iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000000822.4	ENSPTRT00000001558.4	ENSPTRP00000001417.4
ENSPTRG00000000822.4	ENSPTRT00000059133.3	ENSPTRP00000052235.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	2.00e-38	131.3	9	144

Active Site

Position(s)	Description	Evidence
89	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 2    lkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsilkee 89
           l++++ +l++++ +gi+a+pv+e d++ewev+i+G ++++++g vF+l+i+f+++Y++ PP vkf+t  fhPnv+++ G+ C+++l+++
   Q: 9    LHRDFCDLKENNYKGITARPVSE-DMMEWEVEIEGLQNSVWQGLVFQLTIHFTSEYNYAPPVVKFITIPFHPNVDPHtGQPCIDFLDNP 96
           6899*******************.9****************************************************9*********** PP
   S: 90   ekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkv 137
           ekW++ ++++s+ll++q +l++p  e+p+n eaa++l k+++ y++++
   Q: 97   EKWNTNYTLSSILLALQVMLSNPVLENPVNLEAARILVKDESLYRTIL 144
           ******************************************999876 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MHGRAYLLLH RDFCDLKENN YKGITARPVS EDMMEWEVEI EGLQNSVWQG LVFQLTIHFT 60
SEYNYAPPVV KFITIPFHPN VDPHTGQPCI DFLDNPEKWN TNYTLSSILL ALQVMLSNPV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGCAGATGA GGAAGTGCCC AAGTCTTCCT TCGGGAAGTT CTCGTTTAGA GGAGTCAGGA 60
GAAAAAGTCA TTGTTATATC CCAAATTTAG AAGCCACTTA TCTTGGTACC GTTCTGAGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0033503--C:HULC complex
GO:0000790--C:nuclear chromatin
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0006281--P:DNA repair
GO:0016574--P:histone ubiquitination
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002211	Ailuropoda melanoleuca	64.88	6.00e-68	249.00
IUUC-Aca-004682	Anolis carolinensis	42.68	8.00e-51	193.00
IUUC-Bta-013054	Bos taurus	58.86	3.00e-102	364.00
IUUC-Cja-018784	Callithrix jacchus	72.51	1.00e-131	462.00
IUUC-Cfa-020877	Canis familiaris	71.68	1.00e-92	331.00
IUUC-Cpo-022462	Cavia porcellus	59.89	7.00e-59	219.00
IUUC-Csa-023486	Chlorocebus sabaeus	93.78	3.00e-127	446.00
IUUC-Cho-024685	Choloepus hoffmanni	43.61	1.00e-48	186.00
IUUC-Dno-029061	Dasypus novemcinctus	58.86	2.00e-96	345.00
IUUC-Ete-032233	Echinops telfairi	50.67	7.00e-61	226.00
IUUC-Eca-033400	Equus caballus	73.55	2.00e-52	197.00
IUUC-Fca-035778	Felis catus	59.87	3.00e-103	367.00
IUUC-Ggo-044718	Gorilla gorilla	86.96	3.00e-162	563.00
IUUC-Hsa-046798	Homo sapiens	87.85	6.00e-164	569.00
IUUC-Lch-050337	Latimeria chalumnae	38.81	8.00e-61	226.00
IUUC-Loc-051819	Lepisosteus oculatus	36.56	2.00e-47	182.00
IUUC-Laf-054536	Loxodonta africana	68.28	6.00e-89	319.00
IUUC-Mcc-055028	Macaca mulatta	82.92	3.00e-154	537.00
IUUC-Mmr-061623	Microcebus murinus	60.19	7.00e-90	323.00
IUUC-Mdo-062614	Monodelphis domestica	36.47	7.00e-50	190.00
IUUC-Mmu-063194	Mus musculus	57.59	4.00e-69	254.00
IUUC-Mpu-066467	Mustela putorius furo	57.50	1.00e-93	336.00
IUUC-Mlu-067976	Myotis lucifugus	60.62	1.00e-69	256.00
IUUC-Nle-069407	Nomascus leucogenys	83.23	9.00e-153	532.00
IUUC-Opr-070526	Ochotona princeps	62.50	3.00e-53	201.00
IUUC-Oan-073005	Ornithorhynchus anatinus	51.14	1.00e-49	189.00
IUUC-Ocu-074953	Oryctolagus cuniculus	60.94	2.00e-95	342.00
IUUC-Oga-089061	Otolemur garnettii	62.31	1.00e-111	395.00
IUUC-Oar-090147	Ovis aries	56.01	1.00e-93	336.00
IUUC-Pan-091873	Papio anubis	93.33	2.00e-126	444.00
IUUC-Psi-093780	Pelodiscus sinensis	38.55	3.00e-34	138.00
IUUC-Pab-098662	Pongo abelii	97.33	2.00e-131	461.00
IUUC-Pca-100167	Procavia capensis	48.89	5.00e-57	214.00
IUUC-Pva-102119	Pteropus vampyrus	47.39	2.00e-33	135.00
IUUC-Rno-105522	Rattus norvegicus	52.91	6.00e-68	250.00
IUUC-Sar-113070	Sorex araneus	52.22	2.00e-54	204.00
IUUC-Ssc-115890	Sus scrofa	57.99	2.00e-101	362.00
IUUC-Tsy-119341	Tarsius syrichta	60.85	9.00e-82	296.00
IUUC-Tbe-127433	Tupaia belangeri	49.85	4.00e-68	251.00
IUUC-Ttr-128614	Tursiops truncatus	50.47	4.00e-76	277.00
IUUC-Vpa-130777	Vicugna pacos	52.45	1.00e-87	316.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence