssc-115338	Sus scrofa	82.36	0.00e+00	1264.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence