iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000023734.10	ENST00000541731.1	ENSP00000445693.1
ENSG00000023734.10	ENST00000025399.10	ENSP00000025399.6
ENSG00000023734.10	ENST00000419869.6	ENSP00000392270.2
ENSG00000023734.10	ENST00000538718.1	ENSP00000445814.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.40e-25	87.3	276	307

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sdtll.vsGsdDgtikvWDl 30
           gH ++++c++f +d+ l +sGs Dgt+++W +
   Q: 276  GHFGPIHCVRFsPDGELyASGSEDGTLRLWQT 307
           799*********997776************85 PP

Organism

Homo sapiens

Functional Description
(View)

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein.

Protein Sequence
(Fasta)

MAMRQTPLTC SGHTRPVVDL AFSGITPYGY FLISACKGAG QHLPRLSGQH DGKPMLRQGD 60
TGDWIGTFLG HKGAVWGATL NKDATKAATA AADFTAKVWD AVSGDELMTL AHKHIVKTVD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCACTTCCT GCCGATGCCG GTGTGGACGC TGTGAATCGT GGCTGGCCCG GTTCTCCGCT 60
TCTCCCCATC CCCTACTTTC CTCCCTCCCT CCCTTTCCCT CCCTCGTCGA CTGTTGCTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR023302--Pept_S9A_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0032797--C:SMN complex
GO:0034719--C:SMN-Sm protein complex
GO:0003723--F:RNA binding
GO:0030277--P:maintenance of gastrointestinal epithelium
GO:0010633--P:negative regulation of epithelial cell migration
GO:0050680--P:negative regulation of epithelial cell proliferation
GO:0010719--P:negative regulation of epithelial to mesenchymal transition
GO:0060394--P:negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0000387--P:spliceosomal snRNP assembly

KEGG

hsa:11171

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000668	Aegilops tauschii	47.84	4.00e-73	268.00
IUUC-Aml-002091	Ailuropoda melanoleuca	95.60	0.00e+00	650.00
IUUC-Atr-002571	Amborella trichopoda	49.34	1.00e-75	276.00
IUUC-Apl-003327	Anas platyrhynchos	85.03	1.00e-143	502.00
IUUC-Aca-005324	Anolis carolinensis	83.47	2.00e-163	568.00
IUUC-Aly-006452	Arabidopsis lyrata	47.88	2.00e-74	272.00
IUUC-Ath-006646	Arabidopsis thaliana	47.88	2.00e-74	272.00
IUUC-Acl-008014	Aspergillus clavatus	38.86	2.00e-45	176.00
IUUC-Afl-008701	Aspergillus flavus	38.33	5.00e-30	125.00
IUUC-Afu-008942	Aspergillus fumigatus	30.33	7.00e-32	131.00
IUUC-Ani-009394	Aspergillus nidulans	39.60	6.00e-46	177.00
IUUC-Ang-009593	Aspergillus niger	37.22	3.00e-32	132.00
IUUC-Aor-010206	Aspergillus oryzae	40.69	3.00e-46	179.00
IUUC-Ame-011328	Astyanax mexicanus	80.06	9.00e-142	496.00
IUUC-Bgr-012308	Blumeria graminis	38.24	1.00e-52	200.00
IUUC-Bta-013429	Bos taurus	94.21	0.00e+00	634.00
IUUC-Bci-013803	Botrytis cinerea	38.31	5.00e-51	194.00
IUUC-Bdi-014996	Brachypodium distachyon	47.16	4.00e-73	268.00
IUUC-Bol-016595	Brassica oleracea	48.20	1.00e-76	279.00
IUUC-Bra-017775	Brassica rapa	47.39	2.00e-75	277.00
IUUC-Cja-018740	Callithrix jacchus	96.97	0.00e+00	667.00
IUUC-Cfa-021145	Canis familiaris	94.49	0.00e+00	635.00
IUUC-Cpo-022373	Cavia porcellus	93.94	0.00e+00	634.00
IUUC-Cre-022806	Chlamydomonas reinhardtii	42.30	3.00e-57	215.00
IUUC-Csa-023098	Chlorocebus sabaeus	95.59	0.00e+00	645.00
IUUC-Cho-024856	Choloepus hoffmanni	84.85	1.00e-156	545.00
IUUC-Cin-025541	Ciona intestinalis	56.04	4.00e-100	357.00
IUUC-Csv-026287	Ciona savignyi	55.63	4.00e-90	324.00
IUUC-Cgl-026513	Colletotrichum gloeosporioides	39.24	1.00e-50	193.00
IUUC-Cne-026869	Cryptococcus neoformans	44.38	1.00e-66	246.00
IUUC-Dre-028457	Danio rerio	80.49	3.00e-145	507.00
IUUC-Dno-029213	Dasypus novemcinctus	92.56	0.00e+00	630.00
IUUC-Dse-031350	Dothistroma septosporum	38.29	7.00e-46	177.00
IUUC-Dme-031857	Drosophila melanogaster	58.31	4.00e-104	371.00
IUUC-Ete-032558	Echinops telfairi	83.76	1.00e-118	419.00
IUUC-Eca-033934	Equus caballus	94.49	0.00e+00	634.00
IUUC-Eeu-034650	Erinaceus europaeus	95.11	6.00e-145	506.00
IUUC-Fca-035909	Felis catus	94.49	0.00e+00	637.00
IUUC-Fal-036706	Ficedula albicollis	85.94	6.00e-141	493.00
IUUC-Fox-037780	Fusarium oxysporum	39.26	1.00e-48	187.00
IUUC-Fso-038197	Fusarium solani	39.19	2.00e-50	192.00
IUUC-Gmo-039707	Gadus morhua	75.16	3.00e-131	461.00
IUUC-Ggr-040054	Gaeumannomyces graminis	38.22	2.00e-51	196.00
IUUC-Gga-040901	Gallus gallus	84.02	2.00e-168	584.00
IUUC-Gac-041876	Gasterosteus aculeatus	77.64	2.00e-140	491.00
IUUC-Gma-044014	Glycine max	48.68	2.00e-75	276.00
IUUC-Ggo-044583	Gorilla gorilla	89.29	2.00e-171	595.00
IUUC-Hvu-047544	Hordeum vulgare	46.53	3.00e-75	275.00
IUUC-Itr-047980	Ictidomys tridecemlineatus	94.77	0.00e+00	643.00
IUUC-Lch-050078	Latimeria chalumnae	79.12	3.00e-153	534.00
IUUC-Lpe-051246	Leersia perrieri	48.68	8.00e-76	277.00
IUUC-Loc-052598	Lepisosteus oculatus	75.27	2.00e-148	518.00
IUUC-Lma-053226	Leptosphaeria maculans	43.12	1.00e-52	200.00
IUUC-Laf-054053	Loxodonta africana	93.11	0.00e+00	634.00
IUUC-Mcc-054652	Macaca mulatta	96.72	0.00e+00	655.00
IUUC-Mor-057256	Magnaporthe oryzae	37.14	2.00e-48	186.00
IUUC-Mpo-057303	Magnaporthe poae	38.57	8.00e-52	197.00
IUUC-Mtr-058421	Medicago truncatula	48.68	2.00e-75	276.00
IUUC-Mla-059073	Melampsora laricipopulina	43.33	1.00e-60	226.00
IUUC-Mga-059664	Meleagris gallopavo	84.02	2.00e-168	585.00
IUUC-Mvi-060534	Microbotryum violaceum	33.67	6.00e-37	148.00
IUUC-Mmr-061044	Microcebus murinus	95.83	3.00e-179	620.00
IUUC-Mdo-063019	Monodelphis domestica	90.91	5.00e-179	620.00
IUUC-Mmu-064092	Mus musculus	94.21	0.00e+00	634.00
IUUC-Mac-065143	Musa acuminata	49.17	2.00e-74	272.00
IUUC-Mpu-066557	Mustela putorius furo	94.77	0.00e+00	643.00
IUUC-Mlu-068179	Myotis lucifugus	93.11	0.00e+00	632.00
IUUC-Nfi-068553	Neosartorya fischeri	38.86	4.00e-45	175.00
IUUC-Ncr-068934	Neurospora crassa	36.54	4.00e-45	175.00
IUUC-Nle-069482	Nomascus leucogenys	99.17	0.00e+00	686.00
IUUC-Opr-071055	Ochotona princeps	73.28	3.00e-128	451.00
IUUC-Ont-072663	Oreochromis niloticus	72.15	4.00e-137	480.00
IUUC-Ocu-074942	Oryctolagus cuniculus	94.49	0.00e+00	635.00
IUUC-Oba-075160	Oryza barthii	48.52	7.00e-76	277.00
IUUC-Obr-076864	Oryza brachyantha	48.68	9.00e-76	276.00
IUUC-Ogl-077076	Oryza glaberrima	48.52	9.00e-76	277.00
IUUC-Ogu-078591	Oryza glumaepatula	48.52	7.00e-76	277.00
IUUC-Oin-079631	Oryza indica	47.37	4.00e-74	271.00
IUUC-Olo-080389	Oryza longistaminata	44.60	1.00e-50	192.00
IUUC-Ome-081693	Oryza meridionalis	47.19	6.00e-73	267.00
IUUC-Oni-082190	Oryza nivara	48.85	5.00e-76	277.00
IUUC-Opu-084163	Oryza punctata	48.52	7.00e-76	277.00
IUUC-Oru-084730	Oryza rufipogon	48.52	7.00e-76	277.00
IUUC-Osa-086010	Oryza sativa	48.52	8.00e-76	277.00
IUUC-Ola-086704	Oryzias latipes	73.08	1.00e-145	508.00
IUUC-Olu-087796	Ostreococcus lucimarinus	48.70	4.00e-76	277.00
IUUC-Oga-088932	Otolemur garnettii	72.48	4.00e-126	444.00
IUUC-Oar-090398	Ovis aries	94.49	0.00e+00	635.00
IUUC-Ptr-091202	Pan troglodytes	96.42	0.00e+00	655.00
IUUC-Pan-091948	Papio anubis	95.87	0.00e+00	652.00
IUUC-Psi-093863	Pelodiscus sinensis	81.85	4.00e-148	517.00
IUUC-Pma-094255	Petromyzon marinus	74.93	5.00e-139	487.00
IUUC-Pno-095075	Phaeosphaeria nodorum	43.87	2.00e-55	209.00
IUUC-Ppa-095169	Physcomitrella patens	48.71	1.00e-77	283.00
IUUC-Pfo-096438	Poecilia formosa	73.35	3.00e-144	504.00
IUUC-Pab-097994	Pongo abelii	95.59	0.00e+00	650.00
IUUC-Pop-099172	Populus trichocarpa	47.70	1.00e-74	273.00
IUUC-Pca-100761	Procavia capensis	84.82	6.00e-153	533.00
IUUC-Ppe-102035	Prunus persica	49.34	2.00e-73	269.00
IUUC-Pva-102794	Pteropus vampyrus	85.67	3.00e-162	564.00
IUUC-Pgr-103581	Puccinia graminis	44.38	2.00e-61	229.00
IUUC-Ptt-103862	Puccinia triticina	44.41	3.00e-59	221.00
IUUC-Pte-104245	Pyrenophora teres	44.17	2.00e-55	209.00
IUUC-Pyt-104537	Pyrenophora triticirepentis	44.17	2.00e-55	209.00
IUUC-Rno-105712	Rattus norvegicus	94.49	0.00e+00	635.00
IUUC-Sha-107568	Sarcophilus harrisii	90.08	2.00e-177	614.00
IUUC-Ssl-108655	Sclerotinia sclerotiorum	37.46	2.00e-49	189.00
IUUC-Smo-108784	Selaginella moellendorffii	51.48	4.00e-80	291.00
IUUC-Sit-109807	Setaria italica	49.83	9.00e-77	281.00
IUUC-Sly-111555	Solanum lycopersicum	49.17	1.00e-74	273.00
IUUC-Stu-111953	Solanum tuberosum	48.51	7.00e-74	270.00
IUUC-Sar-113491	Sorex araneus	86.25	4.00e-119	420.00
IUUC-Sbi-114290	Sorghum bicolor	49.50	6.00e-77	281.00
IUUC-Sre-115008	Sporisorium reilianum	41.69	1.00e-60	226.00
IUUC-Ssc-116392	Sus scrofa	95.59	0.00e+00	654.00
IUUC-Tgu-116835	Taeniopygia guttata	85.94	1.00e-141	495.00
IUUC-Tru-117558	Takifugu rubripes	73.70	6.00e-146	510.00
IUUC-Tsy-119522	Tarsius syrichta	91.74	3.00e-172	597.00
IUUC-Tni-120330	Tetraodon nigroviridis	78.61	2.00e-140	491.00
IUUC-Tca-121759	Theobroma cacao	49.34	8.00e-75	273.00
IUUC-Tre-122163	Trichoderma reesei	39.37	1.00e-48	187.00
IUUC-Tvi-122609	Trichoderma virens	40.29	1.00e-49	190.00
IUUC-Tae-123053	Triticum aestivum	48.03	2.00e-74	272.00
IUUC-Tur-126808	Triticum urartu	47.13	4.00e-63	234.00
IUUC-Tme-127137	Tuber melanosporum	45.17	3.00e-64	238.00
IUUC-Tbe-127324	Tupaia belangeri	84.19	2.00e-94	338.00
IUUC-Ttr-128202	Tursiops truncatus	93.94	0.00e+00	629.00
IUUC-Uma-129433	Ustilago maydis	41.99	8.00e-60	223.00
IUUC-Vda-129675	Verticillium dahliae	37.78	2.00e-49	189.00
IUUC-Vpa-130382	Vicugna pacos	94.49	0.00e+00	635.00
IUUC-Vvi-131432	Vitis vinifera	49.67	5.00e-78	284.00
IUUC-Xtr-132648	Xenopus tropicalis	69.38	3.00e-131	461.00
IUUC-Xma-133969	Xiphophorus maculatus	69.78	6.00e-135	473.00
IUUC-Yli-134670	Yarrowia lipolytica	32.72	7.00e-41	160.00
IUUC-Zma-135878	Zea mays	49.50	4.00e-77	281.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence