iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000177414.13	ENST00000611228.4	ENSP00000481174.1
ENSG00000177414.13	ENST00000608020.5	ENSP00000477356.1
ENSG00000177414.13	ENST00000608956.1	ENSP00000476556.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC
DNA & RNA Element
UTRdb	CircNet	microRNA	TRANSFAC
RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	GWAS Central
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	19690564

Classification

Family	E-value	Score	Start	End
E2/UBC	1.10e-37	130.6	9	144

Active Site

Position(s)	Description	Evidence
89	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 2    lkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsilkeeekW 92
           l++++ +l++++ +gi+akpv+e d++ewev+i+G ++++++g vF+l+i+f+++Y++ PP vkf+t  fhPnv+++ G+ C+++l+++ekW
   Q: 9    LHRDFCDLKENNYKGITAKPVSE-DMMEWEVEIEGLQNSVWQGLVFQLTIHFTSEYNYAPPVVKFITIPFHPNVDPHtGQPCIDFLDNPEKW 99
           6899*******************.9****************************************************9************** PP
   S: 93   spalsvesvllsiqsllaepnpesplneeaaellkknreeykkkv 137
           ++ ++++s+ll++q +l++p  e+p+n eaa++l k+++ y++++
   Q: 100  NTNYTLSSILLALQVMLSNPVLENPVNLEAARILVKDESLYRTIL 144
           ***************************************999876 PP

Organism

Homo sapiens

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins.

Protein Sequence
(Fasta)

MHGRAYLLLH RDFCDLKENN YKGITAKPVS EDMMEWEVEI EGLQNSVWQG LVFQLTIHFT 60
SEYNYAPPVV KFITIPFHPN VDPHTGQPCI DFLDNPEKWN TNYTLSSILL ALQVMLSNPV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATTTGCTTC CTCCGGTGCG TGGCTGCGGG GTTGCACCTG TGAAGCGAAG ACAACCTGCT 60
AGGACCCTGA TAGGCGTACA CCTCTCACTC CCACTCACGC GCCGACGACA TGGGCTTGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0033503--C:HULC complex
GO:0000790--C:nuclear chromatin
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0006281--P:DNA repair
GO:0016574--P:histone ubiquitination
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination

KEGG

hsa:148581

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002211	Ailuropoda melanoleuca	65.53	5.00e-69	253.00
IUUC-Aca-004682	Anolis carolinensis	42.68	3.00e-51	195.00
IUUC-Bta-013054	Bos taurus	58.70	4.00e-102	364.00
IUUC-Cja-018784	Callithrix jacchus	80.36	6.00e-149	520.00
IUUC-Cfa-020877	Canis familiaris	72.25	8.00e-94	336.00
IUUC-Cpo-022462	Cavia porcellus	59.89	6.00e-59	219.00
IUUC-Csa-023486	Chlorocebus sabaeus	93.81	3.00e-127	447.00
IUUC-Cho-024685	Choloepus hoffmanni	46.75	2.00e-55	209.00
IUUC-Dno-029061	Dasypus novemcinctus	60.62	1.00e-101	362.00
IUUC-Ete-032233	Echinops telfairi	50.67	1.00e-61	229.00
IUUC-Eca-033400	Equus caballus	73.55	3.00e-52	197.00
IUUC-Fca-035778	Felis catus	61.92	6.00e-111	393.00
IUUC-Ggo-044718	Gorilla gorilla	97.52	0.00e+00	643.00
IUUC-Lch-050337	Latimeria chalumnae	40.12	3.00e-60	225.00
IUUC-Loc-051819	Lepisosteus oculatus	34.35	9.00e-48	184.00
IUUC-Laf-054536	Loxodonta africana	67.98	1.00e-89	322.00
IUUC-Mcc-055028	Macaca mulatta	91.61	2.00e-174	604.00
IUUC-Mmr-061623	Microcebus murinus	63.78	2.00e-100	358.00
IUUC-Mdo-062614	Monodelphis domestica	36.76	3.00e-53	202.00
IUUC-Mmu-063194	Mus musculus	55.42	9.00e-72	263.00
IUUC-Mpu-066467	Mustela putorius furo	60.49	6.00e-103	367.00
IUUC-Mlu-067976	Myotis lucifugus	59.15	4.00e-70	257.00
IUUC-Nle-069407	Nomascus leucogenys	92.24	1.00e-174	605.00
IUUC-Opr-070526	Ochotona princeps	63.07	9.00e-54	202.00
IUUC-Oan-073005	Ornithorhynchus anatinus	50.66	7.00e-50	190.00
IUUC-Ocu-074953	Oryctolagus cuniculus	62.85	3.00e-102	364.00
IUUC-Oga-089061	Otolemur garnettii	67.49	2.00e-123	435.00
IUUC-Oar-090147	Ovis aries	56.04	2.00e-97	348.00
IUUC-Ptr-090873	Pan troglodytes	87.85	6.00e-164	569.00
IUUC-Pan-091873	Papio anubis	92.92	5.00e-126	443.00
IUUC-Psi-093780	Pelodiscus sinensis	37.37	5.00e-36	144.00
IUUC-Pab-098662	Pongo abelii	97.79	6.00e-132	462.00
IUUC-Pca-100167	Procavia capensis	48.44	4.00e-57	214.00
IUUC-Pva-102119	Pteropus vampyrus	52.61	9.00e-44	170.00
IUUC-Rno-105522	Rattus norvegicus	47.62	1.00e-70	259.00
IUUC-Sar-113070	Sorex araneus	52.71	8.00e-55	206.00
IUUC-Ssc-115890	Sus scrofa	61.30	2.00e-110	392.00
IUUC-Tsy-119341	Tarsius syrichta	65.64	3.00e-92	331.00
IUUC-Tbe-127433	Tupaia belangeri	53.52	3.00e-78	285.00
IUUC-Ttr-128614	Tursiops truncatus	53.42	1.00e-86	313.00
IUUC-Vpa-130777	Vicugna pacos	55.11	4.00e-94	337.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence