iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-120178

UUCD1 version

UUC-TeN-00743

Ensembl Protein ID

ENSTNIP00000022143.1

UniProt Accession

H3DNP4; H3DNP4_TETNG

Protein Name

Uncharacterized protein

Gene Name

HECW1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000018955.1	ENSTNIT00000022380.1	ENSTNIP00000022143.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.10e-120	402.3	1250	1582

Active Site

Position(s)	Description	Evidence
1550	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+++f+gEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  ++hl++F+f Gr+lg+al ++ lld
   Q: 1250 ELQRNKLYITFLGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFCGRILGLALIHQYLLD 1335
           567899****************************************************985.6************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ + +l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLk+gG++++Vt++Nk++Y+++
   Q: 1336 AFFTRPFYKALLRLPTDLSDLEYLDEEFHQSLQWMKDN---DITDI-LDLTFTVNEEVFGQVTERELKSGGSHVQVTEKNKKDYIER 1418
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           ++++r+++g+ +q+ea+ +Gf+ev++ +l+s+F+++elel+i G+ eid++d++++t+y+ggy++ + +++wFw ++e+f++e+r +
   Q: 1419 MAKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTVEIDLSDWRSNTEYRGGYHDGHIVMRWFWAAVERFNNEQRLR 1505
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s++ l+ekLl+A+eet+ F+l+
   Q: 1506 LLQFVTGTSSVPYEGFAALRgsngLRRFCIEKWGRVASLPRAHTCFNRLDLPPYPSYTLLYEKLLIAVEETSTFGLE 1582
           ************************999***********************************************985 PP

Organism

Tetraodon nigroviridis

Protein Sequence
(Fasta)

SASGSLVIML MPLCSIKNLY QNRFLGLAAM ASPSRSSGAR QSKEAARHSC GPDSYAANGL 60
NQEAFLLGRA RSTSDTDLLS PDARSTLAIS SSPYVIGQSE DLVITWDIKE DVDAGDWIGM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTGCTTCTG GTTCACTGGT CATTATGCTG ATGCCTCTCT GTAGCATTAA GGTTAGTGCA 60
CCTCCGCCTC ATGGCCTCCA CCACCACCCT CATCCGCTCA CCGGCCACCA CCCACTCACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	70.56	0.00e+00	1345.00
IUUC-Apl-003299	Anas platyrhynchos	64.43	0.00e+00	1858.00
IUUC-Aca-005024	Anolis carolinensis	64.82	0.00e+00	1866.00
IUUC-Bta-012604	Bos taurus	62.52	0.00e+00	1827.00
IUUC-Cja-019880	Callithrix jacchus	62.20	0.00e+00	1565.00
IUUC-Cfa-021216	Canis familiaris	76.90	0.00e+00	1329.00
IUUC-Cpo-021466	Cavia porcellus	77.03	0.00e+00	1330.00
IUUC-Csa-023080	Chlorocebus sabaeus	65.57	0.00e+00	1881.00
IUUC-Cho-024740	Choloepus hoffmanni	82.50	0.00e+00	1025.00
IUUC-Dre-028750	Danio rerio	75.35	0.00e+00	1375.00
IUUC-Dno-030019	Dasypus novemcinctus	64.58	0.00e+00	1846.00
IUUC-Dor-031030	Dipodomys ordii	62.85	0.00e+00	957.00
IUUC-Ete-032352	Echinops telfairi	84.02	0.00e+00	1124.00
IUUC-Eca-033948	Equus caballus	70.40	0.00e+00	1358.00
IUUC-Eeu-034474	Erinaceus europaeus	63.12	0.00e+00	753.00
IUUC-Fca-036148	Felis catus	76.91	0.00e+00	1332.00
IUUC-Fal-036957	Ficedula albicollis	64.98	0.00e+00	1875.00
IUUC-Gmo-038714	Gadus morhua	66.59	0.00e+00	1072.00
IUUC-Gga-041194	Gallus gallus	64.83	0.00e+00	1865.00
IUUC-Gac-041366	Gasterosteus aculeatus	73.42	0.00e+00	2214.00
IUUC-Ggo-045442	Gorilla gorilla	60.11	0.00e+00	1482.00
IUUC-Hsa-045730	Homo sapiens	65.57	0.00e+00	1880.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	71.73	0.00e+00	1405.00
IUUC-Lch-050185	Latimeria chalumnae	60.38	0.00e+00	1594.00
IUUC-Loc-052744	Lepisosteus oculatus	82.78	0.00e+00	1335.00
IUUC-Laf-054368	Loxodonta africana	82.69	0.00e+00	1279.00
IUUC-Mcc-055487	Macaca mulatta	65.67	0.00e+00	1866.00
IUUC-Meu-056751	Macropus eugenii	86.88	0.00e+00	699.00
IUUC-Mga-059545	Meleagris gallopavo	65.34	0.00e+00	1866.00
IUUC-Mmr-061078	Microcebus murinus	72.82	0.00e+00	1284.00
IUUC-Mdo-062176	Monodelphis domestica	74.85	0.00e+00	1291.00
IUUC-Mmu-063513	Mus musculus	64.22	0.00e+00	1844.00
IUUC-Mpu-065786	Mustela putorius furo	70.65	0.00e+00	1370.00
IUUC-Mlu-067780	Myotis lucifugus	65.59	0.00e+00	1227.00
IUUC-Nle-069213	Nomascus leucogenys	65.18	0.00e+00	1855.00
IUUC-Opr-070208	Ochotona princeps	82.20	0.00e+00	1267.00
IUUC-Ont-072132	Oreochromis niloticus	86.06	0.00e+00	1499.00
IUUC-Oan-072807	Ornithorhynchus anatinus	77.30	0.00e+00	1344.00
IUUC-Ocu-074745	Oryctolagus cuniculus	71.13	0.00e+00	1391.00
IUUC-Ola-086981	Oryzias latipes	75.48	0.00e+00	2211.00
IUUC-Oga-087965	Otolemur garnettii	75.81	0.00e+00	1311.00
IUUC-Oar-089749	Ovis aries	76.96	0.00e+00	1329.00
IUUC-Ptr-091243	Pan troglodytes	65.14	0.00e+00	1878.00
IUUC-Pan-092201	Papio anubis	64.11	0.00e+00	1848.00
IUUC-Psi-093511	Pelodiscus sinensis	76.46	0.00e+00	1320.00
IUUC-Pfo-097001	Poecilia formosa	72.15	0.00e+00	1773.00
IUUC-Pab-098728	Pongo abelii	63.20	0.00e+00	1788.00
IUUC-Pca-100129	Procavia capensis	66.26	0.00e+00	989.00
IUUC-Pva-102250	Pteropus vampyrus	72.50	0.00e+00	1241.00
IUUC-Rno-105031	Rattus norvegicus	64.82	0.00e+00	1827.00
IUUC-Tgu-117515	Taeniopygia guttata	71.53	0.00e+00	1407.00
IUUC-Tru-117914	Takifugu rubripes	91.01	0.00e+00	1623.00
IUUC-Tbe-127762	Tupaia belangeri	67.34	0.00e+00	1286.00
IUUC-Ttr-128806	Tursiops truncatus	76.60	0.00e+00	1333.00
IUUC-Xtr-132903	Xenopus tropicalis	76.57	0.00e+00	1347.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence