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Tag Content
UUCD2 ID IUUC-Cfa-020324
UUCD1 version UUC-CaF-00930
Ensembl Protein ID ENSCAFP00000030260.3
UniProt Accession E2RE24; E2RE24_CANLF
Genbank Protein ID ENSCAFP00000030260
Protein Name NEDD8-activating enzyme E1 regulatory subunit
Genbank Nucleotide ID AAEX03004132
Gene Name NAE1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSCAFG00000020403.3 ENSCAFT00000032493.3 ENSCAFP00000030260.3
Status Unreviewed
Classification
Family E-Value Score Start End
E1 3.40e-132 441.9 13 525
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E1

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
    YDRQ+rlwG+++qe+l+sa+v+l++a+++G+E+lKnLvl G+gs+t++D+++v+ ++ +++F+++++++gk++A++a+e+l+eln dv+
   Q: 13 YDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFFLQRSSIGKNRAQAAMEFLQELNNDVS 101
    ***************************************************************************************** PP
   S: 90 veaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfc 174
    + ++ees+++l ++++ Ff++f++Vv+++ ++++ ++++++++n ++pl++++t+Gl+G++r+iik++++++s++d +++++++Pf+
   Q: 102 GNFVEESPENLLDNDPsFFCRFTIVVATQLPESTLLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDnalEDLRLDKPFP 190
    ***************************************************************************************** PP
   S: 175 tlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafakt 248
    +l+e+++ +++++++w+v+++k+l+++++e++++ +++++eke+++d++++++ + edeenfeeai+++++a+++t
   Q: 191 ELREHFQsydldrmekKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEKEDFRDLIRQGILKnengapEDEENFEEAIKNVNTALNTT 279
    *****99999999998***********************************************9************************* PP
   S: 249 tins.ikqllksfecdivtkskspfwv.............................................................. 274
    +i+s i++++++++c ++tk++++fw+
   Q: 280 QIPSsIEDIFNDDHCINITKQTPSFWIlaralkefvakegqgnlpvrgtipdmiadsskyiklqnvyrekakkdaaavgnhvakllqsi 368
    ***************************************************************************************** PP
   S: 275 .............sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..a 332
    +c+n++ l+v +++kde+++++++p lyl+lra++rf+k++gr+pg++++++++d+ +
   Q: 369 gqapesisekelkLLCTNSAFLRVVrcrslaeeyglNTINKDEIISSMDNPdneivLYLMLRAVDRFHKQHGRYPGVSNYQVEEDIgkL 457
    *************9999999999777777777788899999999999999999999******************************999 PP
   S: 333 vdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
    +++t ++ +++g++ +++dd+++e++++++++ +t++a++gG+aaqEviK+++++f+ ++n++++ ++
   Q: 458 KSCLTGFL----QEYGLSVMVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGM 525
    ********....********************************************************9776 PP
   

Organism Canis familiaris
Functional Description
(View)

Functional Description



     Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.
Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.
Protein Sequence
(Fasta)
MAQPGKLLKE QKYDRQLRLW GDHGQEALES AHVCLINATA TGTEILKNLV LPGIGSFTII 60
DGNQVSGEDA GNNFFLQRSS IGKNRAQAAM EFLQELNNDV SGNFVEESPE NLLDNDPSFF 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Cfa-020324|E1,E1_ThiF|Canis familiaris
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGGCGGCGA CAGGCGCTCA GTGCGCCTGC GCGCTCGCGG AGGTGGCGGC GGCGCTCGGC 60
GGGGCTCGGC TGTTCGCGCG GCGGGTGCGG CCATGGCGCA ACCGGGGAAG CTGCTCAAGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Cfa-020324|E1,E1_ThiF|Canis familiaris
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0033314--P:mitotic DNA replication checkpoint
GO:0051402--P:neuron apoptotic process
GO:0045116--P:protein neddylation
GO:0043523--P:regulation of neuron apoptotic process

KEGG cfa:610026
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000764 Aegilops tauschii 42.53 5.00e-127 447.00
IUUC-Aml-002333 Ailuropoda melanoleuca 98.32 0.00e+00 1096.00
IUUC-Atr-002644 Amborella trichopoda 41.54 1.00e-115 410.00
IUUC-Apl-003446 Anas platyrhynchos 84.59 0.00e+00 926.00
IUUC-Aca-004450 Anolis carolinensis 80.86 0.00e+00 926.00
IUUC-Aly-006187 Arabidopsis lyrata 40.19 2.00e-126 446.00
IUUC-Ath-007600 Arabidopsis thaliana 40.93 2.00e-128 452.00
IUUC-Ago-007900 Ashbya gossypii 26.79 8.00e-40 157.00
IUUC-Acl-008333 Aspergillus clavatus 34.17 2.00e-81 296.00
IUUC-Afl-008529 Aspergillus flavus 36.38 4.00e-87 315.00
IUUC-Afu-009071 Aspergillus fumigatus 33.51 2.00e-81 296.00
IUUC-Ani-009443 Aspergillus nidulans 33.21 2.00e-78 286.00
IUUC-Ang-009669 Aspergillus niger 33.33 1.00e-82 300.00
IUUC-Aor-009914 Aspergillus oryzae 35.70 7.00e-84 304.00
IUUC-Ate-010450 Aspergillus terreus 34.40 9.00e-84 304.00
IUUC-Ame-011183 Astyanax mexicanus 72.21 0.00e+00 833.00
IUUC-Bgr-012111 Blumeria graminis 33.39 1.00e-67 250.00
IUUC-Bta-012583 Bos taurus 97.75 0.00e+00 1090.00
IUUC-Bci-013892 Botrytis cinerea 33.09 4.00e-67 248.00
IUUC-Bdi-014592 Brachypodium distachyon 43.51 7.00e-130 457.00
IUUC-Bol-016399 Brassica oleracea 40.08 1.00e-124 439.00
IUUC-Bra-017506 Brassica rapa 38.81 9.00e-121 427.00
IUUC-Cel-018456 Caenorhabditis elegans 35.79 1.00e-93 337.00
IUUC-Cja-020007 Callithrix jacchus 97.21 0.00e+00 1087.00
IUUC-Cpo-022248 Cavia porcellus 66.36 0.00e+00 643.00
IUUC-Csa-023149 Chlorocebus sabaeus 97.79 0.00e+00 924.00
IUUC-Cho-024537 Choloepus hoffmanni 85.47 0.00e+00 808.00
IUUC-Cin-025763 Ciona intestinalis 49.72 5.00e-156 544.00
IUUC-Csv-026113 Ciona savignyi 46.48 1.00e-146 513.00
IUUC-Cgl-026428 Colletotrichum gloeosporioides 32.34 1.00e-67 250.00
IUUC-Cne-026884 Cryptococcus neoformans 30.26 2.00e-72 266.00
IUUC-Cme-027210 Cyanidioschyzon merolae 27.11 5.00e-19 89.40
IUUC-Dre-028140 Danio rerio 73.22 0.00e+00 853.00
IUUC-Dno-030033 Dasypus novemcinctus 97.67 0.00e+00 962.00
IUUC-Dor-030513 Dipodomys ordii 68.37 3.00e-115 409.00
IUUC-Dse-031536 Dothistroma septosporum 35.47 4.00e-87 315.00
IUUC-Dme-031683 Drosophila melanogaster 44.70 1.00e-127 449.00
IUUC-Ete-032420 Echinops telfairi 83.53 0.00e+00 889.00
IUUC-Eca-033992 Equus caballus 97.75 0.00e+00 913.00
IUUC-Eeu-034713 Erinaceus europaeus 79.13 2.00e-116 412.00
IUUC-Fca-036548 Felis catus 97.38 0.00e+00 1083.00
IUUC-Fal-037600 Ficedula albicollis 81.23 0.00e+00 892.00
IUUC-Fox-038037 Fusarium oxysporum 33.76 3.00e-77 282.00
IUUC-Fso-038387 Fusarium solani 35.20 4.00e-80 292.00
IUUC-Gmo-038562 Gadus morhua 71.78 0.00e+00 826.00
IUUC-Ggr-040005 Gaeumannomyces graminis 34.89 7.00e-75 274.00
IUUC-Gga-041129 Gallus gallus 85.05 0.00e+00 949.00
IUUC-Gac-042558 Gasterosteus aculeatus 72.88 0.00e+00 836.00
IUUC-Gma-043610 Glycine max 41.34 2.00e-122 432.00
IUUC-Ggo-045611 Gorilla gorilla 97.21 0.00e+00 1084.00
IUUC-Hsa-046563 Homo sapiens 97.75 0.00e+00 1088.00
IUUC-Hvu-047790 Hordeum vulgare 38.11 3.00e-77 282.00
IUUC-Itr-048066 Ictidomys tridecemlineatus 97.19 0.00e+00 1087.00
IUUC-Kpa-049309 Komagataella pastoris 35.86 2.00e-83 303.00
IUUC-Lch-050038 Latimeria chalumnae 76.42 0.00e+00 856.00
IUUC-Lpe-051535 Leersia perrieri 41.45 2.00e-112 399.00
IUUC-Loc-051917 Lepisosteus oculatus 69.74 0.00e+00 795.00
IUUC-Lma-053112 Leptosphaeria maculans 35.58 2.00e-88 320.00
IUUC-Laf-053690 Loxodonta africana 96.63 0.00e+00 1084.00
IUUC-Mcc-055117 Macaca mulatta 95.91 0.00e+00 1071.00
IUUC-Meu-056761 Macropus eugenii 76.99 0.00e+00 830.00
IUUC-Mor-057230 Magnaporthe oryzae 34.35 2.00e-79 289.00
IUUC-Mpo-057514 Magnaporthe poae 34.35 7.00e-73 268.00
IUUC-Mtr-058551 Medicago truncatula 40.14 8.00e-119 420.00
IUUC-Mla-059183 Melampsora laricipopulina 37.18 3.00e-98 352.00
IUUC-Mga-060144 Meleagris gallopavo 83.33 0.00e+00 919.00
IUUC-Mvi-060221 Microbotryum violaceum 36.36 1.00e-84 307.00
IUUC-Mmr-061325 Microcebus murinus 95.16 0.00e+00 1065.00
IUUC-Mdo-062532 Monodelphis domestica 91.18 0.00e+00 1025.00
IUUC-Mmu-063956 Mus musculus 96.82 0.00e+00 1083.00
IUUC-Mac-064521 Musa acuminata 40.93 3.00e-124 438.00
IUUC-Mpu-066716 Mustela putorius furo 98.01 0.00e+00 1034.00
IUUC-Mlu-067459 Myotis lucifugus 95.52 0.00e+00 1063.00
IUUC-Nfi-068245 Neosartorya fischeri 33.87 1.00e-81 296.00
IUUC-Ncr-068910 Neurospora crassa 34.55 6.00e-79 288.00
IUUC-Nle-070034 Nomascus leucogenys 95.05 0.00e+00 1040.00
IUUC-Opr-070552 Ochotona princeps 86.83 0.00e+00 883.00
IUUC-Ont-071426 Oreochromis niloticus 73.53 0.00e+00 853.00
IUUC-Oan-073389 Ornithorhynchus anatinus 84.04 0.00e+00 783.00
IUUC-Ocu-074911 Oryctolagus cuniculus 96.25 0.00e+00 1085.00
IUUC-Oba-075437 Oryza barthii 42.94 2.00e-119 422.00
IUUC-Obr-076684 Oryza brachyantha 43.13 6.00e-115 407.00
IUUC-Ogl-077170 Oryza glaberrima 42.94 2.00e-119 422.00
IUUC-Ogu-078844 Oryza glumaepatula 43.71 9.00e-113 400.00
IUUC-Oin-079105 Oryza indica 42.94 8.00e-119 420.00
IUUC-Olo-080943 Oryza longistaminata 40.44 2.00e-107 382.00
IUUC-Oni-082891 Oryza nivara 40.08 6.00e-113 401.00
IUUC-Opu-083457 Oryza punctata 42.94 6.00e-119 421.00
IUUC-Oru-084960 Oryza rufipogon 40.44 2.00e-107 382.00
IUUC-Osa-085358 Oryza sativa 43.13 1.00e-119 423.00
IUUC-Ola-086420 Oryzias latipes 71.05 5.00e-168 583.00
IUUC-Olu-087625 Ostreococcus lucimarinus 30.89 2.00e-61 229.00
IUUC-Oga-088810 Otolemur garnettii 97.19 0.00e+00 1089.00
IUUC-Oar-089196 Ovis aries 97.21 0.00e+00 1087.00
IUUC-Ptr-090617 Pan troglodytes 97.94 0.00e+00 1090.00
IUUC-Pan-092761 Papio anubis 97.94 0.00e+00 1094.00
IUUC-Psi-093191 Pelodiscus sinensis 87.04 0.00e+00 966.00
IUUC-Pma-094380 Petromyzon marinus 62.07 0.00e+00 668.00
IUUC-Pno-095084 Phaeosphaeria nodorum 33.03 1.00e-75 278.00
IUUC-Ppa-095875 Physcomitrella patens 40.23 6.00e-121 427.00
IUUC-Pfo-096467 Poecilia formosa 72.78 0.00e+00 835.00
IUUC-Pab-098255 Pongo abelii 97.30 0.00e+00 907.00
IUUC-Pop-099722 Populus trichocarpa 40.75 6.00e-126 444.00
IUUC-Pca-100807 Procavia capensis 79.62 2.00e-119 422.00
IUUC-Ppe-101280 Prunus persica 40.41 2.00e-124 439.00
IUUC-Pva-102333 Pteropus vampyrus 92.92 0.00e+00 1026.00
IUUC-Pgr-103401 Puccinia graminis 31.96 1.00e-82 300.00
IUUC-Ptt-103889 Puccinia triticina 28.02 3.00e-60 226.00
IUUC-Pte-104355 Pyrenophora teres 36.36 6.00e-92 331.00
IUUC-Pyt-104545 Pyrenophora triticirepentis 36.36 9.00e-93 334.00
IUUC-Rno-105810 Rattus norvegicus 96.44 0.00e+00 1079.00
IUUC-Sce-106397 Saccharomyces cerevisiae 26.29 6.00e-38 151.00
IUUC-Sha-106770 Sarcophilus harrisii 89.75 1.00e-154 538.00
IUUC-Sja-107926 Schizosaccharomyces japonicus 33.46 4.00e-79 288.00
IUUC-Spo-108276 Schizosaccharomyces pombe 34.90 3.00e-83 302.00
IUUC-Ssl-108387 Sclerotinia sclerotiorum 32.66 1.00e-68 254.00
IUUC-Smo-109296 Selaginella moellendorffii 42.61 4.00e-125 441.00
IUUC-Sit-110157 Setaria italica 44.40 3.00e-136 478.00
IUUC-Sly-111105 Solanum lycopersicum 39.93 3.00e-123 435.00
IUUC-Stu-112469 Solanum tuberosum 39.93 4.00e-125 441.00
IUUC-Sar-113083 Sorex araneus 73.45 0.00e+00 752.00
IUUC-Sbi-113813 Sorghum bicolor 44.40 2.00e-135 475.00
IUUC-Sre-115058 Sporisorium reilianum 39.11 1.00e-85 310.00
IUUC-Tgu-116772 Taeniopygia guttata 81.40 0.00e+00 897.00
IUUC-Tru-118686 Takifugu rubripes 71.83 0.00e+00 837.00
IUUC-Tsy-119111 Tarsius syrichta 90.11 8.00e-151 526.00
IUUC-Tni-120231 Tetraodon nigroviridis 66.60 0.00e+00 754.00
IUUC-Tca-121491 Theobroma cacao 40.78 2.00e-118 419.00
IUUC-Tre-122103 Trichoderma reesei 37.50 6.00e-84 304.00
IUUC-Tvi-122672 Trichoderma virens 37.02 7.00e-77 281.00
IUUC-Tae-125679 Triticum aestivum 43.13 3.00e-129 455.00
IUUC-Tur-126487 Triticum urartu 41.79 1.00e-122 433.00
IUUC-Tme-127097 Tuber melanosporum 39.09 2.00e-96 346.00
IUUC-Ttr-128465 Tursiops truncatus 90.69 0.00e+00 1003.00
IUUC-Uma-129645 Ustilago maydis 33.83 1.00e-90 327.00
IUUC-Vda-129989 Verticillium dahliae 31.47 4.00e-58 218.00
IUUC-Vpa-130529 Vicugna pacos 92.74 0.00e+00 1031.00
IUUC-Vvi-131059 Vitis vinifera 41.34 5.00e-124 437.00
IUUC-Xtr-132002 Xenopus tropicalis 78.94 0.00e+00 905.00
IUUC-Xma-133930 Xiphophorus maculatus 73.19 0.00e+00 841.00
IUUC-Yli-134505 Yarrowia lipolytica 35.24 2.00e-86 312.00
IUUC-Zma-135895 Zea mays 44.66 2.00e-134 472.00
Created Date 25-Jun-2017

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