iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-073464

UUCD1 version

UUC-OrA-00648

Ensembl Protein ID

ENSOANP00000007320.3

UniProt Accession

F7G160; F7G160_ORNAN

Protein Name

Uncharacterized protein

Gene Name

HERC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000004618.3	ENSOANT00000007322.3	ENSOANP00000007320.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.10e-100	334.9	677	1000

Active Site

Position(s)	Description	Evidence
969	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           d kk l+v fvgEe++d+gGv +ef+ l+++el +p++g+f+y e+++  ++ +++      e  +lF+++G+++g+a+++  ++dl
   Q: 677  DYKKPLKVIFVGEEAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEESRLIWFSDKTF-----EDSDLFHLIGVICGLAIYNFTIVDL 758
           78999***********************************************98877.....689********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll+kk sl+dl+e+ p++ +s+++++++ e+d+ee+ ++l+f+++ e++g t+++eL+ +G++i V++eN++e+v+++
   Q: 759  HFPLALYKKLLKKKPSLDDLKELIPDVGRSMQQLLDYPEDDVEET-FCLNFTITVENFGATEVKELIVNGAEIAVNKENRHEFVEAY 844
           *************************************99999997.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y++++++++ ++af++Gf++v+  ++l+lF+++el+ ++ G++++d+++l+k+t+ykg+y +++p+i+ Fwev++e+  e +k f
   Q: 845  VDYIFNKSVASLFDAFHAGFHKVCGGKVLQLFHPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLERKKLF 931
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+++lk    vi+   + +  lP s+TCfn+L+LP+Y+ ke+l+ kL  Ai++++gF+l
   Q: 932  LLFLTGSDRIPILGMRSLK---LVIQPtGGGEGYLPVSHTCFNLLDLPKYTDKETLRCKLNQAIDHNEGFSL 1000
           *******************...6666658899**************************************86 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

DLLLSTKLEL KFLSFLVFVE QVVALDAQNI VAVSCGDAHT LALNDKGQVY AWGLDTDGQL 60
GLPGTEECIR VPRNIKSLSD IQIVQVSCGY YHSLALSKGS EVFSWGQNKY GQLGLGFEFK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGATTTACTT TTAAGTACAA AACTGGAACT TAAATTTCTT TCCTTCTTGG TTTTTGTAGA 60
GCAGGTTGTT GCCCTGGATG CCCAAAATAT TGTAGCTGTT TCATGTGGAG ACGCTCATAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0001650--C:fibrillar center
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007283--P:spermatogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001666	Ailuropoda melanoleuca	92.97	0.00e+00	1776.00
IUUC-Apl-003295	Anas platyrhynchos	87.89	0.00e+00	1728.00
IUUC-Aca-004336	Anolis carolinensis	85.48	0.00e+00	1669.00
IUUC-Ame-010768	Astyanax mexicanus	71.92	0.00e+00	1428.00
IUUC-Bta-013279	Bos taurus	92.87	0.00e+00	1768.00
IUUC-Cel-018150	Caenorhabditis elegans	35.03	2.00e-140	493.00
IUUC-Cja-019023	Callithrix jacchus	92.57	0.00e+00	1769.00
IUUC-Cfa-021074	Canis familiaris	92.87	0.00e+00	1774.00
IUUC-Cpo-021461	Cavia porcellus	90.24	0.00e+00	1716.00
IUUC-Csa-024261	Chlorocebus sabaeus	92.67	0.00e+00	1771.00
IUUC-Cho-024513	Choloepus hoffmanni	72.77	0.00e+00	1272.00
IUUC-Cin-025232	Ciona intestinalis	44.39	0.00e+00	798.00
IUUC-Dre-028829	Danio rerio	73.45	0.00e+00	1416.00
IUUC-Dno-029445	Dasypus novemcinctus	90.65	0.00e+00	1565.00
IUUC-Dor-030158	Dipodomys ordii	91.43	0.00e+00	842.00
IUUC-Dme-032103	Drosophila melanogaster	45.43	0.00e+00	816.00
IUUC-Ete-033072	Echinops telfairi	81.47	0.00e+00	1501.00
IUUC-Eca-033317	Equus caballus	91.55	0.00e+00	1746.00
IUUC-Eeu-035098	Erinaceus europaeus	46.74	0.00e+00	684.00
IUUC-Fca-035682	Felis catus	92.36	0.00e+00	1754.00
IUUC-Fal-036969	Ficedula albicollis	86.66	0.00e+00	1705.00
IUUC-Gmo-038671	Gadus morhua	72.87	0.00e+00	1432.00
IUUC-Gga-041174	Gallus gallus	87.78	0.00e+00	1729.00
IUUC-Gac-042600	Gasterosteus aculeatus	73.30	0.00e+00	1385.00
IUUC-Ggo-044589	Gorilla gorilla	92.77	0.00e+00	1798.00
IUUC-Hsa-046772	Homo sapiens	92.67	0.00e+00	1793.00
IUUC-Itr-048311	Ictidomys tridecemlineatus	55.04	0.00e+00	1019.00
IUUC-Lch-050147	Latimeria chalumnae	80.86	0.00e+00	1310.00
IUUC-Loc-052684	Lepisosteus oculatus	79.84	0.00e+00	1560.00
IUUC-Laf-053844	Loxodonta africana	92.36	0.00e+00	1763.00
IUUC-Mcc-055531	Macaca mulatta	90.36	0.00e+00	1754.00
IUUC-Meu-056274	Macropus eugenii	47.97	3.00e-121	429.00
IUUC-Mga-060151	Meleagris gallopavo	87.39	0.00e+00	1415.00
IUUC-Mmr-060954	Microcebus murinus	92.67	0.00e+00	1765.00
IUUC-Mdo-062246	Monodelphis domestica	90.64	0.00e+00	1762.00
IUUC-Mmu-063369	Mus musculus	91.65	0.00e+00	1756.00
IUUC-Mpu-065936	Mustela putorius furo	92.88	0.00e+00	1781.00
IUUC-Mlu-067326	Myotis lucifugus	92.67	0.00e+00	1736.00
IUUC-Nle-069453	Nomascus leucogenys	91.96	0.00e+00	1745.00
IUUC-Opr-070891	Ochotona princeps	50.27	0.00e+00	838.00
IUUC-Ont-071720	Oreochromis niloticus	74.41	0.00e+00	1445.00
IUUC-Ocu-074207	Oryctolagus cuniculus	90.52	0.00e+00	1770.00
IUUC-Ola-086762	Oryzias latipes	72.78	0.00e+00	1375.00
IUUC-Oga-088435	Otolemur garnettii	92.57	0.00e+00	1764.00
IUUC-Oar-089233	Ovis aries	92.77	0.00e+00	1767.00
IUUC-Ptr-091368	Pan troglodytes	92.97	0.00e+00	1799.00
IUUC-Pan-092300	Papio anubis	92.67	0.00e+00	1771.00
IUUC-Psi-093406	Pelodiscus sinensis	88.70	0.00e+00	1742.00
IUUC-Pma-094113	Petromyzon marinus	70.08	0.00e+00	1117.00
IUUC-Ppa-095354	Physcomitrella patens	32.63	6.00e-135	474.00
IUUC-Pfo-097021	Poecilia formosa	72.48	0.00e+00	1448.00
IUUC-Pab-098327	Pongo abelii	92.77	0.00e+00	1794.00
IUUC-Pca-101075	Procavia capensis	90.44	0.00e+00	792.00
IUUC-Pva-102909	Pteropus vampyrus	81.26	0.00e+00	1476.00
IUUC-Rno-105457	Rattus norvegicus	92.36	0.00e+00	1779.00
IUUC-Sha-106632	Sarcophilus harrisii	91.14	0.00e+00	1768.00
IUUC-Sar-113679	Sorex araneus	83.26	0.00e+00	1094.00
IUUC-Ssc-115473	Sus scrofa	55.50	0.00e+00	1029.00
IUUC-Tgu-116849	Taeniopygia guttata	82.08	0.00e+00	1588.00
IUUC-Tru-118206	Takifugu rubripes	71.92	0.00e+00	1337.00
IUUC-Tsy-119521	Tarsius syrichta	77.70	0.00e+00	1388.00
IUUC-Tni-120233	Tetraodon nigroviridis	70.30	0.00e+00	1317.00
IUUC-Tbe-127941	Tupaia belangeri	76.19	0.00e+00	1302.00
IUUC-Ttr-128926	Tursiops truncatus	92.11	0.00e+00	1087.00
IUUC-Vpa-130448	Vicugna pacos	92.06	0.00e+00	1760.00
IUUC-Xtr-132719	Xenopus tropicalis	71.25	0.00e+00	1312.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence