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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064104
Ensembl Protein ID ENSMUSP00000027929.4
UniProt Accession Q8VHJ5; E9QL17; Q69ZI7; MARK1_MOUSE
Genbank Protein ID AAL50826.1; BAD32459.1
Protein Name Serine/threonine-protein kinase MARK1; ELKL motif serine/threonine-protein kinase 3; MAP/microtubule affinity-regulating kinase 1; PAR1 homolog c
Genbank Nucleotide ID AF453686; AC117826
Gene Name Mark1; Emk3; Kiaa1477
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000026620.11 ENSMUST00000027929.9 ENSMUSP00000027929.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexMentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/UBA 94.34 0.00e+00 1419.00 IUUC-Hsa-046631
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3) (By similarity).
 Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3) (By similarity).
Protein Sequence
(Fasta)
MSARTPLPTV NERDTENHTS VDGYTETHIP PAKSSSRQNL PRCRNSITSA TDEQPHIGNY 60
RLQKTIGKGN FAKVKLARHV LTGREVAVKI IDKTQLNPTS LQKLFREVRI MKILNHPNIV 120
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Protein Fasta Sequence


>IUUC-Mmu-064104|UBD,UBA|Mus musculus
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Nucleotide Sequence
(Fasta)
TCCCCGGCGC GGCCTGCTCG CGCGCGCCCG CCCTCGCCGA AGCCCTCCGC GGCCCGCGAC 60
CCGCCGGACC CCCCGCTCGA CCCCGCTGCC CGCGCAAGAT GTCGGCGCGG ACGCCATTGC 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064104|UBD,UBA|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0418--Kinase
KW-0446--Lipid-binding
KW-0460--Magnesium
KW-0472--Membrane
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0879--Wnt signaling pathway
Interpro

IPR028375--KA1/Ssp2_C
IPR001772--KA1_dom
IPR011009--Kinase-like_dom
IPR033624--MARK/par1
IPR033627--MARK1
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
IPR015940--UBA
PROSITE

PS50032--KA1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50030--UBA
Pfam

PF02149--KA1
PF00069--Pkinase
PF00627--UBA
SMART

SM00220--S_TKc
SM00165--UBA
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0070300--F:phosphatidic acid binding
GO:0005546--F:phosphatidylinositol-4,5-bisphosphate binding
GO:0001786--F:phosphatidylserine binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0050321--F:tau-protein kinase activity
GO:0030010--P:establishment of cell polarity
GO:0035556--P:intracellular signal transduction
GO:0000226--P:microtubule cytoskeleton organization
GO:0001764--P:neuron migration
GO:0006468--P:protein phosphorylation
GO:0016055--P:Wnt signaling pathway
KEGG mmu:226778
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001559 Ailuropoda melanoleuca 94.74 0.00e+00 1420.00
IUUC-Aca-004735 Anolis carolinensis 66.47 0.00e+00 1026.00
IUUC-Ame-011737 Astyanax mexicanus 70.95 0.00e+00 1034.00
IUUC-Bta-013462 Bos taurus 94.09 0.00e+00 1380.00
IUUC-Cja-019358 Callithrix jacchus 94.09 0.00e+00 1481.00
IUUC-Cfa-020498 Canis familiaris 93.57 0.00e+00 1370.00
IUUC-Cpo-022467 Cavia porcellus 91.28 0.00e+00 1399.00
IUUC-Csa-023035 Chlorocebus sabaeus 94.21 0.00e+00 1491.00
IUUC-Dre-028387 Danio rerio 67.40 0.00e+00 994.00
IUUC-Dno-029052 Dasypus novemcinctus 67.92 0.00e+00 1009.00
IUUC-Dor-031094 Dipodomys ordii 86.29 0.00e+00 1246.00
IUUC-Ete-032429 Echinops telfairi 83.27 0.00e+00 1233.00
IUUC-Eca-033265 Equus caballus 94.47 0.00e+00 1360.00
IUUC-Fca-035360 Felis catus 89.23 0.00e+00 1302.00
IUUC-Fal-036617 Ficedula albicollis 89.34 0.00e+00 1186.00
IUUC-Gga-040502 Gallus gallus 71.66 0.00e+00 1067.00
IUUC-Gac-041559 Gasterosteus aculeatus 77.04 0.00e+00 1130.00
IUUC-Hsa-046631 Homo sapiens 94.34 0.00e+00 1492.00
IUUC-Laf-054266 Loxodonta africana 92.02 0.00e+00 1393.00
IUUC-Mcc-054650 Macaca mulatta 94.34 0.00e+00 1487.00
IUUC-Mdo-061932 Monodelphis domestica 86.86 0.00e+00 1324.00
IUUC-Mpu-065989 Mustela putorius furo 93.58 0.00e+00 1150.00
IUUC-Mlu-067700 Myotis lucifugus 92.28 0.00e+00 1308.00
IUUC-Nle-069385 Nomascus leucogenys 93.31 0.00e+00 1467.00
IUUC-Ont-071262 Oreochromis niloticus 79.45 0.00e+00 1181.00
IUUC-Oan-073352 Ornithorhynchus anatinus 89.69 0.00e+00 1373.00
IUUC-Ocu-073777 Oryctolagus cuniculus 94.59 0.00e+00 1428.00
IUUC-Oar-089313 Ovis aries 90.77 0.00e+00 1355.00
IUUC-Ptr-091421 Pan troglodytes 94.09 0.00e+00 1485.00
IUUC-Pan-092891 Papio anubis 69.82 0.00e+00 1056.00
IUUC-Psi-093307 Pelodiscus sinensis 89.46 0.00e+00 1321.00
IUUC-Pma-094666 Petromyzon marinus 68.00 0.00e+00 1033.00
IUUC-Pab-098232 Pongo abelii 94.59 0.00e+00 1495.00
IUUC-Pca-100975 Procavia capensis 81.85 0.00e+00 820.00
IUUC-Pva-102596 Pteropus vampyrus 87.50 0.00e+00 1347.00
IUUC-Rno-105027 Rattus norvegicus 97.23 0.00e+00 1440.00
IUUC-Sha-106668 Sarcophilus harrisii 88.30 0.00e+00 1310.00
IUUC-Ssc-115321 Sus scrofa 69.47 0.00e+00 958.00
IUUC-Tgu-116652 Taeniopygia guttata 89.18 0.00e+00 1386.00
IUUC-Tru-118387 Takifugu rubripes 59.93 0.00e+00 897.00
IUUC-Tsy-119138 Tarsius syrichta 81.69 0.00e+00 914.00
IUUC-Tni-120412 Tetraodon nigroviridis 78.28 0.00e+00 1156.00
IUUC-Tbe-127841 Tupaia belangeri 94.36 0.00e+00 1193.00
IUUC-Ttr-128406 Tursiops truncatus 93.86 0.00e+00 1409.00
Created Date 25-Jun-2017

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