iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-036719

Ensembl Protein ID

ENSFALP00000011879.1

UniProt Accession

U3KA25; U3KA25_FICAL

Genbank Protein ID

ENSFALP00000011879

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AGTO01010937

Gene Name

BTK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000011336.1	ENSFALT00000011928.1	ENSFALP00000011879.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.80e-12	45.7	213	270

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +++kv +ly+ye+ n  +L+l+kG+  +++  ee    W+k+  + +g++G +P+n+v++ 
   Q: 213  EMKKVVALYNYEPMNAQDLQLQKGEEYFIL--EESHLPWWKA-LDKNGREGYIPSNYVTET 270
           689**************************9..888999****.6**************975 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MASVILESIF LKRSQQKKKT SPLNFKKRLF LLTESKLSYY EYDFERGRRG SKKGSVDIEK 60
ITCVETVAPE NNPPPERQVP RKGEDYNNME QISIIERFPY PFQVVYDEGP LYIFSPTEEL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCAGCG TCATCCTGGA GAGCATCTTC CTGAAGCGCT CGCAGCAGAA GAAGAAAACG 60
TCTCCCCTCA ACTTCAAGAA GCGCCTGTTC CTGCTGACAG AGAGCAAGCT GTCCTACTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
IPR001562--Znf_Btk_motif

PROSITE

PS50003--PH_DOMAIN
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
PS51113--ZF_BTK

Pfam

PF00779--BTK
PF00169--PH
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00402--TECBTKDOMAIN
PR00109--TYRKINASE

SMART

SM00107--BTK
SM00233--PH
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005547--F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0002344--P:B cell affinity maturation
GO:0048469--P:cell maturation
GO:0098761--P:cellular response to interleukin-7
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0030889--P:negative regulation of B cell proliferation
GO:0001818--P:negative regulation of cytokine production

KEGG

fab:101820538

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001365	Ailuropoda melanoleuca	86.49	0.00e+00	1162.00
IUUC-Apl-003907	Anas platyrhynchos	95.14	0.00e+00	1262.00
IUUC-Aca-004978	Anolis carolinensis	78.76	0.00e+00	1081.00
IUUC-Bta-012467	Bos taurus	86.04	0.00e+00	1159.00
IUUC-Cja-018841	Callithrix jacchus	85.89	0.00e+00	1152.00
IUUC-Cfa-020983	Canis familiaris	86.19	0.00e+00	1134.00
IUUC-Cpo-021307	Cavia porcellus	86.65	0.00e+00	1164.00
IUUC-Csa-023508	Chlorocebus sabaeus	84.31	0.00e+00	845.00
IUUC-Dno-029828	Dasypus novemcinctus	84.95	0.00e+00	1134.00
IUUC-Dor-030102	Dipodomys ordii	78.10	0.00e+00	943.00
IUUC-Ete-032981	Echinops telfairi	79.21	0.00e+00	1036.00
IUUC-Eca-033594	Equus caballus	86.19	0.00e+00	1159.00
IUUC-Eeu-035281	Erinaceus europaeus	82.54	0.00e+00	912.00
IUUC-Fca-035495	Felis catus	85.58	0.00e+00	1127.00
IUUC-Gga-041193	Gallus gallus	95.43	0.00e+00	1263.00
IUUC-Hsa-045931	Homo sapiens	85.89	0.00e+00	1134.00
IUUC-Itr-048061	Ictidomys tridecemlineatus	86.34	0.00e+00	1160.00
IUUC-Lch-049868	Latimeria chalumnae	75.50	0.00e+00	975.00
IUUC-Laf-053516	Loxodonta africana	85.93	0.00e+00	1176.00
IUUC-Mcc-054795	Macaca mulatta	85.89	0.00e+00	1134.00
IUUC-Meu-056157	Macropus eugenii	76.48	0.00e+00	994.00
IUUC-Mga-059529	Meleagris gallopavo	95.62	0.00e+00	1080.00
IUUC-Mmr-060824	Microcebus murinus	81.94	0.00e+00	1059.00
IUUC-Mdo-063036	Monodelphis domestica	86.99	0.00e+00	1150.00
IUUC-Mmu-064047	Mus musculus	85.89	0.00e+00	1156.00
IUUC-Mpu-066810	Mustela putorius furo	86.19	0.00e+00	1160.00
IUUC-Mlu-067671	Myotis lucifugus	85.37	0.00e+00	1146.00
IUUC-Nle-069108	Nomascus leucogenys	85.89	0.00e+00	1134.00
IUUC-Opr-070505	Ochotona princeps	68.42	2.00e-173	602.00
IUUC-Oan-073495	Ornithorhynchus anatinus	86.15	0.00e+00	1182.00
IUUC-Ocu-074416	Oryctolagus cuniculus	85.89	0.00e+00	1156.00
IUUC-Oga-088995	Otolemur garnettii	85.05	0.00e+00	1125.00
IUUC-Oar-089632	Ovis aries	85.13	0.00e+00	1134.00
IUUC-Ptr-090941	Pan troglodytes	85.89	0.00e+00	1133.00
IUUC-Pan-091900	Papio anubis	83.31	0.00e+00	1090.00
IUUC-Psi-093048	Pelodiscus sinensis	88.77	0.00e+00	1160.00
IUUC-Pab-097587	Pongo abelii	85.89	0.00e+00	1134.00
IUUC-Pca-100374	Procavia capensis	75.25	3.00e-127	448.00
IUUC-Pva-102583	Pteropus vampyrus	86.04	0.00e+00	1130.00
IUUC-Rno-104868	Rattus norvegicus	81.57	0.00e+00	1074.00
IUUC-Sha-106744	Sarcophilus harrisii	86.04	0.00e+00	1169.00
IUUC-Sar-113041	Sorex araneus	85.25	0.00e+00	1008.00
IUUC-Ssc-115294	Sus scrofa	86.04	0.00e+00	1159.00
IUUC-Tsy-118945	Tarsius syrichta	84.98	0.00e+00	768.00
IUUC-Ttr-128769	Tursiops truncatus	77.39	0.00e+00	1028.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence