iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-064155

UUCD1 version

UUC-MuM-00591

Ensembl Protein ID

ENSMUSP00000039955.7

UniProt Accession

Q80XL1; Q99PB6; Q9D6L2; Q9D7A9; CBLC_MOUSE

Genbank Protein ID

AAK01405.1; BAB26265.1; BAB26782.1; AAH46337.1

Protein Name

E3 ubiquitin-protein ligase CBL-C; RING-type E3 ubiquitin transferase CBL-C; SH3-binding protein CBL-3; SH3-binding protein CBL-C; Signal transduction protein CBL-C

Genbank Nucleotide ID

AF319956; AK009399; AK010228; BC046337

Gene Name

Cblc; Cbl3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000040525.13	ENSMUST00000108449.8	ENSMUSP00000104088.2
ENSMUSG00000040525.13	ENSMUST00000043822.7	ENSMUSP00000039955.7

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	74.66	0.00e+00	650.00	IUUC-Hsa-045735

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-424', has the highest ubiquitin ligase activity among CBL family proteins. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.

Protein Sequence
(Fasta)

MAAAAAPRGW QRGEPRALSR AVKLLQRLEE QCRDPRMVTG PPSLRDLLPR TAQLLGEVAK 60
ARREAREDPE GPGGADDFLA IYLANLEVKG RQVAELLPPR GKKDVNQDVF REGSRFRRQL 120

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Nucleotide Sequence
(Fasta)

CCCAGTCCCA AGCCACCCGA GGGACCCATG GCTGCGGCGG CAGCCCCGCG AGGGTGGCAG 60
CGGGGCGAGC CACGCGCGCT TAGCCGGGCG GTGAAGTTGC TCCAGCGCCT AGAAGAGCAA 120

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Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0106--Calcium
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0729--SH3-binding
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3

SMART

SM00184--RING

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0005509--F:calcium ion binding
GO:0005154--F:epidermal growth factor receptor binding
GO:0001784--F:phosphotyrosine binding
GO:0030971--F:receptor tyrosine kinase binding
GO:0017124--F:SH3 domain binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0043407--P:negative regulation of MAP kinase activity
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006508--P:proteolysis
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:80794

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002286	Ailuropoda melanoleuca	68.61	5.00e-173	600.00
IUUC-Bta-012705	Bos taurus	70.14	0.00e+00	630.00
IUUC-Cja-019179	Callithrix jacchus	74.88	0.00e+00	652.00
IUUC-Cfa-020593	Canis familiaris	68.30	1.00e-171	595.00
IUUC-Cpo-021289	Cavia porcellus	71.63	3.00e-167	581.00
IUUC-Csa-023966	Chlorocebus sabaeus	73.32	3.00e-170	591.00
IUUC-Dor-030246	Dipodomys ordii	74.43	8.00e-129	453.00
IUUC-Eca-033921	Equus caballus	63.28	7.00e-136	477.00
IUUC-Fca-035747	Felis catus	57.60	2.00e-156	545.00
IUUC-Ggo-044622	Gorilla gorilla	78.86	3.00e-149	521.00
IUUC-Hsa-045735	Homo sapiens	74.88	0.00e+00	643.00
IUUC-Itr-049001	Ictidomys tridecemlineatus	76.01	3.00e-169	587.00
IUUC-Laf-053983	Loxodonta africana	70.46	0.00e+00	652.00
IUUC-Mmr-061310	Microcebus murinus	65.70	2.00e-174	605.00
IUUC-Mpu-066655	Mustela putorius furo	72.92	2.00e-178	618.00
IUUC-Mlu-067929	Myotis lucifugus	76.22	4.00e-142	496.00
IUUC-Nle-070065	Nomascus leucogenys	61.75	8.00e-142	496.00
IUUC-Ocu-074049	Oryctolagus cuniculus	75.26	1.00e-129	456.00
IUUC-Oga-087952	Otolemur garnettii	75.11	0.00e+00	667.00
IUUC-Oar-089382	Ovis aries	69.14	2.00e-175	608.00
IUUC-Pan-092075	Papio anubis	73.78	8.00e-171	593.00
IUUC-Pab-098100	Pongo abelii	66.82	3.00e-158	551.00
IUUC-Pca-100830	Procavia capensis	72.33	5.00e-104	371.00
IUUC-Pva-102714	Pteropus vampyrus	72.22	3.00e-160	558.00
IUUC-Rno-105348	Rattus norvegicus	86.72	0.00e+00	837.00
IUUC-Sha-107138	Sarcophilus harrisii	70.07	5.00e-122	430.00
IUUC-Ssc-116424	Sus scrofa	71.31	0.00e+00	662.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence